ライフサイエンスコーパス: accrual

1 = 37) and 3B (n = 12; cohort closed for slow accrual).

2 ssessable for toxic effects after completing accrual.

3 efects in replication capacity and bone mass accrual.

4 n accrual and asking how mating affects that accrual.

5 t linear growth but compromised overall bone accrual.

6 rmation is not closely linked with WM lesion accrual.

7 This trial is currently closed to accrual.

8 tive effects of pregnancy against disability accrual.

9 gnaling pathway, thereby facilitating T cell accrual.

10 one arm was discontinued as a result of poor accrual.

11 ion complex, therefore allowing beta-catenin accrual.

12 vents the replication of damaged DNA and DSB accrual.

13 C (STARS and ROSEL) closed early due to slow accrual.

14 , which is a period of substantial bone mass accrual.

15 tracellular enzymatic activities, or biomass accrual.

16 closed early because of lower than projected accrual.

17 calTrials.gov, NCT01527825, and is closed to accrual.

18 calTrials.gov, NCT02275780, and is closed to accrual.

19 was unlikely to change with further patient accrual.

20 100% of cases, which can limit hospital case accrual.

21 er 94 patients were enrolled because of slow accrual.

22 uld require 6.7 years on average to complete accrual.

23 se were documented as challenges for patient accrual.

24 hibited this response at the level of RNF168 accrual.

25 e toxicity was not identified during patient accrual.

26 lled an average of 15% of their total target accrual.

27 orders, may have deleterious effects on bone accrual.

28 alTrials.gov, NCT03055000, and is closed for accrual.

29 closed with 337 patients as a result of slow accrual.

30 hetic tone, thus potently favoring bone mass accrual.

31 osteoblast-secreted Wnt ligands in bone-mass accrual.

32 d as the most important predictors of damage accrual.

33 the trial was halted prematurely due to slow accrual.

34 the brain, is a major regulator of bone mass accrual.

35 ggested futility, so the study was closed to accrual.

36 hronic MS, likely contributing to disability accrual.

37 underpowered and many face difficulties with accrual.

38 istry, ACTRN12612000632897, and is closed to accrual.

39 the control arm, and the study was closed to accrual.

40 th ISRCTN, number 11166984, and is closed to accrual.

41 ternal BMI and with infant adiposity and fat accrual.

42 n of Glut1 itself did not affect normal bone accrual.

43 An analysis was performed for slow accrual: 136 patients were enrolled from 2010 through 20

44 an effect of high-titre plasma even if full accrual (150 participants) was achieved.

45 Median RTOG accrual (1997 to 2002) at HLACs was four versus 65 patie

46 cruitment was closed prematurely due to poor accrual after 89 of 200 planned patients were randomly a

47 ing board recommended the trial be closed to accrual after an interim analysis met prespecified crite

48 embryonic development, as well as bone mass accrual after birth, through two complementary cellular

49 study was discontinued early because of slow accrual after the enrollment of 70 patients.

50 rapy are likely key factors that impair bone accrual, along with downstream effects including malnutr

51 contribute to lifelong growth and bone mass accrual, although the specific role of maternal deficien

52 The trial has completed accrual and 206 patients with similar baseline character

53 safety monitoring board on the basis of slow accrual and a low likelihood of detecting a difference i

54 pose Broadening trial eligibility to improve accrual and access and to better reflect intended-to-tre

55 The reported study has completed accrual and all analyses are final.

56 The study completed accrual and all analyses are final.

57 ggesting a causal link between pretangle tau accrual and altered locus coeruleus fibre morphology.

58 The protocol is closed to accrual and analysis was performed per protocol.

59 habditis elegans germline stem cell mutation accrual and asking how mating affects that accrual.

60 randomised controlled trials with completed accrual and available disease-free survival and overall

61 g oxidative stress-mediated arterial calcium accrual and bone loss.

62 ucing disease activity and preventing damage accrual and death.

63 etely lacking LRP6), we infer that bone mass accrual and dental patterning are more sensitive to redu

64 e relapse recovery contributes to disability accrual and earlier onset of secondary progressive multi

65 = 422) as a result of a lower-than-expected accrual and event rate.

66 Further accrual and follow-up are required to assess longer-term

67 iet (SD) irrespective of age, sex, body mass accrual and functional leptin or melanocortin-4 receptor

68 n fibrillar and soluble amyloid-beta and tau accrual and in the glial response that discriminated dem

69 ort A was closed prematurely because of poor accrual and is not reported.

70 at Rhbdf2 plays a decisive role in bone mass accrual and microarchitecture.

71 ings highlight the importance of CD36 in the accrual and nucleation of NLRP3 ligands from within the

72 Lrp6 are essential for normal postnatal bone accrual and osteoblast function.

73 Ecosystem carbon (C) accrual and storage can be enhanced by removing large he

74 d scheduled interim analysis because of slow accrual and the end of funding, which left the study und

75 This trial is closed to accrual and the final analysis is presented in this repo

76 The study is closed to accrual and this is the planned analysis.

77 ed on Dec 20, 2013, after achieving complete accrual, and follow-up remains ongoing for the primary o

78 cal power calculations, insufficient patient accrual, and incorrect predictions of baseline event rat

79 uences for MSC lineage commitment, fetal fat accrual, and offspring obesity risk.

80 s insufficient evidence to support continued accrual, and the trial was closed.

81 (b) their relation with white matter lesion accrual; and (c) the contribution of 7.0-T cortical and

82 directly control osteoclastogenesis and bone accrual around endosseous implants.

83 fy variables associated with rates of damage accrual as measured by the SDI.

84 ly, Paip2 accumulation was dependent on PABP accrual, as preventing PABP1 accumulation suppressed vir

85 al carnitine content, and prevents body mass accrual associated with carbohydrate feeding alone.

86 rt with carcinoid tumours, and we terminated accrual at 20 patients.

87 nction was increased, accelerating mortality accrual at later ages.

88 ing 53BP1 in BRCA1-null cells restores PALB2 accrual at resected DSBs.

89 g distributional knowledge and incorporating accrual at the design stage could achieve large gains in

90 thway was required for optimal cortical bone accrual at the periosteum in mice.

91 rbon and nutrient cycling: (a) algal biomass accrual; (b) microbial respiration; and (c) decompositio

92 ation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised

93 efined as old versus newer era using initial accrual before or after 1995.

94 Accrual began December 2005 and was completed in 13 mont

95 Patient accrual began in March 2010 and ended in August 2011.

96 Accrual began on September 5, 2012, and ended on June 28

97 ry bowel disease (IBD) leads to lack of bone accrual, bone loss, and increased fractures.

98 This trial is closed to accrual but follow-up is ongoing.

99 re roots drive SOC stabilization causing SOC accrual, but also SOC destabilization causing SOC loss.

100 in the liver because the rates of fatty acid accrual by uptake from plasma and de novo synthesis exce

101 clearance, indicating endogenous free water accrual by urine concentration.

102 all--hormonal changes, and deficits in bone accrual can persist.

103 A (VEGFA) in the mouse did not diminish bone accrual caused by HIF1alpha stabilization.

104 Results Planned enrollment was 356 patients; accrual ceased at 272 because of high relapse incidence

105 Purpose Despite increasing awareness of accrual challenges, it is unknown if accrual of older pa

106 Accrual continues seamlessly to the other research arms

107 .9; P = .04), surpassing white matter lesion accrual (cortical, 2.0 +/- 2.8 vs white matter, 0.7 +/-

108 included study protocols, trial budgets, and accrual data.

109 rty to young adulthood, when bone growth and accrual decelerate.

110 with prospective follow-up and ongoing data accrual designed to facilitate longitudinal, clinically-

111 ren and adolescents did not affect bone mass accrual despite significant increases in serum 25(OH)D c

112 Identifying factors that impair bone accrual during childhood is a critical step toward osteo

113 were assessed based on the timing of damage accrual during cohort participation.

114 ling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis.

115 tions remained about the need for myonuclear accrual during muscle adaptation in a physiological sett

116 gain, DeltaBMIZ is the best indicator of fat accrual during the first 5 postnatal months.

117 Bone accrual during youth is critical to establish sufficient

118 (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis of failur

119 up trials has a positive peak during patient accrual followed by a negative trough during follow-up.

120 accrual to adjuvant trials but worsening of accrual for neoadjuvant/metastatic trials.

121 Accrual for nonsquamous patients halted in 2013.

122 lected following the opening of the study to accrual from October 10, 2006, through December 31, 2014

123 tive propensity-matched cohort analysis with accrual from September 1, 2012, to September 30, 2015.

124 m tertiary academic centers, but prospective accrual from the community over the last 12 years has re

125 Eleven subprotocols reached their accrual goal as of this report.

126 The trial reached its accrual goal of 42 median age, 63 years (range, 45-83 ye

127 the study did not reach its original target accrual goal.

128 istration phase III study failed to meet its accrual goals, it did appear to show some benefit, espec

129 disease (CHD) poses multiple threats to bone accrual; however, the associated fracture risk is not we

130 tation prompted the closure of this trial to accrual in 2017.

131 ry clinical milestone has been completion of accrual in a phase 3 trial of intratumoral herpes simple

132 th LDL containing ceramide promoted ceramide accrual in cells and was accompanied by reduced insulin-

133 elective antibody, to attenuate amyloid-beta accrual in cerebral vessels and to acutely restore vascu

134 PFAS exposure may impair bone accrual in childhood and peak bone mass, an important de

135 allosteric inhibitor impaired human platelet accrual in damaged arterioles.

136 soil and be the dominant contributor to SOC accrual in diversified perennial bioenergy crops.

137 n D and calcium supplementation on bone mass accrual in HIV-infected youth.

138 entrations), production (based on ergosterol accrual in ingrowth cores), and turnover rate (the quoti

139 Random assignment was closed to accrual in March 2018 after a futility boundary had been

140 degeneration that contributes to disability accrual in multiple sclerosis.

141 ide novel therapeutic targets for disability accrual in multiple sclerosis.

142 ive strategy for rapid and efficient patient accrual in pediatric SCA studies.

143 h the total volume of sedentary time and its accrual in prolonged, uninterrupted bouts are associated

144 red sedentary behavior (its total volume and accrual in prolonged, uninterrupted bouts) and all-cause

145 genome-wide measurements of in vivo mutation accrual in stem cells and will enable further characteri

146 Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone

147 phenotypes that includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus

148 was detected in the locus coeruleus prior to accrual in the medial entorhinal cortex or hippocampus,

149 anized lifestyles in later life on bone mass accrual in young adults from a rural community in India

150 Final accrual included 1,738 patients; 865 patients received e

151 Challenges to trial accrual included patient preference of noninvestigationa

152 Accrual information was obtained from trial sponsors.

153 Bone mass accrual is a major determinant of skeletal mass, governe

154 ization is initiated at normal rate, mineral accrual is accelerated, indicating that EphrinB2 in oste

155 mice expressed low levels of CD25, and their accrual is associated with declining levels of IL-2 in a

156 The accrual is complete and final results are presented here

157 Accrual is complete and follow-up is still on-going.

158 Because bone mass accrual is completed by young adulthood, assessing stimu

159 Bone mass accrual is inhibited by sympathetic signaling centrally

160 Accrual is ongoing in some disease cohorts.

161 when trials are forced to close for lack of accrual, it is imperative to build multidisciplinary con

162 trictive eligibility criteria can slow trial accrual, jeopardize the generalizability of results, and

163 e and ecosystem functioning, including algal accrual, leaf decomposition and microbial respiration, w

164 that were stopped early due to insufficient accrual/logistical issues.

165 ions in the aortic media, attenuated calcium accrual more than 2-fold, and doubled longevity as compa

166 Lack of patient accrual (n = 64, 32.1%) and informative termination (n =

167 h circumstances, current (foreground) reward accrual needs to be compared continuously with potential

168 GLS2 expression and nuclear accrual notably increased by treatment of SH-SY5Y cells

169 Accrual occurred from November 2006 through July 2012, w

170 year (mean, 1.3 years) postvaccination until accrual of >/=96 confirmed HZ cases (as determined by te

171 Accrual of 1,113 evaluable patients per treatment arm wa

172 sis of the first cohort, which had a planned accrual of 17 participants.

173 analysis of the second cohort had a planned accrual of 27 participants, based on non-inferiority cri

174 The combination arm completed the full accrual of 28 patients, of whom 22 patients (78.5%) had

175 added 14% more events and shortened time to accrual of a fixed number of events.

176 displayed disrupted fluid flux and increased accrual of autofluorescent material after long-term POS

177 ith children who were healthy weight for the accrual of bone mass in response to an extra 3 servings

178 enting disease relapse, and limiting overall accrual of both disease-related damage and treatment-rel

179 zebrafish, we find that the OFT expands via accrual of both endocardial and myocardial cells.

180 ys over the same period, reducing the annual accrual of C in woody biomass by 41%.

181 detrimental in the failing heart because of accrual of cardiomyocyte death.

182 lly neutralizes MDSCs and triggers the rapid accrual of cytotoxic T cells, with consequent tumor clea

183 Accrual of disability during the RCT (R(2)=0.12; p<0.000

184 s is characterised clinically by the gradual accrual of disability independent of relapses and can oc

185 uts of gene copy number amplification during accrual of distant point mutations can potently facilita

186 Assaying in vivo accrual of DNA damage and DNA mutations by stem cells an

187 5 (K13/K15) upon DNA damage and promotes the accrual of downstream repair factors at damaged chromati

188 is stimulated by autocrine IL-6 and inhibits accrual of Ets-1, Set1 methyltransferase and trimethylat

189 Accrual of further patients was discontinued in any rese

190 roup's biology has also benefited from rapid accrual of genomic resources, particularly with respect

191 In this study, DCs present in seroma, an accrual of human afferent lymph occurring after lymph no

192 tected in seroma fluids, which represents an accrual of human afferent lymph, indicating that they ma

193 The accrual of large genotyped AN case-control samples shoul

194 The factors, however, that regulate the accrual of macrophages in adipose tissue are not well un

195 ta) in the walls of cortical vessels and the accrual of microbleeds and microinfarcts over time.

196 environmental context and proposes that the accrual of mtDNA variation could contribute to animal sp

197 We show that the accrual of mutations should track cell divisions not onl

198 cling correlates with a dramatic increase in accrual of mutations.

199 rm of multiple sclerosis is characterized by accrual of neurological dysfunction from disease onset w

200 st often await development of new methods or accrual of new observations that in retrospect can lead

201 Novel strategies to increase accrual of older patients are critical to meaningfully c

202 Methods We examined accrual of older patients to Alliance for Clinical Trial

203 ness of accrual challenges, it is unknown if accrual of older patients to breast cancer treatment tri

204 edefined primary end point of four ORs after accrual of only 17 patients; of 15 patients who initiate

205 tients, including challenges associated with accrual of patients across different treatment centres a

206 The accrual of patients with RET-rearranged lung cancer to t

207 evelopment of marrow adipocytes and hindered accrual of peak cortical and trabecular bone.

208 Inadequate accrual of pediatric patients precluded conclusions in t

209 With accrual of pedigree data over multiple decades, we retes

210 ifferences in clinical course and pattern of accrual of permanent disability in the two disorders.

211 n the fibrous cap of the plaques lead to the accrual of plaque-destabilizing mechanical stress.

212 en lattice sites locally to adjust the phase accrual of propagating electrons.

213 tropic defects in cellular functions and the accrual of proteinaceous deposits at end-stage disease.

214 dual stromal cells, as evidenced by promoter accrual of repressive histone marks.

215 e use a model of inflammation resulting from accrual of self DNA (DNase II(-/-) type I IFN receptor [

216 Our findings suggest that the lifetime accrual of sensory experience optimizes functional brain

217 cle; two phenotypes were observed: decreased accrual of skeletal muscle mass after weaning and reduce

218 ing that wakefulness can be dissociated from accrual of sleep need.

219 comes but was associated with a reduction in accrual of subcortical white matter disease.

220 icoid and glucocorticoid release, endogenous accrual of surplus body water, and precise surplus excre

221 INT6 silencing impaired the accrual of the ubiquitin ligase RNF8 at DSBs and the for

222 In DNase II-deficient mice, the excessive accrual of undegraded DNA leads to both a STING-dependen

223 se II and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent,

224 es were changes in mobility (gait speed) and accrual of white matter hyperintensity volume after 3 ye

225 We found more, and faster accrual of, absolute numbers of extinction events in bio

226 After additional accrual on an extension phase, total enrollment was 60 p

227 The CHHiP trial completed accrual on June 16, 2011, and the QoL substudy was close

228 The trial was closed to accrual on Oct 14, 2019, after the interim analysis fail

229 required to determine the impact of impaired accrual or actual loss of bone during adolescence on sub

230 no difference according to year of starting accrual or cooperative group.

231 A few trials had poor accrual or had design flaws that led to conflicting resu

232 sociations with ITP duration may reflect CMB accrual over time or more refractory disease.

233 ain serotonin positively regulates bone mass accrual peripheral serotonin is a potent inhibitor of bo

234 Timely accrual poses a challenge to the conduct of a large rand

235 rol the intensity of T cell responses, their accrual probably contributes to age-related immune dysfu

236 ew Madrid region is driven by ongoing strain accrual processes and that, despite low deformation rate

237 We assessed the accrual proportion, investigated their most common reaso

238 Feasibility of large-scale accrual, prospective tumor collection, and molecular str

239 secondary end points as well as a decreasing accrual rate (NCT01233713).

240 The accrual rate of 2.6 patients per month was superior to t

241 Feasibility, defined by the accrual rate, the safety of the preoperative regimen, an

242 decrease in final chlorophyll a biomass and accrual rates the most in the downstream reach containin

243 tive treatment and supportive care, although accrual rates to therapeutic clinical trials remain disa

244 recision) and the quality of the image data, accrual rates, and study power is needed.

245 tients with refractory malignancies at 1,117 accrual sites were analyzed centrally with NGS and selec

246 Patient accrual started on July 16, 2007, and was completed on J

247 Accrual stopped early in 2012 for squamous patients beca

248 mg/m(2)) as a single dose, using a rolling-6 accrual strategy.

249 d by the sympathetic regulation of bone mass accrual take place.

250 rpowered because it did not meet the planned accrual target, and OS was higher than predicted in both

251 onvert to a phase of irreversible disability accrual termed secondary progressive MS.

252 ssed at a preplanned interim analysis, trial accrual terminated in April, 2011.

253 and HFD produced selective deficits in bone accrual that were associated with alterations in progeni

254 After completion of the planned accrual, the protocol was amended to introduce a third a

255 Given the feasibility of accrual, the statistical plan only permitted detection o

256 The study is ongoing but closed to accrual; these are the results of the final analysis of

257 Incorporating accrual time and assuming an increasing hazard rate at t

258 s) or high-accruing centers (HHACs) based on accrual to 21 RTOG HNC trials (1997 to 2002).

259 We expanded accrual to 44 patients to increase our ability to evalua

260 Actual accrual to 93.2% of trials was 1,804 patients, an estima

261 We observed some improvement in accrual to adjuvant trials but worsening of accrual for

262 Completion of accrual to all other arms was not feasible.

263 ta monitoring committee recommended stopping accrual to both celecoxib-containing arms on grounds of

264 Accrual to cohort 2 was stopped after an unplanned inter

265 eliance developing myofibers have on nuclear accrual to establish size, and the limits of adaptabilit

266 The CTD uses revenue from accrual to existing trials to cross-subsidize past trial

267 To examine accrual trends, we modeled age as a function of time, us

268 ition to profoundly low overall cancer trial accrual, vast underrepresentation by age, cancer stage,

269 each of these sources to liver-triglyceride accrual, VLDL-triglyceride synthesis, and hypertriglycer

270 The effect of accrual volume on OS was estimated by Cox proportional h

271 radiation dose, tumor location, institution accrual volume, esophagitis/dysphagia, planning target v

272 Target accrual was 130 patients to detect an increase in median

273 was 2-year event-free survival; the planned accrual was 38 patients.

274 Target accrual was 50 patients, with a one-stage design.

275 Target accrual was 680 patients.

276 Increased plant C accrual was accompanied by higher soil microbial activit

277 Although accrual was based on the therapeutic question, potential

278 The planned trial accrual was completed in May, 2012, and follow-up is ong

279 Accrual was from November 1998 to April 2009.

280 Accrual was from September 2013 to June 2016 (N = 80; co

281 ast to white matter lesions, cortical lesion accrual was greater in participants with secondary progr

282 Accrual was halted on the basis of the data and safety m

283 Subject accrual was plotted as a function of resuscitation durat

284 Finally, Treg accrual was significantly blunted in aged IL-6-deficient

285 orptiometry scanning revealed that bone-mass accrual was significantly inhibited in homozygotes as ea

286 Accrual was stopped early for futility.

287 Accrual was stopped short of 930 patients on the basis o

288 Accrual was terminated at 338 of 2,150 planned patients

289 Patient accrual was terminated in December, 2008, because of slo

290 patient characteristics and rates of damage accrual were assessed based on the damage score at the l

291 e-varying patient characteristics and damage accrual were assessed based on the timing of damage accr

292 l trials open in the United States and their accrual were examined to identify opportunities to accel

293 a phase II/III trial are whether to suspend accrual while the phase II data mature and the choice of

294 indicate that ZO-1 binding regulates channel accrual, while disengagement from ZO-1 is critical for G

295 It is anticipated that clinical trial accrual will increase substantially, providing further g

296 The design stopped accrual with 633 patients at its first sample size asses

297 data show a role for IL-6 in promoting eTreg accrual with age likely through maintenance of ICOS expr

298 Permitting preprotocol therapy facilitated accruals without compromising outcomes.

299 esian predictive calculation that additional accrual would be unlikely to change the qualitative comp

300 s were observed among 12 patients, the study accrual would have continued (sample size, 28).