ライフサイエンスコーパス: actinonin

1 ic versus endothermic) upon interaction with actinonin.

2 : Bcl2-venetoclax, DB3-progesterone and PDF1-actinonin.

3 HsPDF bound to the peptidomimetic inhibitor actinonin (1.7 A) identified the substrate-binding site.

4 eased PDF expression level and resistance to actinonin, a known PDF inhibitor with antibacterial acti

5 The mode of antibacterial action of actinonin, a known PDF inhibitor, was also confirmed wit

6 We have identified actinonin, a naturally occurring antibacterial agent, as

7 Inhibition of bacterial PDF enzymes by actinonin, a naturally occurring antibacterial agent, ha

8 the high-affinity interaction of EcPDF with actinonin, a naturally occurring potent EcPDF inhibitor.

9 Actinonin, a non-specific matrix metalloprotease inhibit

10 We show that actinonin, a peptidomimetic antibiotic that inhibits HsP

11 Further, we analyzed the effects of actinonin, a protease inhibitor, on obstetrical injury o

12 Actinonin, a specific peptide deformylase inhibitor, was

13 st with estrogen, the general MMP inhibitor, actinonin, abrogated injury-induced degradation of FBLN5

14 igned and synthesized 33 chemical analogs of actinonin; all of the molecules with potent activity aga

15 hroline and by the aminopeptidase inhibitors actinonin, amastatin, and leuhistin.

16 Actinonin ameliorated loss of FBLN5, rescued injury-indu

17 Shedding was abrogated using actinonin, an inhibitor for meprinalpha.

18 One prominent example is actinonin, an inhibitor of bacterial peptide deformylase

19 e inhibition of Staphylococcus aureus PDF by actinonin and BB-3497 is consistent with a recent report

20 Of note, actinonin and bestatin had no effect on TNFRII expressio

21 The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-

22 Actinonin and matlystatins are potent metalloproteinase

23 quivocally identify PfFtsH1 as the target of actinonin and suggests that actinonin should not be incl

24 We used an innovative screen to identify actinonin as having a novel mechanism-of-action inhibiti

25 e matrix degradation by local application of actinonin at the time of surgery may lead to improved el

26 tive target for anticancer therapy by use of actinonin-based antibiotics.

27 of cell surface aminopeptidase N (APN) using actinonin, bestatin, or inhibitory peptides significantl

28 arison of the crystal structures of free and actinonin-bound EcPDF with the solution data suggests th

29 ata reveal that the formation of the PDF(Ec)-actinonin complex results in the transfer of one H(+) fr

30 nsation effect upon formation of the PDF(Ec)-actinonin complex.

31 synthesis, and activity of the gammanonins: actinonin homologues from Gammaproteobacteria.

32 on demonstrate that the unexpected target of actinonin in P. falciparum and Toxoplasma gondii is FtsH

33 the metalloprotease TgFtsH1 as the target of actinonin in the related parasite Toxoplasma gondii and

34 The susceptibility of this strain to actinonin increases with decreased levels of PDF express

35 s Parkin onto mitochondrial subdomains after actinonin-induced mitochondrial proteotoxicity and that

36 Early evidence suggested that actinonin inhibited prokaryote-like post-translational m

37 ed levels of PDF expression, indicating that actinonin inhibits bacterial growth by targeting this en

38 A conservation of PDF-actinonin interaction across PDFs was observed.

39 Microbiological evaluation revealed that actinonin is a bacteriostatic agent with activity agains

40 lution studies establish that the potency of actinonin is enhanced by more than 2000-fold upon tighte

41 Actinonin is the most potent natural inhibitor of peptid

42 The antibiotic actinonin kills malaria parasites (Plasmodium falciparum

43 time- and dose-dependent manner; removal of actinonin led to a recovery of the membrane potential co

44 Median inhibitory concentrations (IC50) for actinonin of 73 +/- 16 and 100 +/- 14 nM were obtained i

45 Actinonin provides an excellent starting point from whic

46 Further, actinonin rescued the negative effects of injury on biom

47 allelic replacement was sufficient to confer actinonin resistance in P. falciparum.

48 e authors were not, however, able to recover actinonin resistant malaria parasites, leaving the speci

49 We generated actinonin resistant P. falciparum by in vitro selection

50 veral plant species including Arabidopsis to actinonin resulted in chlorosis and severe reductions in

51 coli with the peptide deformylase inhibitor, actinonin, results in the expected (but previously unrep

52 ugh NAD(+) supplementation, urolithin A, and actinonin) reverses memory impairment through PINK-1 (PT

53 as the target of actinonin and suggests that actinonin should not be included in the highly valuable

54 Slow binding of actinonin to these enzymes is observed under steady-stat

55 binding of a naturally occurring antibiotic, actinonin, to the Ni(2+)-reconstituted recombinant form

56 Actinonin treatment of cells led to a tumor-specific mit

57 ia parasites, leaving the specific target of actinonin uncertain.

58 Actinonin was a tight binding competitive inhibitor (K(i

59 In animal models, oral or parenteral actinonin was well tolerated and inhibited human prostat

60 ate peptide analog inhibitor of collagenase, actinonin, was included in the reaction.