ライフサイエンスコーパス: abuse

1 comorbid with both pain disorders and opioid abuse.

2 between the risk factors for HIV and opioid abuse.

3 ed risk of adverse events and chronic opioid abuse.

4 al responses associated with chronic alcohol abuse.

5 to predispose individuals for future alcohol abuse.

6 al and physiological adaptations to drugs of abuse.

7 t for HIV, hepatitis C virus (HCV), and drug abuse.

8 east, and history of depression or substance abuse.

9 synthesis and the reward value for drugs of abuse.

10 ccumbens or behavioral responses to drugs of abuse.

11 ociated with long-term development of opioid abuse.

12 comorbidity with chronic pain) and substance abuse.

13 id drug (2.2% vs 0.2%, P = 0.023) dependence/abuse.

14 d/or therapeutic targets for human substance abuse.

15 gene expression associated with human opioid abuse.

16 ial in preclinical models of psychostimulant abuse.

17 utes to the subsequent development of opioid abuse.

18 iolence or worsening of ongoing violence and abuse.

19 e somatic diseases, pregnancy, and substance abuse.

20 or fast, on-site detection tools of drugs of abuse.

21 s been implicated in the effects of drugs of abuse.

22 uitry that contributes to subsequent alcohol abuse.

23 ness of BE procedures in the study of opioid abuse.

24 unity violence, and no emotional or physical abuse.

25 cussed as a key process underlying substance abuse.

26 ons for serious infections related to opioid abuse.

27 ular heart disease, tobacco use, and alcohol abuse.

28 in clinical use and are common substances of abuse.

29 , immunocompromising comorbidities, and drug abuse.

30 s, aortic valve disease, smoking, or alcohol abuse.

31 anxiety, depression, and comorbid substance abuse.

32 of drug seeking and motivation for drugs of abuse.

33 owing concerns about PPI misuse, overuse and abuse.

34 parameter >=248 dB/m, in absence of alcohol abuse.

35 including depression, anxiety, and substance abuse.

36 roles in intracellular responses to drugs of abuse.

37 binatorial strategies for treating stimulant abuse.

38 gns and symptoms of withdrawal from drugs of abuse.

39 of frustration, physical pain, and substance abuse.

40 workers than men and are often devalued and abused.

41 using remote sensing to detect forced labor abuses.

42 ues (+2 points), and prior illicit substance abuse (+1 point).

43 cirrhosis (59.8%), diabetes (27.2%), alcohol abuse (17.7%), hepatocellular carcinoma (17.5%), or a li

44 present, as compared to none of them: sexual abuse, 2.39% to 1.80% (ARD: -0.59% points, 95% CI -2.24

45 ellitus; 2.22 (95% CI 1.58-3.11) for alcohol abuse; 2.37 (95% CI 1.53-3.68) for liver disease; 2.04 (

46 81.4 billion to $91.2 billion; and fraud and abuse, $22.8 billion to $30.8 billion.

47 % CI -19.11 to -10.33, p < 0.001); emotional abuse, 25.39% and 12.98% (ARD: -12.41% points, 95% CI -1

48 95% CI -7.26 to -3.20, p < 0.001); physical abuse, 38.58% and 23.85% (ARD: -14.72% points, 95% CI -1

49 icemia (14.0% vs. 7.3%; p < 0.001), and drug abuse (4.3% vs. 0.7%; p < 0.001) compared with medically

50 ts, ex-military personnel and after physical abuse(4-7).

51 present, as compared to none of them: sexual abuse, 5.38% and 1.64% (ARD: -3.74% points, 95% CI -5.31

52 ent sources of sexual harassment (27.2%) and abuse (51.9%).

53 ticemia (15.6% vs. 5.2%; p < 0.001) and drug abuse (7.3% vs. 0.9%; p < 0.001) compared with non-IDU-I

54 Although opioids and most other drugs of abuse acutely increase signaling mediated by midbrain do

55 risk of adverse outcomes, including misuse, abuse, addiction, and overdose, arising from use of TIRF

56 eous prediction of the three most frequently abused addictive drugs with the sensitivity and accuracy

57 multivariable analysis, a history of alcohol abuse (adjusted OR, 2.41; P=0.01) and increased baseline

58 long-term opioid therapy or active substance abuse, age 65 years or older, and sleep apnea should be

59 ointing toward an interaction between sexual abuse, age, urbanicity, and education.

60 upport; (2) limited cognition; (3) substance abuse (alcohol and drug); (4) severe psychiatric disease

61 cent major surgery, and history of substance abuse, alcohol abuse, and self-harm/suicide were associa

62 In FND, physical abuse also correlated with amygdala and insula coupling

63 Drugs of abuse also upregulate DeltaFosB in hippocampus, but the

64 ders (SUDs) and chronic exposure to drugs of abuse alters circadian rhythms, which may contribute to

65 Chronic alcohol abuse alters the molecular structure and function of bra

66 nt data on the prevalence of additional drug abuse among those misusing prescription opioids.

67 bout previous psychiatric illness, substance abuse and abdominal surgery.

68 s for the prevention and treatment of opioid abuse and addiction is essential and urgently required.

69 erapeutics that have a low or absent risk of abuse and addiction relative to u-opioid agonists.

70 ecision-making is a defining feature of drug abuse and addiction, we have yet to ascertain how cocain

71 pamine system are postulated to drive opioid abuse and addiction.

72 ential to be a lead compound to treat opioid abuse and addiction.

73 Alcohol abuse and alcohol dependence are key factors in the deve

74 europsychiatric disorders, particularly drug abuse and attention-deficit/hyperactivity disorder (ADHD

75 als HCV/HIV co-infection, older age, alcohol abuse and CD4/CD8 ratio seem to correlate with fibrogene

76 pain sensation, fear and anxiety, substance abuse and cell death.

77 ed from 65 women with histories of childhood abuse and current posttraumatic stress disorder (PTSD).

78 ulnerable populations at high risk of opioid abuse and death.

79 Chronic METH abuse and dependence predispose the users to participate

80 nificantly increased risk for substance use, abuse and dependence.

81 ds, including antidepressants, substances of abuse and drugs for neuropsychiatric and neurodegenerati

82 Given the increasing reports of abuse and evidence of potential harms associated with ga

83 d maltreatment (CM) comprises experiences of abuse and neglect during childhood.

84 ly invasive transdermal analysis of drugs of abuse and nerve agents holds promise for rapid counterme

85 ation of multiple substances (i.e., drugs of abuse and pesticides) in complex matrices.

86 ecision-making-typified by chronic substance abuse and relapse-observed after drug use.

87 iscovered signatures of age-dependent sexual abuse and sex-dependent physical and sexual abuse, as we

88 Environmental factors, including substance abuse and stress, cause long-lasting changes in the regu

89 rug-seeking associated with several drugs of abuse and thus represents a promising pharmacological ap

90 act the life threatening effects of drugs of abuse and toxins can occur either by pharmacodynamic (PD

91 predicts negative outcomes such as substance abuse and traumatic stress disorders.

92 and Non-Meth-ICH were defined by history of abuse and urine drug screen (UDS).

93 use often progresses into a vicious cycle of abuse and withdrawal, resulting in very high rates of re

94 y, intra- or intercultural conflicts, direct abuse and/or neglect by camp staff and security personne

95 r low-value care, pricing failure, fraud and abuse, and administrative complexity.

96 is adjusted for stroke, head trauma, alcohol abuse, and cancer showed 1-year, 2-5 year, and 6-30 year

97 ict, forcible displacement, childhood sexual abuse, and domestic violence are increasingly prevalent.

98 the 10-item ACEs questions covering neglect, abuse, and household dysfunction.

99 behavioral risk factors of smoking, alcohol abuse, and lack of physical activity, economic (e.g., re

100 There was minimal evidence of abuse, and no evidence of dependence or opioid withdrawa

101 The tolerance, abuse, and potential exacerbation associated with classi

102 Cycles of incarceration, drug abuse, and poverty undermine ongoing public health effor

103 s, malignancies, mental disorders, substance abuse, and road injuries.

104 ery, and history of substance abuse, alcohol abuse, and self-harm/suicide were associated with long-t

105 nt (i.e., discrimination, verbal or physical abuse, and sexual harassment) may contribute to burnout

106 ad a higher prevalence of dyslipidemia, drug abuse, and smoking.

107 rofoundly altered after exposure to drugs of abuse, and some of the functional changes continue to ev

108 Pharmaceutical agents, drugs of abuse, and toxic substances have a large impact, positiv

109 earning, motivated behavior, psychostimulant abuse, and, more recently, sleep/wake state.

110 ids (AAS) have medical utility but are often abused, and the effects of AAS on reward circuits in the

111 .81, 95% CI 1.49-2.19, p < 0.001), substance abuse (aOR 1.72, 95% CI 1.65-1.79, p < 0.001), suicide/s

112 are demonstrated through an electrochemical abuse approach.

113 projection neurons (SPNs) evoked by drugs of abuse are critical for the development of addiction.

114 age group and whether neglect and emotional abuse are increasing.

115 al support, medical adherence, and substance abuse, are emphasized in advanced heart failure and furt

116 ogic findings of patients reporting physical abuse arising from IPV during the statewide COVID-19 pan

117 abuse and sex-dependent physical and sexual abuse, as well as emotional trauma, which projected onto

118 ned the association between childhood sexual abuse (before 18 years of age) and long-term consequence

119 individual differences in childhood physical abuse burden advance our understanding of the pathophysi

120 ith dependence on opiates and other drugs of abuse but its mechanism is unknown.

121 in the acute and chronic effects of drugs of abuse, but their upstream mediators have not been extens

122 signal mechanism would be effective against abuse by cancer if it affects the cell that generates th

123 However, ketamine tends to be abused by adolescents and young adults.

124 lic and genetic diseases, as well as alcohol abuse can also influence both hepatic and cardiovascular

125 or example concerning injuries and substance abuse, cancer, and osteoporosis.

126 ne in trauma but a 35% increase in substance abuse cases during the COVID-19 period.

127 ns of elder or child care neglect and animal abuse cases), requires accurate determination of insect

128 Drugs of abuse cause significant neuroadaptations within the vent

129 , Hepatitis C virus (HCV) infection, alcohol abuse, CD4/CD8 ratio and an increased number of liver re

130 identify diagnoses of cannabis dependence or abuse (CDOA) and associations [adjusted hazard ratio (aH

131 Ethanol is a commonly used and abused chemical substance that affects the prognosis of

132 ability for subject assignment to the opioid abuse cohort, and genes most similarly affected in chron

133 xual exploitation, physical abuse, emotional abuse, community violence victimisation, and youth lawbr

134 ns but also shields those distributing child abuse content, selling or buying illicit drugs, or shari

135 Cocaine abuse continues to be a serious health problem worldwide

136 In exploratory analyses, physical abuse correlated connectivity maps overlapped with the A

137 ells that may contribute to continued opioid abuse, craving, and relapse.

138 in both the care of victims of child sexual abuse (CSA) and the investigation of suspected CSA incid

139 h care services until the late stages of the abuse cycle during the COVID-19 pandemic.

140 sities of alcohol use disorder (AUD) or drug abuse (DA).

141 The incidence of high-risk abuse defined by mechanism was two times greater in 2020

142 ciated with mechanism-of-action of substance abuse disorder for several marketed drugs (such as aripi

143 Substance abuse disorders are linked to alteration of circadian rh

144 development of strategies to treat substance abuse disorders.

145 roposed method could be utilized to identify abuse drugs.

146 Prior exposure to abused drugs leads to long-lasting neuroadaptations culm

147 Contextual memory driven by abused drugs such as opiates has a central role in maint

148 ons similar to those produced by exposure to abused drugs.

149 unction of psychiatric illnesses and certain abused drugs.

150 rapies may reduce demand for many classes of abused drugs.

151 nmental moderators (e.g., sexual or physical abuse during childhood, socioeconomic adversity).

152 transactional sexual exploitation, physical abuse, emotional abuse, community violence victimisation

153 lation, with notably high rates of emotional abuse, emotional neglect, and household dysfunction.

154 and 16 years (sexual, physical, or emotional abuse; emotional neglect; parental substance abuse; pare

155 In the era of opioid abuse epidemics, there is an increased demand for unders

156 or GI clinics if a positive history of opium abuse exists.

157 tified treatment barriers including, alcohol abuse, family conflicts, and mental health issues.

158 samples, which were subjected to temperature abuse for 6 hours.

159 5% CI -16.91 to -6.58, p < 0.001); emotional abuse from 23.72% to 10.72% (ARD: -13.00% points, 95% CI

160 95% CI -4.77 to -0.08, p = 0.043); physical abuse from 37.19% to 25.44% (ARD: -11.74% points, 95% CI

161 When women experienced physical abuse from providers within 1 h before childbirth, their

162 J.C.) from the US National Institute on Drug Abuse has been added to the Acknowledgements in the HTML

163 genetic factors influencing alcohol use and abuse has progressed tremendously; numerous loci have be

164 Methamphetamine (Meth) abuse has reached epidemic proportions in many countries

165 exploited to modulate responses to drugs of abuse have produced contrasting results, in part because

166 olence (hazard ratio=2.72), childhood sexual abuse (hazard ratio=1.85), and medication nonadherence (

167 Three percent had an alcoholism or substance abuse history, 6.4% had hepatitis B and/or C, and 1.1% h

168 significantly correlated with oral opium use/abuse, history of addiction for over the preceding 12 ye

169 ssion for endocarditis, septicemia, and drug abuse, IDU-IE presents a serious challenge to current ma

170 Cocaine is the second most abused illicit drug in the United States.

171 alent psychosocial risk factor was substance abuse in 1941 (12.6%) recipients.

172 galanin (GAL) gene with anxiety and alcohol abuse in different male populations but were unable to d

173 hat the detection of metabolites of drugs of abuse in fingerprints can be used to confirm a drug has

174 (MSEW), which mimics early life neglect and abuse in humans.

175 reased susceptibility to anxiety and alcohol abuse in men.

176 protein array capable of detecting drugs of abuse in solution or in vapour phase was investigated.

177 e foods and enhanced sensitivity to drugs of abuse in the resultant offspring.

178 Opioid abuse in the United States has been declared a national

179 clock can predispose or exacerbate substance abuse in vulnerable individuals.

180 the formation of dependence to many drugs of abuse including alcohol.

181 efficacy in animal models of psychostimulant abuse, including cocaine self-administration, without th

182 , synthetic marijuana, and prescription drug abuse, including several categorized and continuous indi

183 Drugs of abuse increase dopamine (DA) concentration in these brai

184 aversive properties associated with drugs of abuse influence both the development of addiction and re

185 How exactly drugs of abuse interact with individual vulnerability is not full

186 ization of behavioral interventions and drug abuse intervention.

187 Drug abuse is a global problem, requiring an interdisciplinar

188 Opioid abuse is an epidemic in the United States and trauma can

189 ICANCE STATEMENT The pandemic of opioid drug abuse is associated with many socioeconomic burdens.

190 ers are more likely HIV-infected, and opiate abuse is associated with more severe neuroinflammation.

191 This abuse is classified as gene doping, which is banned in s

192 al underpinnings of abstinence from drugs of abuse is critical to allow better recovery and ensure re

193 Opioid abuse is now the most common cause of accidental death i

194 Risk factors include intravenous drug abuse (IVDA), diabetes, indwelling catheters, and immune

195 Alcohol abuse leads to aberrant forms of emotionally salient mem

196 ith promising analgesic activity and reduced abuse liabilities into a more stable series of benzylic

197 tagonist should provide an analgesic without abuse liability and an improved side-effect profile.

198 notoriously unique properties, such as lower abuse liability and induced relief of withdrawal symptom

199 , respiratory suppression, constipation, and abuse liability detract from the general activation of t

200 neuronal connectivity may explain heightened abuse liability in individuals with a history of chronic

201 ilitation of electrotonic coupling and lower abuse liability, which may be exploited in future therap

202 low risk of adverse effects, particularly no abuse liability.

203 tive properties of ketamine and may lack its abuse liability.

204 utic effects of ketamine and appears to lack abuse liability.

205 The antibiotic abuse may cause allergic reactions, resistance in microo

206 rates of certain types of cancer, substance abuse, mental health conditions, infections, and chronic

207 agents for neuromuscular blockers, drugs of abuse (methamphetamine and fentanyl), anesthetics, neuro

208 P-XR in a health-care setting also mitigates abuse, misuse, diversion, and unintentional exposure.

209 Commonly, drugs of abuse modulate the dopaminergic system to induce addicti

210 ectious Diseases, National Institute on Drug Abuse, National Institute of Mental Health, and Massachu

211 ectious Diseases, National Institute on Drug Abuse, National Institute of Mental Health, and the Pres

212 and includes physical, emotional and sexual abuse, neglect and exploitation.

213 priorities by the National Institute on Drug Abuse (NIDA).

214 United States National Institute of Drug Abuse (NIDA).

215 ool enrolment, school progression, no sexual abuse, no high-risk sex, no violence perpetration, no co

216 Connectivity profiles influenced by physical abuse occurred in limbic (amygdalar-hippocampal), parali

217 ain reason for development of the disease is abuse of alcohol and nicotine, but only little data on f

218 ogenesis, virus structure, the viral use and abuse of cellular pathways, and applied double-stranded

219 Due to the widespread abuse of opioids in recent years, the development of qui

220 extreme cases can contribute to neglect and abuse of patients.

221 le testing are not as widely recognized, and abuse of researcher degrees of freedom has received litt

222 tiple testing that arise in model selection, abuse of researcher degrees of freedom, and hypothesis t

223 ployed MRI to assess the effects of ketamine abuse on cerebral gray matter volume (GMV) and functiona

224 , effect of the depression PRS and childhood abuse on depression outcomes.

225 However, the impact of opioid abuse on HIV reservoirs remains unclear.

226 s important to study the effects of drugs of abuse on HIV-infection and immune responses.

227 fishing vessels potentially engaged in these abuses on a global scale.

228 of OxR1 antagonism on demand for the highly abused opioid fentanyl.

229 r studies suggested that people with HIV who abuse opioids had higher reservoirs in CNS than the lymp

230 lasma concentrations to block drug-liking of abused opioids over the entire monthly dosing period, wh

231 HIV reservoirs among people living with HIV abusing opioids could be considered for future HIV cure

232 People infected with HIV also abusing opioids have immune modulatory effects and more

233 associated with tobacco consumption, alcohol abuse or both, whereas pharynx cancers are increasingly

234 for Mental Disorders-IV criteria for alcohol abuse or dependence.

235 He denied alcohol abuse or recreational drug use.

236 ly to people with addictions such as alcohol abuse or smoking(6,7).

237 imination, 30.3% reported verbal or physical abuse (or both), and 10.3% reported sexual harassment.

238 nts who reported exposure to discrimination, abuse, or harassment at least a few times per month were

239 sful environments, e.g., exposure to trauma, abuse, or neglect.

240 hether the risk of future opioid dependence, abuse, or poisoning can be predicted in advance of an in

241 Conversely, cancer cells evolve their abuse over the cancer's lifespan by out-competing their

242 experiencing epidemics of opioid misuse and abuse over this period.

243 abuse; emotional neglect; parental substance abuse; parental mental illness or suicide attempt; viole

244 together form a risk profile for drug use or abuse, particularly in young adults.

245 different multicomponent mixtures: drugs of abuse, peptides, and fentanyl analogs.

246 style characteristics (BMI, smoking, alcohol abuse, physical inactivity) and social factors (educatio

247 emerging pollution resulting from antibiotic abuse, poses a serious threat on ecosystem and human hea

248 gesics worldwide, classified as having a low abuse potential by U.S.

249 In the current study, we investigated the abuse potential of pregabalin using conditioned place pr

250 spared its dissociative-like properties and abuse potential.

251 ubstitution test, suggesting that BCP has no abuse potential.

252 lthough longer incisions and prior substance abuse predict higher likelihood of requesting pain medic

253 Physical abuse predicted both aggression and affective lability a

254 ic pancreatitis secondary to chronic alcohol abuse presented to the hospital with acute abdominal pai

255 anding of Captagon addiction and future drug abuse prevention.

256 Exposure to drugs of abuse produces robust transcriptional and epigenetic reo

257 is, rheumatologic diseases, alcohol and drug abuse, psychoses, and depression compared to the general

258 f dopamine neurotransmission and a target of abused psychostimulants.

259 lcohol are two of the most commonly used and abused recreational drugs, are often used simultaneously

260 With opioid abuse-related deaths rising at unprecedented rates, unde

261 hat men are more sensitive than women to the abuse-related effects of mu-opioid agonists.

262 ine in the absence of any psychotomimetic or abuse-related effects.

263 y of addiction, treatment options for opioid abuse remain limited.

264 Drugs of abuse represent a growing public health crisis.

265 home, free schooling, free school meals, and abuse response services).

266 In two-predictor models, physical abuse's effect on SI variability was no longer significa

267 olescents reporting no emotional or physical abuse (SDG 16.2) with no safe schools, cash transfers, o

268 ents only, we found that early-life physical abuse severity, and to a lesser extent physical neglect,

269 significantly higher prevalence of substance abuse, sexually transmitted diseases, decompensated cirr

270 perturbations, such as exposure to drugs of abuse.SIGNIFICANCE STATEMENT Histone H3.3 is a core hist

271 nt for the recent exponential rise in opioid abuse, so environmental factors must contribute.

272 istinct gene networks associated with opioid abuse, specific genes with predictive capability for sub

273 nputs to this region are altered by drugs of abuse such as alcohol.

274 Potentiostatic charging abuse tests of Li-metal pouch cells result in dendrites

275 thic that people should take care of and not abuse the environment.

276 in levels are influenced by various drugs of abuse, the effect of alcohol exposure on beta-arrestin e

277 HO Department of Mental Health and Substance Abuse, this study (conducted in India, the UK, and the U

278 reened for and counseled regarding substance abuse to facilitate a successful quit.

279 local circuits are key targets for drugs of abuse to tilt the functional output of NAc toward a moti

280 six self-reported violence outcomes (sexual abuse, transactional sexual exploitation, physical abuse

281 d often associated with additional substance abuse, underscoring the importance of drug and alcohol s

282 and addiction to morphine and other drugs of abuse, understanding the molecular mechanisms regulating

283 ge and recorded clinically recognized opioid abuse using relevant diagnosis codes.

284 ful for the resurrection of previous drug of abuse vaccines that have met limited success in the past

285 size that the D1R hypersensitivity underlies abuse vulnerability by facilitating the behavioral respo

286 ubgroups included veterans; childhood sexual abuse; war-affected; refugees; and domestic violence.

287 olescents reporting no emotional or physical abuse was 0.76 (0.67-0.84).

288 Childhood sexual abuse was associated with 26 of 28 specific outcomes: sp

289 Alcohol abuse was nominally associated with advanced epigenetic

290 us, obesity, smoking, dyslipidemia, and drug abuse were analyzed in these patients.

291 ychiatric associations with childhood sexual abuse were reported for conversion disorder (OR 3.3 [95%

292 rotection register and neglect and emotional abuse were the most common reasons.

293 bstance use, school enrolment, and no sexual abuse) were not associated with any hypothesised acceler

294 are the overconsumption of food and drugs of abuse, which are important factors in the development of

295 rding effects of nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate t

296 ly found in behavioral responses to drugs of abuse with drug sensitivity and motivation peaking durin

297 n adults, and its interaction with childhood abuse, with clinically relevant depression outcomes in c

298 P), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence.

299 tensin receptor ligand that may curtail drug abuse without the side effects induced by G protein sign

300 about violence exposure and information for abused women but no standardized IPV training for nurses