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1 cells treated with an inhibitor of lysosomal acid lipase.
2  their cholesterol esters are cleaved off by acid lipase.
3 owing cholesteryl esters to be hydrolyzed by acid lipase.
4 uence derived from the propiece of lysosomal acid lipase.
5 The results indicated that 2.5 ppm lysosomal acid lipase, 0.14 ppm liver carboxylesterase, 1.8 ppm pa
6  Castor bean endosperm contains a well known acid lipase activity that is associated with the oil bod
7 omal/lysosomal pH nor a direct inhibition of acid lipase activity.
8 tudies indicate that administrated lysosomal acid lipase affects the atherogenesis by at least two me
9  that one of the early compartments contains acid lipase (AL), the enzyme required for liberating cho
10 lated with increased expression of lysosomal acid lipase, an M2 macrophage marker.
11 eled by commercial probes, such as lysosomal acid lipase and cytosolic phospholipase A2.
12 s we have previously described, in lysosomal acid lipase and glucocerebrosidase, and localizes to str
13 mal signaling mediated by a LIPL-4 lysosomal acid lipase and its lipid chaperone LBP-8 increases mito
14 eview will focus on the role(s) of lysosomal acid lipase and its use as an enzyme therapy to reduce a
15  LDL-CE hydrolysis is catalyzed by lysosomal acid lipase; (b) neither scavenger receptors nor the LDL
16 NPC1 and NPC2 and several digestive enzymes (acid lipase, beta-glucuronidase, and cathepsins B and D)
17                                    Lysosomal acid lipase deficiency (LAL-D) is caused by mutations in
18 d cell growth and emphysema during lysosomal acid lipase deficiency are partially caused by peroxisom
19 broblasts from patients with WD (a lysosomal acid lipase deficiency characterized by excessive lipid
20 or desaturation in contrast to the lysosomal acid lipase deficiency found in Wolman disease.
21                                    Lysosomal acid lipase deficiency is a rare, autosomal recessive co
22 herapy in children and adults with lysosomal acid lipase deficiency, an underappreciated cause of cir
23  Fabry's disease, Pompe's disease, lysosomal acid lipase deficiency, and five types of mucopolysaccha
24 liver, such as HIV, lipodystrophy, lysosomal acid lipase deficiency, familial hypobetalipoproteinemia
25 Wolman's disease, a severe form of lysosomal acid lipase deficiency, leads to pathologic lipid accumu
26                                    Lysosomal acid lipase deficiency-which can be diagnosed using dry
27 lities in children and adults with lysosomal acid lipase deficiency.
28                                    Increased acid lipase expression and accumulation of free fatty ac
29 ges include a decrease in fat desaturase and acid lipase expression in the intestine and a global shi
30                      By increasing lysosomal acid lipase expression, decreasing metabolic signaling b
31 ter and triglyceride metabolism in lysosomal acid lipase gene knockout mice (lal-/-) results in sever
32 stem was used to reintroduce human lysosomal acid lipase (hLAL) expression into LAL gene knockout (la
33 in kinase C-mediated activation of lysosomal acid lipase in Wnt4-deficient bone marrow-derived macrop
34  or NPC2 protein in NPC disease or lysosomal acid lipase in Wolman disease results in defective cellu
35                                    Lysosomal acid lipase is an essential lipid-metabolizing enzyme th
36                                    Lysosomal acid lipase (LAL) cleaves cholesteryl esters and triglyc
37     The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myel
38                                    Lysosomal acid lipase (LAL) deficiency causes systemic expansion a
39                           Of note, lysosomal acid lipase (LAL) deficiency facilitates melanoma growth
40                                    Lysosomal acid lipase (LAL) has been recently identified as a pote
41                                    Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and
42                                    Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters and trig
43                                    Lysosomal acid lipase (LAL) is a critical lipid hydrolase that gen
44                                    Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholester
45                                    Lysosomal acid lipase (LAL) is essential for the clearance of endo
46                                    Lysosomal acid lipase (LAL) is essential for the hydrolysis of cho
47                                    Lysosomal acid lipase (LAL) is essential for the hydrolysis of the
48                                    Lysosomal acid lipase (LAL) is required for the hydrolysis of intr
49                                    Lysosomal acid lipase (LAL) is the critical enzyme for the hydroly
50                                    Lysosomal acid lipase (LAL) is the critical enzyme for the hydroly
51  and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of el
52                                    Lysosomal acid lipase (LAL), a key enzyme in the metabolic pathway
53 obilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes, is un
54 (CESD), an inherited deficiency of lysosomal acid lipase (LAL), is an underappreciated cause of progr
55 downstream transcriptional target, lysosomal acid lipase (LAL).
56 ult from the deficient activity of lysosomal acid lipase (LAL).
57 the effect of lalistat, a specific lysosomal acid lipase (LAL/Lipa) inhibitor on LD degradation in HS
58                      Deficiency of lysosomal acid lipase (LAL; official name Lipa, encoded by Lipa) i
59 rganelles, which in turn indirectly inhibits acid lipase, leading to a subsequent accumulation of cho
60  by mutations in the gene encoding lysosomal acid lipase (LIPA) that result in reduced or absent acti
61 e maintenance of AT; deficiency in lysosomal acid lipase (Lipa), the enzyme required for lysosome lip
62 ulture, establishing dependency on lysosomal acid lipase (LIPA/LAL) and the microphthalmia/transcript
63 e worm Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization o
64 mice, genomic clones for the mouse lysosomal acid lipase (mLAL) gene were isolated and characterized.
65 .5 ppm lipoprotein lipase, 0.1 ppm lysosomal acid lipase, or 0.3 ppm cathepsin D.
66           RPE-specific knockout of lysosomal acid lipase recapitulates features of AMD.
67                            The corresponding acid lipase(s) catalyzing these reactions remains to be
68 on of the lysosomal hydrolase LAL (lysosomal acid lipase) to mobilize FA for FAO and memory T cell de
69  delivery of a lamellar body content marker, acid lipase, to the stratum corneum interstices.
70  with sham-treated mice, the human lysosomal acid lipase-treated mice also have reduced levels of pla
71            Administration of human lysosomal acid lipase via tail vein into mice with atherosclerosis
72 t involves two lysosomal proteins, lysosomal acid lipase, which hydrolyzes C esters, and NPC1 (Nieman