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1 enic HPVs, but such high coverage is hard to achieve.
2 tered until a tolerable full on response was achieved.
3 ood discrimination based on the cultivar was achieved.
4 of 3, 4 of 6, and 8 of 8 DSA (cases 1-3) was achieved.
5  diffusion coefficient of the fluorophore is achieved.
6 dentify areas where quantum advantage may be achieved.
7  seven recommendations for how this could be achieved.
8  platform with which high selectivity can be achieved.
9 atic reductions in new HCV infections can be achieved.
10   LODs of 0.01 ppm and LOQs of 0.03 ppm were achieved.
11 resolution beyond the Fresnel zone limit was achieved.
12  large majority of the genome was frequently achieved.
13 e from 50 to 10(7) CFU/mL within 100 min was achieved.
14 46 A mg(-1) at 0.45 V) of Pd(delta+)-OCNT is achieved.
15 consumption of 164 kJ.mol(-1) CO(2) could be achieved.
16 Li(3) PS(4) SSE enables LiCoO(2) cathodes to achieve 101.6 mAh g(-1) for 50 cycles.
17  adsorption of CO(2) molecules dramatically, achieving 103.21 mmol g(cat) (-1) h(-1) with near-unity
18 lgorithm to provide an effective approach to achieving 3D sub-diffraction-limit information in subcel
19  upgraded coating over an aluminum plate can achieve 6 degrees C (7 degrees C on a scale-model buildi
20 grees C and pH 7.1 showed that the PBP resin achieved 95% of its equilibrium capacity within 0.64 +/-
21 ic self-organization might allow synapses to achieve a 'Goldilocks' state, striking a balance between
22 y nonlocal design concept and its ability to achieve a fully passive and broadband wave control.
23  protected Zn anode enables a Zn||Ti cell to achieve a high average Coulombic efficiency of 99.1 % fo
24                                           To achieve a high dendrite-suppression capability, SSEs sho
25 eral and dynamic feature replacement methods achieve a higher performance than classic univariate and
26 equired 30-39 threshold cycles of RT-qPCR to achieve a positive detection.
27                       However, it is hard to achieve a room temperature phosphorescence material with
28 and actin cytoskeleton to break symmetry and achieve a stable polarized state.
29    When targeting a single gene, the lipoMSN achieved a 54% gene-editing efficiency, besting the stat
30                     Compared to the GS, SKIE achieved a grading accuracy of 90% and substantial agree
31 f DNA sequence was mappable, variant calling achieved a higher F1 score and 14 713 additional variant
32      Artificial intelligence-based detection achieved a higher level of accuracy.
33                            Patients with PEX achieved a lower maximal workload (PEX group, 8.2 metabo
34  Regarding pneumonia detection, radiologists achieved a maximum diagnostic accuracy of up to 0.87 (95
35           Hence, the PM6-Tz20: Y6-based OSCs achieved a PCE of up to 17.1% with a significantly enhan
36 il now, the most sensitive torque sensor has achieved a remarkable sensitivity of 2.9 x 10(-24) N m H
37 patients, 59.5% (22/37; 95% CI, 42.1%-75.3%) achieved a response at 1 month and 37.9% (11/29; 95% CI,
38 ct of a seven core multi-core fibre, we have achieved a sensitivity of - 1.4 nm/ degrees as a vector
39 ned sections, the decision support algorithm achieved a sensitivity of 100% compared to 68.4% (micros
40                            The AEMS platform achieved a speed of 2.2 s/sample using only 10 nL of sam
41       Consequently, the final ensemble model achieved a superior performance with an accuracy of 0.90
42      Less than one-half of Medicare patients achieved a TO following hepatopancreatic procedures with
43 Li(3) N-LiF layer coating on Li(3) PS(4) SSE achieves a record-high critical current of >6 mA cm(-2)
44 mary endpoint was the proportion of patients achieving a 50% or higher improvement from baseline in F
45 mplemented field observations in the hope of achieving a better understanding of the fate and impact
46  Cadzow denoising on the MCR-processed FIDs, achieving a further increase in the S/N ratio and more e
47 f dynamically coordinating their actions for achieving a joint goal.
48  promising signal amplification strategy for achieving a sensitive biosensor for DNA detection and di
49     This difference in duration required for achieving accumulated temperature can be explained with
50 enchmarked open-access and commercial tools, achieving accuracy close to the expected level of noise
51 experiments we show that similar results are achieved across different stimuli and regions of skin (f
52 nd for understanding how copper active sites achieve activation of strong C-H bonds.
53 ta-Lg) and alpha-lactalbumin (alpha-La), was achieved after 4 h, at E/S ratios of 1/150 U/mg, regardl
54 thoxy groups into other nucleophiles allowed achieving alkene difunctionalization with the constructi
55  goals providing critical tools necessary to achieve an end to the global STIs epidemic.
56                                      The DNN achieved an area under the curve for prevalent diabetes
57 lysis was performed in the derivation cohort achieved an AUC of 0.824 (95% CI 0.814-0.851) and an AUC
58                               The C-CNN also achieved an average root-mean-square deviation (RMSD) of
59     We characterized the setup in detail and achieved an optimum ring-down time of 159.4 ns and a min
60 2, patients treated with combination therapy achieved an overall response rate of 31% (14 of 45 patie
61 buvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) achieved an SVR12 rate of >95% in NS5A-experienced parti
62 ssion with a low threshold 4.16 uJ cm(-2) is achieved and distributed feedback lasers are also demons
63 oved spatial and temporal selectivity can be achieved and subsequently harnessed for new concepts in
64 A difference in the predicted probability of achieving appropriate hand antisepsis was found between
65                                           It achieves approximately 100-fold acceleration in computat
66  how tissue specificity of their function is achieved are poorly understood.
67 ed spectral region is even more difficult to achieve as further nonradiative pathways come into play.
68                      Superior performance is achieved as a Li-ion battery cathode with a high reversi
69 ompared to about 66 per cent for pure Cu) is achieved at a current density of 400 milliamperes per sq
70 In this Perspective, we first discuss how to achieve atomically precise NCs and determine their total
71  USA and Brazil have great potential to help achieve average global CDR goals of 0.5 to 2 gigatonnes
72                    Clear differentiation was achieved between specimens from infected and uninfected
73  mixture mapping with supervised learning to achieve bit error rates as low as 0.11% for single reads
74 tem operates with visible light (400 nm) and achieves borylation of a wide range of chloroarenes with
75 spectrometry with gas-phase ion chemistry to achieve both differentiation and quantification of the d
76 nt OPVs with PCEs of 12% and AVTs of 20% are achieved, both on rigid and flexible substrates.
77 nterparts by ~27- and ~8-fold, respectively, achieving brain/blood ratio >300-fold higher than that o
78  3D complex structures that are difficult to achieve by conventional fabrication approaches.
79 ndent reviewer-assessed overall response was achieved by 20 (47%, 95% CI 31-62) of 43 patients.
80                            The viability was achieved by 22 (71%) organs, that were transplanted afte
81 ry are prevented, with additional protection achieved by a second bolus after the induction procedure
82            Because this target is not easily achieved by all patients, alternative therapeutic option
83            We show that such tracking can be achieved by canonical network architectures and dynamics
84  and high work function (~5.1 eV), which are achieved by combining a simple solution processing with
85            The hybrid epitope imprinting was achieved by electropolymerization in the presence of two
86       The clinic efficiency and cost savings achieved by eliminating formal visual acuity (VA) and di
87 riments show that spatial integration can be achieved by establishing interdependencies among agents
88  imaging under these low-light conditions is achieved by exploiting both the refractive and absorptiv
89 mechanical programmability of the LC gels is achieved by genetically tuning the charge density of pro
90                      Global data fitting was achieved by including experiments in the forward and rev
91 us placebo, and blinding for vemurafenib was achieved by means of a placebo tablet.
92                Blinding for atezolizumab was achieved by means of an identical intravenous placebo, a
93 nt in the amplification of chirality is only achieved by mixing the three components, i.e. the two ac
94       Higher colloidal stability values were achieved by neutral endoprotease (31-89%) compared to th
95 excellence and innovation in research can be achieved by organizations that promote equity, diversity
96                       Cost reductions can be achieved by pooling (or combining) subsamples and testin
97 imary endpoint was met: ACR20 at week 24 was achieved by significantly greater proportions of patient
98 ows that high CD73 inhibitory potency can be achieved by simply introducing a small substituent into
99                 In seed plants, branching is achieved by stem-cell-containing axillary meristems, whi
100 his cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR gene on one
101  SH versus NO from 2 with the pendant SMe is achieved by the employment of [Mn(III)((TMS)PS3)(DABCO)]
102                                     This was achieved by the generation of a library of Cys mutations
103             Specificity of the detection was achieved by the use of hairpin surface-tethered probes a
104 Goal is anchored in an understanding that to achieve cardiovascular health for all, the AHA must incl
105                                 Patients who achieved cCR were managed nonoperatively.
106 ders, and health centers can learn from high-achieving centers to promote early initiation of prenata
107                               The ability to achieve chirality-selective synthesis (chiral induction)
108                                   If this is achieved, clear potential exists for developing a vastly
109         By applying this design strategy, we achieved CO(2) electroreduction on copper in 7 M potassi
110 gh immune-based therapies are more likely to achieve complete cures, acquired resistance remains an o
111  weeks vs 5.87 +/- 2.20 weeks (p = 0.01) and achieved complete epithelialization in significantly mor
112 tagenesis of Individual Offspring (CAMIO) to achieve comprehensive analysis of a targeted region of n
113 t of nearshore fish, making them unlikely to achieve conservation objectives in rural coastal economi
114                                           To achieve containment of transgenic microorganisms, confid
115  at least 6 months of multidrug treatment to achieve cure(1).
116               Venetoclax is highly active at achieving deep remission for most treated patients with
117 C79 and overcomes a soma-retention signal to achieve dendritic localization.
118             Composites are ideally suited to achieve desirable multifunctional effective properties s
119 imizing the nitrogen (N) input is crucial to achieving desirable biomass production of PCG without ne
120          To receive optimal medical care and achieve desired outcomes, persons with HIV must be consi
121 n of enzyme polymerization can be adapted to achieve different regulatory outcomes.
122 ed with the same therapeutic regimen but who achieved different treatment outcomes.
123                                      We then achieved direct bonding between two Au [Formula: see tex
124                            Parameter regimes achieving directional amplification can be elegantly obt
125 , and scalability are challenging metrics to achieve due to trade-offs between carbon use for growth
126             Consensus for all statements was achieved during the first round.
127 tain B cells whose presence were required to achieve EAE recovery.
128 escent and adult women to improve detection; achieve earlier diagnosis and treatment; and improve hea
129 upilumab was expressed as number of patients achieving EASI-50 (Eczema Area and Severity Index) or EA
130 re a promising targeted delivery platform to achieve effective glioblastoma treatment by improving ef
131 th ketones, esters, and carboxylic acids was achieved employing the di-tert-butyl peroxide as a sourc
132 hether these interventions will be enough to achieve epidemic control (incidence of 1 infection per 1
133    The relatively hydrophobic adhesives that achieved equivalent/enhanced bonding performance suggest
134 enitor cell line in a dose-dependent manner, achieving far higher efficiency and concentration than e
135 ee re-DMEK eyes developed graft failure, all achieving final BCVA <=0.30 logMAR (Snellen >=20/40) aft
136 of physical and chemical factors involved in achieving fine control of Li electrodeposition, we belie
137 ion limits at a picogram level can be easily achieved for all n-alkanes.
138 ic location surveillance were simultaneously achieved for the proposed POC test.
139 tensity and 3-10-fold improvement in S/N are achieved for various kinds of molecules including DNA, p
140               We then discussed the advances achieved for various LDG sensing and biosensing schemes
141 ulations, with successful structure solution achieved from room-temperature 3D-ED data with a resolut
142 vestigation is the failure of these cells to achieve full functional maturity.
143 umed and that the majority of patients never achieve full recovery.
144 et counts were observed among recipients who achieved full (>95%) vs low-level (5%-49%) donor myeloid
145 heory of five rational design principles for achieving giant intrinsic SHE in transition metal oxides
146                     Clinical remission rate (achieving grade 0 hepatic steatosis) in HP-diet and beta
147 rected visual acuity (BCVA) and brolucizumab achieving greater fluid resolution.
148                           A mean depth of 15 achieved &gt;99% 5-fold genome coverage (in 9/20 clinical s
149  stable and most of BS conversion assays can achieve&gt; 99.5% efficiency.
150        A common core dataset is proposed, to achieve harmonization of registry-based quality outcome
151                                           To achieve high accuracy, we performed a large number of ex
152 panel of 41 MTs, indicating its potential to achieve high selectivity when targeting the peptide subs
153 pose using MMP-targeting antibodies that can achieve high specificity in interactions with their targ
154 s in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing mor
155 st some centimeter-sized single crystals and achieved high device performance.
156 tment with FDC of sofosbuvir and daclatasvir achieved high SVR12 rates, equivalent to those seen in P
157 convolutional neural network is feasible and achieves high diagnostic performance when both CT and PE
158 ate batteries are a proposed route to safely achieving high energy densities, yet this architecture f
159 nionic redox processes as a potential way of achieving higher capacities for MIBs.
160 nstrate a packed bed flow reactor capable of achieving highly regio- and stereoselective C-H function
161 with prevention interventions, are needed to achieve HIV epidemic control.
162 perantus and Large Skipper Ochlodes sylvanus-achieving impressive buffering through wing positioning.
163 ters for enhancement of tumor selectivity to achieve improved in vivo therapeutic outcomes.
164    Of the 8 patients, 7 patients (87.5%) had achieved improvement in BCVA after the primary surgery,
165  for radiomics studies is often difficult to achieve in prospective trials.
166              Gross total resection (GTR) was achieved in 119 cases (70.8%) with the complications of
167 the diastolic pathway of the clinical VT was achieved in 24/85 (28.2%) patients.
168                   Complete cytoreduction was achieved in 290 (50%) of 576 women with a GCIG CA125 res
169  complete resolution of subretinal fluid was achieved in 93% of patients.
170                            Visualization was achieved in 95% (21/22) of women who used the Callascope
171 s between receptor types, selectivity can be achieved in a number of different ways.
172 demonstrated that intracellular delivery was achieved in all cells in 2D cultures of a human bladder
173 Although gains in newborn survival have been achieved in many low-income and middle-income countries,
174 tion of a laser pulse beyond 0.1 TW has been achieved in nearly 20 years, and only one report of Bril
175 s is one of the essential goals that must be achieved in order to control the electronic properties o
176                  Yet, sterile protection was achieved in the absence of this epitope, substantiating
177 talysis and the realization that this can be achieved in the context of small-molecule catalysts has
178 trade-offs between the biodiversity benefits achieved in the different plans and the delivery of four
179 ed our understanding of how ratio-sensing is achieved in yeast GAL metabolic regulation, but also elu
180 proach, a wide array of polycyclizations are achieved, including variants that involve powerful dearo
181 cal marine fisheries or agricultural sectors achieve income gains for targeted households, but knock-
182 inking Through Other Minds will be useful in achieving it.
183   After a median follow-up of 3.1 years, the achieved LDL-C concentrations were 64 mg/dL (1.64 mmol/L
184                   Our fully automated system achieved levels of accuracy comparable to currently avai
185 tively target disease-afflicted regions, and achieve long-term therapeutic protein expression in the
186 to weight-loss, a substantial variability in achieved long-term outcomes exists among obese but other
187                                              Achieving long-range uniformity remains a challenge, but
188     HIV drug resistance is a major threat to achieving long-term viral suppression in HIV-positive in
189  in such mortality between 1990 and 2017 had achieved low levels of premature avertable mortality fro
190 ith CDAR, delayed rituximab after cladribine achieved lower rate (67% of 21 evaluable patients; P = .
191 atients (24.1%) achieved LVRR and 45 (22.6%) achieved LV full recovery.
192                In total, 48 patients (24.1%) achieved LVRR and 45 (22.6%) achieved LV full recovery.
193         HRR was calculated as the maximal HR achieved minus the HR at: 30-s (HRR30), 1-min (HRR1), 2-
194 has the potential to be widely applicable in achieving more predictable and deletion-only MMEJ-mediat
195 o obtain reaction progress data, this design achieves much higher efficiency by collecting all data d
196 een an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed
197 esults show the possibility of using Tnt1 to achieve near-saturation mutagenesis in B. distachyon, wh
198 of broad task context.SIGNIFICANCE STATEMENT Achieving one's goals requires knowing what to do and wh
199 lowed prior to the initiation of exercise to achieve optimal pain, functional and physiological outco
200                                              Achieving precise nanopore topologies in graphene using
201          Intranasal instillation was used to achieve pulmonary delivery daily over 10 days to M. tube
202                          Our metasurface can achieve Q-factors >2,500 while beam steering light to pa
203            Thus, optogenetics can be used to achieve quantitative and temporal control of gut bacteri
204 mbolize renal and iliac arteries, and it can achieve rapid hemostasis in acutely injured vessels.
205                                     Here, we achieved rapid and homogeneous electrochemical detection
206 e reactivity of benzylic C(sp(3))-H bonds to achieve reactivity at the homobenzylic position can be a
207                                 Once CRIM is achieved, recurrence is common and mandates continued en
208 -electrode configuration will be critical in achieving reliable neurotransmitter detection for the du
209  distal regulatory elements, yet how this is achieved remains poorly understood.
210                  Social network analysis has achieved remarkable popularity in disease ecology, and i
211 ll-blown psychosis over 2 to 3 years and 30% achieving remission.
212 s small as 180 nm and 1 mum line spacing was achieved, resulting in the highest resolution EGaIn patt
213 lass of mechanisms, termed "distal pinning," achieves robustness by combining local sensing of morpho
214  deionization (BDI) systems because they can achieve selective ion removal and low energy deionizatio
215 rapeutic monoclonal antibody and was able to achieve sensitive glycan identification at a low microgr
216 r's cutoff and also to a threshold chosen to achieve sensitivity of >90%, in accordance with the WHO'
217                                           To achieve single RBC trapping, we employ two parallel side
218 ichment of glycogen in live cancer cells and achieved specific glycogen mapping through distinct spec
219 activity, and increased consumption, thereby achieving stable body weight.
220 The rGO@3D-Cu symmetric cells and half-cells achieve state-of-the-art plating and stripping performan
221             Deep neural networks (DNNs) have achieved state-of-the-art performance in identifying gen
222                    Statistically, Our method achieves state-of-the-art accuracy of 99.15% on Human pr
223                                              Achieving step changes in genetic yield potential is cru
224 mparator group, 7 of 39 participants (17.9%) achieved SU.
225                              As a result, we achieved substantially improved photovoltaic performance
226  that symmetric two-sided loop extrusion can achieve such compaction, but recent single-molecule stud
227 hallenges on laboratories in their effort to achieve sufficient diagnostic testing capability for ide
228 by three similar tools, we found that Binner achieves superior performance in the number and accuracy
229                                 Recently, we achieved sustainable H(2) photoproduction by shifting al
230                                    Forty-one achieved SVR(12) , 10 had undetectable viral loads but a
231                    Eighty-two patients (82%) achieved SVR, which was not associated with baseline OAT
232 cally and industrially relevant bacteria and achieved target- and species-specific integration in a c
233 ls this research represents a new concept in achieving targeted delivery of radiopharmaceuticals.
234                                      This is achieved thanks to the sufficient orthogonality of the l
235 ught after nanotechnology is systems able to achieve the assembly-line like production of molecules.
236 ons) are arguably the most powerful means to achieve the construction of multiple ring systems in a s
237  young songbirds develop motor circuits that achieve the goal of imitating a specific tutor song to w
238 ally verified the excitation pulse energy to achieve the minimum photon count required for the detect
239 nfinement and coordination (ACC) strategy to achieve the synthesis of rare-earth single erbium (Er) a
240 ferent IgG antibodies and can be employed to achieve the targeted synthesis of clinically-relevant mo
241 mmend when metformin in monotherapy does not achieve the therapeutic goals.
242 erent platforms showed that using MatchMixeR achieved the best trade-off between true and false disco
243  edge-sharing LiO(4) -SiO(4) tetrahedra that achieves the balance between a short UV absorption edge,
244 ynthesizability and phase stability, thereby achieving the highest conductivity of 2.3 x 10(-4) S cm(
245 ngineering, down to a single defect, towards achieving the smallest memristor for applications in ult
246 ide attention due to its contribution toward achieving the United Nations Sustainable Development Goa
247 of serotonin, but they take several weeks to achieve therapeutic onset.
248                                           To achieve these goals, funding agencies and training progr
249                                  In order to achieve these results, a class of Bronsted basic guanidi
250                                           To achieve this aim, we address regional and local COVID-19
251                                           We achieve this by collecting two images simultaneously tha
252                                  In order to achieve this clinically important goal, the approach nec
253                                           To achieve this goal, 3D MSC sheets are prepared, exploitin
254                                           To achieve this goal, we need a clearer understanding of th
255                                           To achieve this goal, we used data from six paired eddy-cov
256      The data standards and models needed to achieve this integration do not currently exist.
257      It is not understood how water striders achieve this match.
258                                           We achieve this stress by bending single-crystal silicon mi
259                                           To achieve this, a priori selected frequencies are encoded
260 hape memory polymer composite is reported to achieve this.
261 dpoint of the proportion of participants who achieved this concentration by week 96, assessed in all
262                                           We achieved this goal by correcting optical aberrations in
263                   Wnt/beta-catenin signaling achieves this in part by increasing the expression of pr
264                                              Achieving this behavior using conventional approaches is
265 ement evidence-informed interventions toward achieving this goal that undergirds NIH's mission to imp
266 ojected impact against obesity than would be achieved though reformulation alone.
267 that direct readout of H3K27me3 by BAHCC1 is achieved through a hydrophobic trimethyl-L-lysine-bindin
268                                     SPCL was achieved through a sequential three segment ligation on
269 nd suggest that functional redundancy can be achieved through parallelization of molecularly distinct
270 first-generation bifunctional inhibitors was achieved through structure-based inhibitor design.
271      Efficient sulfate diester formation was achieved through systematic optimization of the electron
272 ation of alkyl thiols to disulfides has been achieved under mild conditions using a chemiluminescent
273 ed by the chemical diversity of monomers, to achieve uniform behaviour in heterogeneous systems.
274 ugh immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biologic
275 eral commercially important monoterpenes and achieve up to 125-fold increase over cytosolic productio
276  demonstrate that our proposed mechanism can achieve up to 50% better privacy than traditional DP-bas
277                         100% accuracy can be achieved using a multivariate logistic regression model
278 n), and enrichment for mycobacteria DNA were achieved using an equal volume of thermo-protection buff
279                    Complement inhibition was achieved using B4Crry, an injury site-targeted inhibitor
280    A remarkable PL enhancement by 12 fold is achieved using pressure to modulate the structure of a r
281 ization of allyl and benzyl silyl ethers was achieved using rhodium(II) carbenes derived from N-sulfo
282 ction efficiency of 86-101% for all parabens achieved using the optimum-sized cartridge and a repeata
283 ergy acceptor) provided an ideal platform to achieve very rapid (picosecond time scale) and highly ef
284                        The sequencing method achieved very high coverage (median 99%), specificity (9
285 cess, or even a separation pin, unwinding is achieved via a "dam-and-diversion tunnel" mechanism that
286                                 Centering is achieved via a hydrodynamic mechanism based on Darcy fri
287              This cost-effective strategy is achieved via a two-component regulatory system (BceRS) w
288 owing that significant sensitivity gains are achieved via proton detection under the conditions of ou
289  Optimal quantitative sensing of miR-141 was achieved via the first example of an electrochemical oli
290 aryliminophosphoranes bearing ortho urea was achieved via unprecedented Ph(3)P-I(2) mediated ring-ope
291  in 2D black phosphorus (BP) is exploited to achieve visual memory, wavelength-selective multibit pro
292 ly designed composite acoustic lens that can achieve wave convergence is proposed by assembling a lat
293  ultrasensitive magnetization reversal to be achieved, which may promote the development of novel str
294          Cancer elimination in humans can be achieved with immunotherapy that relies on T lymphocyte-
295  survival benefits that could potentially be achieved with local cytoreductive and/or metastasis-dire
296 erplay between strength and ductility can be achieved with sacrificial bonds in an adhesive.
297                     The protein accumulation achieved with the combinatorial promoter stacking expres
298 vatives (39 examples, 65-94% yield) could be achieved with the generation of synthetically important
299 terial properties, but the best results were achieved with unviable seeds.
300 ng platelet integrin alphaIIbbeta3 cannot be achieved without compromising hemostasis, thus causing s

 
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