ライフサイエンスコーパス: accessibility

1 ts that exhibit cell type-specific chromatin accessibility.

2 protein structure, due to changes in solvent accessibility.

3 and even less has been done to extend their accessibility.

4 3-dependent negative regulation of chromatin accessibility.

5 g studies because of its time efficiency and accessibility.

6 ordination geometry, reactivity, and solvent accessibility.

7 nferred substantial differences in chromatin accessibility.

8 changing demands on transcription and genome accessibility.

9 nsitivity, stoichiometry, and central cavity accessibility.

10 ype, transcriptional landscape and chromatin accessibility.

11 ted mutations conferred precocious chromatin accessibility.

12 rding clinical performance and radiochemical accessibility.

13 the enzymatic pocket and occludes substrate accessibility.

14 e accompanied by the remodeling of chromatin accessibility.

15 cultures and this is not due to reduced drug accessibility.

16 go extensive patterning-dependent changes in accessibility.

17 conformers is correlated with higher solvent accessibility.

18 ription of nearby genes tracked closely with accessibility.

19 d transcription without changes in chromatin accessibility.

20 kinase domain conformations and active site accessibility.

21 s controls because of differential chromatin accessibility.

22 ings are restricted by high cost and limited accessibility.

23 nd publisher are not good predictors of data accessibility.

24 owing histone acetylation-mediated increased accessibility.

25 could dramatically reduce costs and broaden accessibility.

26 tissue specificity, localization and solvent accessibility.

27 hallenges in prediction accuracy and program accessibility.

28 g to ectopic retinal-specific enhancer-GDPD1 accessibility.

29 eferential motif arrangements that influence accessibility.

30 ielding diagnostic information about solvent accessibility.

31 -seq that yield coverage files for chromatin accessibility.

32 and that Hoogsteen base pairs increase this accessibility.

33 g the virus' genetic material could increase accessibility.

34 of the SAWN devices themselves limits their accessibility.

35 Leveraging a granular atlas of chromatin accessibility across 81 immune cell types, we asked if a

36 ation distribution maps and terrain-specific accessibility algorithms to develop a multiobjective geo

37 ymes involved in promoting reduced chromatin accessibility, ameliorated light damage in our mouse mod

38 use embryonic stem cells increases chromatin accessibility and activates transcription in an m(6)A-de

39 hnology, bringing a paradigm shift in speed, accessibility and affordability of small molecule detect

40 crucial in determining the functional state-accessibility and amount of gene expression-of the chrom

41 en improved by biomarker assays, but limited accessibility and batch testing limit the impact.

42 Deletion of -31CBS reduces chromatin accessibility and blocks long-range interaction between

43 Changes in chromatin accessibility and chromatin modifications accompany chan

44 nalyses of mRNAs, miRNAs, lncRNAs, chromatin accessibility and cis-regulatory elements uncover a core

45 phenotype, the transcriptome, and chromatin accessibility and compared these with the effects of a p

46 ces at the point of care would alleviate the accessibility and cost limits of magnetic-resonance imag

47 on in bacteria, but in eukaryotes, chromatin accessibility and energy expenditure may call for a diff

48 Combining nuclease accessibility and epigenetic states produced a set of mo

49 plied the method to analyze paired chromatin accessibility and gene expression data from a retinoic a

50 exhibit genome-wide alterations in chromatin accessibility and gene expression during differentiation

51 We used genome-wide analysis of chromatin accessibility and gene expression following acute lung i

52 alable approach for measurement of chromatin accessibility and gene expression in the same single cel

53 Integrative analysis of chromatin accessibility and gene expression revealed extensive epi

54 sent), enabling advances in vision research, accessibility and healthcare.

55 lterations on the DNA methylation, chromatin accessibility and histone modification level, that can b

56 hod on single-cell RNA sequencing, chromatin accessibility and imaging transcriptomics datasets, and

57 high toxicity, environmental stability, easy accessibility and lack of effective therapeutics.

58 pression correlates with decreased chromatin accessibility and loss of chromatin association of the A

59 of H3K9me3 leads to an increase in chromatin accessibility and loss of Protect-seq signal.

60 elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously.

61 tionship, we developed ATAC-Me, which probes accessibility and methylation from single DNA library pr

62 some association between super-additivity of accessibility and multiplicative or super-multiplicative

63 ulin resistance and restoration of chromatin accessibility and nucleosome positioning near transcript

64 ng a causal link between decreased chromatin accessibility and photoreceptor degeneration, thereby el

65 To demonstrate the accessibility and porosity of the macroscopically orient

66 ticated instrumentation, which restrains the accessibility and portability of the analysis.

67 tin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermoge

68 ce of Smarcad1 leads to changes in chromatin accessibility and significant changes in histone H3K9me3

69 Integrated analysis of chromatin accessibility and single-cell expression data shows that

70 JNK/AP-1 signaling commissions chromatin accessibility and Smad3 DNA binding leading to a transcr

71 regional epigenetic modifications, chromatin accessibility and super-enhancer establishment.

72 c-Maf promoted ILC3 accessibility and supported RORgammat activity and expre

73 test disease-associated changes in chromatin accessibility and the strongest alteration of cell-cell

74 chromatin-profiling data, such as chromatin accessibility and transcript factor binding affinities,

75 The accessibility and utility of both diastereomers of these

76 tive diazoalkane species, vastly improve the accessibility and utility of this derivatization techniq

77 gional, and laminar differences in chromatin accessibility and were correlated with gene expression d

78 rgetting involves losses in precision versus accessibility and whether such losses are modulated by l

79 We map thousands of loci affecting chromatin accessibility and/or transcript abundance, including 10

80 its immediate interactions, (ii) its solvent accessibility, and (iii) its conformational flexibility.

81 oplets in living cells; (2) the size, global accessibility, and compaction of heterochromatin foci ar

82 nome sequence, 3D organization and chromatin accessibility, and determined by protein availability pr

83 itro by profiling DNA methylation, chromatin accessibility, and histone modification changes.

84 r membrane localization attributes, antibody accessibility, and immunogenicity in mice.

85 linear DNA, coupled with enhanced chromatin accessibility, and more frequently resulted in transcrip

86 es the quality, accountability, readability, accessibility, and presence of translation between priva

87 gene expression, DNA methylation, chromatin accessibility, and sensitivity to cisplatin-induced DNA

88 icrofabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantat

89 tion, we measured gene expression, chromatin accessibility, and transcription factor occupancy in wil

90 -wide off-target, chromatin modification and accessibility, and transcriptional data, we found that c

91 reacted slower than what was expected by its accessibility, and we differentiated between two competi

92 promoters and enhancers have tissue-specific accessibility, and we discover regulatory grammars assoc

93 we suggest that subtle changes in chromatin accessibility are a prerequisite during the cell cycle a

94 amlined CUT&Tag protocol that suppresses DNA accessibility artefacts to ensure high-fidelity mapping

95 ne expression data to infer networks and its accessibility as a pipeline for non-bioinformaticians to

96 CA2, GLI1 overexpression increased chromatin accessibility, as indicated by results of the micrococca

97 aps, including DNA methylation and chromatin accessibility, as well as transcriptomes, of osteoblasts

98 Proteinase K accessibility assays and whole-cell partitioning indicat

99 nt proteins and metal transport and cysteine accessibility assays, we demonstrate that two parallel c

100 riptional responses, while sub-additivity of accessibility associated with additive transcriptional r

101 g insight into chemical exchange and solvent accessibility at a site-resolved level.

102 pression is sufficient to regulate chromatin accessibility at a subset of its targets.

103 rovide evidence that GLI1 controls chromatin accessibility at distal regulatory regions by modulating

104 During lineage commitment, chromatin accessibility at DORCs precedes gene expression, suggest

105 verlap between DNA methylation and chromatin accessibility at enhancers of steady-state stem cells, s

106 ssary for both histone modifications and DNA accessibility at hot spots.

107 BAF60a maintains chromatin accessibility at PPARgamma and EBF2 binding sites for ke

108 We observe widespread increases in chromatin accessibility at retrotransposons when HDACs are inhibit

109 y integrating gene expression with chromatin accessibility at transcription factor (TF) motifs in the

110 M5C histone demethylase influenced chromatin accessibility (ATAC-Seq), gene expression (RNA-Seq), and

111 al studies in which nickel was dosed at 100% accessibility/availability, e.g. nickel salts this is ev

112 tested the predictive power of models of DNA accessibility based on the Monod-Wyman-Changeux (MWC) mo

113 del to evaluate differential methylation and accessibility between cancerous and noncancerous cells.

114 , we find locus-specific temporal changes in accessibility both across megabase-long AgR loci and loc

115 d differences in chromosome organization and accessibility, both in gametes(5-8) and after fertilizat

116 to altered epigenetic profiles and chromatin accessibility but the relationship between transcription

117 ecruits TFIIIC, which alters their chromatin accessibility by direct acetylation of histone H3 lysine

118 tly accessible, and this study furthers that accessibility by utilizing only readily available compon

119 y DNA revealed through profiles of chromatin accessibility can be harnessed for fine-tuning gene expr

120 Changes in gene expression and chromatin accessibility caused by LSD1 inhibition were partially r

121 Expression and binding site accessibility change for many other TFs, including closu

122 AT2 chromatin accessibility changed substantially following injury to

123 These accessibility changes mimic those that normally occur la

124 nd orchestrated transcriptomic and chromatin accessibility changes, coupled with stably maintained li

125 e response to injury by regulating chromatin accessibility changes, thereby allowing the activation o

126 Through analysing associated chromatin accessibility changes, we have implicated the transcript

127 ranscription, regulatory activity, chromatin accessibility, chromatin conformation and readouts from

128 nd gastrulation many regions maintain stable accessibility, cis-regulatory modules (CRMs) within the

129 confounding variables associated with sample accessibility, collection, processing and storage.

130 To redress the balance between the accessibility, cost, and acceptance of genetic testing a

131 nown, such pleiotropy suggests that enhancer accessibility could be one of the molecular mechanisms s

132 igh throughput gene expression and chromatin accessibility data from human and mouse FLS from our and

133 rning model, called DeepMEL, using chromatin accessibility data of 26 melanoma samples across six dif

134 By intersecting chromatin accessibility data with single-cell transcriptomics, we

135 uantitative trait studies, such as chromatin accessibility, DNA methylation, protein expression and m

136 lators to the 20S proteasomes modify solvent accessibility due to conformational changes of the beta-

137 highly enriched motifs in regions that gain accessibility during cardiac regeneration.

138 tion factors coordinate changes in chromatin accessibility during development remains unknown.

139 c disease risk variants may affect chromatin accessibility during neurodevelopment.

140 A regions from each sample type with dynamic accessibility during regeneration, and assigned these re

141 esults in alternative splicing and chromatin accessibility events, involving genes such as Npas2 More

142 y structure features and per-residue solvent accessibility features of PTM sites, domain context, pre

143 basal plasma membrane due to partial limited accessibility for antibodies.

144 The ability of STAT5 to mediate accessibility for BATF is observed in other Th lineages

145 will increase risk stratification, increase accessibility for DNA targeting chemotherapeutics and re

146 st of these therapeutic agents, which limits accessibility for many.

147 P = 0.038) CONCLUSIONS: To a certain extent, accessibility for self-performed proximal hygiene is ass

148 In addition, reduced chromatin accessibility for the MYC oncogene pathway correlated wi

149 ate that Opa, like Zld, influences chromatin accessibility genome-wide at cellularization, suggesting

150 tool that analyzes high-throughput chromatin accessibility genomic data to identify cell-type-specifi

151 s by profiling gene expression and chromatin accessibility in 170 genetically heterogeneous mESCs.

152 ing early organogenesis, we mapped chromatin accessibility in 19,453 single nuclei from mouse embryos

153 decreases NP diffusion coefficients and pore accessibility in an NP size-dependent manner and that NP

154 Chromatin accessibility in cT(FH) and T(FR) cells was assessed by

155 y perturb nucleosome structure and chromatin accessibility in different ways.

156 factors, T and Foxa2, results in changes to accessibility in DNA sequences containing their respecti

157 vered that Grh is not required for chromatin accessibility in early embryogenesis, in contrast to its

158 By assaying chromatin accessibility in embryos lacking maternal and/or zygotic

159 The lutein bio-accessibility in enriched eggs decreased after GI digest

160 e expression, DNA methylation, and chromatin accessibility in kidney proximal tubule epithelial cells

161 h cost for diagnostics and limits their wide accessibility in low-resource settings.

162 ce lifetimes and significantly reduced water accessibility in membranes.

163 ng demonstrated a dramatic remodeling of DNA accessibility in the PVN following pubertal adversity.

164 particularly relevant to tackle health care accessibility inequality, which is not only prominent wi

165 vironment characterized by dynamic substrate accessibility, infection-induced hypoxia, and a metaboli

166 principles of data management (findability, accessibility, interoperability and reusability) and pro

167 heres to the FAIR principles of findability, accessibility, interoperability and reusability.

168 GO2-target interactions, but how target site accessibility is controlled in vivo is poorly understood

169 Target site accessibility is critical for AGO2-target interactions,

170 In contrast, chromatin accessibility is dynamically changed during regeneration

171 Therefore, we explored a model where DNA accessibility is not the result of thermal fluctuations

172 hat the regenerating cardiomyocyte chromatin accessibility landscape undergoes extensive changes foll

173 rogramming enhancers and increased chromatin accessibility later in reprogramming.

174 Chromatin accessibility mapping is a powerful approach to identify

175 ession, suggesting that changes in chromatin accessibility may prime cells for lineage commitment.

176 aggregate SMAC-seq signals match bulk-level accessibility measurements, observe single-molecule nucl

177 motif enrichment in differential elements of accessibility (MEDEA), a computational tool that analyze

178 opology obtained by the substituted cysteine accessibility method and revealed that the active site f

179 Data accessibility must become one of the routine and mandato

180 d from G1 to G2M, with distinct differential accessibility near consensus transcription factors sites

181 of epigenomic information such as chromatin accessibility, nucleosome positioning, histone tail modi

182 pendent chromatin-remodeling enzymes control accessibility, nucleosome positioning/occupancy, and nuc

183 We identified waves of accessibility occurring rapidly across thousands of myel

184 y, a widespread down-regulation of chromatin accessibility occurs at a later time point, possibly due

185 f the DDIT4L gene and changing the chromatin accessibility of a DDIT4L enhancer.

186 ntified a pleiotropic site necessary for DNA accessibility of a shared regulatory region.

187 The accessibility of adoptive T-cell transfer therapies (ACT

188 s that seek to increase the availability and accessibility of affordable and sustainable farmed aquat

189 s ALKBH5 expression via increasing chromatin accessibility of ALKBH5 locus, by reducing H3K9me3 level

190 re versions of the scanner could improve the accessibility of brain MRI at the point of care, particu

191 arrangement can be expected to impact on the accessibility of cell adhesion sites and altered fibril

192 Using NicE-viewSeq, we interrogated the accessibility of chromatin in a cell cycle (G1, S, and G

193 ere we systematically examined the state and accessibility of chromatin in the developing mouse fetus

194 e or inactive states, and shifts in nuclease accessibility of CTCF-bound elements.

195 Accessibility of diagnostic testing for COVID-19 has bee

196 and nucleosome positioning contribute to the accessibility of DNA, but widespread regulators of chrom

197 eutralizing mAb, MR235, to MARV GP increased accessibility of epitopes in the receptor-binding site (

198 We then used the model to probe the accessibility of evolutionary trajectories through the m

199 thesis strategy for boosting the density and accessibility of Fe-N(x) species paves a new avenue towa

200 le neurons of the mouse cerebellum increases accessibility of gene regulatory sites genome-wide in vi

201 igenesis in addition to changes in chromatin accessibility of genes involved in lateral sclerosis, ba

202 speckles upon IAV infection, which may alter accessibility of hnRNP K for host transcripts thereby le

203 e lentiviral integration sites and chromatin accessibility of host and viral genomes at the single-ce

204 et been fully realized, due to their limited accessibility of in-pore surface and long mass-diffusion

205 We have developed a method for profiling the accessibility of individual chromatin fibers, a single-m

206 p pKas is computationally intensive, solvent accessibility of ionizable groups is displayed, from whi

207 Improving the accessibility of ions in the electrodes of electrochemic

208 Accessibility of iron at the phagosomal surface inside m

209 CHD7 acts preferentially to alter chromatin accessibility of key genes during the transition of NPCs

210 ing pan-family viral assays to improve early accessibility of large-scale nucleic acid testing.

211 To improve accessibility of local sample collections, efforts have

212 addition to providing information on solvent accessibility of lysine sites, dead end iqPIR cross-link

213 g a negative impact on the affordability and accessibility of medicines.

214 To increase the accessibility of methods for characterizing microparticl

215 Given the increased accessibility of microbial sequencing platforms, many re

216 Recent improvements in the quality and accessibility of next-generation sequencing have made HL

217 trometry, we measure the decrease in solvent accessibility of one of beta2m's Trp residues, which is

218 The accessibility of our reference strains and reagents is r

219 tion and colonic fermentation to examine the accessibility of polyphenols, vitamin C and folates in f

220 forms large domains that control nucleosome accessibility of promoters prior to ZGA in flies.

221 apid and precise gene regulation mediated by accessibility of regulatory regions to transcription fac

222 ther Salmonella serovar is determined by the accessibility of shared O Ags.

223 tain the relatively small size and synthetic accessibility of small molecules while providing high bi

224 Using these mutants, we compared the accessibility of specific mutations (revealed in the flu

225 With the recent rise of accessibility of SPIM systems, SPIM-FRAP is set to provi

226 e splicing events, likely through modulating accessibility of splicing factors.

227 The in vivo consequences of both the accessibility of susceptible cells, and their heterogene

228 host immune functions through increasing the accessibility of TF motifs NR1H4 and OLIG (OLIGI and OLI

229 g diffusional limitations leads to increased accessibility of the active site and higher catalyst tur

230 -1 operates as a redox switch to control the accessibility of the anti-apoptotic pocket.

231 nogenicity studies suggests that the limited accessibility of the CD4bs and the presence of predomina

232 perfectly balanced with the orientation and accessibility of the conjugated antibodies.

233 Accessibility of the essential nutrients nitrogen (N) an

234 Accessibility of the human genome is modulated by the AT

235 perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and

236 etic re-programming with increased chromatin accessibility of the Ifng locus, leading to elevated int

237 utagenesis are likely caused by differential accessibility of the nucleosomal DNA, a consequence of i

238 mulations provided structural explanation of accessibility of the RNA cleavage sites to the peptide w

239 7BL/6 and BALB/c mouse strains indicate that accessibility of these IL-4-induced regions can be regul

240 Chromatin accessibility of these indirect Foxp3 targets depended o

241 The low cost and accessibility of these powerful tools motivated us to pr

242 ps on carbon surface and facilitates the ion accessibility of these surface functional groups even at

243 or bottleneck for routine implementation and accessibility of this technology to the wider scientific

244 Global chromatin accessibility on cardiogenic genes is dependent on ARID1

245 al that ARID1A is required to open chromatin accessibility on promoters of essential cardiogenic gene

246 r various intrinsic reasons (e.g. low target accessibility or nature/extent of gene modification).

247 and orchestrated global changes in chromatin accessibility over time.

248 MIAA recapitulates differential accessibility patterns of 100-nt sequences derived from

249 any-body functional landscape and show DNase accessibility, POLR2A binding, and decreased H3K27me3 ar

250 ave integrated gene expression and chromatin accessibility profiles of human biopsies and identified

251 Brain gene expression and chromatin accessibility profiles were correlated with behavioral v

252 Recent genome-wide chromatin accessibility profiling studies have provided catalogs o

253 bstrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramm

254 The identification of differential accessibility regions (DARs) between different biologica

255 f differential DNA methylation and chromatin accessibility regions associated with genes differential

256 Here, we report that the chromatin accessibility regulator HMGN1, a target of recurrent DNA

257 The accessibility, relative energetics, and bonding nature o

258 tantly, these sites are loci whose chromatin accessibility relies on HOX13.

259 ion involves epigenetic changes in chromatin accessibility resulting from environmental exposures and

260 macroscopic supports, as well as control the accessibility, robustness, and formability of the suppor

261 ng these findings with single-cell chromatin accessibility (scATAC-seq) data, we were able to connect

262 , and visualization of single-cell chromatin accessibility sequencing data.

263 Single-cell chromatin accessibility sequencing has become a powerful technolog

264 ombining single-cell RNA and ATAC (chromatin accessibility) sequencing, we identified mouse and human

265 ng to evaluate CpG methylation and chromatin accessibility simultaneously on long strands of DNA by a

266 r to an epithelial cell and gained chromatin accessibility sites correlated with other epithelial ori

267 learn to infer cell type-specific chromatin accessibility solely from regulatory DNA sequences.

268 idate Runx1 enhancer exhibits high chromatin accessibility specifically in pre-HE cells at the bottle

269 Chromatin accessibility, TF binding, and gene expression patterns

270 in pre-HE cells at the bottleneck, but loses accessibility thereafter.

271 ramatically influences genome-wide chromatin accessibility through subtle refinement of H2A.Z pattern

272 Our findings reveal that accessibility to all positions tested is modulated by th

273 veric corneal graft tissue critically limits accessibility to corneal transplantation in some parts o

274 We explicitly designed a binding site with accessibility to dioxygen units in the open coordination

275 Normally, accessibility to DNA is required for their function.

276 acceptors including microorganisms and poor accessibility to Fe(II) in complex hydrogeologic setting

277 ed rock can create new porosity and increase accessibility to hazardous trace elements such as arseni

278 y, women's education, hygiene practices, and accessibility to health services at the community level

279 to impaired perfusion, resulting in reduced accessibility to immune cells and chemotherapeutic drugs

280 pplicability of this powerful method and its accessibility to non-specialist users.

281 ficiency while accounting for red blood cell accessibility to parasites.

282 in resource-limited settings thus, improving accessibility to point-of-care testing services.

283 RBD closer to the membrane that impacts its accessibility to RAS and with RBD causing local anionic

284 inding fragments (Fabs) and preserves steric accessibility to receptor-binding sites, likely influenc

285 and polycaprolactone to provide a balance of accessibility to reductive agents necessary to ensure st

286 odifications (PTMs) regulate SPRTN chromatin accessibility to repair DPCs and maintain genomic stabil

287 he utility of the method, which provides new accessibility to this area of chemical space.

288 nomic analysis of DNA methylation, chromatin accessibility, transcription factor binding, and gene ex

289 n antibiotic-susceptible cells has increased accessibility upon exposure to beta-lactams and that a j

290 We find that chromatin accessibility varies greatly by cell type and, more mode

291 general pattern, we saw a strong trade-off; accessibility was enhanced, whereas precision was reduce

292 cation, mutation, DNA methylation, chromatin accessibility), we reveal 1000+ cancer driver genes, cor

293 ng single-cell transcriptomics and chromatin accessibility, we gained a better understanding of the p

294 Despite their synthetic accessibility, well-defined protocols for obtaining pure

295 s of the variables with the primary outcome (accessibility) were assessed by means of generalized est

296 es (bQTLs), variants that regulate chromatin accessibility with ATACseq studies (caQTLs), and chromos

297 ow that forgetting involves losses in memory accessibility with no changes in memory precision.

298 Moreover, we integrated chromatin accessibility with transcriptomics to identify putative

299 int profiling of transcriptome and chromatin accessibility within single cells allows for the deconst

300 Genome-wide alteration of chromatin accessibility within TSS and enhancer elements gradually