ライフサイエンスコーパス: acinus

1 tional shaping of a solitary lumen within an acinus.

2 ation of the apical and basal surfaces of an acinus.

3 terizing the 3D morphometry of the pulmonary acinus.

4 er cells and apoptosis of inner cells of the acinus.

5 nsport of inhaled particles in the pulmonary acinus.

6 MDCK II cells mechanically destabilizes the acinus.

7 acinus and through the luminal space of the acinus.

8 on of Akt provokes the apoptotic cleavage of acinus.

9 capillaries (air blood barriers) within each acinus.

10 nd periductal cells expanding into the liver acinus.

11 ogical system (MPS) model of the human liver acinus, a common metastatic site, and have applied this

12 Here, we show that acinus, a nuclear factor required for apoptotic chromati

13 , and its expression is tightly regulated by acinus, a nuclear speckle protein.

14 nt quality control autophagy is regulated by acinus (acn) and the Cdk5-dependent phosphorylation of i

15 ted screen, Cdk5 genetically interacted with Acinus (Acn), a primarily nuclear protein, which promote

16 lator is the Drosophila melanogaster protein Acinus (Acn), which is necessary for autophagy induction

17 is of hepatocytes in zone 3 of the Rappaport acinus (acute damage), supporting the hypothesis of ACLF

18 ore EJC plus the accessory factors RnpS1 and Acinus aid in definition and efficient splicing of neigh

19 ers, showing an aberrant distribution in the acinus, an increase not explained by a reduction in hepa

20 we show that SRPK2 binds and phosphorylates acinus, an SR protein essential for RNA splicing, and re

21 al findings suggest the functions of the SMG acinus and duct and provide a baseline for understanding

22 a-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

23 hanism may adjust bile salt uptake along the acinus and protect periportal hepatocytes from harmful b

24 ntacts the basement membrane surrounding the acinus and through the luminal space of the acinus.

25 n of alpha6-integrin to the periphery of the acinus and thus facilitates the polarization of outer ac

26 Here we report that the SAF-A/B, Acinus, and PIAS (SAP) domain of MANF selectively associ

27 ts highly conserved C-terminal SAP (SAF-A/B, Acinus, and PIAS) domain remains elusive.

28 sts that L(pro) contains a SAP (for SAF-A/B, Acinus, and PIAS) domain, a protein structure associated

29 P1 contains a conserved SAP domain (SAF-A/B, Acinus, and PIAS).

30 ant R248W, R175H, and R273H disrupted normal acinus architectures with filled lumen and led to format

31 c enzymes along the portocentral axis of the acinus are a long-known feature of liver metabolism.

32 Furthermore, both SRPK2 and acinus are overexpressed in some human acute myelogenous

33 , gain of function of Atg1, or its activator Acinus, caused elevated Yorkie phosphorylation and inhib

34 yclin A1 expression through escalating CtBP2/acinus complex formation, and gambogic amide might be us

35 Each acinus contains the same number of air blood barriers pe

36 osomal trafficking, we identified Drosophila acinus (dacn; hook-like).

37 leavage in the nucleus and the inhibition of acinus-dependent chromatin condensation.

38 rdance with the abundance of mRNAs along the acinus-duct axis.

39 m channel; and caspase-3 and its substrates, ACINUS, FEM1, and GSN.

40 BRCA1 in MEC by RNA interference impairs the acinus formation but enhances proliferation.

41 tiation of mammary epithelial cell (MEC) for acinus formation by using the in vitro 3D culture system

42 kinase or hemidesmosome signaling disrupted acinus formation in IKVAV-modified eBMs.

43 igenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epitheli

44 P)-dependent protein kinase A (PKA) promotes acinus formation via two mechanisms.

45 pe p53 in MCF-10A cells was not required for acinus formation, but knockdown of endogenous wild-type

46 ed that KLF8 expression disrupted the normal acinus formation, which could be prevented by the MMP in

47 growth and induced caspase 3 activation and acinus formation.

48 yonic signals, and without any clear duct or acinus formation.

49 and low stiffness, supported normal mammary acinus formation.

50 A single-cell, layered, lumenized acinus forms from a large cohort of epithelial progenito

51 h pulse frequency is observed during initial acinus growth, correlating with rapid cell motility and

52 While Acinus had previously been implicated in apoptosis and w

53 Its mammalian homolog Acinus has been implicated in RNA processing and chromat

54 ensation during apoptosis by phosphorylating acinus in the nucleus, revealing a specific mechanism by

55 t mixture actually reaches the adult alveoli/acinus in therapeutic amounts.

56 ture and morphometry of the intact pulmonary acinus is an essential step toward a more complete under

57 Lumenal collapse occurs because the acinus is unstable to increased mechanical tension that

58 a 3D context form polarized, growth-arrested acinus-like colonies whereas the latter form disorganize

59 l mammospheres, which display a well-defined acinus-like structure with polarized expression of E-cad

60 Acinus-like structures and reconstituted acinar epitheli

61 xamination of day 7 vector controls revealed acinus-like structures characteristic of normal mammary

62 epithelial cells from benign prostate formed acinus-like structures that exhibited differentiated pro

63 which mammary epithelial cells form hollow, acinus-like structures, we previously demonstrated that

64 the morphology of the structures they make (acinus-like versus tumor-like, respectively).

65 nsferase expression across the human hepatic acinus may be important in the manifestation of certain

66 However, the molecular mechanism of how acinus mediates cyclin A1 expression remains elusive.

67 emonstrating that 3He gas diffusivity in the acinus of human lung is highly anisotropic.

68 We demonstrate that Akt phosphorylation of acinus on serine 422 and 573 results in its resistance t

69 Ablation of acinus or SRPK2 abrogates cyclin A1 expression in leukem

70 Overexpression of acinus or SRPK2 increases leukemia cell proliferation.

71 ing OP or EP under conditions known to alter acinus organization, i.e. collagen crosslinking and/or E

72 Abolishing acinus phosphorylation by Akt through mutagenesis accele

73 between CtBP2 and acinus through triggering acinus phosphorylation by Akt.

74 Myocardin belongs to the SAF-A/B, Acinus, PIAS (SAP) domain family of transcription factor

75 A-binding motif related to the SAP (SAF-A/B, Acinus, PIAS) domain in human SDE2 and establish its pre

76 Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associate

77 the PIAS SAP (scaffold attachment factor-A/B/acinus/PIAS) motif with SATB1 N-terminal sequences.

78 ibose) polymerase protein and degradation of acinus protein with a significant increase in the expres

79 AP18 and RNPS1 and different isoforms of the Acinus protein.

80 Loss of function of Atg1 or Acinus raised expression of Yorkie target genes and incr

81 65, Luc7-like protein 3 (Luc7L3), SRSF11 and Acinus S', but not with the bona fide RS-domain of SRSF1

82 Furthermore, the C-terminal end of Acinus-S' and the B domain of RARbeta interact independe

83 These findings identify Acinus-S' as a novel RAR-interacting protein that regula

84 romatin immunoprecipitation assays show that Acinus-S' associates with RAREs within the promoters of

85 Our data demonstrate that Acinus-S' can specifically repress ligand-independent an

86 Acinus-S' is an ubiquitous nuclear protein that has been

87 ndently of ligand, and the C-terminal end of Acinus-S' is sufficient for the repression of RAR-regula

88 tially accounts for the repressive effect of Acinus-S' on RAR-dependent gene expression.

89 Acinus S422, 573D, a mutant mimicking phosphorylation, r

90 c, enhances cyclin A1 transcription, whereas acinus S422A, an unphosphorylatable mutant, blocks the s

91 Acinus S422D, an SRPK2 phosphorylation mimetic, enhances

92 ivity and provides for the dynamic nature of acinus-serine(437) (acn-S437) phosphorylation.

93 Knocking down of acinus substantially decreases chromatin condensation, a

94 iological range (~5-20%) of the normal liver acinus, the estrogen-enhanced growth phenotypes are lost

95 , promotes the interaction between CtBP2 and acinus through triggering acinus phosphorylation by Akt.

96 Engraftment occurs over the entire liver acinus upon transplantation.

97 l as estimation of the number of alveoli per acinus using stereologic methods.

98 ine particles can easily reach the pulmonary acinus, where gas is exchanged, but they need to mix wit

99 grates down the submucosal gland duct to the acinus, where it triggers apical succinate receptors, ca

100 nd occurred in periportal regions of hepatic acinus, whereas perivenous areas were weakly stained or

101 anscription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF),