ライフサイエンスコーパス: acetylation

1 ctivating machineries (p300, MED1, and H3K27 acetylation).

2 vity and changes in global H3 and H4 histone acetylation.

3 exclusive ME1 S336 phosphorylation and K337 acetylation.

4 th cellular signaling by influencing protein acetylation.

5 l as histone modification by methylation and acetylation.

6 RD4L, MED1 and sites of histone H3 lysine 27 acetylation.

7 tions, including protein phosphorylation and acetylation.

8 the genome via chromatin looping and histone acetylation.

9 promote genome-wide histone methylation and acetylation.

10 mechanisms linking Wnt signaling and histone acetylation.

11 TP) production, lipid synthesis, and protein acetylation.

12 ollectively responsible for reversing lysine acetylation.

13 tion of recombinant HDAC enzymes and protein acetylation.

14 brings in HDAC1/2 for localized chromatin de-acetylation.

15 tion or cotransfection with SIRT1 to inhibit acetylation.

16 ylation, phosphorylation, persulfidation and acetylation.

17 sential cell-wall polymer peptidoglycan by O-acetylation.

18 to differentiate and exhibit altered histone acetylation.

19 but not SIRT3, significantly decreased NAT1 acetylation.

20 of a bacterial sirtuin deacylase activity by acetylation, 2) that the Gcn5-related YiaC protein is th

21 operandi for NAA80-mediated actin N-terminal acetylation, a modification with a major impact on cytos

22 s, while enhancers with pre-existing histone acetylation/accessibility confer a permissible chromatin

23 luate the effect of varying levels of NAT1 N-acetylation activity in MDA-MB-231 breast cancer cells o

24 986 and r = 0.944, respectively) with NAT1 N-acetylation activity whereas saccharopine abundance was

25 SPR/Cas9 technologies to vary only in NAT1 N-acetylation activity.

26 erns of DNA methylation, deregulated histone acetylation, altered gene expression levels, distorted m

27 , it was reported that NAT1 undergoes lysine acetylation, an important post-translational modificatio

28 d to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes.

29 ermidine accumulation, which inhibits FOXO3a acetylation and allows subsequent translocation to the n

30 VOR, an HDACi, induces histone acetylation and chromatin remodeling and modulates host

31 our study uncover a mechanism by which PARN acetylation and deacetylation regulate its enzymatic act

32 expression, concomitant with increased H3K27 acetylation and decreased PGC-1alpha promoter methylatio

33 Histone acetylation and deposition of H2A.Z variant are integral

34 and whether epigenetic mechanisms of histone acetylation and DNA methylation may contribute to this n

35 nterface in a reaction that is controlled by acetylation and engagement of the Smc ATPase head domain

36 variants are associated with reduced histone acetylation and GARP expression.

37 It inhibited cellular acetylation and had strong activity with EC(50) of 1-3 m

38 d microtubules against mechanical stress via acetylation and has been implicated in promoting microtu

39 ansport pathways, regulated by p300-mediated acetylation and HDAC2-dependent deacetylation of PD-L1.

40 e oxidative stress leads to increased RECQL4 acetylation and its interaction with OGG1.

41 (p300 HAT), leading to changes in histone H3 acetylation and methylation at specific Bdnf promoters.

42 -binding sites which overlaps with in vivo N-acetylation and N-succinylation.

43 49) revealed that Stattic attenuated histone acetylation and neutralized effects of the histone deace

44 oclasts demonstrate increased K310 NF-kappaB acetylation and NF-kappaB transcriptional activity.

45 atterns of DNase I hypersensitivity, histone acetylation and NFAT1 transcription factor binding aroun

46 majority do not acquire histone H3 lysine 27 acetylation and no longer interact with their target gen

47 NF and LTA promoters display increased H3K27 acetylation and nuclease sensitivity and coordinate indu

48 nd deacetylation complex to regulate histone acetylation and nucleosome occupancy in the beta-globin

49 In male placenta, the levels of H3K27 acetylation and PGC-1alpha promoter methylation correlat

50 Our results also indicate that N-terminal acetylation and phosphorylation both decrease the proteo

51 300, leading to loss of p300-dependent H3K27 acetylation and Pol 2-dependent eRNA transcription.

52 ulted in short cilia with decreased axonemal acetylation and polyglutamylation, but relatively intact

53 stone deacetylase, and led to an increase in acetylation and presumably expression of three hub regul

54 ity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 f

55 yl-CoA levels, which led to decreased Raptor acetylation and reduced lysosomal localization of mTOR,

56 histone acetyltransferase with increased H4 acetylation and subsequent activation of autophagy genes

57 tylase 1 binding, increased histone 4 lysine acetylation and subsequent BRD4-driven transcription and

58 ermore, we found that RGFP966 enhanced STAT1 acetylation and subsequently attenuated STAT1 phosphoryl

59 e dehydrogenase (PDH), which induced histone acetylation and subsequently promoted the differentiatio

60 attic directly or indirectly reduces histone acetylation and suggest reevaluation of Stattic and rela

61 ese sites is ubiquitinated in the absence of acetylation and that acetylation inversely correlates wi

62 acetate supplementation rescues both histone acetylation and the differentiation defects.

63 r (VEGF), where it enhances local histone H3 acetylation and transcription.

64 ty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting

65 ed to TULP3 that include enzymes involved in acetylation and ubiquitination.

66 her PARN is post-translationally modified by acetylation and what effect acetylation has on PARN's ac

67 nal modifications (e.g., phosphorylation and acetylation) and DNA binding cooperativity of p53.

68 cluding decreased histone acetylation (H3K27 acetylation) and increased promoter methylation of perox

69 tosine hydroxymethylation, decreased histone acetylation, and altered expression levels of multiple g

70 lations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, transcripti

71 ed enrichment of HNF4A, histone H3-lysine-27-acetylation, and CTCF.

72 y Bicoid and Zelda, possibly through histone acetylation, and found that this model can predict hunch

73 d nuclear gammaH2AX expression, Lys(382)-p53 acetylation, and genomic instability.

74 t binding protein (ChREBP) activity, histone acetylation, and gluco-lipogenic gene expression.

75 protein determinants for alphaSyn N-terminal acetylation, and identifies important residues for subst

76 assay enables quantitation of alpha-tubulin acetylation, and is applicable across various fields of

77 leading to an increase and spread of histone acetylation, and prevents the positioning of RNA Polymer

78 dent carbon metabolism through histone hyper-acetylation, and Sirtuin-mediated silencing of starvatio

79 portant chromatin modifications such as H3K9 acetylation, and that ARH3 patient cells exhibit measura

80 response to a HFD promotes increased lysine acetylation, and that this may play a role in the develo

81 y elevated levels of histones H3K9 and H4K16 acetylation, and, consequently, increased replication st

82 the differently stated modifications, e.g., acetylation/annealing, extrusion/succinylation, and micr

83 1) and HDAC2 are responsible for reducing H4 acetylation as chromatin matures.

84 fibroblasts showed higher levels of FUS K510 acetylation as compared with healthy controls.

85 Our results reveal PCAF and histone acetylation as critical regulators of fork stability and

86 Results of in vitro acetylation assays showed that CobB(L) was acetylated by

87 Histone acetylation assays with purified variant KAT5 demonstrat

88 nal modifications in histone methylation and acetylation associated with epithelial cells, NKT, MAIT,

89 t post-translational modification of NAT1 by acetylation at K(100) and K(188) may modulate NAT1 effec

90 ecked HDAC6 activity and increased histone 3 acetylation at the Il-10 promoter, resulting in enhanced

91 lular matrix production via control of H3K27 acetylation at the profibrotic genes, ACTA2 and COL1A1 G

92 PopP2 in turn catalyzes O-acetylation at the same site, thereby preventing its pho

93 findings provide evidence that the N (alpha)-acetylation at Thr-2 of EsxA facilitates dissociation of

94 In addition, acetylation attenuated the allosteric effects of ATP on

95 ssue homogenate showed no changes in tubulin acetylation between control, depressed suicides, and dep

96 ically or pharmacologically modulating PD-L1 acetylation blocks its nuclear translocation, reprograms

97 can substantially reduce global levels of H3 acetylation, but how SIRT6 is able to accomplish this fe

98 HDAC6 reversibly regulates tau acetylation, but its role in tauopathy progression remai

99 n, Met-SO formation, phosphorylation, or Lys acetylation, but we currently only understand the functi

100 found that kindlin-2 maintains alpha-tubulin acetylation by inhibiting the microtubule-associated dea

101 idues for substrate-specific recognition and acetylation by NatB enzymes.

102 overexpressed ATAD2 shifts the balance of H4 acetylation by protecting this mark from removal and tha

103 the recognition of lysine crotonylation and acetylation by the AF9 YEATS domain through incorporatio

104 n autophagy are mediated by decreased raptor acetylation causing mTORC1 inhibition, rather than by al

105 Signaling pathway analysis showed that H3K9 acetylation changes are linked to AML-relevant signaling

106 ing from the six patients showed significant acetylation changes in 187 gene loci at different chromo

107 he nucleoside analog DAC induced genome-wide acetylation changes in H3K9, the physiological substrate

108 Despite previous reports that showed histone acetylation changes upon using these agents, the exact m

109 nt of ISGF3 binding motifs from differential acetylation ChIP-seq data compared to other methods.

110 ession is accompanied by a decrease in H3K27 acetylation, consistent with the importance of MAML1 for

111 dent sirtuin deacylase reversible lysine (de)acetylation control, four were not acetylated by two ace

112 g HMGN1 or its downstream effects on histone acetylation could be therapeutically active in AML.

113 Nt-acetylation critically regulates protein degradation by

114 Therefore, how the acetylation/deacetylation cycle is regulated is an impor

115 One critical PTM is acetylation/deacetylation, which is being investigated a

116 Here, we showed that the acetylation-defective p53-4KR mice, lacking the ability

117 ominant missense KAT5 variants cause histone acetylation deficiency with transcriptional dysregulatio

118 O2 functioned as a regulatory motif, and the acetylation-deficient Lys258Arg mutant was enzymatically

119 Conversely, the interaction of LANA with an acetylation-deficient p53 mutant is enhanced.

120 Here we identified OTUD3 as an acetylation-dependent deubiquitinase that restricts inna

121 These results implicate an acetylation-dependent mechanism mediating KSHV persisten

122 Thus, our results reveal an acetylation-dependent regulation of PD-L1 nuclear locali

123 d in the nuclear localization sequence, K510 acetylation disrupted the interaction between FUS and Tr

124 ethod to an AD dataset consisting of histone acetylation, DNA methylation, and RNA transcription data

125 ogy of NTAc-alphaS, we found that N-terminal acetylation does not alter significantly the conformatio

126 on of Nmnats, finding that the absence of Nt-acetylation does not significantly alter the polysome fo

127 l environment for non-enzymatic beta-catenin acetylation downstream of WNT signalling.

128 s) to lipid rafts and that increased tubulin acetylation (due to HDAC6 inhibition) and antidepressant

129 tment hierarchy, where NSL-deposited histone acetylation enables BRD4 recruitment for transcription o

130 (100) and K(188) and that changes in protein acetylation equilibrium can modulate its activity in cel

131 Together, our findings suggest that actin acetylation, especially Lys(328), modulates muscle contr

132 e of polymerization (DP) and the fraction of acetylation (F(A)).

133 significantly reduced mitochondrial protein acetylation following a HFD relative to wildtype (WT) mi

134 ly, we found 35.99% and 16.11% alpha-tubulin acetylation for mouse spinal cord and brain homogenate t

135 RNA expression, DNA methylation, and histone acetylation from ASD and control brains to identify a co

136 ated tubulin showed significant decreases in acetylation from depressed suicides and depressed nonsui

137 ous removal of monomethylation from H3K4 and acetylation from H3K27, respectively.

138 of RiCE2 is dependent on RiCE17 removing 2-O-acetylations from double acetylated mannose.

139 ependent manner, including decreased histone acetylation (H3K27 acetylation) and increased promoter m

140 by RA-regulated deposition of histone H3 K27 acetylation (H3K27ac) (gene activation mark) or histone

141 By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistant CRPC cel

142 Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigen

143 ed widespread changes in histone 3 lysine 27 acetylation (H3K27ac), and was associated with global TG

144 re are rhythms in histone H3 lysine 9 and 27 acetylation (H3K9ac and H3K27ac) and histone H3 lysine 4

145 atory gene promoter as a result of decreased acetylation (H3K9ac) and increased methylation (H3K9me3

146 ely, the euchromatin mark histone 3 lysine 9 acetylation (H3K9ac) is abundant in non-heterochromatic

147 Here, we show that histone H4 lysine 16 acetylation (H4K16ac) is maintained from oocytes to fert

148 ally modified by acetylation and what effect acetylation has on PARN's activity.

149 on of the acetylated units (P(A): pattern of acetylation) has been demonstrated.

150 2 inhibitor K-145, that nuclear S1P, histone acetylation, HIF-1alpha expression, and TNBC tumor growt

151 Disruption of neural acetylation homeostasis has been implicated in multiple

152 Histone acetylation homeostasis, maintained by the antagonistic

153 Thus, acetylation, HSP70, and proteasome activities regulate T

154 The results indicated that NAT1 acetylation impaired its enzyme kinetics, suggesting dec

155 archical view about the functions of histone acetylation in auxin signaling and root morphogenesis.

156 lso detected increased SAGA-mediated histone acetylation in H4 basic patch mutants.

157 eacetylase Hst2 and the removal of lysine 16 acetylation in histone 4.

158 eals a direct link between decreased tubulin acetylation in human depression and the increased locali

159 between these specific TF and local histone acetylation in human hearts.

160 ation-causing mutations or posttranslational acetylation in its RNA recognition motifs) drove TDP-43

161 The role of sialic acid O-acetylation in NmW CPS, however, is not clearly understo

162 HH-responsive enhancers, specifically loses acetylation in the absence of HH signaling.

163 ies have elucidated the functions of histone acetylation in the modulation of auxin signaling as well

164 y K(100) and K(188) as major sites of lysine acetylation in the NAT1 protein.

165 tion of FUS, implicating a potential role of acetylation in the pathophysiological process leading to

166 The involvement of histone acetylation in the regulation of transcription was first

167 lococcus aureus, exhibits decreased rates of acetylation in vitro, and is effective at lowering bacte

168 excess nucleotides decrease protein lysine N-acetylation in vitro.

169 This study examined tubulin acetylation in whole-tissue homogenate, plasma membrane,

170 cytosolic deacetylase that regulates tubulin acetylation, in CF mice restores growth and inflammatory

171 Histone acetylation increased in TH+ neurons and decreased in SS

172 binding was accompanied by increased histone acetylation, increased c-Jun binding, and upregulation o

173 ly, we show that p300-mediated site-specific acetylation increases, whereas HDAC3-mediated deacetylat

174 stitutions at Thr-2 that precluded N (alpha)-acetylation inhibited the heterodimer separation and hen

175 nated in the absence of acetylation and that acetylation inversely correlates with ubiquitination of

176 Lysine acetylation is a key mechanism of post-translational con

177 Lysine acetylation is a posttranslational modification that occ

178 We propose that acetylation is involved in regulating of Pif1 activities

179 plasm in Corynebacterium glutamicum and that acetylation is mediated by the membrane protein TmaT.

180 phaS clarify that the role of the N-terminal acetylation is to regulate the binding affinity of alpha

181 Lysine acetylation (Kac), an abundant post-translational modifi

182 cally, A-485 inhibited p300-mediated histone acetylation, leading to disruption of BRD4-NUT binding t

183 dynamic changes in the global histone lysine acetylation levels (H3K4ac, H3K9/K14ac and H3K27ac).

184 onal NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvest

185 d changes to the enhancer-associated histone acetylation mark H3K27ac by mapping matched tumor-normal

186 A single acetylation mark lysine258 on ACO2 functioned as a regul

187 cidic amino acids and contributed 20% of the acetylation marks in the detected plant proteome.

188 pathways, suggesting that the absence of Nt-acetylation may alter Nmnat protein stability.

189 inding protein-mediated transcription factor acetylation may represent a common mechanism to control

190 Our findings highlight acetylation-mediated control of the nucleolus as an impo

191 ression remained unaltered following histone acetylation-mediated increased accessibility.

192 The results reveal a paradoxical acetylation-mediated molecular clutch that tunes transcr

193 Consequently, a low-DNA-binding-affinity acetylation-mimetic MITF mutation supports melanocyte de

194 ion of CBP, which acetylates p53, or with an acetylation mimicking carboxyl-terminal domain p53 mutan

195 showed that replacement of one of them with acetylation-mimicking glutamine increases the sensitivit

196 er analyses indicated that expression of the acetylation-mimicking p53 mutant in vivo induces activat

197 cinoma (PDAC) mouse model, expression of the acetylation-mimicking p53-mutant protein effectively sup

198 he H3 N-terminal tail or the installation of acetylation mimics or bona fide acetylation within H3 N-

199 f post-translational modifications including acetylation, myristoylation, and iron binding were ident

200 ith Sirt3-dependent 3-fold increases in SOD2 acetylation, NF-kappaB (nuclear factor kappa-light-chain

201 N(alpha)-terminal acetylation (NTA) is a prevalent protein modification in

202 N(~)-terminal acetylation (NTA) is one of the most abundant protein mo

203 N-terminal acetylation (NTA) is one of the most widespread protein

204 Acetylation of ACO2 was reversibly regulated by SIRT3, w

205 More recently, acetylation of actin itself was revealed to regulate cyt

206 lobular domains of actin and NAA80, and thus acetylation of actin.

207 Acetylation of alpha-tubulin at conserved lysine 40 (K40

208 V-miRNA-BART12, which, in turn, inhibits the acetylation of alpha-tubulin, and promotes the dynamic a

209 Of note, acetylation of alpha-tubulin, which maintains microtubul

210 Human NatB (hNatB) mediated N-terminal acetylation of alphaSyn has been demonstrated to play ke

211 remodels the cytoskeleton, and enhances the acetylation of beta-catenin.

212 ighly selective inhibitor of HDAC8, restored acetylation of contactin and reduced expression of those

213 Acetylation of ectopically expressed NAT1 in HeLa cells

214 TNF-alpha- and STS-induced acetylation of H3 and H4 histones was attenuated by the

215 their expression likely through reducing the acetylation of H3K9 at these loci.

216 lases (HDACs 1/2), thereby decreased histone acetylation of H3K9/14ac and H4K8ac.

217 DNA accessibility increase upon progressive acetylation of H4 might be utilized by the cell for sele

218 ranscription factor IRF-1, which induced the acetylation of Histone H3 at CD274 promoter followed by

219 ters their chromatin accessibility by direct acetylation of histone H3 lysine-18 (H3K18).

220 ell-associated unspliced HIV-1 RNA (CA-RNA), acetylation of histone H3-lysine-9 (H3K9ac+) and phospho

221 ese phenotypes are associated with increased acetylation of histones and with increased phosphorylati

222 nd lead to decreased occupancy and increased acetylation of histones within gene coding regions.

223 y, the catalytic activity of OTUD3 relies on acetylation of its Lys129 residue.

224 osphorylation of ME1 S336 and ACAT1-mediated acetylation of K337 strongly influences NADPH generation

225 and HDACi treatment as a result of increased acetylation of key histone lysine residues (acetylated h

226 cationic charge resulting from partial de-N-acetylation of native PNAG is critical for PNAG-dependen

227 els is specifically due to the absence of Nt-acetylation of Nmnat (Nma1 and Nma2) proteins and not of

228 are regulated in vivo Here, we report lysine acetylation of nuclear Pif1 and demonstrate that it infl

229 d3 are primarily responsible for the dynamic acetylation of nuclear Pif1.

230 Reversible lysine acetylation of nuclear proteins such as histones is a lo

231 ng mTORC1 inhibition, rather than by altered acetylation of other autophagy regulators.

232 We also revealed how acetylation of PARN can decrease its enzymatic activity

233 O-Acetylation of peptidoglycan protects bacteria from the

234 Acetylation of Pif1 exacerbated its overexpression toxic

235 Limited proteolysis assays indicate that acetylation of Pif1 induces a conformational change that

236 Biochemical assays demonstrated that acetylation of Pif1 stimulated its helicase, ATPase, and

237 S1-R in its inactive state and also inhibits acetylation of RRS1-R by PopP2.

238 or CREB-binding protein (CBP), and increased acetylation of specific histones, including H2BK12, H3K9

239 L-6 signaling led to the phosphorylation and acetylation of STAT3 that targeted DNA methyltransferase

240 Finally, we observed that inhibitory acetylation of superoxide dismutase 2 (SOD2) at K122 was

241 We have previously shown that transient acetylation of the glycolipid trehalose monohydroxycoryn

242 ibits autophagy by enhancing EP300-dependent acetylation of the mTORC1 component raptor, with consequ

243 Moreover, acetylation of the N(4) position of cytidine (ac4C) was

244 further demonstrated with the regioselective acetylation of the natural product quercetin.

245 K379, K383, and K384) to mimic constitutive acetylation of the p53 C-terminus.

246 sis, we obtained evidence that the N (alpha)-acetylation of the Thr-2 residue on EsxA, a post-transla

247 Acetylation of tubulin enables microtubules emanating fr

248 We show that acetylation of two key lysine residues on TULP3 by p300

249 itu control of site-selectivity of catalytic acetylations of partially protected sugars using light a

250 ng SIRT1 by RNAi led to elevated H3 lysine 9 acetylation on the promoter region of miR-1185-1, which

251 termine the residue-specific consequences of acetylation on Tn-Tpm-based regulation of actomyosin act

252 ells after nicotinamide treatment to enhance acetylation or cotransfection with SIRT1 to inhibit acet

253 ssion of the enzymes responsible for tubulin acetylation or deacetylation.

254 Acetylation or mutation of the lysine residue stabilizes

255 tion could also be carried by the pattern of acetylation (PA): the sequence of beta-1,4-linked glucos

256 s show how intricate structural features and acetylation patterns of dietary fibre can be customized

257 ing developed to yield chitosans of specific acetylation patterns, and, recently, a correlation betwe

258 sand eight hundred ninety-seven differential acetylation peaks (FDR [false discovery rate], 5%) point

259 MOF-mediated acetylation plays a critical role in the DNA damage resp

260 have differing effects on cardiomyocyte YM: Acetylation provides flexibility, whereas detyrosination

261 To identify cardiac histone acetylation quantitative trait loci (haQTLs), we regress

262 enumerated by esterification, reducing, and acetylation reactions, respectively, followed by FTICR M

263 ated in the RNA recognition motif, K315/K316 acetylation reduced RNA binding to FUS and decreased the

264 investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metabolic pr

265 Histone acetylation regulates chromatin structure and gene expre

266 Mitochondrial lysine acetylation regulates several metabolic pathways in card

267 These findings demonstrate that FUS acetylation regulates the RNA binding, subcellular local

268 ized-only populations, an increased level of acetylation results in a decline of detyrosinated MTs in

269 ow reduced enrichment of Tip60 and epigentic acetylation signatures at all gene loci examined with ce

270 try, we identify a novel HDAC6-regulated tau acetylation site as a disease specific marker for 3R/4R

271 By identifying a novel p53 acetylation site at lysine K136, we found that simultane

272 ound that simultaneous mutations at all five acetylation sites (p53-5KR) diminished its remaining tum

273 arry a total of 75 phosphorylation sites, 92 acetylation sites, and two ubiquitination sites.

274 Histone deacetylases 3 (HDAC3) modulates the acetylation state of histone and non-histone proteins an

275 membrane-localized tubulin maintains a lower acetylation state, permitting increased sequestration of

276 mplex regulates target genes by altering the acetylation status at enhancers.

277 Thus, PARN's acetylation status may play a role in regulating telomer

278 The acetylation status of electron transport chain Complex I

279 gulate chromatin dynamics by maintaining the acetylation status of histones.

280 ique cytoplasmic localization, modulates the acetylation status of tubulin, HSP90, TGF-beta, and pero

281 zation of the MT is dependent in part on its acetylation status, and HDAC6 is capable of reversing th

282 tributions of PTMs, such as phosphorylation, acetylation, SUMOylation, methylation, O-GlcNAcylation,

283 An extensive genome-wide acetylation survey yielded insights into regulatory mech

284 these proteins is similarly modulated by an acetylation switch.

285 ee proteomics assay to measure alpha-tubulin acetylation targeting protease AspN-generated peptides h

286 ry for robust H3K4 monomethylation and H3K27 acetylation that mark active enhancers, but not for the

287 mulations to show that XOAT1 catalyzes xylan acetylation through formation of an acyl-enzyme intermed

288 n-activated protein kinase (MAPK)-stimulated acetylation to promote increased occupancy of their regu

289 how physiological/pathological signals link acetylation to specific gene expression programs and whe

290 asets comprising of DNA methylation, histone acetylation, transcriptome- and genome-wide association

291 were near or below our detection limit (e.g. acetylation, ubiquitination).

292 y reported an induction of alpha-tubulin K40 acetylation upon Trichostatin A stimulation of ONS cells

293 r tension and causing an increase in histone acetylation via deactivation of histone deacetylases (HD

294 ified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expr

295 We identified several proteins whose acetylation was lost in the Deltakatms strain, and whose

296 experiments support a catalytic mechanism of acetylation where residues D567 and E491 are general bas

297 trol of the percentage and the location of O-acetylation which is labile and susceptible to migration

298 ylates Ser-12 on p300 to stimulate C/EBPbeta acetylation, which is necessary and sufficient to cause

299 downstream effector of Ctf18-RFC is cohesin acetylation, which we place toward a late step during re

300 tallation of acetylation mimics or bona fide acetylation within H3 N-terminal tail alters the condens

301 Next, we examined whether the status of Nt-acetylation would affect the translation of Nmnats, find