ライフサイエンスコーパス: actin-binding domain

1 is a monomer with a functional C-terminal F-actin binding domain.

2 ATP:guanidino kinases, and an "actinin-type" actin binding domain.

3 tary homologous motifs or "repeats" near the actin binding domain.

4 ing inclusion of exon 16 within the spectrin/actin binding domain.

5 ent on the integrity of the carboxy terminal actin binding domain.

6 mature 4.1R mRNA encoding an intact spectrin-actin binding domain.

7 y the latter possessed a functional spectrin-actin binding domain.

8 as at least three and potentially a fourth F-actin binding domain.

9 ratio, every actin monomer contacts a Sac6p actin binding domain.

10 in mouse LSP1 are in the basic C-terminal F-actin binding domain.

11 isoforms having a fully functional spectrin-actin binding domain.

12 g random mutagenesis and shown to lie in the actin binding domain.

13 ound that the C-terminal half constitutes an actin binding domain.

14 of alternative splicing within the spectrin/actin binding domain.

15 t (PEVK), and, at the N-terminus, a unique F-actin-binding domain.

16 ith utrophin, which binds via one contiguous actin-binding domain.

17 to co-purifying actin through the N-terminal actin-binding domain.

18 ed by point mutations in the alpha-actinin-4 actin-binding domain.

19 an N-terminal kinase domain and a C-terminal actin-binding domain.

20 erminus of 3beta contains a Ca(2+)-dependent actin-binding domain.

21 phin through a specific interaction with its actin-binding domain.

22 f the rod domain, but retains the rod domain actin-binding domain.

23 in filaments directly via a carboxy terminal actin-binding domain.

24 calponin-homology domains that comprise the actin-binding domain.

25 inding domain, but block interactions of the actin-binding domain.

26 encodes a new Filamin isoform that lacks the actin-binding domain.

27 s seen in myo2-66, a mutant defective in the actin-binding domain.

28 ated platelets within its conserved putative actin-binding domain.

29 inking proteins that share a conserved 27-kD actin-binding domain.

30 ease severing requires the internal (I/L)WEQ actin-binding domain.

31 ylation of a conserved tyrosine in the Canoe actin-binding domain.

32 tion of a conserved threonine residue in the actin-binding domain.

33 on of the conserved threonine residue in the actin-binding domain.

34 both its membrane-remodeling domain and its actin-binding domain.

35 (up to nine) and the fewest (two) predicted actin binding domains.

36 truncated LSP1 peptides and to define the F-actin binding domains.

37 rophin-glycoprotein complex (DGC), but lacks actin-binding domains.

38 f each lobe that mutational data suggest are actin-binding domains.

39 of human caldesmon containing the principal actin-binding domains.

40 st likely structural similarity within their actin-binding domains.

41 , and this bundling activity requires both F-actin-binding domains.

42 vely spliced so that each isoform has unique actin-binding domains.

43 ors together with proteins bearing predicted actin-binding domains.

44 nal role for a dystrophin protein that lacks actin-binding domains.

45 se-causing missense mutations are located in actin-binding domain 1 (ABD1) of dystrophin.

46 xons 7 and 8 corresponding to the end of the actin-binding domain 1 and the N-terminal part of hinge

47 depolymerize F-actin, or the deletion of the actin binding domain (100-252 amino acids) of ACTN4Y265E

48 The crystal structure of the F-actin binding domain 2 of severin, the gelsolin homologu

49 The interaction between fimbrin ABD2 (actin binding domain 2) and F-actin is different from an

50 ified are predicted to contain an N-terminal actin binding domain, a long central triple helical coil

51 P-280, beta-filamin contains an NH2-terminal actin-binding domain, a backbone of 24 tandem repeats, a

52 ys 30 spectrin repeats, a modestly conserved actin-binding domain, a conserved membrane association d

53 ELF3 is characterized by an actin-binding domain, a long repeat domain, and a short

54 Tensin3 binds DLC1 through its actin-binding domain, a region that is missing in cten,

55 ort sequence containing LKKTETQ, the central actin-binding domain (aa 17-23) plus 1 additional amino

56 of the dystrophin molecule [from N-terminal actin binding domain (ABD) 1 through ABD2] bound actin f

57 to a ternary complex between the N-terminal actin-binding domain (ABD) and an adjacent helical neck

58 We show that the alphaE-catenin actin-binding domain (ABD) binds cooperatively to indivi

59 BK(Ca) channels contain a novel cytoplasmic actin-binding domain (ABD) close to the C terminus, cons

60 0 kDa cytoskeletal protein (consisting of an actin-binding domain (ABD) followed by 24 sequential rep

61 rea victoria and the 25 kDa highly conserved actin-binding domain (ABD) from the amino terminus of th

62 amplifies the function of the beta-spectrin actin-binding domain (ABD) in forming the spectrin-actin

63 r ataxia type 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of beta-III-spectrin causes h

64 We report that Ca(2+)-calmodulin binds the actin-binding domain (ABD) of FLNa and dissociates FLNa

65 he molecular conformation of alpha-actinin's actin-binding domain (ABD) regulates its association wit

66 ucine-to-proline substitution (L253P) in the actin-binding domain (ABD) was shown to cause a 1000-fol

67 These domains include an actin-binding domain (ABD), a plakin domain, a coiled co

68 at melanophilin, specifically its C-terminal actin-binding domain (ABD), is a target of PKA.

69 middle of the actin-binding interface of the actin-binding domain (ABD).

70 es of BMD, truncations within the N-terminal actin-binding domain (ABD1) typically decrease dystrophi

71 regulatory headpiece domain followed by two actin-binding domains (ABD1 and ABD2).

72 c subunits have N-terminal spectrin family F-actin binding domains (ABDs) and an elongated flexible s

73 rous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal p

74 Talin contains three actin-binding domains (ABDs).

75 sophila S2 cells, anillin lacking the entire actin-binding domain (ActBD) exhibits defective cortical

76 these two domains and whether the rod domain actin-binding domain alone can support a mechanically fu

77 usters with F-actin through an alpha-catenin actin-binding domain (alphaABD) dramatically extended cl

78 model transmembrane protein with a cytosolic actin-binding domain also exhibits the temperature-indep

79 to replace verprolin is dependent on its WH2 actin binding domain and a putative profilin binding dom

80 ithelium, is of interest both as a compact F-actin binding domain and as a model folded protein.

81 a flexible spacer between the amino-terminal actin binding domain and carboxyl-terminal membrane-asso

82 ti-parallel fashion through its C-terminal F-actin binding domain and delays dilution-induced F-actin

83 This segment is adjacent to the actin binding domain and is within the region of the bet

84 Deletion of the C-terminal actin binding domain and N-terminal Rab binding domain o

85 cted with filamin A constructs that lack the actin binding domain and that do not bind actin in vivo

86 om ocular isolates that contained up to four actin binding domains and as few as one tyrosine-rich re

87 ions that predicted that this would bury the actin binding domains and lead to a decrease in actin bi

88 Filamins are composed of an N-terminal actin-binding domain and 24 filamin-type immunoglobulin-

89 ouse SH3P7 protein, containing an N-terminal actin-binding domain and a C-terminal Src homology 3 dom

90 flanked in the sequence by the spectrin- and actin-binding domain and a domain containing the binding

91 ticulated-consisting of a globular catalytic/actin-binding domain and a long lever arm that may rotat

92 mACF7 contains a putative actin-binding domain and a plakin-like domain that are h

93 shed the interaction between the fragment of actin-binding domain and alpha-actin.

94 ough interactions between its NH(2)-terminal actin-binding domain and COOH-terminal EF-hand-GAS2 doma

95 rt a novel neural splice form that lacks the actin-binding domain and instead binds and stabilizes mi

96 We find that the actin-binding domain and membrane-association domain 1 (

97 aa, has structure/function activity via its actin-binding domain and numerous biological affects on

98 Shot interacts with the cortex through its actin-binding domain and recruits the microtubule minus-

99 clustered into four regions of the gene: the actin-binding domain and rod domain repeats 3, 10 and 14

100 the plakin repeats are inserted between the actin-binding domain and spectrin repeats, generating is

101 lly rescued by a transgene encoding only the actin-binding domain and the first six filamin repeats.

102 e preferred cleavage site occurs between the actin-binding domain and the proline-rich region, genera

103 tory intramolecular interactions between the actin-binding domain and the rest of alpha-catenin.

104 also revealed possible crosstalk between the actin-binding domain and the rest of the protein.

105 CryAB features a conserved actin-binding domain and, when attenuated, leads to clus

106 Arg has two distinct actin-binding domains and interacts physically and funct

107 Arg requires both its F-actin-binding domains and its MT-binding domain to rescu

108 ls show variation in the distance separating actin-binding domains and the angle of the alpha-actinin

109 phin constructs require the presence of both actin-binding domains and the C-terminal domain for full

110 d region that is predicted to be helical, an actin binding domain, and a region(s) that participates

111 d overall structure, including an N-terminal actin-binding domain, and a series of 20 immunoglobulin

112 associate with F-actin through a conserved F-actin-binding domain, and mutants defective for F-actin

113 tify C-terminal tyrosines, the fourth repeat actin-binding domain, and the N-terminal Arp2/3-binding

114 n binding proposed for fimbrin, the utrophin actin-binding domain appears to associate with actin in

115 Only the isoforms containing full-length actin binding domains are detectably expressed in the ne

116 All F-actin binding domains are located in the basic C-termina

117 ate that the C-terminal filamentous actin (F-actin)-binding domains are responsible for Tarp-mediated

118 Both of Arg's F-actin-binding domains are necessary and sufficient for t

119 ecule, which contain the calmodulin-like and actin binding domains, are held in distinctly different

120 BPAG1-n contains an actin-binding domain at its NH2 terminus and a putative

121 ed-coils, a leucine zipper, and a talin-like actin-binding domain at the COOH terminus.

122 kinases are known to contain filamentous (F)-actin-binding domains at their C termini, it is unclear

123 vitro and in vivo studies suggested that the actin-binding domain attenuated protein kinase A (PKA) p

124 Neurabin-I actin-binding domain bundled F-actin, promoted filopodia

125 rminal segment of smMLCK is connected to the actin-binding domain by a long, flexible tether.

126 ells and in vitro, we perturbed the utrophin actin-binding domain by making point mutations at the CH

127 ng domain (N-ABD) but retains the C-terminal actin-binding domain (C-ABD).

128 Point mutations in the actin-binding domain cause aberrant membrane ruffling an

129 Overexpression of the KASH domain or the actin-binding domain caused a dominant negative anchorag

130 nding domains but lacking the lever arms and actin-binding domains colocalized with markers of the tr

131 acids 535-636, which overlaps with the known actin-binding domains composed of the Xin repeats.

132 ontains an N-terminal calponin homology (CH)/actin-binding domain connected by a series of 24 immunog

133 Here, we report the NMR structure of the actin-binding domain contained in the cell adhesion prot

134 f nexilin and that the expressed fragment of actin-binding domain containing p.Q131E completely lost

135 e, LC2NT, a LC2 truncated mutant lacking the actin-binding domain, could not rescue Ca(v)2.2 surface

136 , which lies within a region of the spectrin-actin-binding domain critical for erythrocyte membrane s

137 NH(2)-terminal sequences corresponding to an actin binding domain defined by in vitro cosedimentation

138 cellular studies showed that an N-terminal F-actin-binding domain dictated neurabin I localization at

139 of one NrbI deletion mutant, containing the actin binding domain, dramatically increased the density

140 tantly, activation of DLC1 by tensin3 or its actin-binding domain drastically reduced the anchorage-i

141 Despite sharing homology through two shared actin binding domains, drebrin and mAbp1 have different

142 We overexpressed dystrophin's actin-binding domain (Dys-ABD), K8 and K19, as well as c

143 there is a crystal structure of the utrophin actin-binding domain, electron microscopy of the actin-b

144 the protein's functionally critical spectrin-actin binding domain, essential for maintenance of red c

145 midline attraction through its C-terminal F-actin binding domain (FABD) and (2) a kinase-dependent i

146 he c-Abl gene has the unique feature of an F-actin binding domain (FABD).

147 nase domains are joined via a linker to an F-actin-binding domain (FABD).

148 rminal 248 amino acids contained an apparent actin binding domain followed by 24 tandem repeats each

149 re 280-kDa proteins containing an N-terminal actin-binding domain followed by 24 characteristic repea

150 sslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgF

151 Human filamins are composed of an N-terminal actin-binding domain followed by 24 immunoglobulin-like

152 similar to spectrin and dystrophin, with an actin-binding domain followed by spectrin repeats.

153 isoform (betaIVSigma1 spectrin) includes an actin-binding domain, followed by 17 spectrin repeats, a

154 though cten is shorter and does not have the actin-binding domain found in other tensins, analysis of

155 g of actin have been generated by fusing the actin-binding domain from an actin-interacting protein t

156 transient and stable expression of the talin actin-binding domain fused to the C-terminus of the gree

157 calponin homology domains that comprise the actin-binding domain have a closed conformation at one e

158 ow that MFM-associated ZASP mutations in the actin-binding domain have deleterious effects on the cor

159 tinin - which serve as spacers between their actin-binding domains - have provided important insights

160 Myosin V is biomolecular motor with two actin-binding domains (heads) that take multiple steps a

161 the cytoskeleton: their sequences include an actin-binding domain homologous to that found in calponi

162 sing two dominant negative polypeptides: the actin-binding domain III of EF1alpha and the EF1alpha-bi

163 These results establish the location of an F-actin binding domain in native talin, demonstrate that d

164 , and that interaction may be mediated by an actin binding domain in subunit B of the enzyme.

165 aMKIIbeta binding depended upon a putative F-actin binding domain in the variable region of CaMKIIbet

166 econd, previously uncharacterized internal F-actin-binding domain in Arg.

167 s via a previously unknown phospho-regulated actin-binding domain in Ent1 and the THATCH domain in Sl

168 s shown an important role for the C-terminal actin-binding domain in proliferation and transformation

169 of the MyBP-C sequence identifies a possible actin-binding domain in the Pro-Ala-rich sequence found

170 This bimodal mechanism requires two separate actin-binding domains in Crn1.

171 evidence for the critical role of the Tarp F-actin-binding domains in host cell invasion and for the

172 lponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and

173 ded a small "dimer initiation" site near the actin binding domain is present.

174 We found that the VASP-F-actin binding domain is required for the recruitment of

175 Unlike full-length talin, the C-terminal f-actin binding domain is unable to nucleate actin polymer

176 f of the protein containing the Arp2/3 and F-actin binding domains is necessary and sufficient for sp

177 The actin-binding domain is between the modular PDZ and LIM

178 The FLNA actin-binding domain is essential for the suppression of

179 domain I-deletions indicates that an intact actin-binding domain is not essential, although it does

180 n ACTN4 isoform, ACTN4 (Iso), that loses its actin-binding domain is still capable of potentiating a

181 Of the eight domains in alpha-actinin, the actin-binding domain is the most highly conserved.

182 hila ortholog Filamin/cheerio that lacks the actin-binding domain, is here shown to govern the growth

183 domain 1 (CH1), within the filamin A (FLNa) actin-binding domain, is the minimal fragment sufficient

184 p7 subgroup of SNARE proteins [9] containing actin-binding domains, is a novel ER membrane-associated

185 a "mini-dystrophin," lacking one of the two actin-binding domains, is less effective than dystrophin

186 tain a Fes/CIP4 homology (FCH) domain and an actin-binding domain-like sequence.

187 idarum, and C. caviae harbor between 1 and 4 actin binding domains located in the C-terminal half of

188 The functionality of the actin binding domains located near the N terminus was co

189 In this report, we demonstrate that the actin-binding domain, located between amino acids 561 an

190 Using two independent actin-binding domains, mAbp1 binds to actin filaments wi

191 An actin-binding domain maps to the LKKAET hexapeptide loca

192 vity: when unphosphorylated, dematin's two F-actin binding domains move independent of one another pe

193 se mutant Dyn1-K44A and the loss-of-function actin binding domain mutant Dyn1-K/E.

194 Dyn1 actin binding domain mutant inhibits filopodial formatio

195 trigger the disease occur in the N-terminal actin binding domain (N-ABD or ABD1).

196 ave been determined, of which the N-terminal actin-binding domain (N-ABD or ABD1) is of particular in

197 isoform of 29 kDa that lacks the N-terminal actin-binding domain (N-ABD) but retains the C-terminal

198 We find that Ig repeats 9-15 contain an F-actin-binding domain necessary for high avidity F-actin

199 62 to proline (S to P) that occur within the actin binding domain of alpha-actinin-4 (ACTN4) cause an

200 Deletion of the actin binding domain of Bcr-Abl (Bcr-AbI-AD) dramaticall

201 The actin binding domain of drebrin decreases the intrastran

202 actin complex, which can be formed via the F-actin binding domain of either protein.

203 tively charged cluster of amino acids in the actin binding domain of Mlph, suggesting that Mlph acts

204 Using an Arp2/3 complex that is fused to the actin binding domain of WASP, we confirm that the NPF-in

205 ylation on CaD are located in the myosin and actin binding domains of CaD and that Tyr-27 is the majo

206 its amino terminus with high homology to the actin binding domains of conventional spectrins.

207 The N-terminal acidic and F-actin binding domains of cortactin were both necessary t

208 g factor homology (ADFH) and charged/helical actin binding domains of drebrin and mAbp1 are sufficien

209 motif (LKKNFMES) within the 10 kDa spectrin-actin-binding domain of 4.1R plays a critical role in bi

210 These results show that the actin-binding domain of Abl enhances leukemia developmen

211 termined that CRP1 associates with the 27-kD actin-binding domain of alpha-actinin.

212 Although the C-terminal F-actin-binding domain of alpha-catenin has been shown to

213 The C-terminal actin-binding domain of alpha-catenin has no influence o

214 The function of the actin-binding domain of alpha-catenin, alphaABD, includi

215 Because the actin-binding domain of alpha-E-catenin is necessary for

216 E-catenin in the autoinhibited state and the actin-binding domain of alphaN-catenin.

217 Previous in vivo studies identified the actin-binding domain of drebrin (DrABD), which causes th

218 The functional significance of the actin-binding domain of dystrophin, the protein lacking

219 the interaction of the cytokeratins with the actin-binding domain of dystrophin.

220 Site-directed mutagenesis of the actin-binding domain of eNOS replacing leucine and trypt

221 C (epsilonV1-2) and a peptide (ABP) from the actin-binding domain of epsilonPKC (epsilon(223-228)).

222 ther immobilized CLIC-5A or the C-terminal F-actin-binding domain of ezrin and that actin polymerizat

223 on is observed independently of the proposed actin-binding domain of HIV-1.

224 aper, we demonstrate that the NH(2)-terminal actin-binding domain of mACF7 is functional both in vivo

225 Using the green fluorescent protein-tagged actin-binding domain of mouse talin, we found a dynamic

226 stent with these findings, a mutation in the actin-binding domain of Myo2p, a class V unconventional

227 that corresponds topologically to the major actin-binding domain of myosin.

228 In contrast to studies in fibroblasts, the actin-binding domain of Nesprin-2 was dispensable for ne

229 An actin-binding domain of periplakin was required to initi

230 The actin-binding domain of Shot directly interacts with Act

231 the first time that variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effac

232 n-dependent PK 5 (Cdk5) (Ser-17), within the actin-binding domain of spinophilin.

233 -94 and Ser-177, that are located within the actin-binding domain of spinophilin.

234 uires RhoA and actin polymerization, and the actin-binding domain of STARS is necessary and sufficien

235 e, we report the structure of the C-terminal actin-binding domain of talin, the core of which is a fi

236 nic mouse model of FHC with mutations in the actin-binding domain of the alpha-myosin heavy chain (My

237 y conserved evolutionarily, localizes to the actin-binding domain of the perinatal myosin head, and i

238 putative serine phosphorylation site in the actin-binding domain of UNC-115.

239 We present the structure of the actin-binding domain of utrophin in complex with F-actin

240 construct actin filaments decorated with the actin-binding domain of utrophin, which contains two cal

241 lexible linker or if it was replaced with an actin-binding domain of utrophin.

242 We constructed mice that lack the actin-binding domain of WIP (WIPDeltaABD mice).

243 Mutations in the actin-binding domain of ZASP-LDeltaex10, but not other i

244 ponin homology domains and is related to the actin-binding domains of a superfamily of proteins inclu

245 Here, we show that the actin-binding domains of accessory proteins can be sensi

246 Both beta-cat- and actin-binding domains of alpha-cat are required to inhib

247 nal domain to wedge apart the membrane and F-actin-binding domains of ezrin.

248 conserved surface patches near the putative actin-binding domains of fascin, which conformational dy

249 We showed that the actin-binding domains of nesprin 1 were dispensable, whe

250 mino acid sequences highly homologous to the actin-binding domains of two known F-actin binding prote

251 complex, and the effect of the alpha-catenin actin-binding domain on beta-catenin association.

252 It contains two actin-binding domains, one containing the talin-like I/L

253 The 4.1 spectrin-actin binding domain or NuMA binding C-terminal domain p

254 Other isoforms lack all or part of the actin binding domains or are truncated and contain a dif

255 ion deficient nuclei assembled when spectrin-actin-binding domain or NuMA-binding C-terminal domain p

256 ion protein, consisting of GFP fused to an F-actin binding domain, overlaps with GFP-PHPKB in the tim

257 ptides with low homology or variant spectrin-actin binding domain peptides that were incapable of bin

258 However, control variant spectrin-actin-binding domain peptides incapable of binding actin

259 In contrast, overexpression of the actin-binding domain plus spectrin repeat domain acts as

260 tinin-4 and E3KARP, which occurs through the actin-binding domain plus spectrin repeat domain of alph

261 croM at 25 degrees C, 20 times stronger than actin-binding domain produced by thermolysin digestion o

262 Each of utrophin's actin-binding domains promotes resilience in actin, whil

263 ACTN2 c.683T>C (p.Met228Thr), located in the actin-binding domain, proved to be the only mutation ful

264 ains, including a pair of alpha-actinin-like actin binding domains; regions of homology to plakins at

265 hPIV1 and one domain that is similar to the actin-binding domain required for budding induced by M p

266 Recombinant actin-binding domain (residues 2-269) binds actin filame

267 aE-catenin mutant lacking the modulation and actin-binding domains restores cadherin-dependent cell-c

268 It therefore appears that actin binding domains separated on the dystrophin molecu

269 , which has a sequence similar to that of an actin-binding domain, significantly reduced release of t

270 ant lacking the C-terminal calponin homology actin-binding domain stimulates actin branch formation b

271 n or coexpression of CaMKIIbeta carrying its actin-binding domain strongly modulated CaMKII diffusion

272 The open and closed conformations of the actin-binding domain suggests flexibility that may under

273 zation with Tarp is dependent on two novel F-actin binding domains that endow the Tarp effector with

274 ain and the cargo adapter Mlph, which has an actin-binding domain that acts as a tether, are sensitiv

275 hylogenetic analyses of the highly conserved actin-binding domain that alpha-actinin 2 was the first

276 Domain analysis of TARP identified an actin-binding domain that bears structural and primary a

277 inds directly to actin filaments via a novel actin-binding domain that defines a superfamily of thirt

278 structed a minispectrin heterodimer from the actin-binding domain, the EF domain, and 4 adjacent spec

279 rrowed to a region that does not include the actin-binding domain, the PDZ domain, or the coiled-coil

280 nd carboxyl-terminal ends, which include the actin-binding domain, the Src homology 2 (SH2) domain, a

281 ation domain (called the KASH domain) and an actin-binding domain; this structure was conserved with

282 -iLID can be used to temporally recruit an F-actin binding domain to MT plus ends and cross-link the

283 ne-rich domain and the binding of the VASP-F-actin binding domain to the side of growing filaments is

284 degrees C the rate constants for recombinant actin-binding domain to bind to (0.8-2.7 microM-1 s-1) a

285 damental role of CH domains as a widely used actin-binding domain underlines the necessity to underst

286 ains two inseparable villin headpiece-like F-actin binding domains (VI, VII).

287 ty, reducing conformational flexibility of F-actin-binding domains via interdomain cross-talk and con

288 A putative kinase target site at Y265 in the actin binding domain was also generated as a phosphomime

289 was deleted (triangle upSH2), the C-terminal actin-binding domain was deleted (triangle upABD), or ki

290 nsable, whereas nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viabili

291 The three actin binding domains were identified as amino acids 1-1

292 reas the inositol phospholipid-binding and F-actin-binding domains were essential.

293 Remarkably, PLS3 mutants lacking both actin-binding domains were still able to rescue motor ax

294 tructure of the F-actin-bound alphaE-catenin actin-binding domain, which in solution forms a five-hel

295 ly, human filamins are dimers composed of an actin-binding domain with 24 immunoglobulin (Ig)-like re

296 a-actinin by blocking the interaction of the actin-binding domain with actin filaments.

297 Conversely, filamin that shares actin-binding domains with alpha-actinin had a strong in

298 In contrast, profilin that shares actin-binding domains with gelsolin, significantly incre

299 er, the exact numbers and locations of the F-actin binding domains within LSP1 are not clearly define

300 igate the significance of the C-terminal Abl actin-binding domain within Bcr/Abl p190 in the developm