ライフサイエンスコーパス: acid catalysis

1 ol by chiral BINOL-phosphoric acid (Bronsted acid catalysis).

2 ction was developed, using chiral phosphoric acid catalysis.

3 hydrolysis of mNBP, consistent with general acid catalysis.

4 rates and a His-Glu pair involved in general acid catalysis.

5 e on the leaving group and efficient general acid catalysis.

6 at these reactions involve only weak general acid catalysis.

7 eviously been unavailable using chiral Lewis acid catalysis.

8 n transition state stabilization and general acid catalysis.

9 sted plot that was characteristic of general acid catalysis.

10 ydrogen bond (H-bond) activation or Bronsted acid catalysis.

11 e phosphatase conformation, enabling general acid catalysis.

12 e ester was studied with and without general-acid catalysis.

13 PT is likely to involve general base-general acid catalysis.

14 ue Trp354 to Ala completely disables general acid catalysis.

15 ion strategy has been developed via Bronsted acid catalysis.

16 ubstrate and the acid cofactor for a general acid catalysis.

17 hanism involving nucleobase-mediated general acid catalysis.

18 rocess that generates allylic lactones via n-acid catalysis.

19 al electric fields on heterogeneous Bronsted acid catalysis.

20 e product 3 (all equatorial) conveniently by acid catalysis.

21 orientation and nucleobase-mediated general acid catalysis.

22 alysts that could avoid undesirable Bronsted acid catalysis.

23 lkenyl allylic boronates via chiral Bronsted acid catalysis.

24 sential for catalyst development in Bronsted acid catalysis.

25 ving group, which is consistent with general acid catalysis.

26 low-energy pathways under water or sulfuric acid catalysis.

27 indolines using silver(I)/chiral phosphoric acid catalysis.

28 gen bonding plays a crucial role in Bronsted acid catalysis.

29 blished as a new activation mode in Bronsted acid catalysis.

30 aC excision, which involves solvent-mediated acid catalysis.

31 ith a range of amines and thiols under Lewis acid catalysis.

32 rahydrothiophene derivatives with phosphinic acid catalysis.

33 metal photoredox catalysis with chiral Lewis acid catalysis.

34 rolodiketopiperazine by protic or gold Lewis acid catalysis.

35 nted phenomenon in enantioselective Bronsted acid catalysis.

36 ctivity and position the metal ion for Lewis acid catalysis.

37 , and its rate is not markedly influenced by acid catalysis.

38 reaction merges aerobic oxidation and Lewis acid catalysis.

39 ons brings about unusual reactivity in Lewis acid catalysis.

40 peroxides in the presence of H(2)O(2) under acid catalysis.

41 mical cycles that define energy relations in acid catalysis.

42 ither under thermal conditions or with Lewis acid catalysis.

43 ate is subject to both specific- and general-acid catalysis.

44 metals such as Zn(2+) for mediating nucleic acid catalysis.

45 solid HF equivalents for similar alkylation acid catalysis.

46 ese properties capitalize on effective Lewis acid catalysis, a chemical strategy for accelerating Die

47 clearly indicated the involvement of general acid catalysis, a hallmark of protein-tyrosine phosphata

48 as recently realized using chiral phosphoric acid catalysis, although in that study the substrates we

49 that ligate RNA expand the scope of nucleic acid catalysis and allow preparation of site-specificall

50 is innovative approach, emphasizing Bronsted acid catalysis and careful control of reaction condition

51 Classical SNAr methods using acid catalysis and elevated temperatures could not be ex

52 ansition-state stabilization through general-acid catalysis and freeing of three water molecules trap

53 is acids in stoichiometric reactivity, Lewis acid catalysis and frustrated Lewis pair (FLP) reactivit

54 , 'metal-free' reactivity, hidden (Bronsted) acid catalysis and hidden borane catalysis.

55 ities for metal carbene generation and Lewis acid catalysis and in the cost of the precious metal rho

56 e of a halogenating agent and under Bronsted acid catalysis and proceeds via a transannular amidohalo

57 synergistic palladium and chiral phosphoric acid catalysis and produced chiral cis-1,3-disubstituted

58 nabled by synergistic palladium and Bronsted acid catalysis and produced chiral isoindolines with goo

59 ize N3-protonated forms of caC to facilitate acid catalysis and suggesting that N191A-TDG could poten

60 omatic systems can be carried out under mild acid catalysis and thus under far milder conditions than

61 olysis; this reaction is subject to specific acid catalysis and to nucleophilic catalysis by 1-hydrox

62 f biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica l

63 ionalization, counteranions for simple Lewis acid catalysis, and components of materials like liquid

64 ammonium ion activates the enone by Bronsted acid catalysis, and the catalyst's hydroxyl group orient

65 dings and their relevance to chiral Bronsted acid catalysis are discussed.

66 en bond mechanism as well as hidden Bronsted acid catalysis are frequently discussed as possible expl

67 nt of the flexible loop that enables general acid catalysis are presented.

68 ther enzymatic KIEs with and without general acid catalysis, are consistent with a loose transition s

69 ate on the amide carbonyl coupled to general acid catalysis at the amide oxygen can also be ruled out

70 Using the concept of boronic acid catalysis (BAC), electrophilic activation of carbox

71 t a role for rescuing nucleobases in general acid catalysis, because a nucleobase that contributes ge

72 ition state for cleavage of 1-F from general acid catalysis by 0.80 M cyanoacetate buffer at pH 1.7.

73 atalysis by a carboxylate coupled to general acid catalysis by a carboxyl is not operative.

74 de support for a mechanism involving general-acid catalysis by a conserved adenine residue in the act

75 ected to enable further advancement in Lewis acid catalysis by building upon the activation principle

76 Acid catalysis by hydronium ions is ubiquitous in aqueou

77 erful tool to promote heterogeneous Bronsted acid catalysis by orders of magnitude, leveraging interf

78 ntal investigations rule out hidden Bronsted acid catalysis by partial decomposition of I2 to HI and

79 ion of fructose and HMF compared to Bronsted acid catalysis by promoting side reactions.

80 e was the major product as a result of Lewis acid catalysis by Sn(2+).

81 p of the substrate in conjunction with Lewis acid catalysis by the bound zinc.

82 te the individual rate constants for general-acid catalysis by the diacid and monoacid forms of succi

83 aving group (Cys-35) via an enforced general acid catalysis by trapping mechanism.

84 the catalytic diad which strengthens general acid catalysis by Tyr-14.

85 Cleavage of BPA in HTW occurs by specific acid catalysis, by specific base catalysis, and by gener

86 base-promoted reaction is E-selective, while acid catalysis can, through the choice of solvent, selec

87 vorable C=O hydrogenation and weak concerted acid catalysis cause unsatisfactory catalytic performanc

88 inia, we have examined the effect on general acid catalysis caused by mutations to two conserved resi

89 Application of the new acid catalysis conditions has afforded diverse bacterioc

90 urvey of >20 acids identified four promising acid catalysis conditions of which TMSOTf/2,6-di-tert-bu

91 The prior acid-catalysis conditions [BF(3) x O(Et)(2) in CH(3)CN a

92 se reactions are the first examples of Lewis acid catalysis employing nitrogen as the site of substra

93 he huge success of enantioselective Bronsted acid catalysis, experimental data about structures and a

94 e applicability of enantioselective Bronsted acid catalysis, experimental insight into transition sta

95 We established the requirement of general acid catalysis for E-P formation in reactions with high

96 yl, and benzyl moieties are found to require acid catalysis for efficient hydrolysis.

97 e ion on the scissile phosphate, and general acid catalysis for protonation of the leaving 3'-O anion

98 revious studies that Cdc25A utilizes general acid catalysis for substrates with a leaving group pK(a)

99 system reacted by means of concerted general acid catalysis (found to be a so-called D(N)A(N)A(H)D(xh

100 The process takes place under Bronsted acid catalysis, giving rise to final products in moderat

101 azones and 2-oxo-3-butenoates under Bronsted acid catalysis, has been developed.

102 d sodium hypophosphite (peroxide initiators, acid catalysis, heat), the method proceeds under neutral

103 latter stepwise mechanism involving Bronsted acid catalysis hinged upon the formation of an oxocarben

104 In Bronsted acid catalysis, hydrogen bonds play a crucial role for r

105 llenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFI

106 ivity of various types of lignin linkages in acid catalysis in conjunction with stabilization of reac

107 uction cascade using TEMPO-BAIB-HEH-Bronsted acid catalysis in DMPU as solvent and a stoichiometric a

108 The role of acid catalysis in oxacalix[3]arene synthesis has been in

109 General acid catalysis in protein tyrosine phosphatases (PTPases

110 ted by TFA and is a rare example of Bronsted acid catalysis in radical addition reactions.

111 ew general approach to accelerating Bronsted acid catalysis in solution.

112 ecause a nucleobase that contributes general acid catalysis in the cleavage pathway should provide ge

113 a general base mechanism with likely general acid catalysis in the oxidative decarboxylation of D-mal

114 ssess the functional significance of general acid catalysis in the system.

115 This is a key feature of acid catalysis in zeolite solvents, which lack the isotr

116 Our results show that the process of general acid catalysis is complex and suggest that Lys-167 and A

117 ity via cooperative isothiourea and Bronsted acid catalysis is demonstrated.

118 nic acids under sequential palladium/triflic acid catalysis is described.

119 the alkane peroxyflavin intermediate, while acid catalysis is needed for the protonation of the FMNO

120 y clearly corroborating that hidden Bronsted acid catalysis is not operating with our Lewis acid.

121 In the Phe mutant, general acid catalysis is partially effective, but the proton is

122 General acid catalysis is rendered inoperative by the Lys mutati

123 these as ligands for enantioselective Lewis acid catalysis is reported.

124 Diarylborinic acid catalysis is shown to be an efficient and general m

125 igh and low pH, indicating that general base/acid catalysis is the rate-limiting step.

126 alkane C-H bond activation in heterogeneous acid catalysis is unknown.

127 The hydrolysis is accelerated via acid catalysis, leading to self-amplifying HF generation

128 Biochemical experiments suggest that general acid catalysis may occur through the N3 position, which

129 Furthermore, the prediction that general acid catalysis may only be effective in low dielectric m

130 This unique acid-catalysis mechanism had been ascribed to the nucleo

131 ides an explanation for the impaired general acid catalysis observed in kinetic experiments with Trp

132 acid and the imidazolium ion showed general acid catalysis of 18.5 and 1.5 M-1 sec-1, respectively,

133 the native protein, this H(2)O could provide acid catalysis of dioxygen reduction at the reduced trin

134 the conclusion that Glu-461 provides general acid catalysis of leaving group departure, which is most

135 sion with the alkyl substrate, while general acid catalysis of pNPP by YopH is more synchronous with

136 Recently, Bronsted-acid catalysis of related substrates was similarly propo

137 4 on the scissile phosphodiester and general-acid catalysis of the expulsion of the 5'-deoxyribose ox

138 is observation supports Glu19-CO(2)H general acid catalysis of the formation of mutant.III.

139 HN) and CHI.TS, we found: (i) Lys-97-general-acid catalysis of the O2'(-) nucleophilic addition; (ii)

140 tial abstraction of the 2-proton by Lys 220, acid catalysis of the vinylogous beta-elimination of the

141 9 2 x 10(3) M(-1) s(-1) ( 2o), implying that acid catalysis of thermal persulfate activation may be t

142 gly catalyzed by the hydroxide ion but shows acid catalysis only at pH < 1.

143 ical reaction (carbonyl reduction) by either acid catalysis or by a propinquity effect and where thes

144 btained cleanly from the Cl(9) compound with acid catalysis or by reduction with mercury.

145 phosphodiester cleavage, either for general acid catalysis or for electrostatic stabilization.

146 ndergo spontaneous decomposition via general acid catalysis or reduction/oxidation chemistry is avert

147 synthetic xanthone targets it was found that acid catalysis promoted their isomerization to thermodyn

148 efficient and operationally simple Bronsted acid catalysis provides a direct scalable route to indol

149 chemical experiments are indicative of Lewis-acid catalysis rather than a metal template-controlled p

150 ed with Fe(III) imparting activity for Lewis acid catalysis (regioselective methanolysis ring-opening

151 rs to incorporate a lesser degree of general-acid catalysis, relative to the 2,3-isomer.

152 We address here the manner in which acid catalysis senses the strength of solid acids.

153 to study the proton-transfer step in general acid catalysis that is facilitated by the catalytic Mg2+

154 Even without general acid catalysis, the D262N mutant reaction is activated b

155 Leveraging mild acid catalysis, the reaction demonstrates a high toleran

156 d 1,3-hydroxyalkyl azides with ketones under acid catalysis; the initial reaction affords an iminium

157 allylidene-indenedione derivatives and under acid-catalysis they are additionally transformed to 2-(1

158 riegee intermediates and H2 S under water or acid catalysis, thioladehydes could be detected in a hyd

159 We have shown that, under Bronsted acid catalysis, this reaction is reversible and therefor

160 data that points to a novel mode of general acid catalysis through the N3 position of an adenine nuc

161 bvious path from an interest in chiral Lewis acid catalysis to a project focused on the development o

162 rplay of aerobic photoredox and selenium-pai-acid catalysis to allow for the installation of a broad

163 on of the alkyl radical and subsequent Lewis acid catalysis to construct stereodefined C-C bonds.

164 thers 1a-e reacted with styrenes under Lewis acid catalysis to give novel polysubstituted thiochroman

165 their detailed understanding of chiral Lewis acid catalysis to stereocontrol in reactions involving e

166 nd the proton field is postulated to provide acid catalysis to the conjugation reaction.

167 h upgrades the catalyst from a single "Lewis acid catalysis" to "frustrated Lewis pairs (FLPs) cataly

168 levels of endo addition attained from Lewis acid catalysis translate to trans hydrindene junctions u

169 ition can be achieved with chiral phosphoric acid catalysis under mild conditions.

170 f a dual C-C bond intramolecularly via Lewis acid catalysis under mild reaction conditions.

171 f the substrates are polarized through Lewis acid catalysis via complexation with the beta-metal ion,

172 Acid catalysis was a factor when there was reduced react

173 imized with phospholipid standards and fatty acid catalysis was confirmed using lipid extracts from r

174 Finally an acid catalysis was used to break down proanthocyanidin c

175 Acid catalysis, which is often employed in Schiff base s

176 A1 performs general acid catalysis while G33 acts as a general base.

177 that activates the electrophile by Bronsted acid catalysis, while the urea group binds the nucleophi

178 We anticipate that confined acid catalysis will open new avenues for addressing chal

179 Instrument parameters for MOLI MS fatty acid catalysis with CeO(2) were optimized with phospholi