ライフサイエンスコーパス: accrue

1 dose-response relationship as complications accrue.

2 changes in biodiversity can take decades to accrue.

3 ons, and updates its predictions as new data accrue.

4 low-up of 9.4 years, 654 diabetes cases were accrued.

5 n follow-up of 27 y, 2131 incident CAD cases accrued.

6 ry 2001 and February 2002, 946 patients were accrued.

7 dots, as a result fluorescence quenching was accrued.

8 for 10.1 years, and 50,620 incident cancers accrued.

9 ce is determined by the magnitude of fatigue accrued.

10 Stage 2 follow-up is ongoing and is fully accrued.

11 e cycle and intergenerational effects can be accrued.

12 n 1700 additional ARIC CAD events have since accrued.

13 These guidelines will be updated as evidence accrues.

14 nizing temperatures where most embryogenesis accrues.

15 Patients accrued 116,073 person-years of follow-up.

16 with baseline T-scores of -2.0 or more were accrued (147 allocated exemestane, 153 anastrozole); and

17 icenter FinXX randomized clinical trial that accrued 1500 women in Finland and Sweden between January

18 s: Standard management yielded 9.6 QALYs and accrued $155261 in lifetime costs, while intensive manag

19 intensive management yielded 10.5 QALYs and accrued $176584 in costs.

20 The algorithm accrued 21,644 subjects (65.83% European American and 34

21 The trial accrued 210 eligible patients (105 randomly assigned to

22 On average, trials accrued 25 to 35 patients over a 2-year period and teste

23 toring board recommend study closure, having accrued 295 patients.

24 Between Aug 28, 2014, and May 18, 2016, we accrued 30 eligible patients and treated them with BAT.

25 The study planned to accrue 324 patients and was powered for a 50% improvemen

26 The study accrued 344 patients from 2008 to 2013.

27 The EHR-based classifications were used to accrue 4,500 bipolar disorder cases and 5,000 controls f

28 en May 13, 2016, and Jan 30, 2019, the study accrued 46 patients.

29 ry outcomes for the pilot phase were time to accrue 500 participants and retention; secondary outcome

30 The study accrued 59 patients (human papillomavirus [HPV] positive

31 with an incremental impact as complications accrued (6.7% 1 complication vs 26.1% >/=3, lowest quint

32 r surgery (n=8,097) without radiotherapy and accrued 60,065 and 81,227 person-years of follow-up, res

33 Forty-four patients were accrued; 60% had stage III to IV disease; median age was

34 rising 41.7% of the sample population) would accrue 81.8% of reductions in premature deaths and 87.1%

35 ber of events and shortens the time taken to accrue a target number of end points in an event-driven

36 Of this total, decreased caregiver costs accrued a $31 406 savings against the direct medical cos

37 medical costs, whereas decreased wage losses accrued a $3978 savings.

38 g mortality between treatment arms, 13 (38%) accrued a sample size large enough to find an absolute m

39 , those who had an improvement in EF to >35% accrued a similar relative reduction in mortality with I

40 re, old CD154 (CD40L)-deficient mice did not accrue ABCs, confirming that they arise primarily throug

41 ise from inefficiently repaired lesions will accrue according to absolute time; thus, unless life his

42 tions between biomarkers and memory z-scores accrued after 70 years of age.

43 A significant proportion of bone is accrued after adult height is achieved.

44 ed States government and nvAMD patients have accrued an estimated savings of $9.0 billion and $2.2 bi

45 his or her lifetime, an infected individual accrues an average net present value of $3456 and 3.57 D

46 stry informative SNP (AISNP) panels can best accrue and be properly evaluated only as sufficient refe

47 es generally perceive socioeconomic benefits accrue and that community funding structures are prefera

48 r of paid malpractice claims that physicians accrued and exits from medical practice, changes in clin

49 of cases of WNV-mediated memory dysfunction accrue annually, the mechanisms responsible for these im

50 These results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant

51 We note that biases are accrued as part of the recording process (e.g. species'

52 ontributes to the maintenance of adaptations accrued at NAc MSN synapses during incubation of cocaine

53 erence needs to be maintained to continue to accrue benefit.

54 ology and pT3, pT4, or node-positive disease accrued between 2006 and 2010 to the double-blind random

55 One hundred twenty patients were accrued between February 2009 and September 2013.

56 Data were accrued between January 2010 and June 2013.

57 the rates at which organisms and ecosystems accrue biomass as a function of P supply.

58 This study is fully accrued but remains active.

59 monstrate how low-density fitness advantages accrue by the Janzen-Connell mechanism.

60 were stratified by the number of prior cases accrued by each operator.

61 ective cohort of outpatient CAD patients was accrued by identifying patients with at least 1 visit to

62 we showed that additional ICU time is often accrued by patients after they are deemed ready for disc

63 The CEACOV model tracks infections accrued by students and faculty, accounting for communit

64 NK cells to participate in cytotoxicity via accrued CD16-mediated signaling and by increasing serial

65 ssified as historically low- (HLACs) or high-accruing centers (HHACs) based on accrual to 21 RTOG HNC

66 Using these prospectively accrued clinical data, relatively large treatment effect

67 In all, 98 patients were accrued (cohort A, 12; cohort B, 86).

68 Neurodevelopmental Cohort is a prospectively accrued, community-based sample of 9498 youth who receiv

69 lls that express immunoglobulin J-which also accrue concurrently across diverse organs.

70 b, ranibizumab and aflibercept monotherapies accrue considerable financial, ROIs to patients and insu

71 billion years, ancestral complexes that have accrued contemporary components, and rarer metazoan inno

72 ial carbon benefits, it comes at the rapidly accruing cost of woody plant species adapted to the open

73 However, along the way the industry has accrued critics whose accusations have tainted its reput

74 this provided adequate time for hospitals to accrue data and engage in collaborative learning.

75 In this article, by analyzing the accrued data in The Cancer Genome Atlas (TCGA), we show

76 Using previously accrued data, with alpha of 0.05 and power 80%, the samp

77 the spectrum of Guillain-Barre syndrome are accruing data for clinical and biological databases to i

78 lenges to investigators who need to keep the accruing data up to date, comply with potential consent

79 egative impacts of warming have continued to accrue despite lower heat sensitivity from the widesprea

80 Animals can accrue direct fitness benefits by accurately classifying

81 s been suggested that model-free value might accrue directly to the preconditioned cue through mediat

82 size of the protein assembly also favorably accrues dissociation yields.

83 even in cells that retained short telomeres, accrued DNA damage, and exhibited p53 stabilization, suc

84 These benefits could accrue due to larger group sizes in general but also to

85 ed as reflecting the replication errors that accrue during spermatogenesis.

86 rs to be related to the magnitude of fatigue accrued during exercise, which may explain the reported

87 ay be determined by the magnitude of fatigue accrued during exercise.

88 positive impacts, allowing repair of damage accrued during exposure to thermal extremes, or negative

89 , 12,434 (15.9%) incident frailty cases were accrued during follow-up.

90 A previous study correlated changes accrued during mouse adaptation in the VP40 gene of a MA

91 study demonstrates how genetic changes that accrued during mouse adaptation of the Ravn strain of Ma

92 vation is related to the sleep pressure that accrued during the prior waking period.

93 low-wave sleep to recover from the "fatigue" accrued during wake, when overall synaptic activity is h

94 ise increases as the number of complications accrued (e.g.: low-risk-9.2% in patients with >=3 compli

95 Autoantibodies accrue early in disease development, and several are so

96 e warming effects, paying climatic debt with accrued environmental credit.

97 mathematically identical across species, and accruing evidence indicates economic-based descriptors o

98 Despite accruing evidence supporting its benefit following pancr

99 ing a high-fat diet, obesity prone (OP) rats accrued excess fat, whereas obesity resistant (OR) rats

100 hes between quiet and loud, midbrain neurons accrue experience to find an efficient code more rapidly

101 es in today's oceans, regular echinoids have accrued far less morphological diversity than irregular

102 s studies have shown that target information accrues faster at attended locations than at unattended

103 shown that information about visual targets accrues faster at attended than at unattended locations.

104 rop to native plants because unrelated crops accrue fewer herbivores and pathogens.

105 It also accrues financial value to patients, public and private

106 consistent with the suggestion that females accrue fitness benefits by timing peak energy demands of

107 urther reduction in risk of ischaemic stroke accrued for aspirin only versus control from 6-12 weeks,

108 years; median age, 61 years; 33 males) were accrued for the phase II study.

109 Nevertheless, evidence is accruing for broad, threat-neutral sensory hyperactivity

110 Minor increases in usable DCD kidneys could accrue from increased use of pediatric DCD kidneys and f

111 MSC) studies assume that therapeutic effects accrue from local myocardial effects of engrafted MSCs.

112 Additional benefits accrue from prioritizing emissions reductions in countie

113 t in part, to the biological advantages that accrue from recognizing and responding to conspecific vo

114 numerate the significant benefits that would accrue from sequencing a broader range of taxa, as well

115 ntribution from Canadian forests will likely accrue from wood substitution that reduces fossil fuel-b

116 FRS profiles and outcomes of 5533 PDs were accrued from 17 international institutions (2003-2019).

117 Ovarian Cancer Association Consortium (data accrued from 1992 to 2010).

118 Data were accrued from 1994 to April 1, 2014.

119 age 10 years (both children and adults were accrued from 2013 to 2018).

120 pain flare after radiotherapy, patients were accrued from 23 Canadian centers from May 30, 2011, to D

121 Data were accrued from 2846 patients who underwent pancreatoduoden

122 state cancer diagnosed in 2011 through 2012, accrued from 5 Surveillance, Epidemiology and End Result

123 cer younger than 50 years were prospectively accrued from 51 hospitals into the Ohio Colorectal Cance

124 f-inhibition, we surveyed enzymological data accrued from a century of experimentation and generated

125 e experimental tools and knowledge that have accrued from a long history of reductionist biology, we

126 an be offset by savings due to reduced costs accrued from a reduction in complication rates and hospi

127 ly, new opportunities to apply the knowledge accrued from BHJ solar cells to generate free charges fo

128 Similar benefits accrued from genetically deleting 1 SCD allele, providin

129 letion status determined with FISH that were accrued from January 1, 2010 to October 1, 2017, were in

130 Most of the savings are accrued from lower costs of case management and househol

131 Of 113 patients accrued from March 2011 through November 2012, 42 patien

132 e analysis, we sequenced five bladder tumors accrued from patients with muscle-invasive transitional

133 ture of PreC CatD-positive-layer III neurons accrued from postmortem tissue obtained from the Rush Re

134 Follow-up time accrued from the date of return of the baseline question

135 The principles accrued from the study of the latter Ru carbenes and Mo

136 This regulation likely accrues from a phosphorylation-sensitive nuclear localiz

137 hanging impact of prognostic factors as time accrues from the date of surgery.

138 The difference in blood pressure elevation accruing from DC activation was abrogated on the Rag1(-/

139 fits on school climate and adolescent health accruing from extending lay counsellor-delivered interve

140 Recent data accruing from frequentist and network meta-analysis have

141 dium handling and the hypertensive response, accruing from the functions of the cytokines that they p

142 In all, 107 patients were accrued: gemcitabine-docetaxel plus placebo (n = 54) and

143 larization of the electromagnetic fields are accrued gradually along an optical path.

144 [SE 0.006] fewer using US EQ-5D scores) and accrued greater hospital costs (UK pound101 [SE pound37]

145 , comprised of syncytial myofibers that each accrue hundreds of nuclei during development.

146 , revealing that strand breaks significantly accrue in HSCs during aging.

147 chanism through which premalignant mutations accrue in HSCs.

148 th thermodynamically stable E-O bonds, which accrue in large quantities in industry.

149 y differences in the types of mutations that accrue in males and females.

150 Thousands of somatic mutations accrue in most human cancers, and their causes are large

151 Although expansions can accrue in non-dividing cells, we also show that cell cyc

152 cular disorders, similar benefits might also accrue in patients with chronic kidney disease.

153 rdial ischemic injury, Ly-6C(high) monocytes accrue in response to a brief C-C chemokine ligand 2 bur

154 ne time have made such evidence difficult to accrue in the clinical setting.

155 Linear growth deficits accrue in the first 1000 d of life.

156 on ineffective and allowing new mutations to accrue in the genome.

157 Th17 cells accrue in the intestine in response to particular microb

158 dozen layers, excess positive sites begin to accrue in the multilayer.

159 bosomes based on 3' RNA decay fragments that accrue in UPF1 ATPase mutants.

160 crobial evolution, but genome sequences have accrued in a haphazard manner, with biased sampling of n

161 e $30462 ($582) and $30965 ($629) and mainly accrued in ambulatory care for ART (70% of mean costs).

162 49 lung cancer growth and additional benefit accrued in combination with cisplatin.

163 The levels of PhIP accrued in dyed hair from volunteers on a semicontrolled

164 f PhIP were comparable to the levels of PhIP accrued in hair of subjects with natural hair color.

165 ommodities, and capital inputs that would be accrued in implementing the SPRP.

166 and congenital heart anomaly burden, 34% was accrued in people under age 30 years in the poorest coun

167 neuroscientific research on this domain has accrued in recent years, no previous study has compared

168 hat characters permitting terrestrialization accrued in the arachnid stem lineage and suggests the Ca

169 deaths, obtained by multiplying person-time accrued in the cohort by mortality rates for a reference

170 is due to sudden release of strain that has accrued in the crystal of form I, which is a metastable

171 The outcomes measured were health-care costs accrued in the last year of life, number of inpatient da

172 on to describe the insidious disability that accrues in many patients who satisfy traditional criteri

173 cause of the different ways in which fitness accrues in the two sexes.

174 Given the amount of knowledge and data accruing in the neurosciences, is it time to formulate a

175 hether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical re

176 hether the manner in which sedentary time is accrued (in short or long bouts) carries prognostic rele

177 Evidence continues to accrue indicating that the complex relationship between

178 In parallel, a wealth of evidence has accrued indicating that aberrations in phase transitions

179 Despite the accruing insights in the use of these tools, delivery co

180 l hydrogen-bonding network which effectively accrues internal strain to elicit propulsion solely by e

181 (<= 5 cm) N0M0 centrally located NSCLC were accrued into a dose-escalating, five-fraction SBRT sched

182 As the experience with lung transplantation accrues, it has become increasingly apparent that not al

183 incurred early, while environmental benefits accrue later.

184 g retrospectively reviewed 217 consecutively accrued lesions by using protocols that were HIPAA compl

185 surviving an additional time frame based on accrued lifespan, offers dynamic survival projections as

186 imates across variables strata diverged with accrued lifespan.

187 ermine the ability of replication origins to accrue limiting factors and have the potential to reprog

188 Bleeding events accrued linearly over time, reaching 10.4% at 96 h post-

189 Despite the fact that there is rapidly accruing literature on CBCT, there are still no current

190 Over 12-month follow-up, 274 (71%) survivors accrued lost earnings, averaging $26,949 +/- $22,447 (60

191 equently, replicating primary cells steadily accrue macroH2A1.2 at fragile regions, whereas macroH2A1

192 A total of 298 patients were accrued (median age, 68.8 [range, 32-94] years at day 10

193 year cohort of cataract surgery patients was accrued: Medicare, $36.4 billion; Medicaid, $3.3 billion

194 bone forms when collagen-containing osteoid accrues mineral crystals.

195 ioned cue in our procedure does not directly accrue model-free value and further suggest that the cue

196 charides (EPS), such that cospecies biofilms accrue more biomass and harbor more viable S. mutans cel

197 ift from mid-Holocene to present: some areas accrue more permanent uplift than others.

198 tation rates, which imply that substitutions accrue more slowly than previously believed.

199 cific leaf area, light seeds, short heights) accrued more biomass in low diversity communities, where

200 After accruing more skin lesions in contest 1, individuals wer

201 whereas species with conservative strategies accrued most biomass in high diversity communities.

202 cells may suffer diminished lifespan due to accrued mutation burden.

203 ransformed PEL cell lines, which have likely accrued mutations during the transformation process.

204 when analysis was restricted to person-time accrued on ART with CD4 counts of at least 500 cells per

205 agricultural commodities, ensuring annually accruing (on-farm) benefits of US$14.6-19.5 billion yr(-

206 Concerning sleep homeostasis, KO mice accrued only half the extra REM sleep wild-type (WT) lit

207 effects of higher temperatures are likely to accrue over time as nitrogen availability in grasslands

208 Although the benefits of statins accrue over time, treatment discontinuation is common.

209 nsistency in the total number of heart beats accrued over a lifetime across a range of animal species

210 A total of 2250 incident HF events accrued over a median follow-up of 20.6 y.

211 These spatial data, accrued over time and appended with detailed cohort info

212 How ecological and morphological diversity accrues over geological time has been much debated by pa

213 tion: Noisy evidence in favor of each option accrues over time, until the evidence in favor of one op

214 for interactions between costs and benefits accruing over different parts of a growth cycle.

215 RDS was used to accrue participants at 27 sites (15 PWID sites and 12 MS

216 A prospectively accrued patient database was analyzed from September 1,

217 low incidence rate has made it difficult to accrue patients to prospective randomized trials.

218 calTrials.gov (NCT03404193) and continues to accrue patients.

219 ents, and 11 (26.8%, 95% CI 14.2-42.9) of 41 accrued patients (specifically in four patients with non

220 er Trials Group MA.31 phase 3 clinical trial accrued patients from 21 countries and randomized 652 wi

221 These clinical trials accrued patients included in this analysis from May 2010

222 pragmatic, open-label, randomised trial that accrued patients with histologically proven and complete

223 Among accrued patients, FISH group 1 breast cancers were stron

224 The phase 2 trial is no longer accruing patients.

225 In the single-patient stage, one patient was accrued per dose level.

226 pmental Cohort is a genotyped, prospectively accrued, population-based sample of almost 10,000 youths

227 ajor cause of neurological disability, which accrues predominantly during progressive forms of the di

228 small case series and articles based on data accrued prior to 2000.

229 have substantial human health benefits that accrue quickly and locally.

230 data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the

231 etes (P-nonlinearity = 0.006), with benefits accruing rapidly at the lower end of MVPA range (<30 min

232 ly dense world, and substantial evidence has accrued regarding multitasking difficulties and cognitiv

233 o models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicte

234 s. 3% of the participants had >/=24 weeks of accrued remission; odds ratio, 5.91; 95% confidence inte

235 Accruing sedentary time in prolonged, uninterrupted bout

236 ay provide restorative benefit by mitigating accrued senescent burden.

237 s were enrolled in two separate cohorts that accrued sequentially: in cohort 1, patients were enrolle

238 Much new evidence has accrued since previous reviews were published.

239 eening large numbers of patients at numerous accruing sites in a complex trial to test investigationa

240 responses also significantly decreased with accrued sleep debt.

241 unting perspective, there is an imbalance in accrued social costs and benefits.

242 rshes have a relatively open N cycle and can accrue soil organic matter rapidly.

243 iving kidney donors (LDs) also may expect to accrue some personal benefit following donation.

244 iants typically precludes the possibility of accruing statistical evidence that they are associated w

245 ns fold in a strict N-to-C-terminal fashion, accruing structures in units of helical hairpins.

246 March 2015, 63 patients from a prospectively accrued study population who underwent MR imaging of the

247 ind, placebo-controlled, clinical trial that accrued subjects from five clinical sites in Mexico and

248 tions were similar in screened compared with accrued subpopulations.

249 was a divergence of MS outcomes; some people accrued substantial disability early on, whereas others

250 In the future, once we have accrued sufficient cases, we aim to build on this study

251 nitial number of rapidly but non-selectively accrued synapses.

252 ethod to identify individuals most likely to accrue the largest benefit from continued treatment.

253 ations 50% larger than humans, they may have accrued the energetic and mechanical benefits of out-of-

254 e in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not w

255 Overall, 27 evaluable patients were accrued; the median number of prior therapies was 4.

256 d September 2014 (response rate, 71.0%) were accrued through 2 population-based Surveillance, Epidemi

257 In these systems, molecular complexity is accrued through sequential transformations to a mobile s

258 Nonrandom outcomes could accrue throughout ontogeny, or the processes that genera

259 ersity maintenance is how fitness advantages accrue to a species as it becomes rare, as this is the d

260 ortance of the marketing based benefits that accrue to Leadership in Energy and Environmental Design

261 of sperm velocity and that fitness benefits accrue to males from such adjustment.

262 Most cost savings are expected to accrue to Medicare, and most increased access to transpl

263 s to study participants, but serious dangers accrue to nonparticipants, including sex partners of stu

264 ALYs gained and healthcare costs saved would accrue to the most disadvantaged quintiles in Australia.

265 emotional effect, and benefits often do not accrue to the payer; avoidable harm is accepted as norma

266 As metals become depleted or, conversely, accrue to toxicity, microbes will activate cellular resp

267 Among patients accrued to BCIRG-005, group 4 was not associated with si

268 Among patients accrued to BCIRG-006, only group 1 showed a significant

269 r probability of 0.1, 48 patients were to be accrued to detect an ORR of 42%.

270 Patients and Methods Patients accrued to four sequential studies of ibrutinib were inc

271 The proportions of HIV deaths that accrued to men and women at different stages in the HIV

272 o 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications, in

273 015, 25 eligible and evaluable patients were accrued to stratum 1, and between Aug 28, 2013, and June

274 015, 25 eligible and evaluable patients were accrued to stratum 3.

275 Evidence has accrued to suggest that excessive intra-PFC mu-opioid re

276 , 2011, and Aug 11, 2017, 1917 patients were accrued to the maintenance treatment randomisation of th

277 The greatest health benefits were accrued to the most socioeconomically disadvantaged quin

278 Results Of 17 patients accrued to the study, 15 had mutations in APC or CTNNB1

279 rch 2009 to December 2012, 153 patients were accrued to the study.

280 Thus, fear that accrues to a stimulus paired with danger simultaneously

281 f health benefits of RGGI, the only benefits accruing to children were limited to prevented cases of

282 a small but significant vocational advantage accruing to recipients of evidence-based supported emplo

283 lation, with 49.5% of the total health gains accruing to the 2 lowest quintiles.

284 n in CCL2-deficient mice failed to maximally accrue Tregs and monocytic MDSCs.

285 s in the poorest countries, while only 3% is accrued under age 30 years in high-income countries.

286 000 to $150 000/quality-adjusted life year) accrued under current Medicare policy (stroke payment no

287 t species' benefits to assess are those that accrue unexpectedly or are wholly unanticipated.

288 The time to survival benefit did not accrue until 8 months after transplantation.

289 planar 'white-light cavities', the benefits accrued upon optically interacting with a cavity - such

290 stent placement, and procedure success with accrued volume, albeit with increased contrast use, fluo

291 exposed by all of the genomic data that has accrued: We still do not know how to interpret them.

292 The two primary end points were the accrued weeks of remission over a 52-week period, accord

293 olizumab treatment led to significantly more accrued weeks of remission than placebo (28% vs. 3% of t

294 ocols must assess whether benefits are being accrued, whether such "benefits" are real, and whether h

295 From 255 hospitals, 22,346 patients were accrued who underwent a colon resection in 2010, most co

296 s that benefits of metformin may continue to accrue with longer treatment.

297 be taken, so larger absolute benefits would accrue with more prolonged therapy, and these benefits p

298 lectrical activity within the recurrent loop accrues with abstinence and, through the activity-depend

299 Clinical trial evidence is accruing with the goal to develop less destructive treat

300 tein microcrystals, roughly a micron across, accrue within infected cells.