ライフサイエンスコーパス: accessible

1 based tools to make causal discovery methods accessible.

2 use the unfolded structure of Tau makes them accessible.

3 cing data becomes more easily and affordably accessible.

4 ially, O-atom bearing molecules) are solvent accessible.

5 iting both the number and types of compounds accessible.

6 exposed in serum APOL1, with less of the PFD accessible.

7 d 1,2-cis-O-pyranosylations employing easily accessible acetonide-protected donors.

8 ls are: (1) ensure that clinical research is accessible, affordable, and equitable; (2) design more p

9 re required to detect sequences that are not accessible after tryptic digest.

10 heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride allows formation

11 omocoupling of benzophenone imine, a readily accessible ammonia surrogate.

12 the primary V3 loop bnAb epitope is equally accessible among CCR5- and CXCR4-using strains, although

13 To organize these data in an accessible and across-species framework, we interpret th

14 MPN) secondary AML (sAML) cells demonstrated accessible and active chromatin in specific superenhance

15 n should make typhoid conjugate vaccine more accessible and affordable in low-income countries, which

16 ei into quantum chemistry calculations in an accessible and computationally efficient manner.

17 All reagents used are more easily accessible and cost-effective as compared to the enginee

18 e NCs with continuous metal atom numbers are accessible and crystallizable when meticulously designed

19 ich posits that chromatin fluctuates between accessible and inaccessible states.

20 oscopic parameters driving MChD with an easy-accessible and nondamaging light source, such as visible

21 f the nanobody suite in S. cerevisiae detect accessible and obstructed surfaces of the Y complex and

22 MichelaNGLo is an accessible and open-source web-based application that su

23 Thus, QMAP-Seq provides a broadly accessible and scalable strategy for chemical-genetic pr

24 ong them, azobenzenes are synthetically well accessible and show excellent fatigue resistance.

25 te external force (CoGEF) method is a highly accessible and straightforward computational technique t

26 viously generated data to develop a publicly accessible and user-friendly database to enable explorat

27 reas in OTUB2 the catalytic site was solvent-accessible, and a larger number of water molecules reach

28 health care and coverage that are adequate, accessible, and affordable for everyone living in the Un

29 cause they are easy to use, low-cost, widely accessible, and disposable.

30 wound dressings as a novel, cost effective, accessible, and non-invasive method of isolating viable

31 bistable sequences for which both states are accessible, and obtained a single designed protein seque

32 t vacuolated lymphocytes is a rapid, readily accessible, and sensitive screening test for JNCL.

33 Microbial membrane production is inherently accessible, and this study furthers that accessibility b

34 ted olefin containing oxindoles from readily accessible anilides has been developed.

35 Our model provides an accessible approach at the single cell level to study in

36 S oxidation rate correlated with the solvent-accessible area of the crystal structures.

37 This work provides a simple and readily accessible assay to engineer stabilized GP variants for

38 ng that this (3)d-d state is tetrahedral and accessible at ambient temperature.

39 lored femtosecond PYP dynamics to timescales accessible at synchrotrons.

40 all high-level LINCS datasets and make them accessible at the data point level enabling users to dir

41 here provide new insights including surface accessible atoms, overall assemblage, and interactions a

42 Here, we expand the range of accessible behaviors with a retroreflective marker-based

43 Peripheral blood is a highly accessible biofluid providing a rich source of informati

44 y potential disease biomarkers that exist in accessible biofluids at levels below the detection limit

45 FAD suggests potential utility as an easily accessible biomarker of AD pathology.

46 ulating new research on MCPs as reliable and accessible biomarkers in cancer, as well as effective an

47 they are cultured in vitro makes them easily accessible both genetically and for live assays such as

48 This expands the range of chemicals accessible by biotechnology and has yielded the first co

49 Such information is only accessible by combining data from the two modalities, wh

50 with novel properties and functionality not accessible by conventional CVD growth.

51 detectable thermodynamic states that are not accessible by currently available methods.

52 more rigid structures that are otherwise not accessible by direct nucleation and growth.

53 m(-3) and temperatures of kT = 50 to 100 eV, accessible by double-shell-target implosions.

54 enantioselective version of this reaction is accessible by employing chiral phosphorous ligands was o

55 ) carbon-conjugated frameworks and cannot be accessible by imine-linked frameworks, amorphous analogu

56 Although all tissues of the eye are accessible by injection, topical application is preferab

57 llular and subcellular changes that are only accessible by microscopic visualization, and are current

58 can readily be incorporated into any peptide accessible by standard solid-phase methods.

59 The method utilizes accessible carbamate esters bearing gamma-propargylic C-

60 These reactions couple easily accessible carbonyl compounds (aldehydes or ketones) wit

61 es Project, which created the largest openly accessible catalogue of human genomic variation develope

62 mbrane helix 7 that exposes a large membrane-accessible cavity.

63 For vaccine testing, an easily accessible cell platform would be desirable as an altern

64 abilities such as linear guest alignment and accessible channels, both of which are observed in CNTs

65 ritize different substituents from the large accessible chemical space.

66 We report that a readily accessible chiral carboxylic acid catalyst exerts contro

67 When the amount of accessible cholesterol in the PM exceeds a threshold lev

68 ntiviral mechanism by 25HC through depleting accessible cholesterol on the plasma membrane to suppres

69 The increased accessible cholesterol pool in the PM was accompanied by

70 In follow-up studies, we depleted "accessible cholesterol" from the plasma membrane of [(13

71 lopmental differences in gene expression and accessible chromatin between progenitors and MG, primari

72 Deleted clones exhibited an accessible chromatin conformation within the IRF8 locus

73 Using the Assay for Transposase-Accessible Chromatin coupled to high-throughput sequenci

74 tor (Bdnf) as a STAT3 target gene with newly accessible chromatin in a unique population of regenerat

75 derlying these events, we generated a map of accessible chromatin in human three-dimensional forebrai

76 Assaying transposase-accessible chromatin in single cell sequencing (scATAC-s

77 Mapping transposase-accessible chromatin in single cells by sequencing defin

78 ic elements contribute to differences in the accessible chromatin landscape of alternatively activate

79 , 2018) we characterized transcriptional and accessible chromatin landscapes of acutely isolated mous

80 distance to transcriptional start sites and accessible chromatin of the host genome and were enriche

81 Functional enhancers, in contrast with accessible chromatin regions that lack enhancer activity

82 cells was assessed by assay for transposase-accessible chromatin sequencing (ATAC-seq) to investigat

83 Moreover, genome-wide analyses of accessible chromatin showed key changes in the regulator

84 -exome sequencing, and Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) analyse

85 formed RNA sequencing, assay for transposase-accessible chromatin using sequencing (ATAC-seq), chroma

86 We performed Assay for Transposase-Accessible Chromatin using sequencing on human pluripote

87 quencing and ATAC-seq (assay for transposase-accessible chromatin using sequencing) experiments in mi

88 LM) that integrates an assay for transposase-accessible chromatin with visualization, PALM super-reso

89 oped three-dimensional assay for transposase-accessible chromatin-photoactivated localization microsc

90 cis-regulatory modules defined by regions of accessible chromatin.

91 count (ALC) has potential to be a useful and accessible clinical indicator of overall infection risk.

92 his approach is remarkably facile and easily accessible compared to conventional vapor-phase depositi

93 a low-coordinate Au(III) center with two cis accessible coordination sites and the first true dianion

94 hin such structures will potentially lead to accessible device fabrication for 'on-demand' applicatio

95 , there remains an unmet need for simple and accessible diagnostic tools that can perform important a

96 photoplethysmography could provide a widely accessible digital biomarker for diabetes.

97 und congeners supported by a more sterically accessible dipyrrinato scaffold (tBu)L ((tBu)L = 5-mesit

98 transposase inserts sequencing adapters into accessible DNA ('tagmentation').

99 We find that accessible DNA elements in skin-resident dendritic cells

100 arrow stem cell transplantation had not been accessible during her childhood, so she had been submitt

101 Instructions and help menus were accessible during the entire analytical process via the

102 virtual screening on computer clusters in an accessible, efficient and flexible manner has remained d

103 tion record universally available and easily accessible; enabling communication between patients and

104 Human serum is a rich source of readily accessible EVs; however, the separation of EVs from seru

105 of magnetic solitons and establish a readily accessible experimental framework to study relativistic

106 by simulations over timescales that are not accessible experimentally.

107 bitrary quantum system can be manipulated by accessible external interactions (coherent or dissipativ

108 nfraorbital foramen (AIOF) with reference to accessible external landmarks in order to facilitate orb

109 tions that all depend on W491, a potentially accessible extracellular residue that could become a tar

110 synthesized through the reactions of readily accessible feedstock olefins with beta-nitrostyrenes by

111 These bromo-terphenyls are accessible following the discovery that chiral anion pha

112 the partially flattened penultimate subunit accessible for binding monomers.

113 et cleavage site, constraining the sequences accessible for editing.

114 required:(1)What organic functionalities are accessible for electrocatalytic hydrogenation under a se

115 86 wt %), ensuring the foam pores are highly accessible for excellent adsorption and catalytic capaci

116 Many pathosystems are not accessible for genetic amendments or other spatially-res

117 a h 6 immune complex, thus rendering Ara h 6 accessible for its immunodetection.

118 hat miRNA target sites were not structurally accessible for miRISC binding prior to cleavage in vivo.

119 , and the full baseline dataset will be made accessible for researchers outside the consortium in Sep

120 ters, interior active sites in UiO-66 become accessible for the reaction of TBA, with the activity de

121 put, transform the input into a structurally accessible form for circuit wiring, translate the input

122 e portions of the brain become noninvasively accessible from embryo to sexually mature adult in a ver

123 The rich datasets accessible from experience sampling allow researchers to

124 o support various web-based systems that are accessible from laptops, workstations, or tablets, under

125 full network of prebiotic chemical reactions accessible from these substrates under generally accepte

126 eported, thus expanding the types of product accessible from this class of intermediates.

127 the transporter adopts at least two states, accessible from two different sides of the membrane to e

128 To image the accessible genome at nanometer scale in situ, we develop

129 A freely accessible graphical user interface is provided.

130 Phenothiazinium dyes represent an accessible group of candidates with the potential to com

131 e analysis on regions in the same cluster at accessible heights using a range of complementary spectr

132 nts in genomics methods coupled with readily accessible high-throughput sequencing have contributed t

133 ed vehicle, and included locations that were accessible (ice edge) or inaccessible (solid fast ice) t

134 They are easily accessible in biological fluids and contain specific dis

135 tion and enrichment of protein N-termini not accessible in GluC- or trypsin-digested samples.

136 cluding a vestibule binding site that is not accessible in some pLGICs.

137 substrates, with the majority becoming less accessible in the presence of saturating concentrations

138 hysiological reporters, and establish highly accessible, inexpensive protocols for their investigatio

139 These readily accessible intermediates are converted to transient imin

140 Interestingly, the remaining less accessible intermediates, yet to be experimentally descr

141 d how to make the data and results Findable, Accessible, Interoperable, and Reusable (FAIR) by submit

142 principle, which aims to make data Findable, Accessible, Interoperable, and Reusable.

143 itional diet predominates, and Waiben a more accessible island with greater access to takeaway food a

144 th risks from chemical exposures vastly more accessible, it could ultimately enable computational met

145 , we report a structurally simple and easily accessible l-proline derived aminocatalyst, phenyl l-pro

146 Transformations are promoted by a readily accessible l-threonine-derived aminophenol-based boryl c

147 This is a simple, accessible laboratory measure.

148 All simulations resulted in a water accessible ligand-binding pocket that lacked sodium ions

149 Here, we used the experimentally-accessible locust ear (male, Schistocerca gregaria) to c

150 While explaining the behavior at the highest accessible magnetic fields, our results imply a differen

151 Causal attributions for poverty offer one accessible means of shaping inequality-reducing attitude

152 tructure of the protein and providing easily accessible means to produce biomacromolecular assemblies

153 ience and will lead to more reproducible and accessible measurements of translation regulation.

154 ese results suggest that both bulky and more accessible medium-sized DeltaAAs should be valuable tool

155 ZSM-5 zeolite nanoboxes with accessible meso-micro-pore architecture and strong acid

156 r journals do display a higher likelihood of accessible metagenomic data sets.

157 tions are frequently less common due to less-accessible metal-based redox couples.

158 In summary, this represents a new, easily accessible method for calculating fully three-dimensiona

159 e applications establish Spec/SEAM-seq as an accessible method to rapidly and reliably evaluate the s

160 esh strawberries contained higher amounts of accessible micronutrients than frozen strawberries, whil

161 he unique role of the mouse as a genetically accessible model system for mammalian brain circuit anal

162 use of the Malpighian tubules and hindgut as accessible models of human disease biology.

163 ce in the frequencies of their intrinsically accessible modes of motion.

164 strategy, especially considering the easily accessible monomer diversity and peptoid helical folding

165 , we demonstrate that two parallel cytoplasm-accessible networks of conserved hydrophilic residues in

166 3H-Phosphaallenes are accessible on a new and facile route and show a fascinat

167 imal ensemble model, we further developed an accessible online predictor, PeNGaRoo, to serve users' d

168 s and Tau tangles in Alzheimer's disease are accessible only via invasive cerebrospinal fluid assays,

169 pe supramolecular structures are now readily accessible, only a few are known to accelerate chemical

170 Hypothesis article aims first to provide an accessible overview of phyllotaxis, and second to argue

171 nsport over the full range of experimentally accessible parameters.

172 incremental aaRS improvement as a viable and accessible path to improve GCE systems challenged by tru

173 stepping stone towards the development of an accessible PD screening tool that will passively monitor

174 emperature has the potential to be an easily accessible physiological biomarker and predictor of inju

175 the light-mediated epimerization of readily accessible piperidines to provide the more stable diaste

176 s, the plant microbiota, that colonize every accessible plant tissue.

177 -encoded qudits, thus establishing an easily accessible platform for unitary computation.

178 stallinity, diverse framework topologies and accessible pore systems.

179 cleavage at a significantly more anodic-yet accessible-potential, thereby restoring the availability

180 s a result of two reversible redox events at accessible potentials (E(1/2) = 0.014, 0.52 V vs Ag/AgCl

181 rse, spiroannulated pyrazolones from readily accessible precursors.

182 ion are in linear correlation to the readily accessible properties of the linker substituent, such as

183 e capability for substantially enlarging the accessible range of CTE.

184 Publicly accessible records are sparse, especially from developin

185 ing a smaller reorganization energy and more accessible redox states than the monomeric analogues.

186 We tested this by targeting an accessible region of the hippocampal network via transcr

187 ompetence factors (e.g., AP1) make chromatin accessible, regional specifiers (e.g., Zic1) target spec

188 genomic data to identify cell-type-specific accessible regions and lineage-specific motifs associate

189 We find that bipolar-specific accessible regions are more frequently linked to bHLH mo

190 principal component analysis (PCA) from all accessible regions by co-varying transcription factor mo

191 transcription factors in stem cell-specific accessible regions that become repressed in endoderm.

192 hat uses latent space models to better model accessible regions, termed ChromA.

193 and facilitating the establishment of these accessible regions.

194 our method identifies transcription-coupled accessible regulatory sites.

195 ered a global community focused on achieving accessible, reproducible, and collaborative research.

196 d with pneumonia may serve as a reliable and accessible sample to evaluate biomarkers that may diagno

197 n myocarditis have been unsuccessful in more accessible samples such as peripheral blood.

198 ata-model integration requires investment in accessible, scalable, and transparent tools that integra

199 t were published from 2019 onwards but never accessible showed that 51.1% of the tools could be resto

200 and novel approaches to making PrEP services accessible, simplified and efficient.

201 mic annotation (e.g. insulator and chromatin accessible sites from the ENCyclopedia Of DNA Elements [

202 Using widely accessible software tools, the volume of a guest is esti

203 on as a cofactor demands that such a readily accessible source of iron exist, but overaccumulation re

204 hat can be accommodated in a given amount of accessible space in an adequately modelled host structur

205 ric [4+3] annulation reaction of two readily accessible starting materials has been developed for bui

206 requires mild reaction conditions and easily accessible starting materials, and it shows excellent fu

207 Easy operation, readily accessible starting materials, and short syntheses of th

208 triazines under mild conditions from readily accessible starting materials.

209 into digital biobanks-ecosystems of readily accessible, structured, and annotated datasets that can

210 s cerevisiae Spf1 revealed a large, membrane-accessible substrate-binding pocket that alternately fac

211 uinoline derivatives from simple and readily accessible substrates.

212 Here we show that a readily-accessible sugar-polyolefin conjugate quantitatively pro

213 alent labeling approaches "mark" the solvent accessible surface area (SASA) of proteins to reflect pr

214 structural observables, such as the relative accessible surface area and the interaction energy, can

215 hotosensitizing materials require both large accessible surface areas and excitons of suitable energi

216 approach that harnesses the large chemically accessible surface areas of nanomaterials to yield massi

217 did not correlate strictly with the (1)O(2)-accessible surface areas of those amino acids.

218 into the hydrophobic hot spot region of the accessible surface of WW1.

219 of nuclear spin polarization but reduces the accessible target concentration.

220 A-seq has been established as a reliable and accessible technique enabling new types of analyses, suc

221 information using an inexpensive and widely accessible technology.

222 s also formed in situ, starting at a readily accessible temperature of 200 degrees Celsius.

223 which does not undergo a spin transition at accessible temperatures, was synthesized and characteriz

224 Across these five tissues, 453 accessible TEs are found to create the transcription sta

225 Most accessible TEs are rodent-specific.

226 Chromatin of the smaller D genome is more accessible than that of the larger A and B genomes.

227 restricted and quiescent and one more blood accessible, that gradually lost TCF1 as it divided and c

228 nctions, and identify many potential surface-accessible therapeutic targets.

229 chondrial morphology has become increasingly accessible, there is a need for new tools to generate an

230 Protein solubility, accessible thiols and secondary structures were measured

231 particular, when computing resources are not accessible, this task can be performed using precomputed

232 tional framework to generate informative and accessible three-dimensional atlases of cancer transitio

233 set of possible morphologies that are highly accessible through genetic change, enabling adaptive con

234 The traces of past human cognition accessible through historical texts and artifacts can se

235 deposition with light is a state that is not accessible through liquid quenching, aging, or vapor dep

236 n (such as selection permissiveness), hardly accessible through measurements.

237 t gives rise to a fourth electronic state is accessible through one-electron oxidation of the neutral

238 s of the natural product, which would not be accessible through the biosynthetic machinery.

239 even of mutations in genes not expressed in accessible tissue.

240 ool, rendering state-of-the-art segmentation accessible to a broad audience by requiring neither expe

241 ing the high versatility of ATR spectroscopy accessible to a broader audience.

242 trial fluxes of carbon in those budgets more accessible to a broader community.

243 own modifies the distribution of cholesterol accessible to a D4H probe, between late endosomes and th

244 e that Watson-Crick faces of nucleobases are accessible to alkylating agents in canonical dsDNA and t

245 will make automated fraction collection more accessible to all researchers.

246 imation of RSFs and SSFs with random effects accessible to anyone in the field.

247 To make these models computationally accessible to applied geneticists, we wrote an R package

248 None of these results are accessible to bioinformatic methods hitherto available.

249 hiphilic groups exposed to water, making DOM accessible to both polar and nonpolar species.

250 s of such charge distributions have not been accessible to date.

251 are free from lattice contacts and therefore accessible to fragments during soaks.

252 lengths beyond the optical range(8) that are accessible to frequency combs(9).

253 newable nitrogenous material on earth and is accessible to humans in the form of crustacean shell was

254 ntification of pathways that are potentially accessible to increase myelin clearance and improve remy

255 ASIMOV is accessible to inspection, modification, and experiment,

256 k prediction models using information easily accessible to medical practitioners to forecast caries a

257 potential to reveal particle properties not accessible to more conventional 1D techniques.

258 storing images of shapes in memory that are accessible to more than one sensory modality.

259 roplet state could be, at least transiently, accessible to most proteins under conditions found in th

260 that makes protein-ligand simulation easily accessible to non-expert users.

261 need for a real-time web application that is accessible to non-expert users.

262 0 each), we varied the amount of information accessible to participants in number estimation.

263 ic areas, these antibiotics may be no longer accessible to patients.

264 ere used to identify online information most accessible to patients.

265 ol makes thousands of low-abundance proteins accessible to quantitative measurements down to zeptomol

266 ed physiological data and human tissue, made accessible to researchers to enhance collaboration and r

267 ntibodies, they harbor pockets that are only accessible to small molecules and constitutes a rich sub

268 s mediated by neurons bearing cilia that are accessible to the environment.

269 al commercial platforms and controls broadly accessible to the research community to quantify all bio

270 hat most of the void space within the MOF is accessible to the solvent.

271 This protocol is accessible to uninitiated users with little experience i

272 To render this analysis accessible to users across all levels of expertise, we h

273 ation predicts how the amount of information accessible to viewers should influence the perception of

274 etiology from a variety of genetic variants accessible to WGS but not by previous technologies.

275 It is accessible to young children.

276 verlooked, largely due to the lack of easily accessible tool for reliable and natural respiration mon

277 provide the community with a fast and easily accessible tool for the analysis of LCRs with additional

278 high-resolution, reproducible, and publicly accessible tool, this study presents a wind damage model

279 The number of accessible tools almost linearly increases in time with

280 Among many accessible tools in diagnostic imaging, IVIM MRI aroused

281 y, we have formatted this data as a publicly accessible track hub, enabling researchers to explore th

282 CD8+ T cells in PBMCs, and 37 differentially accessible transcription factor (TF) motifs were identif

283 It becomes accessible upon pocket opening for selective covalent at

284 < 0.001) for a model including 9 clinically accessible variables.

285 contact with the solution phase and readily accessible via "liquid-like" diffusion.

286 Our approach deeply probes ligand space accessible via our synthetic methodology and provides a

287 Ras into functionally inactive forms may be accessible via subtle perturbations of Ras' orientationa

288 to features manually extracted from readily accessible videos (e.g., from smartphones) has the poten

289 It has been implemented on a freely accessible webserver.

290 a low equilibrium population (~1%), is only accessible when GLUex is protonated.

291 unless the axial conformer was energetically accessible, which is consistent with the transition stat

292 inclusion of functional groups not otherwise accessible with current synthetic routes.

293 For an optimum choice of parameters accessible with our design, the sensitivity of our absor

294 We report broad ranges of color shades accessible with rhodoxanthin across an unprecedented wid

295 reactions, including reactions that were not accessible with their better-known Bpin counterparts, sh

296 n becomes reversible at room temperature and accessible within a narrow potential window.

297 ws that regulatory elements gradually become accessible within pre-existing TADs during early differe

298 rrogation of multiscale network communities, accessible within the popular Cytoscape network analysis

299 tored in lakes and rivers and is universally accessible without pipelines or dams.

300 ore affordable, less time-consuming and more accessible worldwide, especially for early-career resear