1 haled CO2 to induce an acidosis and activate
acid sensing ion channels.
2 t, is essential for proton activation of the
acid-sensing ion channels.
3 and selectivity in voltage-gated sodium and
acid-sensing ion channels.
4 at of previously described native and cloned
acid-sensing ion channels.
5 l probably see many advances in the study of
acid-sensing ion channels.
6 trimeric degenerin/epithelial sodium channel/
acid-sensing ion channels.
7 er subdomains in the extracellular domain of
acid-sensing ion channels.
8 mediated by the capsaicin receptor TRPV1 and
acid-sensing ion channels.
9 he extracellular thumb domain in the chicken
acid sensing ion channel 1 structure.
10 Acid-sensing ion channel 1 (ASIC1) is a H(+)-gated chann
11 Acid-sensing ion channel 1 (ASIC1) is critical in acidot
12 Acid-sensing ion channel 1 (ASIC1) is homologous to ENaC
13 We previously reported that
acid-sensing ion channel 1 (ASIC1), a non-selective cati
14 dy, we show that breast cancer cells express
acid-sensing ion channel 1 (ASIC1), a proton-gated catio
15 The resolved crystal structure of
acid-sensing ion channel 1 (ASIC1), a structurally relat
16 e current study provides novel evidence that
acid-sensing ion channel 1 (ASIC1)-mediated Na(+) influx
17 Targeting
acid-sensing ion channel 1 (encoded by the ASIC1 gene),
18 We also found that expression levels of
acid-sensing ion channel 1 and endoperoxide 4 receptor i
19 es to describe in detail the distribution of
acid-sensing ion channel 1 and its relationship with neu
20 lammatory lesions is unknown and, crucially,
acid-sensing ion channel 1 expression has not been deter
21 ver, the extent and cellular distribution of
acid-sensing ion channel 1 expression in neurons and gli
22 ther these findings suggest that blockade of
acid-sensing ion channel 1 has the potential to provide
23 ctivation in in vivo migraine models, via an
acid-sensing ion channel 1 mechanism.
24 The expression of
acid-sensing ion channel 1 was associated with axonal da
25 We found that
acid-sensing ion channel 1 was upregulated in axons and
26 We previously showed that the
acid-sensing ion channel 1 which, when activated under t
27 Moreover, blocking
acid-sensing ion channel 1 with amiloride protected both
28 Based on structural homology with
acid-sensing ion channel 1, gammaAsp(516) was predicted
29 Acid-sensing ion channel-
1 (ASIC-1) is a proton-gated io
30 The
acid-sensing ion channel-
1 (ASIC1) contributes to synapt
31 The neuronally expressed, proton-gated
acid-sensing ion channel-
1 (ASIC1) is permeable to Na+ a
32 SGK1.1 decreases expression of the
acid-sensing ion channel-
1 (ASIC1); thereby, SGK1.1 may
33 k examines the interaction of amiloride with
acid-sensing ion channel-
1, a protein whose structure is
34 Acid sensing ion channels 1a (ASIC1a) are of crucial imp
35 Acid-sensing ion channel 1a (ASIC1a) has been shown to p
36 macologic methods to investigate the role of
acid-sensing ion channel 1a (ASIC1a) in cardiac IRI at t
37 Protons activate
acid-sensing ion channel 1a (ASIC1a) in the central nerv
38 Acid-sensing ion channel 1a (ASIC1a) is a proton-gated c
39 Acid-sensing ion channel 1A (ASIC1A) is abundant in the
40 The
acid-sensing ion channel 1a (ASIC1a) is abundantly expre
41 Because
acid-sensing ion channel 1a (ASIC1a) is exquisitely sens
42 In CA1, the
acid-sensing ion channel 1a (ASIC1a) is known to facilit
43 Acid-sensing ion channel 1a (ASIC1a) is the primary acid
44 The
acid-sensing ion channel 1a (ASIC1a) is widely expressed
45 We reported previously that
acid-sensing ion channel 1a (ASIC1a) mediates acidic neu
46 Acid-sensing ion channel 1a (ASIC1a) promotes neuronal d
47 ces and biolistic transfection, we found the
acid-sensing ion channel 1a (ASIC1a), localized in dendr
48 The
acid-sensing ion channel 1a (ASIC1a), which is expressed
49 ischemic stroke, induces neuronal death via
acid-sensing ion channel 1a (ASIC1a).
50 e methods to prepare pure samples of chicken
acid-sensing ion channel 1a (cASIC1) and Caenorhabditis
51 are homologous to the Cl(-) binding site in
acid-sensing ion channel 1a and tested the effect of Cl(
52 imaging that the Sig1R binds to the trimeric
acid-sensing ion channel 1A with 3-fold symmetry.
53 of Held synapse express functional homomeric
Acid-sensing ion channel-
1a (ASIC-1as) that can be activ
54 Acid-sensing ion channel-
1a (ASIC1a) contributes to mult
55 Acid-sensing ion channel-
1a (ASIC1a) is a potential ther
56 Acid-sensing ion channel-
1A (ASIC1A) is a proton-gated c
57 The
acid-sensing ion channel-
1a (ASIC1a) is composed of 3 su
58 Acid-sensing ion channel-
1a (ASIC1a) is localized in bra
59 Acid-sensing ion channel-
1a (ASIC1a) mediates H(+)-gated
60 these models to test the hypothesis that the
acid-sensing ion channel-
1a (ASIC1a) might be targeted t
61 Because the amygdala expresses
acid-sensing ion channel-
1a (ASIC1a), and ASIC1a is requ
62 and anxiety-related behaviors and expresses
acid-sensing ion channel-
1A (ASIC1A), we hypothesized th
63 We discover that mice lacking
acid-sensing ion channel 2 (ASIC2) exhibit persistently
64 the role of the vertebrate DEG-ENaC protein,
acid-sensing ion channel 2 (ASIC2), in auditory transduc
65 The acid-sensitive cation channel
acid-sensing ion channel-
2 (ASIC2) is widely believed to
66 Ion channels, such as
acid-sensing ion channel-
2 or ASIC2 are known to be upre
67 , GFRalpha2-expressing sensory neurons), the
acid-sensing ion channel 2a, and transient receptor pote
68 d to correlate with significant increases in
acid-sensing ion channels 2A and 2B and transient recept
69 ly through regulating membrane expression of
acid sensing ion channel 3.
70 Through its location on nociceptors,
acid-sensing ion channel 3 (ASIC-3) is activated by decr
71 ptors, they also express the pro-nociceptive
acid-sensing ion channel 3 (ASIC3) (2-5).
72 t receptor potential vanilloid 1 (TRPV1) and
acid-sensing ion channel 3 (ASIC3) are peripheral mechan
73 We demonstrate here that
acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic
74 In rodent sensory neurons,
acid-sensing ion channel 3 (ASIC3) has recently emerged
75 Acid-sensing ion channel 3 (ASIC3) is highly expressed o
76 Acid-sensing ion channel 3 (ASIC3) is involved in acid n
77 ouse model by altering the expression of the
acid-sensing ion channel 3 (ASIC3) which we had identifi
78 Acid-sensing ion channel 3 (ASIC3), a proton-gated ion c
79 Here we show that
acid-sensing ion channel 3 (ASIC3), but no other known a
80 and IV muscle afferents via upregulation of
acid-sensing ion channel 3 (ASIC3), leading not only to
81 t receptor potential vanilloid 1 (TRPV1) and
acid-sensing ion channel 3 (ASIC3), on development of be
82 APETx2 is a potent and selective blocker of
acid-sensing ion channel 3 (ASIC3).
83 was found exclusively in neurons expressing
acid-sensing ion channel 3, where SP enhances M-channel-
84 The
acid-sensing ion channel-
3 (ASIC3) is a degenerin/epithe
85 on and balance to investigate if deletion of
acid-sensing ion channel 5 (Asic5), which is richly expr
86 at a specific cation conductance composed of
acid-sensing ion channels and ENaC subunits regulates mi
87 In the LC,
acid-sensing ion channels and proton pumps serve as H(+)
88 hed by pretreatment with antagonists of both
acid-sensing ion channels and transient receptor potenti
89 Acid-sensing ion channels are cation channels activated
90 Acid-sensing ion channels are proton-activated ion chann
91 Acid-sensing ion channels are proton-activated, sodium-s
92 Acid-sensing ion channels are proton-gated Na(+) channel
93 ASICs (
acid-sensing ion channels)
are proton-gated channels tha
94 oral artery is attenuated by blockade of the
acid sensing ion channel (
ASIC) 3.
95 We found that eliminating the
acid sensing ion channel (
ASIC) abolished H(+)-gated cur
96 In the healthy decerebrate rat, a subtype of
acid sensing ion channel (
ASIC) on the sensory endings o
97 Acid sensing ion channel (
ASIC)2 belongs to the amilorid
98 ation, and to investigate the involvement of
acid-sensing ion channel (
ASIC) -3 in the response.
99 Interestingly,
acid-sensing ion channel (
ASIC) 1, 2a, 2b, and 3 mRNAs w
100 Acid-sensing ion channel (
ASIC) 1a and ASIC2a are acid-s
101 Acid-sensing ion channel (
ASIC) 1a subunit is expressed
102 release and a low extracellular pH, leads to
acid-sensing ion channel (
ASIC) activation and reflexive
103 nt in glomus cells that was inhibited by the
acid-sensing ion channel (
ASIC) blocker amiloride, absen
104 Other types of
acid-sensing ion channel (
ASIC) channels were intact to
105 modulate the proton-sensitive members of the
acid-sensing ion channel (
ASIC) family.
106 date transducer molecules are members of the
acid-sensing ion channel (
ASIC) family; nerve fibre reco
107 protein-coupled receptor 68 gene (Gpr68) and
acid-sensing ion channel (
ASIC) genes Asic1, Asic2, and
108 ude the epithelial sodium channel (ENaC) and
acid-sensing ion channel (
ASIC) members of the DEG/ENaC
109 oresis of acid, suggesting an involvement of
acid-sensing ion channel (
ASIC) receptors.
110 to test the hypothesis that a member of the
acid-sensing ion channel (
ASIC) subfamily of the DEG/ENa
111 Acid-sensing ion channel (
ASIC) subunits associate to fo
112 id channel composed of a mixture of ENaC and
acid-sensing ion channel (
ASIC) subunits.
113 ions, dramatically increases activity of an
acid-sensing ion channel (
ASIC) that is highly expressed
114 Acid-sensing ion channel (
ASIC)-1a, the major ASIC subun
115 d trigger the activation of proton-activated
acid-sensing ion channels (
ASIC).
116 ns exhibited transient, amiloride-sensitive,
acid-sensing ion-channel (
ASIC) currents.
117 Hippocampal neurons express subunits of the
acid-sensing ion channel (
ASIC1 and ASIC2) and exhibit l
118 pha subunit and the resolved structure of an
acid-sensing ion channel (
ASIC1) have conserved acidic p
119 The
acid-sensing ion channel,
ASIC1, contributes to synaptic
120 osensing of acidosis in the amygdala via the
acid-sensing ion channel ASIC1a.
121 ently of VR1, has characteristics similar to
acid sensing ion channels (
ASICs) and is found in the ai
122 Acid sensing ion channels (
ASICs) are cation-selective m
123 Acid sensing ion channels (
ASICs) play important roles i
124 Although thin fibre muscle afferents possess
acid sensing ion channels (
ASICs), their contribution to
125 Because acidosis can activate
acid sensing ion channels (
ASICs), we also studied ASIC1
126 Acid-sensing ion channels (
ASICs) act as neurotransmitte
127 Neuronal
acid-sensing ion channels (
ASICs) act as sensors for ext
128 across animal phyla, including the mammalian
acid-sensing ion channels (
ASICs) and Drosophila pickpoc
129 Despite the sequence homology between
acid-sensing ion channels (
ASICs) and epithelial sodium
130 Acid-sensing ion channels (
ASICs) are a class of trimeri
131 The
acid-sensing ion channels (
ASICs) are a family of ion ch
132 Acid-sensing ion channels (
ASICs) are a group of trimeri
133 Acid-sensing ion channels (
ASICs) are cation-selective p
134 Acid-sensing ion channels (
ASICs) are expressed in skele
135 Acid-sensing ion channels (
ASICs) are expressed in the n
136 Acid-sensing ion channels (
ASICs) are H(+)-gated members
137 Acid-sensing ion channels (
ASICs) are highly expressed i
138 Acid-sensing ion channels (
ASICs) are key sensors of aci
139 Acid-sensing ion channels (
ASICs) are members of the div
140 Acid-sensing ion channels (
ASICs) are neuronal Na(+) cha
141 Acid-sensing ion channels (
ASICs) are neuronal Na(+)-sel
142 Acid-sensing ion channels (
ASICs) are neuronal non-volta
143 Acid-sensing ion channels (
ASICs) are neuronal proton-ga
144 Acid-sensing ion channels (
ASICs) are neuronal receptors
145 Acid-sensing ion channels (
ASICs) are neuronal sodium-se
146 Acid-sensing ion channels (
ASICs) are neuronal, voltage-
147 Acid-sensing ion channels (
ASICs) are proton-activated c
148 Acid-sensing ion channels (
ASICs) are proton-activated N
149 The
acid-sensing ion channels (
ASICs) are proton-gated catio
150 Acid-sensing ion channels (
ASICs) are proton-gated catio
151 Acid-sensing ion channels (
ASICs) are proton-gated catio
152 Acid-sensing ion channels (
ASICs) are proton-gated catio
153 Acid-sensing ion channels (
ASICs) are proton-gated catio
154 Acid-sensing ion channels (
ASICs) are proton-gated membe
155 Acid-sensing ion channels (
ASICs) are proton-gated Na(+)
156 The
acid-sensing ion channels (
ASICs) are proton-gated, volt
157 Acid-sensing ion channels (
ASICs) are sodium channels ga
158 Acid-sensing ion channels (
ASICs) are trimeric cation ch
159 Acid-sensing ion channels (
ASICs) are trimeric cation-se
160 Acid-sensing ion channels (
ASICs) are trimeric cation-se
161 Acid-sensing ion channels (
ASICs) are trimeric cation-se
162 Acid-sensing ion channels (
ASICs) are trimeric proton-ga
163 Acid-sensing ion channels (
ASICs) are trimeric proton-ga
164 Acid-sensing ion channels (
ASICs) are voltage-independen
165 Acid-sensing ion channels (
ASICs) are voltage-independen
166 Acid-sensing ion channels (
ASICs) are voltage-independen
167 Acid-sensing ion channels (
ASICs) are widely expressed p
168 Peripheral sensitization depended on
acid-sensing ion channels (
ASICs) because treatment of s
169 Acid-sensing ion channels (
ASICs) constitute a family of
170 tion in response to inflammatory conditions,
acid-sensing ion channels (
ASICs) contribute to the path
171 ility of neuronal networks via activation of
acid-sensing ion channels (
ASICs) could have therapeutic
172 We identify the novel and conserved
acid-sensing ion channels (
ASICs) DEL-7 and DEL-3 as NSM
173 Acid-sensing ion channels (
ASICs) detect extracellular p
174 Acid-sensing ion channels (
ASICs) form both homotrimeric
175 In contrast, RFamide neuropeptides modulate
acid-sensing ion channels (
ASICs) from vertebrates via b
176 In central and peripheral neurons,
acid-sensing ion channels (
ASICs) have emerged as key re
177 The exact roles of
acid-sensing ion channels (
ASICs) in synaptic plasticity
178 The role of
acid-sensing ion channels (
ASICs) in the ventrolateral m
179 t receptor potential V1 (TRPV1) channels and
acid-sensing ion channels (
ASICs) is that their ion cond
180 This synaptic transmission is mediated by
acid-sensing ion channels (
ASICs) located on the neurite
181 Acid-sensing ion channels (
ASICs) mediate chemosensitivi
182 atory neurotransmission by protons acting at
acid-sensing ion channels (
ASICs) mediates mechanical fo
183 Here, we explored whether
acid-sensing ion channels (
ASICs) might play a role.
184 The
acid-sensing ion channels (
ASICs) open in response to ex
185 Acid-sensing ion channels (
ASICs) open when extracellula
186 Neuronal proton-gated
acid-sensing ion channels (
ASICs) participate in the det
187 Acid-sensing ion channels (
ASICs) regulate synaptic acti
188 mba venom that specifically inhibit a set of
acid-sensing ion channels (
ASICs) to relieve pain.
189 Recently,
acid-sensing ion channels (
ASICs) were shown to act as n
190 Acid-sensing ion channels (
ASICs), a novel class of liga
191 -inflammatory drug (NSAID) pharmacology with
acid-sensing ion channels (
ASICs), a small family of exc
192 Acid-sensing ion channels (
ASICs), activated by a decrea
193 Acid-sensing ion channels (
ASICs), activated by lowering
194 Acid-sensing ion channels (
ASICs), expressed in thin mus
195 show that acidosis activates Ca2+ -permeable
acid-sensing ion channels (
ASICs), inducing glutamate re
196 questioned bilaterian animals' employment of
acid-sensing ion channels (
ASICs), LGICs that mediate fa
197 Our previous results have shown that the
acid-sensing ion channels (
ASICs), members of the epithe
198 Potential receptors for protons are
acid-sensing ion channels (
ASICs), Na(+)- and Ca(2+)-per
199 Acid-sensing ion channels (
ASICs), newly discovered memb
200 potent, persistent and selective agonist for
acid-sensing ion channels (
ASICs), showing equal or grea
201 ar approach was used to open and close human
acid-sensing ion channels (
ASICs), which are also trimer
202 The activation of
acid-sensing ion channels (
ASICs), which are highly perm
203 s to the same region as the acidic pocket of
acid-sensing ion channels (
ASICs), which binds peptide l
204 n brain sodium channel family, also known as
acid-sensing ion channels (
ASICs).
205 dings via pH-sensing channels, including the
acid-sensing ion channels (
ASICs).
206 t cocaine-induced synaptic changes depend on
acid-sensing ion channels (
ASICs).
207 are converted to excitatory sodium influx by
acid-sensing ion channels (
ASICs).
208 teractions between extracellular protons and
acid-sensing ion channels (
ASICs).
209 rosophila Ppk/Bba is homologous to mammalian
acid-sensing ion channels (
ASICs).(11) However, Do6a did
210 retreatment with amiloride (an antagonist of
acid-sensing ion channels,
ASICs) and AMG8910 (a selecti
211 endent calcium channels, potassium channels,
acid-sensing ion channels,
chloride channels and the ATP
212 Analysis of the known ASIC1 (
acid-sensing ion channel)
crystal structure suggested th
213 to the initiation of cough and we identified
acid-sensing ion channels expressed by vagal sensory ner
214 scover a degenerin/epithelial sodium channel/
acid-sensing ion channel from the brachiopod (lamp shell
215 Acid-sensing ion channels have important functions in ph
216 ere we present the structure of a functional
acid-sensing ion channel in a desensitized state at 3 A
217 sensing ion channel (ASIC) 1a and ASIC2a are
acid-sensing ion channels in central and peripheral neur
218 opagation, probably via mechanisms involving
acid-sensing ion channels in the pilocarpine model of te
219 Hyperactivation of the
acid-sensing ion channels including degenerin/epithelial
220 39 had no effect on the structurally related
acid-sensing ion channels,
indicating specificity for EN
221 s support the possibility that modulation of
acid-sensing ion channels may have therapeutic potential
222 These results suggest that
acid-sensing ion channels may integrate multiple extrace
223 n neuronal DEG/ENaC channels known as ASICs (
acid-sensing ion channels)
mediate sensory perception an
224 also found that down-regulation of Nach, an
acid sensing ion channel,
mitigates SCA3 pathogenesis in
225 ith acid by increasing the pH sensitivity of
acid-sensing ion channel number 3 (ASIC3), the molecule
226 Acid-sensing ion channels,
or ASICs, are members of the
227 Acid-sensing ion channels,
or ASICs, are proton-gated ca
228 ut not by nicotinic acetylcholine receptors,
acid-sensing ion channels,
or Substance P.
229 eract with the epithelial sodium channel and
acid-sensing ion channel proteins, as well as sodium/hyd
230 ng ion channel 3 (ASIC3), but no other known
acid-sensing ion channel,
reproduces the functional feat
231 Comparison of the
acid-sensing ion channel structure with the ATP-gated P2
232 Activation of
acid sensing ion channel subtype 1a (ASIC1a) on the sens
233 Studies further demonstrate that
acid-sensing ion channel subtype 3 (ASIC(3)) in thin-fib
234 loride, a potent and nonselective blocker of
acid-sensing ion channels,
suppresses generalized seizur
235 an example for mutant screening, a range of
acid-sensing ion channel variants were tested and the su
236 nds but enhanced by FMRFa, such as mammalian
acid-sensing ion channels,
we show that it nonetheless c