ライフサイエンスコーパス: accessory

1 Accessory alpha4 forms an agonist-binding site with anot

2 s own and agonists' occupancy of primary and accessory alpha4 subunits.

3 equires intact Br-PBTC sites in at least one accessory and one primary alpha4 subunit.

4 ture across genomic functional regions, with accessory and structural ORFs containing the highest str

5 Accessory and transmembrane proteins assemble in signali

6 adiofrequency ablation of the main arteries, accessories, and side branches was not.

7 standard optical components and extra-cavity accessories) as well as basic fiber splicing and laser p

8 ther findings found in AI: diverticula (30), accessory auricular appendages (5), septal aneurysms (8)

9 e main nuclei (lateral [La], basal [Ba], and accessory basal [AB]) in six Macaca fascicularis monkeys

10 ressing neurons in the shell division of the accessory basal nuclear cluster, appear to be consistent

11 tical nucleus (p = 0.032, r(2) = 0.35), left accessory basal nucleus (p = 0.04, r(2) = 0.28) and bila

12 ctin filaments in cells could help to direct accessory binding proteins to different actin cytoskelet

13 , synergistic alphaalpha-hub:ligand folding, accessory binding sites, and supramodules.

14 subnasal point would successfully block the accessory branch of the infraorbital nerve.

15 ermo- and hygrosensory neuropil, the lateral accessory calyx (lACA), by reconstructing neurons downst

16 insic muscles, a robust tympanum and several accessory cartilages.

17 uced activation of NK cells was dependent on accessory cells and TLR-4-dependent innate cytokine secr

18 clude that vaccination-induced "training" of accessory cells combines with the generation of CIML NK

19 population of antigen-presenting and immune-accessory cells.

20 utilizing a novel over the scope additional accessory channel, termed EMR Plus (EMR+), was developed

21 Cleavage also requires the accessory cleavage factors IA and IB, which bind substra

22 Thus, Dnmt3b functions as an accessory cofactor supporting catalytic activities perfo

23 Atp6ap2 is an essential accessory component of the vacuolar ATPase required for

24 uss the roles of the CCV core, adaptors, and accessory components in plant defense signaling and immu

25 protein biogenesis, cells lacking different accessory components show reduced levels of one such cli

26 by MutTs, and in the absence of this system, accessory DNA polymerases and MutY/M contribute to antib

27 The catalytic-like domain of the accessory DNMT3B3 binds to the acidic patch of the nucle

28 sting of a ring-shaped core trailed by three accessory domains and requires an N-terminal segment of

29 y contained several domains, including known accessory domains and some domains never identified in a

30 Meiotic DSBs are generated by Spo11 and accessory DSB proteins, including Rec114 and Mer2, which

31 essory pancreatic ducts since persistence of accessory ducts will lead to maintenance of exocrine pan

32 pants revealed extensive in situ exchange of accessory elements as well as evidence of adaptive evolu

33 Accessory elements were predominantly promiscuous and pr

34 eria from two participants, including 12,251 accessory elements.

35 truction by discretely expressed ligases and accessory enzymes.

36 ology with minimal requirement for power and accessories, facilitating future POC applications.

37 faceted protein that serves as an enzyme, an accessory factor for other methyltransferases, and as a

38 predominantly serine-linked and require the accessory factor HPF1, which is specific for the DNA dam

39 n serine residues(6-8) and requires HPF1, an accessory factor that switches the amino acid specificit

40 olog-Hook-FHIP (FHF) complex as a novel AP-4 accessory factor.

41 p41/p46 complex, alone or in the presence of accessory factors (PCNA and RPA) indicates that transles

42 together with lineage-specific expression of accessory factors allows VAB-3/Pax6 to either promote or

43 o life, and RNA polymerase (RNAP) depends on accessory factors for recovery from stalled states and a

44 Reversible phosphorylation of Pol II and accessory factors helps order the transcription cycle.

45 interactions between retromer and associated accessory factors on the endosome membrane drives cluste

46 er and that neither membrane association nor accessory factors potentiate oligomerization.

47 he presence of membrane-associated cargo nor accessory factors substantially affected this distributi

48 onality is further regulated by a variety of accessory factors such as Sec1/Munc18 (SM), double C2-do

49 its nsp7/nsp8(2)/nsp12) along with a cast of accessory factors.

50 x comprising the core Sec61 channel and five accessory factors: TMCO1, CCDC47 and the Nicalin-TMEM147

51 eat potential of becoming an advanced energy accessory for wearable electronics.

52 tes to viral replication as well as to virus accessory functions-however, we find that the fitness ef

53 including the calculation of trees based on accessory gene content or allelic differences between co

54 Cells that entirely lose accessory gene function or plasmid mobility dominate in

55 ratory syndrome coronavirus (MERS-CoV) ORF4a accessory gene is expressed in yeast it causes a slow-gr

56 combination and overlaid with high levels of accessory gene plasticity.

57 Each compound inhibits all S. aureus accessory gene regulator (agr) alleles (IC(50) 2-70 muM)

58 ng inhibition activity against all S. aureus accessory gene regulator (agr) alleles in absence of gro

59 The accessory gene regulator (agr) QS system plays an import

60 The accessory gene regulator (agr) quorum-sensing system is

61 . aureus mutant containing a deletion of the accessory gene regulatory system (Agr), wherein both str

62 intrahost level showed low diversity in the accessory gene vpx in all patients.

63 volve 'satellite plasmids' with deletions of accessory genes and genes required for plasmid replicati

64 ation analyses revealed a large reservoir of accessory genes and single-nucleotide variants, many of

65 isolates the ones having a greater number of accessory genes and virulence-associated factors.

66 Our results liken ORF3d to other accessory genes in emerging viruses and highlight the im

67 rough encapsidated DNA synthesis and encodes accessory genes that antagonize specific antiviral effec

68 Here, we use the frequencies of accessory genes to predict changes in the pneumococcal p

69 requency of ABR genes remained stable, other accessory genes, especially those associated with mobile

70 frequency of antibiotic resistance (ABR) and accessory genes.

71 ntage from reducing burdensome expression of accessory genes.

72 enes, 46.13% (3195) unique and 30.82% (2135) accessory genes.

73 tbreak strain carried distinct mutations and accessory genetic elements that impacted genes with role

74 fer, adaptation and transmission to discover accessory genome changes linked to novel subtypes.

75 E. coli clade that arose through changes in accessory genome content.

76 We exemplify that viral-like accessory genome elements that decrease virulence can be

77 evidence suggests the Pseudomonas aeruginosa accessory genome is enriched with uncharacterized virule

78 operon-like structures that are part of the accessory genome of a genus.

79 aits, including multidrug resistance; 3) the accessory genome of the megaplasmid family is highly fle

80 given species and can be subdivided into the accessory genome, present in only some of the genomes, a

81 wing extensive gene gain and loss within the accessory genome.

82 tween ST313 L1 and L2, with a characteristic accessory genome.

83 c study highlights the dynamic nature of the accessory genomes in ST131, suggesting that surveillance

84 olutionary relationships across the core and accessory genomes using published reference genomes, lon

85 erformed whole-genome sequencing to identify accessory genomic elements correlated with increased bac

86 hospital surveillance and for characterizing accessory genomic elements that may impact MRSA virulenc

87 ure is characterized by dispensable genes in accessory genomic regions that exceed by orders of magni

88 velopmental stages and derived from both the accessory gland and other female organs.

89 duces production of storage proteins and key accessory gland components, a feature that impacts adult

90 , permitting more rapid replenishment of the accessory gland luminal contents.

91 omposition that is expressed from the female accessory gland.

92 mating or treatment with extracts from male accessory glands (MAG), which make seminal fluid molecul

93 in the size of mating plugs and reproductive accessory glands from which major plug proteins originat

94 state and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that e

95 We previously showed that in fly accessory glands, secondary cells (SCs) and their nuclei

96 melanogaster, most SFPs are produced in the accessory glands, which are composed of ~1,000 fertility

97 ne sets along with those associated with the accessory glands.

98 s, and larvae, as well as in male and female accessory glands.

99 ng, along with a variable angle of incidence accessory, have been used to differentiate between the s

100 Accessory helicase action during replication-transcripti

101 All eukaryotes contain the accessory helicase Pif1, which tracks in a 5'-3' directi

102 ically-encoded fluorescent constructs of the accessory helicase Rep and core replisome protein DnaQ i

103 Biochemical and genetic studies indicate accessory helicases play essential roles in replication

104 Cells use accessory helicases that help the replisome bypass diffi

105 e properties, dynamics, variable topologies, accessory helices, and malleability and abetted by adapt

106 this study was to define the location of the accessory infraorbital foramen (AIOF) with reference to

107 ons, high interference and high costs due to accessory instrumentation need to be addressed before th

108 r visual working memory representations are "accessory items", which have little direct influence on

109 na organ were suggested to send terminals to accessory laminae.

110 neurons that provide input from the lateral accessory lobe (LAL) to the noduli (NO).

111 unostained tangential neurons of the lateral accessory lobe cluster were also immunoreactive for GABA

112 rched for photic entrainment pathways to the accessory medulla (AME), the circadian clock of the Made

113 s in the lACA to the circadian clock via the accessory medulla.

114 ages for impact-driven shock-recrystallised accessory minerals.

115 deling occurring within a loosely connected 'accessory' module.

116 ecule shown to interact with and bind to the accessory molecule CD4, retain their significant disease

117 histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medull

118 adhesion molecules, the immunoreceptors DNAX accessory molecule-1 (DNAM-1), CD96 molecule (CD96), and

119 er, activating receptors such as NKp46, DNAX accessory molecule-1, and NKG2C and stimulatory receptor

120 Accessory molecules (major histocompatibility complex cl

121 l need to sacrifice the facial and/or spinal accessory nerves and because of a likely margin-positive

122 procedures and underscore the importance of accessory, non-HSC to accelerate hematopoietic engraftme

123 find that the ABC transporter NosFY and the accessory NosD protein are essential for the formation o

124 mediated remain unclear, as are the roles of accessory nuclear components in these processes.

125 R/Cas systems, where they likely function as accessory nucleases activated by cyclic oligoadenylate s

126 nal cuneate, X, and Z nuclei, and the median accessory nucleus.

127 tivation, correct glomeruli formation in the accessory olfactory bulb (AOB) and survival.

128 ty and an increase in the amount of incoming accessory olfactory bulb (AOB) inputs, as confirmed by e

129 ANCE STATEMENT Information processing in the accessory olfactory bulb (AOB) plays a central role in c

130 The accessory olfactory bulb (AOB), the first neural circuit

131 (EGCs), a major class of interneurons in the accessory olfactory bulb (AOB).

132 reflects the functional organization of the accessory olfactory bulb circuitry remain unclear.

133 tic drive are key elements in organizing the accessory olfactory bulb into functional microcircuits,

134 ynchronized microcircuits that subdivide the accessory olfactory bulb into segregated functional clus

135 activity, indeed, reflect the idle state of accessory olfactory bulb output in awake male and female

136 ically determined circuit-extending from the accessory olfactory bulb to the posterior medial amygdal

137 nar organization of the deeper layers of the accessory olfactory bulb was indistinct, perhaps as a co

138 In the mouse accessory olfactory bulb, the first central stage of inf

139 Within the accessory olfactory bulb, the glomeruli did not appear d

140 al stage of information processing along the accessory olfactory pathway, projection neurons (mitral

141 w dimension to chemosensory coding along the accessory olfactory pathway.

142 in the MOB.SIGNIFICANCE STATEMENT The mouse accessory olfactory system (AOS) interprets social chemo

143 (AOB), the first neural circuit in the mouse accessory olfactory system, is critical for interpreting

144 by vomeronasal sensory neurons (VSNs) in the accessory olfactory system.

145 , we detail the organization of the main and accessory olfactory systems of the African wild dog.

146 roup contains conserved (core) and variable (accessory) open reading frames (ORFs) grouped at fixed r

147 hich detect global motion and project to the accessory optic system (AOS), oscillated with the same f

148 well as the parabigeminal nucleus, while the accessory optic system includes the dorsal, lateral and

149 e-forming, nonimage forming, oculomotor, and accessory optic, vision-associated systems in the brain

150 the main renal arteries, side branches, and accessories; or (3) an endovascular ultrasound-based RDN

151 The human microbiome, described as an accessory organ because of the crucial functions it prov

152 ingly, we find that the esophageal gland, an accessory organ of the digestive tract, develops before

153 It is important to identify and ligate accessory pancreatic ducts since persistence of accessor

154 insufficiency most likely due to undetected accessory pancreatic ducts.

155 o identify risk factors for recurrence after accessory pathway (AP) ablation.

156 period of 7 years, 2 patients had undergone accessory pathway ablation, 8 patients (36%) underwent p

157 ventricular pre-excitation or had undergone accessory pathway ablation; 17 (19%) had pacemakers (med

158 Nodoventricular and nodofascicular accessory pathways (AP) are uncommon connections between

159 r homeostatic response and also the indirect accessory pathways that deal with copper-induced damage.

160 Small subunit 18S rRNA gene sequencing and accessory pigment analysis displayed similar trends, ind

161 re predominantly vertically inherited, while accessory plasmid gene families show significantly incre

162 ring-like architecture, with catalytic Rev3, accessory Pol31' Pol32 and two Rev7 subunits forming an

163 on rather than correcting OG incorporated by accessory polymerases (DinB1/DinB2/DinB3/DnaE2).

164 oses its interaction with all other core and accessory PRC2 subunits.

165 The melanocortin receptor accessory protein 2 (MRAP2) plays a pivotal role in the

166 the retina and require association with the accessory protein basigin, encoded by Bsg, for maturatio

167 activity, most lentiviruses express a viral accessory protein called the virion infectivity factor (

168 ngle amino acid replacements in a regulatory accessory protein can affect protein-protein interaction

169 Each accessory protein contributed to Dmc1's activity, with t

170 Viral protein U (Vpu) is an accessory protein encoded by HIV-1 as well as by some si

171 viral factors-in particular, HIV subtype and accessory protein function-in modulating viral reservoir

172 expressing LPL with a soluble variant of its accessory protein glycosylphosphatidylinositol-anchored

173 The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent

174 sociated mutations are able to impair Na(V) -accessory protein interactions without altering other pr

175 structural and biophysical details of Na(V) -accessory protein interactions.

176 ow activity in TKO mESCs, indicating that an accessory protein is absolutely required for its functio

177 canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G(2)/M cell c

178 ed DNA, self-assembly or interaction with an accessory protein is needed to activate its helicase act

179 ed by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP.

180 e possibility that natural variation in this accessory protein may contribute to viral pathogenesis a

181 Here, we showed that the accessory protein MRAP2 altered GHSR1a signaling by inhi

182 The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control

183 dditionally, viral factors such as the HIV-1 accessory protein Nef can antagonize this antiviral acti

184 The HIV-1 accessory protein Nef is essential for viral pathogenesi

185 The HIV accessory protein Nef modulates key immune evasion and p

186 The accessory protein Nef of human immunodeficiency virus (H

187 fect of SERINC5 is counteracted by the viral accessory protein Nef.

188 Nef is an accessory protein of primate lentiviruses that is essent

189 The Nef accessory protein of simian immunodeficiency virus (SIV)

190 Our data suggest that IGF2BP2 is an accessory protein of the argonaute (AGO2)-miR-33a/b-RISC

191 Our results demonstrate that the viral accessory protein Orf6 exerts this anti-IFN activity.

192 one and blood pressure (BP), the role of its accessory protein phospholemman has not been characteriz

193 y is the CovR/S two-component system and the accessory protein RocA.

194 Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-re

195 ococcus (GAS), regulator of Cov (RocA) is an accessory protein that functions with the control of vir

196 region that expresses a membrane-associated accessory protein that limits AAV production through com

197 l component of HIV-1 and show that ASP is an accessory protein that promotes viral replication.

198 volved regulator of Cov (RocA), a regulatory accessory protein to CovRS.

199 Previously, the accessory protein UL21 was found to be important for the

200 The HIV-1 accessory protein viral protein U (Vpu) enhances release

201 human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr enhances viral replication in both

202 The HIV-1 accessory protein Vpu counteracts BST-2 by downregulatin

203 hogenesis and/or spread.IMPORTANCE The HIV-1 accessory protein Vpu enhances viral spread by downregul

204 ted to plasmodesmata, while two forms of the accessory protein were differentiated on the basis of th

205 text of a Syn variant, removal of a required accessory protein will block cell fusion, again forcing

206 ted protein severely disrupts binding of the accessory protein, HMGB1.

207 We found that stable expression of an HTLV-1 accessory protein, HTLV-1 bZIP factor (HBZ), in Jurkat T

208 ptor (ST2) and its coreceptor, IL-1 receptor accessory protein, into a single fusion protein.

209 The Kv1.3 accessory protein, potassium voltage-gated channel subfa

210 homology containing 4 (Lrch4) as a novel TLR accessory protein.

211 d within the carboxy-terminal domain of this accessory protein.

212 1 (ICU11) as a Polycomb Repressive Complex 2 accessory protein.

213 nism of MERS-CoV open reading frame (ORF) 8b accessory protein.

214 Thus, the C protein, rather than being an "accessory" protein as qualified in textbooks so far, is

215 ilient machinery that includes >70 endocytic accessory proteins (EAP).

216 lated process involves a myriad of endocytic accessory proteins (EAPs), many of which are multidomain

217 rus (RSV) is no exception, as it encodes two accessory proteins (NS1 and NS2) which are well establis

218 Recent work demonstrates that accessory proteins and post-translational modifications

219 Translation is controlled by numerous accessory proteins and translation factors.

220 ut their RNA-targeting function, how Type VI accessory proteins are able to modulate Cas13 activity,

221 ncluding where MR1 acquires ligands and what accessory proteins assist ligand binding.

222 rolases, 200 membrane proteins, and numerous accessory proteins associated with the cytosolic surface

223 kinetic transitions are tightly regulated by accessory proteins at the synapse.

224 PRC2.1 and PRC2.2, are defined by the set of accessory proteins bound to the core PRC2 subunits.

225 e, we show that the actin-binding domains of accessory proteins can be sensitive to filament conforma

226 They also show that accessory proteins can bias signaling downstream of GPCR

227 Numerous endocytic accessory proteins collaborate with clathrin and AP2 to

228 /N interference by Vif.IMPORTANCE Of all the accessory proteins encoded by HIV-1 and other primate le

229 which recombinase specificities for meiotic accessory proteins enhance separation of the recombinase

230 Viral accessory proteins hijack host cell E3 enzymes to antago

231 RAD51 is regulated by many accessory proteins including the highly conserved Shu co

232 Accessory proteins interact with TCSs to fine-tune their

233 that endogenous abundance of CEBPB and saRNA accessory proteins may dictate efficacy of CEBPA-saRNA w

234 cells due to CD4 downregulation by the HIV-1 accessory proteins Nef and Vpu.

235 tivation of nickel enzymes requires specific accessory proteins organized in multiprotein complexes c

236 ns from budding yeast including Dmc1 and its accessory proteins RPA, Rad51, Rdh54/Tid1, Mei5-Sae3 and

237 structural elements that modulate them, and accessory proteins that appear to control RNA polymerase

238 cellular processes are described, as well as accessory proteins that control their activity, and curr

239 nt silencing is developmentally regulated by accessory proteins that either increase the concentratio

240 Here, genome-wide screening identified accessory proteins that enable reconstitution of human a

241 cludes the viral fusion proteins and various accessory proteins that prevent cells from fusing.

242 psis thaliana Epsin-like proteins, which are accessory proteins to APs facilitating vesicle biogenesi

243 be prevented by removing various individual accessory proteins to further disable the machinery.

244 In contrast, removal of individual accessory proteins will block cell-to-cell spread, forci

245 rial Sec translocon, SecYEG, associates with accessory proteins YidC and the SecDF-YajC subcomplex to

246 tivation, signal transduction, regulation by accessory proteins, and crosstalk with other GPCRs.

247 e structural nitrogenase components and many accessory proteins, and occurs both in situ, for the P-c

248 ed in vivo with PRC2 core components and the accessory proteins, EMBRYONIC FLOWER 1 (EMF1), LIKE HETE

249 uses, especially in regard to the variety of accessory proteins, it is crucial to characterize the sp

250 cterize the products of the HM synthases and accessory proteins, we chose a synthetic biology approac

251 s of the filament, such as the 11 stripes of accessory proteins.

252 ctivated and regulated by cargo adaptors and accessory proteins.

253 n machinery (gD, gH/gL, and gB) and numerous accessory proteins.

254 ounteraction of these host defenses by viral accessory proteins.

255 nal domain, which in turn recruits endocytic accessory proteins.

256 usion complex, including multiple SNAREs and accessory proteins.

257 sely regulated by the assembly of SNAREs and accessory proteins.

258 modulation are complex and involve multiple accessory proteins.

259 of zeste 12 (SUZ12), along with a number of accessory proteins.

260 pore transitions, and to define the role of accessory proteins.

261 alyze all 10 (structural, non-structural and accessory) proteins from SARS-CoV-2 using predictive alg

262 ain, which associates with the amyloid as an accessory proteolytic fragment.

263 yelid abnormalities (including ectropion and accessory puncta).

264 e electronics requires a revolution of power accessories regarding flexibility and energy density.

265 The staphylococcal accessory regulator (sarA) plays an important role in St

266 VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retro

267 Accessory resistance mechanisms including upregulation o

268 mand-line arguments that preclude the use of accessory scripts.

269 These adaptations are also reflected in the accessory sensory pathways in the brain that process the

270 e study outlined herein aims to determine if accessory sex glands and epididymal epithelial cells are

271 Surprisingly, we found that an acellular accessory structure close to the stereocilia, the tector

272 m axonemal repeat includes dynein motors and accessory structures as the foundation for motility of e

273 To understand how an accessory subunit (CoREST) enables a chromatin enzyme (L

274 f a gene, NCU04278, encoding an unknown PRC2 accessory subunit (PAS).

275 Our structure contains a previously unknown accessory subunit CydH, the L-subfamily-specific Q-loop

276 ompetent DNMT3A2, the catalytically inactive accessory subunit DNMT3B3 and a nucleosome core particle

277 d1 knockout mice revealed GLMP as a critical accessory subunit for MFSD1.

278 ith the acidic pocket of nucleosomes and the accessory subunit Ioc3 with nucleosomal DNA.

279 toplasmic domain of either the channel or an accessory subunit is thought to plug the open pore to in

280 nic mice lacking the mitochondrial complex I accessory subunit NDUFS4 develop early-onset optic atrop

281 Barttin is the accessory subunit of the human ClC-K chloride channels,

282 Depletion of the Pol delta accessory subunit POLD2 destabilizes the complex, result

283 Diverse accessory subunits are involved in the recruitment of po

284 etry and the presence or absence of specific accessory subunits for determining the activity of these

285 reveals significant differences in core and accessory subunits of the plant complex compared to yeas

286 UZ12-RBBP4 complex bound to fragments of the accessory subunits PHF19 and JARID2.

287 mprising the catalytic subunit POLD1 and the accessory subunits POLD2, POLD3, and POLD4.

288 four core subunits, PRC2 comprises multiple accessory subunits that vary in their composition during

289 ls function in macromolecular complexes with accessory subunits to regulate brain function.

290 ramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together ga

291 chromatin interaction modes are modulated by accessory subunits, oncogenic histone mutations, and the

292 xity of its activity and the function of its accessory subunits.

293 lines for OST isoform-specific catalytic and accessory subunits.

294 e binding to dissect the role of NBS2 of the accessory SUR1 subunit of K(ATP) in channel gating.

295 ersatility to interface with a wide range of accessory technologies in the future.

296 it how NCBP3, as an alternative to CBP20, an accessory to the canonical CBP20-CBP80 CBC, and/or an RN

297 e megaplasmids encode diverse niche-adaptive accessory traits, including multidrug resistance; 3) the

298 tients with AF, analyzing the number of PVs, accessory variants and veins, diameter and ostial shape,

299 Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad im

300 tenuated total internal reflectance sampling accessory was exploited to monitor the reaction.