ライフサイエンスコーパス: acetyl-CoA synthetase

1 M (S-adenosylmethionine) synthetases, and an acetyl-CoA synthetase.

2 tudy expand the ASKHA superfamily to include acetyl-CoA synthetase.

3 sphate needed for the synthesis of ATP by an acetyl-CoA synthetase.

4 istone deacetylase activity and up-regulated acetyl-coA synthetases.

5 of acetyl-CoA by the level of acetylation of acetyl-CoA synthetases.

6 -CoA by modulating the enzymatic activity of acetyl-CoA Synthetase 1 (AceCS1).

7 The expression of acetyl-CoA synthetase 1, another cytosolic enzyme for pr

8 values with the native acetylated substrate acetyl-CoA synthetase-1; measurement of Sirt1, Sirt2, an

9 Eukaryotic acetate-dependent acetyl CoA synthetase 2 (Acss2) is predominantly cytosol

10 at these processes require acetate-dependent acetyl CoA synthetase 2 (ACSS2).

11 We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matr

12 production by regulating phosphorylation of acetyl-CoA synthetase 2 (ACSS2) by cyclin-dependent kina

13 genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer ce

14 Acetyl-CoA synthetase 2 (ACSS2) converts acetate to acet

15 Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histo

16 In particular, acetyl-CoA synthetase 2 (ACSS2) mediates histone acetyla

17 AMP-activated protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659,

18 ate to citrate metabolism by down-regulating acetyl-CoA synthetase 2 (ACSS2) while maintaining ATP-ci

19 is produced from acetate by chromatin-bound acetyl-CoA synthetase 2 (ACSS2)(2).

20 dies have shown that cancer cells upregulate acetyl-CoA synthetase 2 (ACSS2), an enzyme that converts

21 ng acetyl-CoA synthesis from acetate through acetyl-CoA synthetase 2 (ACSS2).

22 part, from local acetate by metabolic enzyme acetyl-CoA synthetase 2 (ACSS2).

23 ction of cytosolic acetyl-CoA is mediated by acetyl-CoA synthetase 2 (ACSS2).

24 ining acetyl lysine of its natural substrate acetyl-CoA synthetase 2, a reaction intermediate structu

25 Knockdown of the acetyl-coA synthetases abrogated the effect of ethanol o

26 pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclini

27 We demonstrate that mammalian Acetyl-CoA synthetases (AceCSs) are regulated by reversi

28 yltransferase protein and is responsible for acetyl-CoA synthetase acetylation.

29 Acetate-dependent acetyl CoA synthetases (ACS) are de novo sources of acet

30 resent here mutations to Salmonella enterica acetyl-CoA synthetase (Acs) and test the ability of the

31 enzyme A (acetyl-CoA) by means of the enzyme acetyl-CoA synthetase (Acs) and utilize it to generate e

32 obB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase (Acs) at an active site lysine to

33 In this study, we investigated the acetyl-CoA synthetase (ACS) enzyme from Leishmania infan

34 R2 function was required for activity of the acetyl-CoA synthetase (Acs) enzyme.

35 Acetyl-CoA synthetase (Acs) generates acetyl-coenzyme A

36 inctly localized acetate-activating enzymes, ACETYL-COA SYNTHETASE (ACS) in plastids and ACETATE NON-

37 The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that a

38 Acetyl-CoA synthetases (Acs) have emerged as drug target

39 own to contain an unusual acetyl coenzyme A (acetyl-CoA) synthetase (ACS) which catalyzes the formati

40 AMP-forming acetyl-CoA synthetase [ACS; acetate:CoA ligase (AMP-form

41 Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, a

42 ressing the expression of acetyl coenzyme A (acetyl-CoA) synthetase (Acss), leading to decreased acet

43 Acetyl-CoA synthetases (ACSS1, ACSS2) are involved in th

44 rial [ATP-citrate lyase (ACLY)]-, cytosolic [acetyl-CoA synthetase (ACSS2)]-, and peroxisomal [peroxi

45 response to acetyl-CoA and the regulation of acetyl-CoA synthetase activity by the acetylation level.

46 acetylation of AceCS2 by SIRT3 activates the acetyl-CoA synthetase activity of AceCS2.

47 ular acetate levels resulting from decreased acetyl-CoA synthetase activity.

48 The gene coding for the acetyl-CoA synthetase (ADP-forming) from the amitochondr

49 The presence of homologs of acetyl-CoA synthetase (ADP-forming) in such human pathog

50 This gene codes for a 726 residue long acetyl-CoA synthetase (ADP-forming).

51 th of a strain of S. enterica devoid of Acs (acetyl-CoA synthetase; AMP-forming) activity on 10 mm ac

52 tylates SlAacS more efficiently than it does acetyl-CoA synthetase, an enzyme known to be under acety

53 ional and/or posttranslational regulation of acetyl-CoA synthetase and ADP-Glc pyrophosphorylase, and

54 abidopsis seeds, we isolated cDNA clones for acetyl-CoA synthetase and for the ptE1alpha- and ptE1bet

55 rophosphate generated by reactions involving acetyl-CoA synthetase and luciferase can be readily dete

56 but two enzymes are thought to be involved: acetyl-CoA synthetase and plastidic pyruvate dehydrogena

57 s regulation of acetyl-CoA by acetylation of acetyl-CoA synthetase and raises the possibility that pr

58 tion, control of p53 activity, regulation of acetyl-CoA synthetase, and aging.

59 Knockdown of acetyl-coA synthetases by short hairpin RNA (shRNA) was

60 We also show that acetyl-CoA synthetase can be a significant contributor t

61 ve determined the X-ray crystal structure of acetyl-CoA synthetase complexed with adenosine-5'-propyl

62 In contrast, the level of mRNA for acetyl-CoA synthetase does not correlate in time and spa

63 ighest level of accumulation of the mRNA for acetyl-CoA synthetase during silique development is with

64 inhibitors (lithium, allicin and sodium) of acetyl CoA synthetase (EC 6.2.1.1 acetate: CoA ligase),

65 tients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2.

66 and further develop a model to simulate the acetyl-CoA synthetase enzyme reaction network using the

67 Here, we show that the nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key sour

68 cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA) synthetase enzymes that use acetate to produ

69 diauxic shift, along with expression of both acetyl-CoA synthetase genes ACS1 and ACS2 We conclude th

70 ess elevated levels of ATP citrate lyase and acetyl-CoA synthetase genes, both of which are involved

71 ology (CSH) module, flanked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bou

72 Mxr1p is a key regulator of ACS1 encoding acetyl-CoA synthetase in cells cultured in YPA.

73 ypnozoites was validated using MMV019721, an acetyl-CoA synthetase inhibitor that affects histone ace

74 The central metabolic enzyme acetyl-CoA synthetase is regulated in both bacteria and

75 nthesis of acetyl-coenzyme A (acetyl-CoA) by acetyl-CoA synthetase is used here as a case study for t

76 of acs, the gene encoding acetyl coenzyme A (acetyl-CoA) synthetase, leading to uptake of the excrete

77 c activity of key metabolic enzymes, such as acetyl-CoA synthetase, long-chain acyl-CoA dehydrogenase

78 They also suggest that the enzyme acetyl CoA synthetase mediates extracellular acetate upt

79 Here, genes encoding malic enzyme and acetyl-CoA synthetase (nucleoside diphosphate forming) w

80 yl-CoA was mainly produced from acetate (via acetyl-CoA synthetase) or citrate (via ATP citrate lyase

81 The Arabidopsis acetyl-CoA synthetase preprotein has a calculated mass o

82 esulting structural features in AMP- and ADP-acetyl-CoA synthetase proteins in this study expand the

83 To our knowledge, this is the first reported acetyl-CoA synthetase sequence from a plant source.

84 N- and C-terminal parts of the G. lamblia acetyl-CoA synthetase sequence were found to be homologo

85 Acetyl-CoA synthetase short-chain family member 1 (ACSS1

86 CLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2

87 Here, we report that acetyl-CoA synthetase short-chain family member 2 (ACSS2

88 We further show that acetyl-CoA synthetase short-chain family member 2 (ACSS2

89 more closely related to the Giardia lamblia acetyl-CoA synthetase than to those of archaea.

90 The activity of acetyl-CoA synthetase, the first enzymatic step in aceta

91 embers of this enzyme family (exemplified by acetyl-CoA synthetase) use a large domain rotation to ca

92 coding these enzymes, as well as AMP-forming acetyl-CoA synthetase, were expressed at increased level

93 The E. histolytica acetyl-CoA synthetase, which converts acetyl-CoA to acet

94 of ethanol and acetate on acetyl-coenzyme A (acetyl-coA) synthetases, which convert acetate to acetyl

95 tion in bacteria involves the acetylation of acetyl-CoA synthetase, whose activity must be tightly re