ライフサイエンスコーパス: acetylase

1 titution interferes with binding to the de-N-acetylase.

2 between p300/CBP and its associated histone acetylase.

3 ortactin deacetylase and p300 as a cortactin acetylase.

4 tudied how FXR activity is regulated by p300 acetylase.

5 ral gene of the pneumococcal peptidoglycan O-acetylase.

6 d conditions using the enzyme family of de-N-acetylases.

7 t may harbor a high concentration of histone acetylases.

8 present evidence for novel roles of histone acetylases.

9 by acetylation and inhibition of histone de-acetylases.

10 ng complex], and STAGA [SPT3-TAF(II)31-GCN5L acetylase]).

11 ses, 5 of 20 acetyl-transferases, 5 of 19 de-acetylases, 1 of 4 DNA methyl-transferases and 0 of 3 DN

12 ay) and subsequent recruitment of histone de-acetylase 2 (HDAC2), which mediates epigenetic gene sile

13 d p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE com

14 rus E1A, which inhibits both coactivator and acetylase activities of p300.

15 RbAp48 lowered the K(m) of CBP histone acetylase activity and facilitated p300-mediated in vitr

16 ar distribution of PIG-L and Glc-NAc-PI-de-N-acetylase activity and then studied the localization of

17 logy, and that both SWI/SNF and p300 histone acetylase activity are required for hormone-dependent ac

18 thymoma cells, both PIG-L and GlcNAc-PI-de-N-acetylase activity are uniformly distributed between ER

19 signaling to Elk-1 enhances the net histone acetylase activity associated with the c-fos promoter, w

20 naC, IpaM, and CTL0480) that required Cdu1's acetylase activity for protection from degradation and d

21 es to AMF-1 or E2 immunoprecipitated histone acetylase activity from cell lysates.

22 ated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes wit

23 Here we investigate the role of CBP acetylase activity in CREB-mediated gene expression.

24 a decline in coactivators containing histone acetylase activity in myometrium may contribute to the o

25 Lastly, Geminin inhibits HBO1 acetylase activity in the context of a Cdt1-HBO1 complex

26 ates the recruitment of p300 and its histone acetylase activity into complexes with E2 and represents

27 use thymoma cells showed that GlcNAc-PI de-N-acetylase activity is localized to the endoplasmic retic

28 HBO1 acetylase activity is required for licensing, because a

29 These results indicate that MCM3 acetylase activity of MCM3AP is required to inhibit init

30 However, it remains unclear whether the acetylase activity of p300 is necessary for regulating M

31 k by further examining whether the intrinsic acetylase activity of p300 is necessary for stimulating

32 lpha1 on Lys(22), a process dependent on the acetylase activity of p300.

33 ion of MDM2, on the other hand, requires the acetylase activity of p300.

34 PgaB displays de-N-acetylase activity on beta-1,6-GlcNAc oligomers but not

35 Besides histone acetylase activity on chromatin, the TIP60 complex posse

36 ells, suggesting the positive effect of p300 acetylase activity on Sp3.

37 expression of mutated TIP60 lacking histone acetylase activity results in cells with defective doubl

38 ults demonstrate that p300 does not need its acetylase activity to be a coactivator of p73.

39 The p300-acetylase activity was dispensable since expression of a

40 s ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivator.

41 ional coactivators possess intrinsic histone acetylase activity, providing a direct link between hype

42 onent of a multiprotein complex with histone acetylase activity, scored as a significant SB hit.

43 nner dependent on HDAC activity, p300 lysine acetylase activity, the p300 bromodomain, and RB K873/K8

44 cribed c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5

45 of cyclin D1 at least partially required de-acetylase activity.

46 riptional coactivator with intrinsic histone acetylase activity.

47 iption factors through its intrinsic histone acetylase activity.

48 ne deacetylases with those that have histone acetylase activity.

49 complex has been discovered to house histone acetylase activity.

50 the wild-type peptide and inhibits CBP/p300 acetylase activity.

51 likely to involve inhibition of HBO1 histone acetylase activity.

52 the underlying mechanism, we found that the acetylase ACTR can be acetylated by p300/CBP.

53 using deacetylase inhibitors or the tubulin acetylase alphaTAT1 prevents association of mutant LRRK2

54 thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1; 2) iloprost

55 Importantly, manipulating histone acetylase and deacetylase activities established that hi

56 ble acetylation is executed by the intrinsic acetylase and deacetylase activities of co-regulators as

57 We thus suggest that protein acetylase and deacetylase interact with ETA in a ligand-

58 act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities.

59 that E2F1 activity is stimulated by p300/CBP acetylase and repressed by an RB-associated deacetylase,

60 loss of Eaf3, a subunit of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, greatl

61 Eaf3, a component of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, is imp

62 The CBP/p300 acetylase and the CARM1 methyltransferase can positively

63 s with CREB-binding protein (CBP), a histone acetylase and transcriptional coactivator.

64 the Elongator complex-an established protein acetylase and tRNA methylase involved in the fidelity of

65 TRRAP links Myc with histone acetylases and appears to be an important mediator of it

66 ry bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spre

67 polymerase II but requires specific histone acetylases and chromatin remodelers.

68 Targeted acetylases and deacetylases can locally perturb this equ

69 dification of chromatin structure by histone acetylases and deacetylases is an important mechanism in

70 proteins, suggesting that the action of both acetylases and deacetylases is important in the regulati

71 inhibitors and activators of various lysine acetylases and deacetylases offer a new potential strate

72 ng activators and repressors recruit histone acetylases and deacetylases to promoters, thereby genera

73 ss involving chromatin remodeling by histone acetylases and deacetylases, yet the role of this proces

74 ynamic equilibrium between competing histone acetylases and deacetylases.

75 This mechanism is regulated by histone acetylases and deacetylases.

76 maturation together with competition between acetylases and deacetylases.

77 n modification activities, including histone acetylases and enhancer- and insulator-associated factor

78 hat Myc can interact indirectly with histone acetylases and have suggested that Myc mediates transcri

79 y coordinating the functions of both histone acetylases and HDACs.

80 cent studies demonstrated the effect histone acetylases and histone deacetylases (HDACs) have on fine

81 eraction of two families of enzymes: histone acetylases and histone deacetylases (HDACs).

82 the human HAT complex STAGA (SPT3-TAF9-GCN5-acetylase) and a "core" form of the Mediator complex dur

83 ack the NatA N(alpha)-terminal acetylase (Nt-acetylase) and therefore cannot N-terminally acetylate a

84 ced an interaction between KLF5 and the p300 acetylase, and acetylation of KLF5 was necessary for Sma

85 lexes, including SWI/SNF, NuA4/TIP60 histone acetylase, and INO80.

86 a member of the STAGA [SPT3-TAF(II)31-GCN5L acetylase] and TFTC (GCN5 and TRRAP) chromatin remodelin

87 variant affects the function of the PG de-O-acetylase (Ape 1).

88 It is well known that histone acetylases are important chromatin modifiers and that th

89 Acetylases are now known to modify a variety of proteins

90 The characterization of GlcNAc-PI de-N-acetylase as a zinc metalloenzyme will facilitate the ra

91 s and cofactors, including the TIP60 histone acetylase-associated proteins transactivation/transforma

92 t drive the translocation of the microtubule acetylase ATAT1 from the nucleus to the cytoplasm, leadi

93 keratin RE (KRE), co-activators and histone acetylase become co-repressors of the RA/T3 receptors in

94 type IIa histone deacetylase to p300 histone acetylase binding that correlated with increased MEF2D-d

95 es Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex.

96 inds to this new site and recruits its H3K27 acetylase-binding partner CBP, as well as core component

97 erridden not only by ablation of the NatA Nt-acetylase but also by overexpression of the Arg/N-end ru

98 Here, we determined that Cdu1's acetylase but not its DUB activity is important to prote

99 ction in chromatin remodelers and histone(de)acetylases but they have not previously been found in nu

100 ee system and recombinant rat GlcNAc-PI de-N-acetylase by divalent metal cation chelators demonstrate

101 (ii) The Plasmodium de-N-acetylase can act on analogues containing N-benzoyl, Gal

102 Acetylases can also target other proteins such as transc

103 A de-N-acetylase capable of hydrolyzing the N-acetyl group of L

104 otein screen by interaction with the histone acetylase CBP.

105 on domain-induced recruitment of the histone acetylase CBP/p300.

106 l functional interaction between the protein acetylases CBP and p300, and deacetylases, is essential

107 phosphatase, DUSP1, induction of the histone acetylase, CBP, and decline in the histone deacetylase,

108 similar results were observed with a related acetylase, CBP, GCN5 did not enhance FXR transactivation

109 es have shown that Sp1, Sp3, and the histone acetylase co-activator p300 are components of the comple

110 xpression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP

111 n domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.

112 chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex.

113 tone acetyltransferase 1 (HAT1)-RBBP7 lysine acetylase complex as an interaction partner of the Lsm4

114 The Esa1-containing NuA4 histone acetylase complex can interact with activation domains i

115 plex, whereas liganded TR recruits a histone acetylase complex for gene activation.

116 g protein (TBP), TFIIB, and the SAGA histone acetylase complex in vivo.

117 e transcription factor TFIID and the histone acetylase complex PCAF/SAGA.

118 the catalytic subunit of a novel histone H3 acetylase complex that harbors a histone chaperone subun

119 7, which is also present in the SAGA histone acetylase complex, causes a decrease in transcription of

120 ent of the human PCAF (human Gcn5 homologue) acetylase complex.

121 ome-remodeling complex, and the SAGA histone acetylase complex.

122 II holoenzyme/mediator and the SAGA histone acetylase complex.

123 f chromatin remodeling complex, Gcn5 histone acetylase complexes Ada and SAGA, and Rad6, which ubiqui

124 ompletely understood; the SAGA (Spt-Ada-Gcn5 acetylase) complexes from yeast to Drosophila that are m

125 hereafter as the STAGA (SPT3-TAF9-GCN5/PCAF acetylase) complexes.

126 Most importantly, we show that the histone acetylase components of TFIID and SAGA (TAF(II)145 and G

127 E1a's interactions with the nuclear acetylases conferred epithelial morphologies but did not

128 those inactivating the SAS-I histone H4 K16 acetylase, consist of cells all with an intermediate lev

129 We asked whether the acetylase CREB-binding protein (CBP) could acetylate pro

130 leosomes or covalently modify histones (e.g. acetylases, deacetylases, methyltransferases, and kinase

131 p300, but not its acetylase-defective mutant AT2, stimulated p63gamma-depe

132 Also, an acetylase-defective mutant p300 named p300AT2 was able t

133 Finally, both wild type and acetylase-defective mutant p300 proteins associated with

134 Similarly, the acetylase-defective p300 AT2 mutant stabilized the MDM2

135 n and methylation of R17 in vivo, whereas an acetylase-deficient CBP mutant is unable to induce these

136 Both wild type and acetylase-deficient mutant MCM3AP, however, can bind to

137 show here that wild type MCM3AP, but not the acetylase-deficient mutant, inhibits initiation of DNA r

138 efore confused in databases because the MCM3 acetylase DNA sequence is contained entirely within the

139 ated using biotechnology because chitin de-N-acetylases do not efficiently deacetylate crystalline ch

140 AMP-response element-binding protein histone acetylase domain reduced ligand-dependent AR function.

141 ithout either the MSL complex or MOF histone acetylase, dosage compensation is retained but autosomal

142 Overexpression of P/CAF acetylase drives DEK into IGCs, and addition of a newly

143 promoted the recruitment of the p300 histone acetylase (EP300) and, in turn, induced histone H3 acety

144 SC and DRG mediated by FFAR3-induced histone acetylases expression.

145 on has been established, it is not clear how acetylases function in the nucleus of the cell and how t

146 s HDACs are associated with PCAF and another acetylase, GCN5, in HeLa cells.

147 An insertion mutation in a putative PG acetylase gene (designated pacA) resulted in loss of PG

148 A role for histone acetylase has been implicated in leukemias and developme

149 frican sleeping sickness, and GlcNAc-PI de-N-acetylase has previously been validated as a drug target

150 c patients (D-CMSC), identifying the histone acetylase (HAT) activator pentadecylidenemalonate 1b (SP

151 is the catalytic subunit of the NuA4 histone acetylase (HAT) complex that acetylates histone H4, and

152 xpression via their association with histone acetylase (HAT) or deacetylase complexes.

153 Histone deacetylase (HDAC), histone acetylase (HAT), and intracellular cAMP levels were meas

154 is required for licensing, because a histone acetylase (HAT)-defective mutant of HBO1 bound at origin

155 ITA ubiquitination was controlled by histone acetylases (HATs) and deacetylases (HDACs), indicating t

156 aving opposing enzymatic activities, histone acetylases (HATs) and deacetylases affect chromatin and

157 mutants are epistatic to the loss of the (de)acetylase hda1Delta; reinforcing the importance of the r

158 show that blockade of corepressor histone de-acetylase (HDAC) activity reverses the differential inhi

159 SPT10 gene, which encodes a putative histone acetylase implicated in regulation at core promoters.

160 s sequence is acetylated by the related Nat3 acetylase in eukarya.

161 onists, suggesting functional specificity of acetylases in FXR signaling.

162 ndicate a new but undefined role for nuclear acetylases in maintaining the transformed phenotype.

163 regulators, such as ARA24 or PCAF, a histone acetylase, in an additive manner.

164 and the mof gene product, a putative histone acetylase, in msl mutant males returns to a uniform geno

165 iption of DNA methyltransferases and histone acetylases including p300, contributing to regulation of

166 nnot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and inhibited

167 ich results in the accumulation of p53 in an acetylase-independent manner.

168 Histone acetylase inhibition in the hippocampus during consolida

169 n 32A, PP32A), which together form a histone acetylase inhibitor complex.

170 nger than the synergistic effects of histone acetylase inhibitors or additive effects of doxorubicin

171 The acetylase inhibitors sodium butyrate and trichostatin A

172 (iv) Three GlcNR-PI analogues are de-N-acetylase inhibitors, one of which is a suicide inhibito

173 roup of the GlcN is dispensable for the de-N-acetylase, inositol acyltransferase, all four of the man

174 ntial for substrate recognition for the de-N-acetylase, inositol acyltransferase, and first mannosylt

175 BF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of bZIP prot

176 HBO1 histone acetylase is a coactivator both for AP-1 transcription f

177 PCAF histone acetylase is found in a complex with more than 20 associ

178 HBO1 histone acetylase is important for DNA replication licensing.

179 HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licen

180 MCM3 acetylase (MCM3AP) and germinal-centre associated nuclea

181 cells, which lack the NatA N(alpha)-terminal acetylase (Nt-acetylase) and therefore cannot N-terminal

182 homologue of oafA, a putative O-antigen LPS acetylase of Salmonella typhimurium, that was present in

183 of E1A, an inhibitor of the CBP/p300 histone acetylase, on LCR function.

184 Strains lacking Sas2 histone acetylase or the histone methylases that modify lysines

185 acetylation, and had identified the histone acetylase P/CAF and the transcription factor NF-Y as the

186 acetyl lysine reader BRD4 that binds to the acetylase p300 and enables formation of long-range intra

187 ascade involving HSF1 binding to the histone acetylase p300 and positive translation elongation facto

188 oxygen through its interaction with histone acetylase p300 and the hypoxia-inducible factor (HIF)1 p

189 Mechanistically, TGFbeta recruited acetylase p300 to acetylate KLF5, and acetylation in tur

190 d to the Trx promoter, recruited the histone acetylase p300 to the Trx promoter, and formed a transcr

191 n gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylatio

192 wn substrates of CBP and the closely related acetylase p300, we identified G/SK (in the single-letter

193 e Lys residues are acetylated by the nuclear acetylase p300.

194 The histone acetylases p300 and P/CAF directly acetylate the AR in v

195 E1a protein interacts with the nuclear acetylases p300, CBP and P/CAF, and also with the co-rep

196 multaneous interactions with the host lysine acetylases p300/CBP and the tumor suppressor RB.

197 epigenetic regulators including the histone acetylases P300/CBP, histone acetylation readers includi

198 (garcinol and antisense against the histone acetylase, p300) or activators of histone deacetylase (t

199 REB is acetylated by CBP, but not by another acetylase, p300/CBP-associated factor.

200 he orchiectomy-induced expression of histone acetylases, p300 and CBP, which are AR cofactors.

201 y enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300).

202 transfer analysis, we demonstrated that the acetylase PCAF and histone deacetylase 1 (HDAC1) are in

203 Whereas the histone acetylase PCAF has been suggested to be part of a coacti

204 stability by counteracting the action of the acetylases PCAF/GCN5.

205 d to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein an

206 Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-st

207 PCAF histone acetylase plays a role in regulation of transcription, c

208 We report that Gcn5, a histone H3 acetylase, plays a central role in initiation of meiosis

209 etween the RXR/RAR heterodimer and a histone acetylase presented elsewhere.

210 s by p300 indicates a mechanism in which the acetylase promotes formation of longer flaps in the cell

211 The TIP60 histone acetylase purifies as a multimeric protein complex.

212 Remodeling ATPases or histone acetylases release some of the negative supercoiling pre

213 sly reported cases identified PIGL, the de-N-acetylase required for glycosylphosphatidylinositol (GPI

214 ex of a related protein, dihydrolipoyl trans-acetylase, reveals that both substrates localize to the

215 e chromatin remodeller, Rsc, and the histone acetylase, Rtt109, to generate a histone-depleted region

216 The histone acetylases, SAS-I and NuA4, functioned in insulation, in

217 (i) The de-N-acetylases show little specificity for the lipid moiety

218 p nor TAF65p are associated with the histone acetylase Spt-Ada-Gcn5 complex or other non-TFIID TBF.TA

219 ctivator AceI, and also requires the histone acetylase Spt10 for full induction.

220 access or function of an H4-specific histone acetylase such as Esa1.

221 tic mechanism similar to metalloprotein de-N-acetylases such as LpxC.

222 in part, due to an interaction with histone acetylases, such as CREB-binding protein (CBP).

223 wo analogues with the known nonspecific de-N-acetylase suicide inhibitor, GalNCONH(2)-PI and GlcNCONH

224 YopP is a protein acetylase that inhibits mitogen-activated protein kinase

225 pha)(x) barrel domains: a metal-binding de-N-acetylase that is a member of the family 4 carbohydrate

226 , ARD1 is recently described as a HIF-1alpha acetylase that regulates its stability.

227 These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA r

228 is histone deacetylase or recruits a histone acetylase to allow the formation of a functional transcr

229 incides with recruitment of the Esa1 histone acetylase to RP gene promoters.

230 pecific to males, which sequesters a histone acetylase to the X.

231 Here, we recruit histone deacetylases and acetylases to a well-defined yeast promoter in a regulat

232 mbers of a Myb protein complex in recruiting acetylases to the origin.

233 bly by preventing the recruitment of histone acetylases to the promoter.

234 Their association with histone acetylases, to mediate activation, or deacetylases, to m

235 with chromatin modification (methylases and acetylases), transcription (RNA polymerase II), translat

236 acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-co

237 ed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorb

238 al antibodies raised against p300, a histone acetylase, well-known as a marker of active enhancers, f

239 osoma brucei and human (HeLa) GlcNAc-PI de-N-acetylases were determined using 24 substrate analogues.

240 Histone acetylases were originally identified because of their a

241 reduced by the overexpression of histone de-acetylases, which rescues PARP-1 activation.

242 ociated commonly with recruitment of histone acetylases, while repression involves histone deacetylas

243 Reconstitution of metal-free GlcNAc-PI de-N-acetylase with divalent metal cations restores activity