ライフサイエンスコーパス: acetamide

1 4-(pyridin-2-yl)piperidin-1-yl)- N-( m-tolyl)acetamide).

2 king place during rotation of the CN bond in acetamide.

3 including acetamide enolate and O-protonated acetamide.

4 an methionine's side chain or the N-terminal acetamide.

5 under mild conditions without removal of the acetamide.

6 olysis of the nitrilium ion yielded N-benzyl acetamide.

7 ea, 1,3-dimethyl urea, 1,1-dimethyl urea and acetamide.

8 presence of small-molecule inducers, such as acetamide.

9 to provide benzo[4,5]imidazo[2,1-a]isoindole acetamide.

10 itude more stable than acetamidine, urea, or acetamide.

11 arboxylation of tryptophan to yield indole-3-acetamide.

12 hexanoic acid, and n-octane and 2-ethylhexyl acetamide.

13 from compounds where the N-substituents were acetamides.

14 edstock chemicals, such as methyl esters and acetamides.

15 ones from 2-(2-bromophenyl)-N-(2-cyanophenyl)acetamides.

16 with MeOH and EtOH affording formamides and acetamides.

17 onformation generally preferred by secondary acetamides.

18 )-5,7-dimethylpyrazolo[1,5-a]pyrimidin -3-yl)acetamide].

19 henylthiazolo[2,3-c][1,2,4]triazol-3-yl)thio)acetamide 1 through high-throughput screening (HTS).

20 a potent and selective sPLA2 inhibitor, 3-(3-acetamide 1-benzyl-2-ethylindolyl-5-oxy)propanesulfonic

21 l-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide (1) was prepared and evaluated for their abili

22 sic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 1, has given rise to (E)-2-(4-chloro-6-fluoro

23 ogen bond in a simple enolate anion: lithium acetamide, 1.

24 ted by the selective sPLA(2) inhibitors 3-(3-acetamide-1-benzyl-2-ethylindolyl-5-oxy)propane sulfonic

25 Using the selective sPLA(2) inhibitor 3-(3-acetamide-1-benzyl-2-ethylindolyl-5-oxy)propane sulfonic

26 14-kDa secretory phospholipase A(2) by 3-(3-acetamide-1-benzyl-2-ethylindolyl-5-oxy)propanephosphoni

27 -(2-methoxybenzyl)- N-(4-phenoxypyridin-3-yl)acetamide ( 10, PBR28).

28 3- or 4-aminophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide (10 and 14) were prepared either without or wi

29 5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3- yl]-acetamide ((11)C-DPA-713), has been described that binds

30 )-5,7-dimethylpyrazolo[1,5-a]pyrim idin-3-yl)acetamide ((125)I-iodo-DPA-713) SPECT/CT or (18)F-FDG PE

31 (2S)-2-amino-2-substituted-N-(4-methylphenyl)acetamides 12a-d, easily prepared in two steps from N-Bo

32 rophenoxy)-N-(4-oxo-4H-3,1-benzothiazin-2-yl)acetamide (13), were identified as a novel class of pote

33 l-5-yl)-2-phenyl-N-(2,4,6-trimethoxypheny l) acetamide (13a) and (+/-)-2-(5-dodecylisoxazol-3-yl)-2-p

34 (2S)-2-amino-2-substituted-N-(4-nitrophenyl)acetamides 16a-c, succindialdehyde (13), and benzotriazo

35 l-3-yl)-2-phenyl-N-(2,4,6-trimethoxypheny l) acetamide (16a), were selected for further study and wer

36 1-yl)pyrimidin-4-yloxy)benzo[d] thiazol-2-yl)acetamide (16p), a potent TRPV1 antagonist [rTRPV1(CAP)

37 relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17.

38 nyl)5,7dimethylpyrazolo[1, 5a]pyrimidin-3-yl)acetamide ((18)F-DPA-714) (TSPO) PET imaging on days 7,

39 )-5,7-dimethylpyrazolo[1,5-a]pyri midin-3-yl)acetamide ((18)F-DPA-714) has been suggested to serve as

40 )-5,7-dimethylpyrazolo[1,5-a]pyri midin-3-yl)acetamide ((18)F-DPA-714), as a translational probe for

41 -1-yl)-N-(2,2,3,3,3-(18)F-pentafluoropropyl)-acetamide ((18)F-EF5) PET to monitor and predict tumor r

42 oxybenzyl)-2-(18)F-fluoro-N-(2-phenoxyphenyl)acetamide ((18)F-PBR06) for detecting alterations in tra

43 enyl)5,7dimethylpyrazolo[1,5a]pyrimidin-3-yl)acetamide ([(18)F]DPA-714) binds with high affinity to T

44 nyl)5,7dimethylpyrazolo[1,5a] pyrimidin-3-yl)acetamide ([(18)F]DPA-714), which binds with high affini

45 entified as [18F]2-fluoro-N-(2-phenoxyphenyl)acetamide ([18F]11).

46 luoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([18F]FEPPA).

47 ently bonded to N-(4-hydroxy-3-methoxybenzyl)acetamide (2) by ether or carbonate linkages.

48 )-5,7-dimethylpyrazolo[1,5-a]pyrimidin- 3-yl)acetamide (2, DPA-714), were synthesized and biologicall

49 1-methylethyl)phenyl]-2,6-dioxo-7H-purine- 7-acetamide, 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-

50 Acetamide, 2-amino-N-[[3,5-bis(trifluoromethyl)phenyl]-m

51 ino)-2-pyrimidinylthio-(N-beta-hydroxyethyl) acetamide (200 mg/kg) induced a wave of DNA synthesis in

52 ds for the synthesis of 7-substituted indole acetamides 3 and N-methyl (indol-7-yl)oxoacetates 6.

53 4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2- yl)acetamide (3).

54 nd vinyl azides to afford 3-oxoisoindoline-1-acetamides (32 examples) in high yields (up to 97%).

55 -4H-chromen-8-yl)dibenzo[b,d]th io-phen-1-yl)acetamide, 39; DNA-PK IC(5)(0) = 5.0 +/- 1 nM, IR dose m

56 H-benzo[e][1,4]diazepin-3(4H)-on-2-yl]phenyl}acetamide 5'a led to a new heterocyclic system, 6-methyl

57 H-benzo[e][1,4]diazepin-2(1H)-on-3-yl]phenyl}acetamides 5, the not previously described 14-dihydro-5H

58 -1-(3-aminophenyl)-2-(1-pyrrol idinyl) ethyl]acetamide (5) were synthesized and evaluated in mice for

59 drothiazol-5-yl}-N-(3-tr ifluoromethylphenyl)acetamide (5), showed a mixed-type inhibition pattern, w

60 5-b]pyridin-2-ylthio)-N-(3,4-dimethoxyphenyl)acetamide (5a) as a hit compound with a Ki value of 217

61 yl]-ethyl}-[1,3,4]thiadiaz ol-2-yl)-2-phenyl-acetamide 6, exhibited similar potency and better solubi

62 generate a C-3 quaternary carbon resulted in acetamide 6, which showed CCK-A receptor binding selecti

63 The N-methyl acetamide 7a showed the optimal in vitro profile and was

64 rifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acetamide] (8-azaquinazolinone) without any basic group.

65 -2-(4-ethyl-6,6-dimethyl-2-oxomorpholin-3-yl)acetamide (87), which, in addition to fungicidal activit

66 zol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl ]acetamide, a helicase-primase inhibitor for the treatmen

67 enthalpies at the alpha carbons of acetone, acetamide, acetic acid, and acetyl fluoride, which were

68 (1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)acetamide (ACTH) via interactions with ketonic oxygen, t

69 2 kcal/mol, depending on substituents on the acetamide acyl group.

70 Titration of the subcomplex with iodo[(14)C]acetamide after prolonged treatment with CuCl(2) in the

71 rahydro-7H-purin-7-yl)-N-(4-isopropylphenyl) acetamide) after its initial stimulation (and the calciu

72 henyl]-4-yl)-N-(5-cyclobutyl-1H-pyrazol-3-yl)acetamide (analog 24), which selectively inhibited cycli

73 osaminidase inhibition by an azetidine ADMDP-acetamide analogue is compared to an azetidine carboxyli

74 n the proline amides is found with the ADMDP-acetamide analogues bearing an acetamidomethylpyrrolidin

75 -5-oxo-3-vinyl-(1, 5-dihydropyrrol-2-ylidene)acetamide and 3-methyl-5-oxo-4-vinyl-(1, 5-dihydropyrrol

76 rease in 30 % (v/v) choline chloride (ChCl): acetamide and 4.1-fold in 95 % (v/v) ChCl: ethylene glyc

77 sing a combination of N,O-bis(trimethylsilyl)acetamide and catalytic tetramethylammonium pivalate as

78 ant stereodivergent reaction between azaaryl acetamide and cinnamyl methyl carbonate.

79 used to compute the CN rotation barriers for acetamide and eight related compounds, including acetami

80 oro-2,4-dimethoxyphenyl)-thioureido]-phenyl)-acetamide and its 2-fluoro-benzamide derivative inhibite

81 ent parameters (bis(trimethylsilyl)trifluoro-acetamide and sterol exposure time, sterol concentration

82 e aliquots were then treated with iodo[(14)C]acetamide and the incorporation of radioactivity was mea

83 drolysis of 1 with hydrochloric acid affords acetamide and the previously known diarylhydroxytelluron

84 -5-oxo-4-vinyl-(1, 5-dihydropyrrol-2-ylidene)acetamide and the third was 4-methyl-3-vinylmaleimide (M

85 to replace protecting groups with N-terminal acetamides and C-terminal methyl amides led to the intro

86 rise to a mixture of indanyl (or tetralinyl) acetamides and dehydrotetralins (or pallidols) (both or

87 The reaction of N-allyl-N-(2-halobenzyl)-acetamides and derivatives was investigated in liquid am

88 cological activities of a series of indole-3-acetamides and related compounds derived from this lead.

89 ons from a series of secondary N-(4-X-benzyl)acetamides and tertiary amides to the phthalimide-N-oxyl

90 With the acetamides and the alkanamides almost exclusive HAT from

91 mino]-N-hydroxy-2-(tetrahydro-2H -pyran-4-yl)acetamide, and LF at the LF-active site.

92 onic spectra of formamide, N-methyformamide, acetamide, and N-methylacetamide at 300 K calculated usi

93 ent in potency over the best of the indole-3-acetamides, and LY315920 (6m) was selected for evaluatio

94 oglycans have been found to exist as amines, acetamides, and N-sulfonates.

95 )-5,7-dimethylpyrazolo[1,5-a]py rimidin-3-yl)acetamide] and [(11)C]SSR180575 (7-chloro-N,N-dimethyl-5

96 reagents such as BSA [N,O-bis(trimethylsilyl)acetamide] and BSTFA [N,O-bis(trimethylsilyl)trifluoroac

97 des has been realized using N-(2-aminophenyl)acetamide (APA) as a new bidentate directing group for t

98 Glycinal and acetamide are accessed via barrierless radical-radical r

99 de and 2-(6-methylpyridin-2-yl)-N,N-diphenyl-acetamide are described along with results from the chem

100 Thus, N-(benzothiazolyl)-2-phenyl-acetamides are valuable drug candidates for further stud

101 idine give pK(a)(C) = 28.4 for ionization of acetamide as a carbon acid.

102 The utilization of N-(2-aminophenyl)acetamide as a novel directing group, Mn(OAc)2 as a co-o

103 s can be significantly enhanced by using the acetamide as a quasi-leaving group in a subsequent conve

104 C bond coupling and formation of acetate and acetamide as additional products.

105 by addition of ethylene glycol, glycerol and acetamide as small organic co-solutes.

106 otent and selective 2-amino-N-pyrimidin-4-yl acetamides as hA2A receptor antagonists with excellent a

107 l the development of functionalized indole-3-acetamides as inhibitors of hnps-PLA2.

108 gioselective palladium(II)-catalyzed primary acetamide assisted ortho arylation of arylacetamide has

109 In the same study, a polyamide with an acetamide at the beta-position of the gamma-turn resulte

110 of the conformational probe, methyl coumarin acetamide, attached specifically to the ryanodine recept

111 hese challenges, we develop an e-caprolactam/acetamide based eutectic-solvent electrolyte, which can

112 cular C-N and C-O cyclization of N-(biphenyl)acetamides based on the substituent electronic effects i

113 hrough a systematic study of a series of bis(acetamide)-based networks with record-low melting temper

114 The barrier to rotation of "mimics" for acetamide-based radicals are estimated.

115 methacrylate-functionalized bisdicyclohexyl acetamide (BDCA-MA) receptor enabled binding and release

116 s and crystalline phases of a Co-ethylenebis(acetamide) binary network feature a large reflectivity c

117 and S [N-(4-(3-acetamidophenyl)thiazol-2-yl-acetamide)] bind to CG and TA base pairs, respectively.

118 Unlike the residues forming the acetamide binding cavity, these acidic side-chains are n

119 1)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) binds to the 18-kDa translocator protein (TSP

120 N-Acetamide bond of peptides is extremely stable even unde

121 uctural modifications to the benzoyl-phenoxy-acetamide (BPA) structure present in a common lipid-lowe

122 xylidino)-2-pyrimidinylthio (N-beta-hydroxyl)acetamide (BR931) alter hepatic sex steroid metabolism a

123 ds, by treatment with N,O-bis(trimethylsilyl)acetamide (BSA) and then PhFCl/NMM/AgNO(3).

124 des are alkylated in the absence of indole-3-acetamide but not in its presence.

125 .8 x 10(-8) M(-1) s(-1) for deprotonation of acetamide by quinuclidine (pK(BH) = 11.5) and k(BH) = 2-

126 by deuterioxide ion and for deprotonation of acetamide by quinuclidine.

127 In addition, the primary acetamide can be manipulated into synthetically importan

128 Finally, we show that sulfamate acetamides can be used for covalent ligand-directed rele

129 dendrimers in ascending order at pH 7.4 was: acetamide-capped, -NHC(O)CH3, neutral charge; carboxylic

130 attributed to chelate formation between the acetamide carbonyl group and the glycosidic oxygen in th

131 Polyamide 3, with an alpha-acetamide, caused no significant evidence of rodent toxi

132 mer complex and the addition of the inducer, acetamide, causes a conformational change which alters t

133 5-bromofuran-2-yl)-4-oxo-4H-chromen-3-yl)oxy)acetamide (CB7993113), was further tested for its abilit

134 Glycinal (HCOCH(2) NH(2) ) and acetamide (CH(3) CONH(2) ) are simple molecular building

135 first report where functionalizable primary acetamide (-CH2CONH2) is used as a directing group for C

136 A phenotypic screen uncovered the N-aryl acetamide class that inhibits the development of P. falc

137 o[1,2-a]pyrimidin-9-yl)dibe nzothiophen-1-yl]acetamide) combined high potency against the target enzy

138 identified sALT629, a butoxyphenyl-tetrazole-acetamide compound that inhibits de novo lipid synthesis

139 30 compounds described, the most active were acetamides containing alkylsulfonyl substituents.

140 2-yl)-6-(trifluoromethyl)pyrimidin-2-ylt hio]acetamide (CP9), that binds to Hsp90(alpha/beta) and dis

141 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide (cysmethynil).

142 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide (cysmethynil).

143 tions of N-(cyclohex-2-enyl)-N-(2-iodophenyl)acetamides depend critically on the configurations of th

144 The AmiC.AmiR butyramide complex exhibits acetamide-dependent, sequence-specific RNA binding activ

145 rystal-to-single-crystal manner to yield the acetamide derivative (Me(2) NH(2) )[In(BDC-NHC(O)Me)(2)

146 9) and the C1 N-isopropyl-N-(4-methoxyphenyl)acetamide derivative of 3-(1H-Indazol-3ylmethyl)-3-methy

147 ydro)octafluoro[2.2]paracyclophane, from its acetamide derivative utilizing the Cadogan method led to

148 However, the C-5 acetamide derivative, 3b, was greater than 100-fold sele

149 ctivating oximes, predominantly hydroxyimino acetamide derivatives (for hAChE) and imidazole-containi

150 reen, we identified 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as fungicidal agents against Candi

151 bond in a series of N-cycloalkenyl-N-benzyl acetamide derivatives have been measured in different so

152 The acetamide derivatives PBN-CH(2)NHAc, 4-AcNHCH(2)-PBN-CH(

153 t when these cyclizations are attempted with acetamide derivatives, an unprecedented cluster C-B bond

154 stitued piperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide derivatives, showed low nanomolar inhibitory a

155 sertion of alpha-diazo-alpha-(phenylsulfonyl)acetamides derived from alpha-amino acids, which possess

156 -piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide dihydrochloride (17v, SUVN-G3031) as a clinica

157 The cis-directing effect was studied in N-acetamide dipeptoid model systems and evaluated in terms

158 onyl containing species acetone and N-methyl-acetamide dissolved in D(2)O are used to experimentally

159 -dimethylpyrazolo[1,5-alpha]pyrimi dine-3-yl)acetamide (DPA-714) is a radioligand for the 18-kDa tran

160 idazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of t

161 midazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide (EF5) and beta-hCG and pimonidazole, two extri

162 midazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide (EF5) was coadministered with the second one.

163 ole-1[H]-y1)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5), we showed that the brain is hypoxic dur

164 henyl)sulfonyl]amino]-N-(3-pyridinyl methyl)-acetamide (EMPA), suppressed this effect, whereas a sele

165 amide and eight related compounds, including acetamide enolate and O-protonated acetamide.

166 s are generally more potent than their ADMDP-acetamide equivalents.

167 ging to the N-(4-(3-aminophenyl(thiazol-2-yl)acetamide family.

168 to an activated state (high methyl coumarin acetamide fluorescence) as T-tubule depolarization did.

169 hemical conversion of CO(2) and NO(2) (-) to acetamide for the first time over copper catalysts under

170 containing nucleotide gave rise to undesired acetamide formation resulting from nucleophilic attack o

171 nt quantum mechanical calculations show that acetamide forms through nucleophilic addition of NH(3) t

172 , whereas the competitive inhibitor indole-3-acetamide fully protects the enzyme from inactivation.

173 e is a good replacement for the conventional acetamide functionality found in oxazolidinones.

174 elations in both single and binary metal-bis(acetamide) glasses and highlights the important role of

175 potency of thiotetroamide C ascribed to the acetamide group and the unusual enzymology involved, we

176 The acetamide group enables regioselective oxidative ortho-C

177 intramolecular hydrogen bond to the adjacent acetamide group.

178 he phenyl was para substituted with amine or acetamide groups, the NR1A/2B potency order was butynyl

179 opentyl methyl, benzyl, phenyl, acetate, and acetamide groups, which smoothly produced the respective

180 etermined that parasites resistant to N-aryl acetamides had mutations in rhomboid protease 8 (ROM8) a

181 6336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as a novel, potent inhibi

182 silylation employing N, O-bis(trimethylsilyl)acetamide, hexamethyldisilazane, and 1-(trimethylsilyl)i

183 high in their 2-hydroxy-N-(2-hydroxyphenyl) acetamide (HHPAA) concentration (40-48microg/g DM).

184 (HBOA-d4) and 2-hydroxy-N-(2-hydroxyphenyl) acetamide (HHPAA-d4) were synthesized, to allow quantifi

185 l N-[(5-hydroxy-1H-imidazole-2yl)methylidene]acetamide (HIMA) compound.

186 PMA-resistant TR19-9, and hexamethylene bis-acetamide (HMBA)- and PMA-resistant DS19/R1.

187 tudies support the role of hexamethylene bis-acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor s

188 dihydrophenanthridin-2-yl)(N,N-dimethylamino)acetamide hydrochloride (PJ34), using virtual screening;

189 -acetylglucosamine regioisomer the picolinyl-acetamide hydrogen bond persists and leads to an enhance

190 ryptophan mono-oxygenase) and iaaH (indole-3-acetamide hydrolase).

191 as acetic acid, benzoic acid, formaldehyde, acetamide, hydroxyacetic acid, oxoacetic acid, hydroxyac

192 eparation of dendrimers with terminal amino, acetamide, hydroxyl, and carboxylate groups was obtained

193 x, indole-3-acetonitrile (IAN), and indole-3-acetamide (IAM).

194 The location of bound indole-3-acetamide in the active site allows identification of re

195 hesis of C4-, C7-aryl-substituted 1-naphthyl acetamides in good yields.

196 ts, in contrast to other aliphatic secondary acetamides in which significant E-rotamer populations ar

197 ucer of HEXIM1 expression, hexamethylene-bis-acetamide) in PyMT mice resulted in inhibition of metast

198 A broad range of substituted phenyl acetamides including commercially available drug molecul

199 zation of these attributes is required for N-acetamide indoles to be pursued for development as a cur

200 14 (2-(triethylamino)-N-(2,6-dimethylphenyl)-acetamide) induces internal pore blockade of single card

201 the mouse homolog of human hexamethylene bis-acetamide inducible-1 (HEXIM-1), regulates the pTEFb act

202 We report on the role of hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) as an inhibitor o

203 e previously reported that hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) inhibits ERalpha

204 t the transcription factor Hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) is a tumor suppre

205 ass of compounds, 1,3-diaryl-[1H]-pyrazole-4-acetamides, initially identified from their ability to i

206 Implementation of CF(2)X acetamides into our HEFLibs and biophysical evaluation (

207 damine dimers form when tetramethylrhodamine acetamide is attached to two different sites in the N-te

208 he heteroatomic core of a pyrazolopyrimidine acetamide is sufficient to induce complex binding to wil

209 pensive and abundant benzoquinones with aryl acetamides is demonstrated.

210 bsequent recyclization into 2-(1H-indol-2-yl)acetamides is developed.

211 idazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] is such a drug, and it has been shown to be p

212 hoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide (JT010), a potent and specific TRPA1 agonist,

213 ptical assay based on the hypotonic lysis of acetamide-loaded mouse erythrocytes.

214 ensitive fluorescence probe, methyl coumarin acetamide (MCA), was incorporated into RyR in a protein-

215 hyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benzene-acetamide methanesulfonate (U-50,488H; 1 microM), and ba

216 2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil, (+/-)-1) is a unique dopamine upta

217 at C4 and/or C7 are replaced by stabilizing acetamide moieties.

218 tamide, confirming specificity for the alkyl acetamide moiety and showing that the primary element of

219 is simply the sterically unhindered terminal acetamide moiety of an acetylated lysine residue.

220 vity forms a specific binding pocket for the acetamide moiety.

221 The N-methylpiperazine acetamide (MPA) of ampicillin was adsorbed into polyelec

222 1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide (MR-L2), was microinfused into NAcs bilaterall

223 ,6-dioxo-1,3-dipropyl-1H-purin-8-yl)p henoxy]acetamide (MRS 1754).

224 ,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide (MRS1220) at the A(3) receptor and xanthine am

225 ere determined in D(2)O for deprotonation of acetamide, N,N-dimethylacetamide, and acetate anion by d

226 el series of glass-forming metal-ethylenebis(acetamide) networks that undergo reversible glass and cr

227 tly via the acetyl group with the oxygen and acetamide nitrogen hydrogen-bonded to the protein and th

228 upper side chain (proton donor) and glycine acetamide of the lower side chain (proton acceptor).

229 A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetam

230 3-(trifluoromethyl)-1H-pyrazol-1-yl]-phe nyl}acetamide (OSU-03012) killed primary human glioma and ot

231 3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl }-acetamide (OSU-03012) on both primary and glioblastoma c

232 3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a previously characterized PDK1 i

233 3-(trifluoromethyl)-1H-pyrazol-1-yl]phen yl]-acetamide (OSU-03012).

234 the formation of C-N bonds in formamide and acetamide over the Ni-Fe nitride heterostructure under s

235 of indole-based ligands characterized by an acetamide, oxalylamide, or carboxamide chain, respective

236 cleavable amide bond in 4-aminopyrazolyloxy acetamide peptide analogues under mild acidic conditions

237 luoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide PET scan.

238 1)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) PET scans were acquired with arterial blood s

239 were shown to be optimal for activity at the acetamide position.

240 nyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide positron emission tomography ([11C]DPA-713 PET

241 is of aqueous solutions of alpha-(methylthio)acetamide produced unexpectedly large quantities of acet

242 The ESI-MS readout of the resulting acetamide products reproduced the selectivity factors fr

243 The pyridin-4-yl alpha-substituted acetamide products were obtained in moderate to high yie

244 ammonium, nitrate, nitrite, urea, formamide/acetamide, purines, pyrimidines, polyamines, amino acids

245 5 mM 2(triethylamino-N-(2,6-dimethyl-phenyl)acetamide (QX-314) to block voltage-dependent Na+ curren

246 when 2(triethylamino)-N-(2,6-dimethylphenyl)acetamide (QX-314) was omitted from the recording pipett

247 tic [2-(triethylamino)-N-(2,6-dimethylphenyl)acetamide] (QX-314).

248 ecular homolytic substitution, S(H)2, of the acetamide radical fragment by a H atom is the most likel

249 de produced unexpectedly large quantities of acetamide radicals that were identified by time-resolved

250 activation kinetics of the lead hydroxyimino acetamide reactivator of hAChE, when analyzed in terms o

251 rahydro-7H-purin-7-yl)-N-(4-isopropylphenyl )acetamide] reduces cold hypersensitivity in rodent model

252 ivatized to the corresponding thiourea and N-acetamides, respectively, and were quantified by positiv

253 leimide (SM), thiol-vinylsulfone (SV), thiol-acetamide (SA), penicillamine-thiol-maleimide (PM) or pe

254 To this end, carbazole acetamide scaffolds were synthesized and structure activ

255 through co-electrolysis of CO and NH(3) with acetamide selectivity of nearly 40% at industrially rele

256 ivity relationships of a lead pyrimidin-4-yl acetamide series to provide potent and selective 2-amino

257 yl-3,5-dihydro-4H-pyridazino[4 ,5-b]indole-1-acetamide), showed a significant binding in the lenti-CN

258 line68 in myoglobin has been replaced by the acetamide side chain of asparagine in an attempt to engi

259 achieved when one of the phenyl rings of the acetamide side chain was replaced with an alkyl group, p

260 oimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl) acetamide staining.

261 (PBN) bearing a hydroxyl, an acetate, or an acetamide substituent on the N-tert-butyl moiety and par

262 roarylmethyl)piperazine 1a, benzamide 2, and acetamides such as 3a,b exhibit poor oral bioavailabilit

263 the 3-(2-phenethylamino)-6-methylpyrazinone acetamide template (e.g., 1) which resulted in the modif

264 ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl] acetamide (termed CK37) that inhibited purified recombin

265 s chemotype 2-(alkylsulfonamido)thiazol-4-yl)acetamides that act as pan-selective inhibitors of cytid

266 tions with substrates (allyl GlcNAc, N-allyl acetamide) that were previously not possible for the cor

267 -2-methyl-1H-inden-3-yl)-N-(furan-2-ylmethyl)acetamide, that binds nucleotide-free RAS to block GTP a

268 yl isocyanate, acetone, propionaldehyde, and acetamide-that had not previously been reported in comet

269 the chloroacetamide was fully reduced to an acetamide the pentasaccharides were obtained in four and

270 the key deficiency of noncovalent pyridinone acetamide thrombin inhibitor L-374,087 (1), namely, its

271 hydroxyalkylation with an N-protected 2-oxo-acetamide to close the heterocyclic ring.

272 ascribed to either direct cation 9 attack by acetamide to form cation 16 via O-alkylation or by rever

273 Addition of the inducing ligand acetamide to the complex trips the molecular switch, cau

274 2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide ] to investigate the influence of KCC2 functio

275 N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide) to determine nondisplaceable distribution vol

276 ino)-2-pyrimidinylthio-(N-beta-hydroxyethyl) acetamide) to male wistar rats induced a wave of hepatoc

277 rocyte lysis assay based on UT-B-facilitated acetamide transport.

278 ethyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide (U50,488) for the kappa OR (KOR).

279 ntiomer, (R)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide (UCB L060).

280 tonitrile and followed by hydrolysis to give acetamide under highly local alkaline environment and el

281 is described to access unsymmetrical diaryl acetamides under TM-free conditions from sec- and tert-a

282 econdary amine or a readily removable Cbz or acetamide unit.

283 family of purine molecules bearing triazole-acetamide units is presented.

284 usceptibility patterns, citrate utilization, acetamide utilization, and assimilation of inositol and

285 enzoylaminophenyl)-2-(4-methylpiperazin-1-yl)acetamide was prepared by thioacylation of the correspon

286 [2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)acetamide] was identified as a highly effective TMS (tri

287 yl)phenyl)-N-(1-(5-methoxypyridin-2-yl)ethyl)acetamide], we demonstrated that polyunsaturated lipids,

288 arbony lamino]-2-(4-hydroxy-3-methoxyphenyl) acetamide), were further characterized in enzyme, cellul

289 rker EF5 [2-8-N-(2,2,3,3,3-pentafluoropropyl)acetamide] were done in serial tumor slices.

290 in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as in

291 bba)(3)[CoCl(4)] [bba = N,N'-1,4-butylenebis(acetamide)], which features a record-low melting tempera

292 the auxins indole-3-acetic acid and indole-3-acetamide, which were produced by various (micro)algae s

293 [(E)-(5-hydroxy-1H-imidazol-2-yl)methylidene]acetamide, which, to our knowledge, has not been previou

294 had little or no incorporation of iodo[(14)C]acetamide, while the others that were treated with dithi

295 nhibitor to a potent and selective sulfamate acetamide with improved buffer stability.

296 mide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic

297 ontinued SAR development to produce indole-3-acetamides with additional functionalities which provide

298 yclohex-2-enyl)-N-(2-iodo-4,6-dimethylphenyl)acetamides with an additional ortho-methyl group did not

299 f alpha,alpha-difluoro-alpha-(trimethylsilyl)acetamides with aryl and heteroaryl bromides catalyzed b

300 lved the reaction of bis(ethylsulfenylacetyl)acetamides with dimethyl(methyl)thiosulfonium tetrafluor