ライフサイエンスコーパス: actin-binding

1 o contain conserved amino acids required for actin binding.

2 ie-Tooth disease result from reduced CAP-KAc-actin binding.

3 -SMA transcription and itself regulated by G-actin binding.

4 tion of S509, within the AMD, may regulate F-actin binding.

5 e, that the mutant ABD retains high-affinity actin binding.

6 WH2 domains compete directly with MRTF-A for actin binding.

7 e enriched for cytoskeletal organization and actin binding.

8 n-tropomyosin binding and weaker tropomyosin-actin binding.

9 autophosphorylation states, also abolished F-actin binding.

10 type 5 (SCA5) causes a dramatic increase in actin binding.

11 actin, thus likely outcompeting myosin for F-actin binding.

12 f the tail domain of metavinculin (MVt) upon actin binding, a muscle-specific splice isoform that sup

13 h a novel role for the AMD in regulating the actin-binding ability of an alpha-catenin and its proper

14 of FSGS ACTN4 mutants to downregulate their actin binding activities for ameliorating the glomerulos

15 unlike known actin-binding proteins, SHTN1's actin binding activity is intrinsically inhibited by a p

16 We queried whether the elevated actin binding activity of FSGS mutants can be downregula

17 found that Y4/31E significantly reduced the actin binding activity of K255E, T259I and S262P, dramat

18 in binding domains and lead to a decrease in actin binding activity.

19 elegans HMP-1/alpha-catenin regulates its F-actin-binding activity and organization of junctional-pr

20 large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major

21 f a GRE reporter while still maintaining its actin-binding activity.

22 eceptor ICAM-1 is negatively regulated by an actin-binding adaptor protein, i.e., CD2AP, to allow a b

23 es, we directly compared their G-actin and F-actin binding affinities, and quantified the actin filam

24 0.5 muM in U2OS cell cytosol, suggesting the actin-binding affinity measured here (Kd = 0.6 muM) is i

25 zone" must exist for each protein where the actin-binding affinity must be optimal for accumulation.

26 king proteins and identify a zone of optimal actin-binding affinity that allows for mechanical stress

27 ) was shown to cause a 1000-fold increase in actin-binding affinity.

28 redominantly in the heart, is a constitutive actin-binding alpha-catenin.

29 ilament surface, making them unavailable for actin binding and ATP hydrolysis.

30 We conducted x-ray crystallography, F-actin binding and bundling assays, and immunofluorescenc

31 Dematin is a relatively low abundance actin binding and bundling protein associated with the s

32 yosin motor domain that are triggered upon F-actin binding and contribute critically to the mechanoch

33 D) of beta-III-spectrin causes high-affinity actin binding and decreased thermal stability in vitro.

34 are conserved family proteins that regulate actin binding and endocytosis.

35 ized that ExoY oligomerizes in response to F-actin binding and have used the ExoY structure to constr

36 Collectively, our work suggests that both actin binding and MKlp2-dependent midzone targeting coop

37 es with other parts of the Sca2 molecule for actin binding and nucleation.

38 fragments of Sca2 and their contribution to actin binding and nucleation.

39 lly modulated via interaction with Ajuba, an actin binding and scaffolding protein.

40 rmation in the presence of calcium, enabling actin binding and severing.

41 f vertebrate cofilin at Ser-3 regulates both actin binding and severing.

42 human genetic modifier plastin 3 (PLS3), an actin-binding and -bundling protein, fully protects agai

43 contributes to the mechanisms involving the actin-binding and -polymerizing proteins neural Wiskott-

44 in's C-terminus eliminates force-activated F-actin binding, and addition of this motif to vinculin co

45 aptor protein ZO-1, which is responsible for actin binding, and show that this interaction is essenti

46 dulating F-actin, while mutants disrupting F-actin binding are defective in its tumorigenic capabilit

47 This establishes direct force-activated F-actin binding as a mechanosensing mechanism by which cyt

48 g stroke, which can occur within <200 mus of actin binding by beta-cardiac myosin.

49 Our data suggest that high-affinity actin binding by SCA5 beta-spectrin interferes with spec

50 ol governs core elements of IQGAP1 dynamics, actin binding by the N-terminal calponin homology domain

51 t report that a mutation in ADD3 that alters ACTIN binding causes renal vascular dysfunction and prom

52 cting with actin, the kinetic parameters for actin binding changed only slightly for the mutant const

53 Here, we have expressed and validated actin-binding chromobodies as F-actin-sensors in Plasmod

54 The ADP-bound structure reveals that the actin-binding cleft is closed, even though MgADP is tigh

55 the specificity of the previously discovered actin-binding compounds for effects on skeletal and card

56 d biochemical assays can be used to identify actin-binding compounds that differentially affect skele

57 at CNN-3, the acidic isoform of calponin, an actin binding contractile protein, is expressed preferen

58 phaT286D mutant, indicating that transient F-actin binding contributes to the synaptic localization o

59 rrowing in MKlp2-depleted cells in an INCENP-actin binding-dependent manner.

60 62 to proline (S to P) that occur within the actin binding domain of alpha-actinin-4 (ACTN4) cause an

61 -iLID can be used to temporally recruit an F-actin binding domain to MT plus ends and cross-link the

62 A putative kinase target site at Y265 in the actin binding domain was also generated as a phosphomime

63 r ataxia type 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of beta-III-spectrin causes h

64 he molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its association wit

65 ucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fol

66 at melanophilin, specifically its C-terminal actin-binding domain (ABD), is a target of PKA.

67 sophila S2 cells, anillin lacking the entire actin-binding domain (ActBD) exhibits defective cortical

68 nase domains are joined via a linker to an F-actin-binding domain (FABD).

69 Shot interacts with the cortex through its actin-binding domain and recruits the microtubule minus-

70 also revealed possible crosstalk between the actin-binding domain and the rest of the protein.

71 ells and in vitro, we perturbed the utrophin actin-binding domain by making point mutations at the CH

72 n ACTN4 isoform, ACTN4 (Iso), that loses its actin-binding domain is still capable of potentiating a

73 In contrast to studies in fibroblasts, the actin-binding domain of Nesprin-2 was dispensable for ne

74 An actin-binding domain of periplakin was required to initi

75 The actin-binding domain of Shot directly interacts with Act

76 ain and the cargo adapter Mlph, which has an actin-binding domain that acts as a tether, are sensitiv

77 hila ortholog Filamin/cheerio that lacks the actin-binding domain, is here shown to govern the growth

78 tructure of the F-actin-bound alphaE-catenin actin-binding domain, which in solution forms a five-hel

79 ylation of a conserved tyrosine in the Canoe actin-binding domain.

80 ions that predicted that this would bury the actin binding domains and lead to a decrease in actin bi

81 ate that the C-terminal filamentous actin (F-actin)-binding domains are responsible for Tarp-mediated

82 regulatory headpiece domain followed by two actin-binding domains (ABD1 and ABD2).

83 rous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal p

84 Talin contains three actin-binding domains (ABDs).

85 evidence for the critical role of the Tarp F-actin-binding domains in host cell invasion and for the

86 lponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and

87 Here, we show that the actin-binding domains of accessory proteins can be sensi

88 nal domain to wedge apart the membrane and F-actin-binding domains of ezrin.

89 We showed that the actin-binding domains of nesprin 1 were dispensable, whe

90 ty, reducing conformational flexibility of F-actin-binding domains via interdomain cross-talk and con

91 reas the inositol phospholipid-binding and F-actin-binding domains were essential.

92 In contrast, profilin that shares actin-binding domains with gelsolin, significantly incre

93 p7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated

94 nsable, whereas nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viabili

95 present data suggesting that neuron-specific actin-binding drebrin A may be a part of such a switch.

96 /ArhGAP12 interaction, by treatment with the actin-binding drugs latrunculin B or cytochalasin D, has

97 and noncompetitively inhibits ATP turnover, actin binding during ATP turnover, and motor activity of

98 GDP and GTP accelerate and decelerate Drp1/actin binding dynamics, respectively.

99 egion binds actin in vitro and that its main actin-binding element is the CT region, which does not i

100 g multiprotein complexes at the ankyrin- and actin-binding ends of spectrin.

101 is setting, ArhGAP12 mutants defective for G-actin binding exhibit more effective downregulation of R

102 s for spectrin repeats within the N-terminal actin-binding half of utrophin compared to those in the

103 secondary mechanism decreases the number of actin-binding heads transitioning from the weakly to the

104 roponin and tropomyosin hinder strong myosin-actin binding in several different ways, apparently barr

105 Deletion of the first helix produces strong actin binding in the absence of force, suggesting that t

106 IM domain of these proteins disrupt tensed F-actin binding in vitro and cytoskeletal localization in

107 Deleting the AMD increases F-actin binding in vitro and leads to excess actin recruit

108 e-binding regions of myosin assures a proper actin-binding interface and active site have formed befo

109 F-actin binding is mediated by the "linker" domain of Hof1

110 odan-tropomyosin fluorescence changes and S1-actin binding kinetics revealed that at pCa 8, the high-

111 t force-responsive cardiomyocyte AJs recruit actin-binding ligands to selectively couple actin networ

112 ted C-C couplings enable construction of the actin-binding marine polyketide swinholide A in only 15

113 hich led to the down-regulation of Ezrin, an actin-binding membrane-bound protein, which we found was

114 SORB-1 is recruited to the actin-binding, membrane-distal regions of dense bodies v

115 eity suggests that CaMKII adopts different F-actin binding modes, which is most easily rationalized b

116 the potential of our assay for detection of actin-binding modulators.

117 tor activity, and an extended tail with tail actin-binding motif, allow it to play an important role

118 ndothelial permeability without MLC-P via an actin-binding motif, DVRGLL.

119 s an extended tail domain with an additional actin-binding motif.

120 s cell membranes to the cytoskeleton via its actin-binding motor domain and its phosphatidylinositol

121 ounts of Taxol rescues cytokinesis in INCENP actin-binding mutant-expressing cells.

122 Importantly, the actin-binding N-terminal LIM domain and nebulin repeats

123 adhesion kinase) complex is essential for F-actin binding of ACF7.

124 Reducing actin binding of L253P is thus a potential therapeutic a

125 lusters form by phase separation, and direct actin binding of ZO-1 is required for stable incorporati

126 conformation that makes them unavailable for actin binding or ATP hydrolysis, although a small fracti

127 ch is mainly composed of actin filaments and actin-binding partners.

128 Exon 16 of protein 4.1R encodes a spectrin/actin-binding peptide critical for erythrocyte membrane

129 ent proteins fused to the mutant ABD and the actin-binding peptide Lifeact, in HEK293-6E cells.

130 This appears due to elevated actin binding propensity in podocytes resulting in a 'fr

131 Dematin's actin binding properties are regulated by phosphorylatio

132 H1-CH2 domains can have remarkably different actin-binding properties, with disease-associated point

133 which have reversible knockdown of anillin, actin binding protein (ANLN).

134 tyostelium) and the Cdc42-GEF FGD1-related F-actin binding protein (Frabin) (in human cells).

135 ctin cytoskeleton via beta-catenin and the F-actin binding protein alphaE-catenin.

136 adhesion kinase (FAK) and phosphorylate the actin binding protein cofilin.

137 Michael and colleagues (2016) show that the actin binding protein Coronin plays a critical role in a

138 Further, we show that the F-actin binding protein cortactin binds the PLS and is req

139 rylation of Y573 influences association of F-actin binding protein cortactin to MT1-MMP-positive endo

140 Furthermore, the actin binding protein ezrin relocated from the plasma me

141 egy was used to knock down expression of the actin binding protein ezrin, which is expressed almost e

142 Tropomyosin is a coiled-coil actin binding protein key to the stability of actin fila

143 Synaptopodin, an actin binding protein that is important in maintaining p

144 show that gene inactivation of cortactin, an actin binding protein that modulates actin dynamics and

145 Palladin is a key cytoskeletal actin binding protein whose normal function is to enable

146 G-actin binding protein, profilin-1, colocalized in the te

147 chemical analysis revealed CORO1C, another F-actin binding protein, whose direct binding to PLS3 is d

148 s of afadin (Afdn) - an obligate nectin- and actin-binding protein - induces a high penetrance of CP,

149 tes WH2 domain functions with those of the F-actin-binding protein Abp1.

150 We recently found that the F-actin-binding protein afadin is required for lumen conti

151 l dynamics, in part, by interacting with the actin-binding protein alpha-actinin 4 during tumor cell

152 Mutations in the ACTN4 gene, encoding the actin-binding protein alpha-actinin-4, are a rare cause

153 Additionally, we found that PMD1 is an actin-binding protein and that a functioning actin cytos

154 We identify the endothelial actin-binding protein CD2-associated protein (CD2AP) as

155 example, through compromised function of the actin-binding protein Cdc3-profilin.

156 is known to initiate changes to the cortical actin-binding protein cofilin to stimulate the depolymer

157 ccumulation of the inactive, phosphorylated, actin-binding protein cofilin.

158 osome transport in vivo also depend on the F-actin-binding protein cortactin.

159 anism linking a signaling intermediate to an actin-binding protein critical to T cell migration.

160 self-administration negatively regulates the actin-binding protein drebrin in the NAc.

161 Cortactin is an actin-binding protein expressed in virtually all cell ty

162 Here, we report that the actin-binding protein filamin A (FlnA) physically intera

163 The actin-binding protein FLNA (filamin A) regulates signal

164 own that villin, an epithelial cell-specific actin-binding protein functions as an anti-apoptotic pro

165 ied profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and neurot

166 Villin is a tissue-specific, actin-binding protein involved in the assembly and maint

167 a missense mutation in FLNA (Filamin A), an actin-binding protein located at Xq28, mutations in whic

168 ind actin monomers directly, formins use the actin-binding protein profilin to dynamically load actin

169 rst time, direct evidence of the role of the actin-binding protein profilin1 (Pfn1) in VASP-mediated

170 Actin-binding protein sorting is critical for the self-o

171 Because Asef2 interacts with the F-actin-binding protein spinophilin, which localizes to sp

172 we identified the dominant regulation of the actin-binding protein synaptopodin (SYNPO).

173 at alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cad

174 extensions involves flightless I (FliI), an actin-binding protein that contains a leucine-rich-repea

175 Talin is a major actin-binding protein that controls both the inside-out

176 Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and re

177 Twinfilin 2a (Twf2a) is a small actin-binding protein that inhibits actin filament assem

178 LIM and SH3 protein 1 (LASP1) is a unique actin-binding protein that is expressed in a wide range

179 Cofilin-2 is an actin-binding protein that is predominantly expressed in

180 PFN1 is a small actin-binding protein that promotes formin-based actin p

181 One of these is Phactr1, an actin-binding protein that recruits protein phosphatase

182 e identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive prope

183 Vinculin is an actin-binding protein thought to reinforce cell-cell and

184 ing edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFbeta rec

185 The actin-binding protein villin (Vil1) is used as a marker

186 ough alphaE-catenin, and also recruits the F-actin-binding protein vinculin.

187 l change that exposes a cryptic site for the actin-binding protein vinculin.

188 atory proteins, caldesmon (a calmodulin- and actin-binding protein) and calpain 1 and 2 (calcium-depe

189 regulator of ubiquitin ligases) and LCP1 (an actin-binding protein), are completely repressed in 2-KO

190 Furthermore, we show that a related actin-binding protein, advillin which shares 75% homolog

191 Here, we reported that an actin-binding protein, alpha-actinin (ACTN)4, was dysreg

192 The actin-binding protein, cortactin, in endothelial cells i

193 s only 40 years ago that the first nonmuscle actin-binding protein, filamin, was identified and chara

194 LSP1, a F-actin-binding protein, is expressed in hematopoietic cel

195 Gelsolin, a multifunctional actin-binding protein, mediates cell death involving the

196 We find that the actin-binding protein, Moesin, is essential for NB proli

197 CLAMP is an actin-binding protein, rather than a microtubule-binding

198 Mammalian actin-binding protein-1 (mAbp1) is an adaptor protein th

199 g domains, is a novel ER membrane-associated actin-binding protein.

200 ene, is a large sarcolemmal myosin II- and F-actin-binding protein.

201 vered that competition between fission yeast actin binding proteins (ABPs) for binding F-actin facili

202 an alteration of filament interactions with actin binding proteins and myosin motors, consistent wit

203 etitive and cooperative interactions between actin binding proteins help define their associations wi

204 gnaling, a function for afadin and adducin-1 actin binding proteins in thrombin-induced endothelial b

205 the coordinated action of a large number of actin binding proteins that reorganize the actin cytoske

206 n cytoskeletal dynamics (e.g. RhoGTPases and actin binding proteins).

207 n-interacting proteins, actin filaments, and actin binding proteins, in a highly ordered and regulate

208 Actin binding proteins, including spectrin and alpha-act

209 xoplasma gondii contains a limited subset of actin binding proteins.

210 present in a complex with cofilin and other actin binding proteins.

211 llular cues, is regulated by an abundance of actin binding proteins.

212 In cells, actin-binding proteins (ABPs) sort to different regions

213 [PI(4,5)P2], regulate the activities of many actin-binding proteins (ABPs), including profilin, cofil

214 N-termini of SK2 channels interact with the actin-binding proteins alpha-actinin2 and filamin A, res

215 he band 3 macrocomplex, CD47 associates with actin-binding proteins and we confirm that CD47 membrane

216 Actin's interactions with myosin and other actin-binding proteins are essential for cellular viabil

217 and how the dozens of PI(4,5)P(2)-sensitive actin-binding proteins are selectively recruited to memb

218 These genes encode numerous actin-binding proteins as well as actin.

219 nical cues control the activities of various actin-binding proteins in different cellular, developmen

220 Targeting the actin-binding proteins LIMK1 and LIMK2 significantly dim

221 Conversely, how different sets of actin-binding proteins properly sort to distinct actin f

222 Actin and actin-binding proteins regulate chromatin and gene expre

223 Numerous actin-binding proteins regulate the dynamics of actin st

224 Filamins are a family of actin-binding proteins responsible for diverse biologica

225 Importantly, other actin-binding proteins such as fimbrin and espin show hi

226 Here, we demonstrate how the actin-binding proteins talin and vinculin cooperate to p

227 depolymerizing factors (ADFs) are a group of actin-binding proteins that contribute to reorganization

228 indicate that ExoY represents a new class of actin-binding proteins that modulate the actin cytoskele

229 Filamins (FLNs) are large dimeric actin-binding proteins that regulate actin cytoskeleton

230 transcriptome data for different classes of actin-binding proteins to demonstrate that increased mRN

231 ipid bilayer coupled via membrane-associated actin-binding proteins to dynamic actin filaments and my

232 ng sites (VBSs) from different nonhomologous actin-binding proteins use conserved helical motifs to a

233 the cytoskeleton in IECs via changes in the actin-binding proteins VIL1 and GSN.

234 We studied the actin-binding proteins villin 1 (VIL1) and gelsolin (GSN

235 Subsequently many other nonmuscle actin-binding proteins were identified and characterized

236 Tropomyosins comprise a large family of actin-binding proteins with critical roles in diverse ac

237 ement in these processes is mediated by many actin-binding proteins, among which the cofilin family p

238 hemical and functional properties of diverse actin-binding proteins, both alone and in combination, h

239 ic events are choreographed by a plethora of actin-binding proteins, but the exact mechanisms are poo

240 Filaments are regulated by actin-binding proteins, but the nucleotide state of acti

241 We selected two vital Plasmodium berghei G-actin-binding proteins, C-CAP and profilin, in combinati

242 which beta-III-spectrin, and likely similar actin-binding proteins, interact with actin, and how thi

243 network of actin filaments and associated F-actin-binding proteins, is fundamentally important in eu

244 process requiring the involvement of several actin-binding proteins, many of which are still unidenti

245 SHTN1 (shootin1) and show that, unlike known actin-binding proteins, SHTN1's actin binding activity i

246 Actin dynamics is also regulated by actin-binding proteins, such as the actin-related protei

247 Devoid of all known canonical actin-binding proteins, the prevalent parasite Giardia l

248 led by a vast array of intricately regulated actin-binding proteins.

249 cific member of the NETWORKED superfamily of actin-binding proteins.

250 ytoskeleton, via transmembrane integrins and actin-binding proteins.

251 cess, requiring the activity of more than 75 actin-binding proteins.

252 ns that are specifically recognized by other actin-binding proteins.

253 oskeleton are controlled by a large array of actin-binding proteins.

254 the coordinated action of different sets of actin-binding proteins.

255 act as gatekeepers for the binding of other actin-binding proteins.

256 Precise control of actin dynamics requires actin-binding proteins.

257 zation and the interaction between actin and actin-binding proteins.

258 from actin, thus allowing the association of actin-binding regions of FH2 to the barbed end.

259 heads that increase the surface area of the actin-binding regions promoting myosin interaction with

260 myosin that increase the surface area of the actin-binding regions, promoting myosin interaction with

261 changes in the spatiotemporal expression of actin binding/regulatory proteins.

262 piece with functional assays to identify the actin-binding residues in FL villin that regulate its fi

263 By careful evaluation of these conserved actin-binding residues in human advillin protein, we dem

264 The villin "headpiece" domain and the actin-binding residues within it regulate its actin-bund

265 in headpiece, including a description of the actin-binding residues within the headpiece, is availabl

266 RPEL proteins, which contain the G-actin-binding RPEL motif, coordinate cytoskeletal proces

267 novo actin nucleation activity via a cryptic actin-binding sequence near JMY's N terminus, and STRAP

268 demonstrate that, in addition to inhibiting actin binding, Ser-3 modification favors formation of a

269 e late endosomes likely through its PI3P and actin binding SH3YL1 Ysc84/Lsb4p Lsb3p plant FYVE (SYLF)

270 A mutation, LK(47)/AA, within a predicted actin binding site (ABS) of F0 diminishes its interactio

271 ics and mutagenesis, we found that the EB1:F-actin binding site partially overlaps the well-character

272 ired vinculin and at later times the central actin binding site, ABS2.

273 t force transfer required talin's C-terminal actin binding site, ABS3, but not vinculin.

274 t this mutation destabilizes a critical ADD3-ACTIN binding site.

275 increased by vinculin and depends mainly on actin-binding site 2 (ABS2) within the middle of the rod

276 , a major cardiac isoform, has an N-terminal actin-binding site located within residues 43-90.

277 In the proposed model, the N-terminal actin-binding site of leiomodin can act as a "swinging g

278 We further find that a proposed actin-binding site within the missing connecting region

279 data suggested that ExoY possesses only one actin-binding site.

280 nts, executing a random diffusive search for actin binding sites at each step.

281 wt dystrophin, suggesting a finite number of actin binding sites at the sarcolemma.

282 hat the anillin ActBD harbors three distinct actin-binding sites (ABS 1-3).

283 k growing filament barbed ends while three G-actin-binding sites (GABs) on other arms are available t

284 reas Tmods have alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, ABS2), Lmods la

285 h, and comprise alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, and ABS2).

286 s a 139-amino-acid protein containing five F-actin-binding sites and two G-actin-binding sites, and i

287 binds calmodulin and creates two coordinated actin-binding sites that constrain the actomyosin intera

288 taining five F-actin-binding sites and two G-actin-binding sites, and interacts with wheat (Triticum

289 Bundling is known to require multiple actin-binding sites, yet small-angle X-ray scattering ex

290 post-power-stroke conformation in the strong actin-binding states, whereas the F750L decreased this p

291 ase gates a transition from weak to strong F-actin-binding states.

292 in induce an allosteric restructuring of the actin-binding surface on myosin to increase the rate of

293 as a pharmacologic inhibitor of ALDOA-gamma-actin binding that produced antimetastatic and survival

294 Reducing actin binding through a compensatory mutation in the C-t

295 Using a specific and high-affinity actin-binding tool compound, swinholide A, we demonstrat

296 We show here that direct actin binding, via the inner centromere protein (INCENP)

297 nsion featuring a proline-rich domain and an actin-binding WASP-Homology 2 domain.

298 ribing CH2 as a steric negative regulator of actin binding, we find that utrophin CH1-CH2 affinity is

299 sion containing a proline-rich domain and an actin-binding Wiskott-Aldrich syndrome protein homology

300 cleator Cobl, despite having only a single G-actin-binding Wiskott-Aldrich syndrome protein Homology