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1 pha-amylase in vitro, comparable to the drug acarbose.
2 f inhibition was assessed in comparison with acarbose.
3 far lower than that of the antidiabetic drug acarbose.
4 se, being almost 9 times more effective than acarbose.
5 with EC(50) values lower than that found for acarbose.
6 s effective as the pharmaceutical inhibitor, acarbose.
7 erium thermosaccharolyticum with and without acarbose.
8 s who do not respond to diet adjustments and acarbose.
9 lase, being nearly as potent an inhibitor as acarbose.
10 d glucose by the alpha-glucosidase inhibitor acarbose.
11 orylate a clinically used antidiabetic drug, acarbose(1,2), resulting in its inactivation.
12  centralised computer system to receive oral acarbose (50 mg three times a day) or matched placebo, w
13 on (IC(50) = 4.48 +/- 0.32 muM), compared to acarbose (7.40 +/- 0.41 muM), based selectively on the p
14 al structures of the two enzymes soaked with acarbose, a transition-state analog.
15  diabetes medication other than metformin or acarbose alone, or 1 encounter with type 2 diabetes Inte
16 g bead immobilization and lectin analysis of acarbose, an antidiabetic drug, to dabsyl-tagged enzyme
17                 Complexes of the enzyme with acarbose and 1-dexoynojirimycin and two different covale
18 ention-to-treat population, 3272 assigned to acarbose and 3250 to placebo.
19 IC50: 0.86 muM), which is even comparable to acarbose and amphotericin B.
20 xtracts potentiated the inhibition caused by acarbose and could replace the inhibition lost by reduci
21 ymethyl group of the nonreducing end of both acarbose and D-gluco-dihydroacarbose toward a more axial
22  report the complete biosynthetic pathway to acarbose and its structural components, GDP-valienol and
23                                              Acarbose and lactulose were used to examine the disaccha
24 o model drugs of differing hydrophilicities, acarbose and ruxolitinib and 16 ILs, the dependence of s
25  and glucose transport were not inhibited by acarbose and that the presence of glucose induced lactul
26 he mechanisms underlying the synergy between acarbose and the berry polyphenols and the lack of syner
27 n the presence of four different inhibitors: acarbose and three sulfonium ion compounds.
28 l diet containing 14 ppm rapamycin, 1000 ppm acarbose, and 1000 ppm phenylbutyrate was fed to 20-mont
29 protective advantage against the activity of acarbose, and are widespread in the microbiomes of weste
30 g behavior compared to the reference ligand, acarbose, as indicated by multiple structural parameters
31 ex soaked with the tetrasaccharide inhibitor acarbose, at 1.9 A, reveal a decasaccharide moiety, span
32  transition state analog acarviosine-glucose-acarbose, at resolutions down to 2.1 A.
33 emonstrating that the glucoamylase inhibitor acarbose binds PhK, perturbs its structure, and stimulat
34 dy clarifies all previously unknown steps in acarbose biosynthesis and establishes a complete pathway
35                                          The Acarbose Cardiovascular Evaluation (ACE) trial was a ran
36      The crystal structure of HSAmy-ar as an acarbose complex was determined at a resolution of 1.5 A
37 5 A and compared with the existing wild-type acarbose complex.
38 tallographic analysis of the enzyme in free, acarbose-complexed, and trapped 5-fluoro-beta-glucosyl-e
39                   We aimed to assess whether acarbose could reduce the frequency of cardiovascular ev
40                                              Acarbose demonstrated auspicious inhibitor activity acco
41 nits, clearly demonstrates synthesis of this acarbose-derived decasaccharide by a two-step transglyco
42 tes in the structure of W58A in complex with acarbose-derived pseudooligosaccharide.
43 eart disease and impaired glucose tolerance, acarbose did not reduce the risk of major adverse cardio
44  replace the inhibition lost by reducing the acarbose dose.
45 ase, isomaltase and glucoamylase activity by acarbose, epigallocatechin gallate, epicatechin gallate
46                                              Acarbose exhibited similar IC(50) values (50% inhibition
47                                              Acarbose exhibited similar IC(50) values (50% inhibition
48  B shows promise as a natural alternative to acarbose for inhibiting alpha-amylase.
49 uctose-glucose (FruGlu) and fructose-glucose-acarbose (FruGluA) solutions than from fructose-mannitol
50 ose-mannitol (FruMann) and fructose-mannitol-acarbose (FruMannA) solutions, but there was no differen
51    Diabetes developed less frequently in the acarbose group (436 [13%] of 3272; 3.17 per 100 person-y
52 470 (14%; 3.33 per 100 person-years) of 3272 acarbose group participants and in 479 (15%; 3.41 per 10
53 se changes (215 [7%] of 3263 patients in the acarbose group vs 150 [5%] of 3241 in the placebo group
54 on the rise worldwide, the market demand for acarbose has also increased.
55        Analysis of the complex of GTase with acarbose has revealed the locations of five sugar-bindin
56 ima GTase and its complex with the inhibitor acarbose have been determined at 2.6A and 2.5A resolutio
57 tetrasaccharides D-gluco-dihydroacarbose and acarbose have been refined to R-factors of 0.147 and 0.1
58 L, which was lower than other samples expect acarbose (IC(50) = 0.48 mg/mL) (p < 0.05).
59 ol and ethyl acetate fractions comparable to acarbose (IC(50) = 120.43 ug/mL) with IC(50) values of 1
60 C(50) = 357.63 +/- 3.3 ug/mL), comparable to acarbose (IC(50) = 635.70 +/- 4.9 ug/mL).
61 vastly outperforming the reference inhibitor acarbose (IC(50) = 871.40 +/- 1.24 uM).
62 ucosidase inhibitors than the clinical drug, acarbose (IC(50)=200muM).
63 surpassing the efficacy of the standard drug acarbose (IC50: 77.42 ug/mL).These multifunctional silve
64 gh only Trp120 is indicated to interact with acarbose in the crystal structure.
65                                              Acarbose is a bacterial-derived alpha-glucosidase inhibi
66                                              Acarbose is an inhibitor of both human and bacterial a-g
67 justment is the agreed first treatment step; acarbose is effective for late dumping syndrome symptoms
68 -dihydroacarbose (K1 = 10(-8) M) relative to acarbose (K1 = 10(-12) M) may stem in part from the weak
69 ic analyses, we show that microbiome-derived acarbose kinases are specific for acarbose, provide thei
70           Existing enzyme inhibitors such as acarbose, miglitol, and voglibose are used for inhibitin
71  conjugate in comparison with COS, EGCG, and acarbose on alpha-amylase were studied.
72 he effect of the alpha-glucosidase inhibitor acarbose on cardiovascular outcomes in patients with cor
73 ar more powerful than the anti-diabetic drug acarbose, OPVS-E exhibited a strong antiradical capacity
74  extracts exhibited the potential to replace acarbose (or reduce the dose required) in its current cl
75             Tea extracts in combination with acarbose, produced a synergistic inhibitory effect on ra
76 me-derived acarbose kinases are specific for acarbose, provide their harbouring organism with a prote
77                        The positive control (acarbose) range is 1.273 +/- 0.12 ug.
78 e to a non-antibiotic drug, and suggest that acarbose resistance has disseminated in the human microb
79 (P < 0.05) sucrose absorption than a sucrose-acarbose solution.
80 r includes rapamycin, senolytics, metformin, acarbose, spermidine, NAD(+) enhancers and lithium.
81 ural products, such as the antidiabetic drug acarbose, the crop protectant validamycin, and the natur
82                                              Acarbose, the dipeptidyl-peptidase 4-inhibitor sitaglipt
83 lidamycin A biosynthesis, as well as that of acarbose, the valienamine and validamine moieties are ul
84 tion therapy of metformin, glipizide XL, and acarbose to lower A1C to 6.7% and 2-day repeated hypogly
85                          Both enzymes modify acarbose upon binding through hydrolysis, condensation o
86 uM for pancreatic alpha-amylase (compared to acarbose with IC(50) values of 1.2 +/- 0.1 muM and 0.5 +