ライフサイエンスコーパス: action potential

1 f embryonic development (prior to ubiquitous action potentials).

2 s to the repolarization phase of the cardiac action potential.

3 ted ion channels involved in the ventricular action potential.

4 in excitable cells, in which they shape the action potential.

5 release multiple vesicles in response to an action potential.

6 e plateau phase or repolarizing phase of the action potential.

7 essary for healthy conduction of the cardiac action potential.

8 on and physiologic shortening of the cardiac action potential.

9 insic ability to generate rhythmic bursts of action potential.

10 late" Ca(2+) sparks) during phase 2-3 of the action potential.

11 , and prevents the traveling of the invading action potentials.

12 membrane potential during the propagation of action potentials.

13 ed by currents responsible for generation of action potentials.

14 ps of neurons based on the waveform of their action potentials.

15 us system by facilitating fast conduction of action potentials.

16 channel 3 (TPC3), which generates ultralong action potentials.

17 nnel-dependent broadening of backpropagating action potentials.

18 l as subsequent signalling in the absence of action potentials.

19 of cholesterol in the propagation of axonal action potentials.

20 plifying small membrane depolarizations into action potentials.

21 d) or without (spontaneous) the influence of action potentials.

22 scale, enabling the resolution of individual action potentials.

23 on initial segment to regulate the firing of action potentials.

24 generate large Na(+) - and Ca(2+) -dependent action potentials.

25 Kr)) important for repolarization of cardiac action potentials.

26 ndation for our current understanding of the action potential [1], ionic gradients across cells [2],

27 Ca(2+) channels regulate action potential activity across many types of excitable

28 an circadian clock encodes time via rhythmic action potential activity in the suprachiasmatic nucleus

29 y dependent on experience-independent Ca(2+) action potential activity.

30 ane to release neurotransmitter following an action potential, after which new vesicles must 'dock' t

31 These resulted from a reduction in action potential afterhyperpolarization and alterations

32 latency to fire, and transiently diminished action potential afterhyperpolarization.

33 a cuff electrode, and b) the propagation of action potentials along the axons.

34 oligodendrocytes enable fast propagation of action potentials along the ensheathed axons.

35 idespread intense activation and stereotyped action potential alterations in tissue that was invaded

36 hlight a previously unrecognised role of the action potential amplitude as a key regulator of pancrea

37 dingly, the inhibitory effect of the reduced action potential amplitude exceeds the stimulatory effec

38 G amplitude due to the overlap of motor unit action potentials (amplitude cancellation), however, may

39 ks Kv11.1 channels lengthens the ventricular action potential and causes cardiac arrhythmias.

40 Similarly, long-term blockade of action potentials and Ca(2+) entry did not disrupt activ

41 sed by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness.

42 to temporarily lose the ability to initiate action potentials and control network excitation, potent

43 hannels effectively measure the frequency of action potentials and convert it into Na(+) current avai

44 ut3(lineage) DRG neurons fire menthol-evoked action potentials and exhibited robust, transient recept

45 ically excitable, exhibiting backpropagating action potentials and fast dendritic calcium spikes.

46 0% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates a

47 ed sodium channel Na(v)1.5 generates cardiac action potentials and initiates the heartbeat.

48 Rhythmic action potentials and intercellular Ca(2+) waves are gen

49 amp mode, the array intracellularly recorded action potentials and postsynaptic potentials from thous

50 was expended on reversing Na(+) entry during action potentials and pumping Ca(2+) out of the cell.

51 rs of similar diameters tended to lock their action potentials and reduce their conduction velocities

52 Axon initial segments (AISs) generate action potentials and regulate the polarized distributio

53 Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicl

54 um channels is crucial for the generation of action potentials and regulation of firing frequency(1,2

55 striatal astrocyte-converted neurons showed action potentials and synaptic events, and projected the

56 The duration of the action potentials and the QT interval were significantly

57 these channels function in cells not firing action potentials and what the consequences of their act

58 scle endplate reinnervation, compound muscle action potential, and functional whisker twitch analysis

59 e the morphology and duration of the cardiac action potential, and individuals with these disorders o

60 dopamine neurons, decreased the amplitude of action potentials, and narrowed action potential width.

61 energetic cost of generating and propagating action potentials, and the importance of information tra

62 undergo nanometer-scale deformations during action potentials, and the underlying mechanism has been

63 of network synchrony, coordinated firing of actions potentials, and enhanced evoked response to stim

64 ue properties promotes the genesis of atrial action potential (AP) alternans and conduction alternans

65 o subcellular Ca waves that occur during the action potential (AP) and are triggered by LCC openings.

66 dog atrial myocytes which occurs during the action potential (AP) and is absent during diastole.

67 ynaptic transmission at this connection, and action potential (AP) firing rates of PV-INs were unchan

68 Changes in Kv3 currents and action potential (AP) firing were analysed from wild-typ

69 , translating the generation potentials into action potential (AP) firing.

70 tonic driving force, axial current flow, and action potential (AP) generation from cell-to-cell.

71 rtebrates.SIGNIFICANCE STATEMENT The site of action potential (AP) initiation in invertebrates is unk

72 Atrial action potential (AP) morphology was altered in Akita mi

73 several electrophysiological changes such as action potential (AP) prolongation (~50%), reduced L-typ

74 Kv3 voltage-gated potassium channels mediate action potential (AP) repolarization.

75 feature of priming, measured as reduction in action potential (AP) rheobase, was found in weakly isol

76 The action potential (AP) waveform controls the opening of v

77 modifying the I(CaL) contribution to atrial action potential (AP) waveform; (ii) to investigate the

78 of L5 pyramidal tract (PT) cells to suppress action potential (AP)-evoked Ca(2+) signals.

79 ization of cardiomyocytes during the cardiac action potential (AP).

80 ent (I(NaL)) significantly shape the cardiac action potential (AP).

81 t1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca(2+) releas

82 all-optical systems simultaneously measuring action potentials (APs) and Ca(2+) transients (CaTrs).

83 like IHCs, fire spontaneous Ca(2+) -induced action potentials (APs) during immature stages of develo

84 he impact of inward rectification in shaping action potentials (APs) in ventricular cardiomyocytes un

85 In multipolar vertebrate neurons, action potentials (APs) initiate close to the soma, at t

86 STATEMENT Auditory information is encoded by action potentials (APs) phase-locked to sound frequency

87 lease that occurs independent of presynaptic action potentials (APs) shows significant sensitivity to

88 lease, and a higher incidence of spontaneous action potentials (APs) when exposed to ISO (9.99 +/- 4.

89 a] (i) corresponded to different patterns of action potentials (APs), a train of APs in L1 neurons, a

90 ane-potential dynamics immediately following action potentials (APs), as measured in whole-cell recor

91 s, immature OHCs elicited spontaneous Ca(2+) action potentials (APs), but only during the first few p

92 ciated HCs exhibit spontaneous Ca(2+) -based action potentials (APs), yet it is unclear if APs occur

93 ase their content independent of presynaptic action potentials (APs).

94 Action potentials are a key component of neuronal commun

95 In cardiac myocytes, action potentials are initiated by an influx of sodium (

96 amidal neurons; the subcellular domain where action potentials are initiated.

97 mparing to prior single-cell studies because action potentials are too sparse and the deflection resp

98 In most vertebrate neurons, action potentials are triggered at the distal end of the

99 ith their intrinsic properties, and generate action potentials as outputs.

100 KO mice showed increased firing frequency of action potentials at early postnatal ages and were hyper

101 ansmission, especially for neurons that fire action potentials at high frequencies.

102 c nerves, but causes transient activation of action potentials at the onset of the blocking current.

103 Gadd45b knockdown decreases striatal neuron action potential burst duration in vitro, without alteri

104 acilitation of dopamine release triggered by action potential bursts separated by short intervals (se

105 cell types that are not expected to support action potentials, but definitive data were lacking.

106 MNTB neurons inhibit MOC action potentials, but this effect depresses with repeat

107 ouse hippocampal synapses, we induced single action potentials by electrical field stimulation, then

108 depolarization reduces the amplitude of the action potentials by voltage-dependent inactivation of t

109 r hair cells reduced auditory nerve compound action potentials (CAPs) and provided reference times fo

110 Imaging compound action potentials (CAPs) in peripheral nerves could help

111 rences in the resting membrane potential and action potential characteristics between vessels from wi

112 I(K1) measurements, action potential characterization, and intracellular Ca(

113 In male rats, we employed the action potential-clamp technique to determine the underl

114 Rapid and efficient saltatory action potential conduction depends on the myelin sheath

115 affects axonal electrophysiology, increasing action potential conduction velocity.

116 els necessary for rapid and efficient axonal action potential conduction.

117 perpolarization during hypokalemia and short action potential configurations.

118 ast physiological characteristics of the VCS action potential, defining the identity of the adult VCS

119 O and OVLT are strongly rhythmic and require action potential-dependent communication to maintain syn

120 The cardiac ventricular action potential depends on several voltage-gated ion ch

121 bal dendritic calcium transients elicited by action potentials disappeared rapidly after hearing onse

122 ity of mature DYN neurons, and reduced their action potential discharge in response to sensory input,

123 Action potential driven neuronal signalling drives sever

124 release are different from those underlying action potential-driven synchronized transmitter release

125 c spines during an EPSP and back-propagating action potential due to the opening of NMDA receptors an

126 ed hearts, there were no differences in mean action potential duration (APD(80)) between groups; howe

127 Adult hearts had the shortest action potential duration (APD) and Ca(2+) transient dur

128 enerating a late Na(+) current that prolongs action potential duration (APD) and triggering proarrhyt

129 ucting a probability density function of the action potential duration (APD) at different cycle lengt

130 nel is a critical regulator of cardiomyocyte action potential duration (APD).

131 es exhibited average CVs of 14 +/- 0.6 cm/s, Action Potential Duration (APD)80 and APD30 of 152 +/- 1

132 pecific characteristics, including increased action potential duration and cellular automaticity.

133 Q(+/-) myocytes (n=5) demonstrated prolonged action potential duration at 90% repolarization and afte

134 ta or IL-6 in the absence of hMSCs prolonged action potential duration but only IL-6 increased Ca2+ a

135 th nonfailing hMSCs, failing hMSCs prolonged action potential duration by 24% (P<0.001, n=15), increa

136 chronic inactivity homeostatically increases action potential duration by changing alternative splici

137 1/14 hearts at 100 nmol/L) without altering action potential duration or restitution and dispersion.

138 are responsible for the surprisingly modest action potential duration shortening.

139 arrest is proarrhythmogenic by reducing the action potential duration through calcium channel inhibi

140 sodium channel expression, I(Na) and atrial action potential duration were reduced and potassium cha

141 AF burden, restored I(Na), I(Ca,L), I(Kur), action potential duration, and reversed atrial fibrosis

142 Using fluorescent indicators, action potential duration, Ca2+ alternans, and spontaneo

143 We have demonstrated that shortened action potential duration, slow conduction and triggered

144 rectifier potassium currents and normalized action potential duration.

145 in and a nonsignificant 15% prolongation of action potential duration.

146 racellular recordings demonstrated shortened action-potential duration (APD) and abbreviated refracto

147 imulation and on the relative timing between action potentials during propagation.

148 ectively increases gain in models possessing action potential dynamics typical for somatostatin inter

149 e memristors not only function at biological action potentials (e.g., 100 mV, 1 ms) but also exhibit

150 Similar to the familiar electrophysiological action potential (eAP), the gAP also provides a means fo

151 onse to therapy via recorded evoked compound action potentials (ECAPs) in patients during daily use.

152 y, such that myotonia triggered by firing of action potentials (electrically induced myotonia) was un

153 Ex vivo, single action potentials evoked alkalinizing pH transients of o

154 We found that mice can detect single action potentials evoked synchronously across <20 olfact

155 transmission is initiated via spontaneous or action-potential evoked fusion of synaptic vesicles.

156 Grouping single action potential-evoked calcium responses by neuron type

157 ed that presynaptic Na(+) did not affect the action potential-evoked intracellular Ca(2+) transient a

158 More often than not, action potentials fail to trigger neurotransmitter relea

159 Action potentials fired from right BLA neurons of LB fem

160 important regulators of neuronal and cardiac action potential firing (excitability) and have major ro

161 Action potential firing and synaptic responses were reco

162 roperties required to maintain high rates of action potential firing and transmitter release.

163 o membrane depolarization and an increase in action potential firing but this stimulation of electric

164 insic UBC excitability, reducing spontaneous action potential firing by slowing maximum depolarizatio

165 Some neurotransmitters can facilitate action potential firing by suppression of a low voltage-

166 ntrast, basal release that is independent of action potential firing does not require RIM.

167 hole-cell electrophysiology to determine how action potential firing drives calcium responses within

168 MA reduces neuronal action potential firing elicited by mechanical stimuli i

169 hat activation of OXTRs in the CeL increased action potential firing frequency recorded from neurons

170 ers, which could explain a stronger shift in action potential firing in 112A/A mice.

171 C14 decreases outward currents and increases action potential firing in hippocampal neurons.

172 ht into the mechanism that produces rhythmic action potential firing in SCN.

173 Circadian oscillations in spontaneous action potential firing in the suprachiasmatic nucleus (

174 ordings from lamina I neurons, we found that action potential firing induces calcium responses within

175 IP1) and Ca2+ signaling in cell lines and on action potential firing of GnRH neurons in brain slices.

176 Action potential firing of serotonin dorsal raphe neuron

177 itability, with a shift from phasic to tonic action potential firing patterns in KO neurons.

178 citatory/inhibitory balance and an increased action potential firing rate.

179 enhanced neuronal intrinsic excitability and action potential firing rates.

180 pressed spontaneous firing and increased the action potential firing threshold of patient-derived neu

181 tromedial hypothalamus (VMH), leptin-induced action potential firing was enhanced, whereas nuclear pS

182 ve contributions to synaptic integration and action potential firing.

183 ed by a delayed depolarization that triggers action potential firing.

184 ransmitter release with Ca(2+) influx during action potential firing.

185 alcium responses have the capacity to encode action potential frequency and number in all compartment

186 mulatory effect resulting from the increased action potential frequency.

187 ted in an approximately two-fold increase in action potential frequency.

188 exta We simultaneously recorded nearly every action potential from all major wing muscles and the res

189 icroscopy, RhoVR-Halos provide a read-out of action potentials from labeled cortical neurons in a rat

190 50 um in length) for recording physiological action potentials from small autonomic nerves.

191 2000)] introduced the concept of the genomic action potential (gAP)-a structured genomic response in

192 We found that single action potentials generated at the soma increase calcium

193 ficiently and coordinately tune the speed of action potential generation and propagation and transmit

194 tabolism, cardiac beta-adrenergic signaling, action potential generation, and cell survival.

195 activation of the Na(+) channels involved in action potential generation.

196 e of a low-dimensional model for ventricular action potential generation.

197 CNE1) is effective in shortening the cardiac action potential in human-induced pluripotent stem cell-

198 ng of cellular deformations accompanying the action potential in mammalian neuron somas (-1.8 to 1.4

199 Generating neuromorphic action potentials in a circuit element theoretically req

200 ral ventral neurons (LNvs) need I(h) to fire action potentials in a high-frequency bursting mode and

201 ramatic reductions in spontaneous and evoked action potentials in a Purkinje cell model, suggesting t

202 ing ECORE, we optically recorded spontaneous action potentials in cardiomyocytes, cultured hippocampa

203 Action potentials in ChINs evoke large inhibitory respon

204 timulus and produces responses that resemble action potentials in excitable cells.

205 ntensity solitary tract stimulation to evoke action potentials in LepR neurons.

206 We show that RhoVR-Halos can record action potentials in single trials from cultured rat hip

207 ctivation of the cervical vagus nerve evokes action potentials in the splenic nerve.

208 illimeter magnetic coil can reversibly block action potentials in the unmyelinated axons from the mar

209 Recordings of monophasic action potentials in vivo reveal that the peri-infarct z

210 n VMs from Shams, resulting in shortening of action potentials in VMs and ex vivo optically mapped Sh

211 seizure, while penumbral tissue shows stable action potentials, in keeping with the "dual territory"

212 onvulsive sesquiterpene (-)-jiadifenolide on action potential-independent inhibitory currents at GABA

213 ialysis further reveals that these modes and action potential-independent release provide significant

214 ke neural Ca(2+) events were consistent with action-potential-independent spontaneous glutamate relea

215 which pairs of single pre- and postsynaptic action potentials induce synaptic modifications is not v

216 Ion channel complexes promote action potential initiation at the mammalian axon initia

217 ing to activation of L-type Ca(2+) channels, action potentials, intercellular Ca(2+) waves and contra

218 calcium (Ca(V) 1/Ca(V) 2) channels translate action potentials into Ca(2+) influx in excitable cells

219 rs, termed neurotransmitters, in response to action potential invasion (evoked release).

220 Ca(2+) release synchrony at the start of the action potential leads to an increase in number of micro

221 The monophasic action potential (MAP) is a near replica of the transmem

222 This developmental transition coincides with action potential maturation.

223 Thus, any presynaptic action potential may elicit temporally highly coordinate

224 Multicellular action potentials, membrane ion-currents (perforated pat

225 cells to model the contribution of TRPM7 to action potential morphology.

226 ver, siRNA knockdown did not directly affect action potential morphology.

227 tially selective recording of micro-compound action potentials (muCAPs) by electrical stimulation of

228 name GJA1) facilitates rapid propagation of action potentials necessary for each heartbeat.

229 postnatal, differentiated neurons that fire action potentials - notably ion channels mutated in the

230 equency and number in all compartments, with action potential number being preferentially encoded.

231 o record biological signals by measuring the action potentials of a Venus flytrap is demonstrated.

232 Under some conditions, the normally-long action potentials of cardiac cells are extended even fur

233 We extracellularly recorded action potentials of cells in the prelimbic region of th

234 ANCE STATEMENT Information is encoded by the action potentials of neurons in various cortical areas i

235 Action potentials of Tbx5-deficient VCS myocytes adopted

236 yperpolarized VP with longer latency to fire action potentials on depolarization compared with bottom

237 The propagation of action potentials on realistic biventricular geometries

238 yed rectifier current (I(Ks)) of the cardiac action potential or as a constitutively active epithelia

239 al to be direct cell contraction rather than action potentials or calcium signaling.

240 pagates, and transforms synaptic inputs into action potential output.

241 ne potential while simultaneously decreasing action potential output.

242 ion component of spikelets (a synapse-evoked action potential passively propagating from electrically

243 depolarizing I(NCX) thereby suppressing the action potential plateau and delaying the activation of

244 ding additional depolarizing currents during action potential plateau phase, (2) increasing intracell

245 es in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons.

246 Action potentials propagate through long axons to their

247 intercellular coupling, which ensures rapid action potential propagation and synchronized heart cont

248 The myelin sheath increases the speed of action potential propagation by insulating the axons of

249 ls at nodes of Ranvier are critical for fast action potential propagation in myelinated axons.

250 between axons, the effects of temperature on action potential propagation were moderate and supported

251 monstrated macroscale beating and continuous action potential propagation with responsiveness to drug

252 reversal potentials, can result in blocking action potential propagation.

253 5 inhibitor olomoucine affected the compound action potential recorded in the spinal nerves, as well

254 Machine learning of action potential recordings in patients revealed novel p

255 is a novel interface for in-vivo intraneural action potential recordings.

256 movement across the entire neuron during the action potential remained unclear.

257 this current to the net current that causes action potential repolarization shows that late Ca(2+) s

258 evance to neuronal excitability: 1) enhanced action potential repolarization via increased current fl

259 e plasma membrane of cardiomyocytes prolongs action potential repolarization, which associates with c

260 rdepolarizations that occurred at phase 3 of action potential repolarization.

261 cal neurons from both patients had prolonged action potential repolarization.

262 t neurons displayed similar abnormalities in action potential repolarization.

263 actory bulb neurons with cellular and single-action-potential resolution.

264 Analysis of the presynaptic action potential's (AP(syn)) role in synaptic facilitati

265 ate the presence of actively backpropagating action potentials, shifting our understanding of how the

266 A longitudinal study of compound motor action potentials showed a progressive decrease in all n

267 assium channels, which usually act to reduce action potential signaling.

268 and organoids manifest increased spontaneous action potentials, slow oscillatory events (~1 Hz), and

269 during the repolarization phase of a cardiac action potential that can trigger fatal ventricular arrh

270 which is an alternation in the width of the action potential that typically occurs when the heart is

271 with excitability and the means to propagate action potentials that form the basis of all neuronal si

272 spiking, the threshold driven spiking of the action potential, the post-firing refractory period of a

273 maller than the currents responsible for the action potential, they are hard to identify and easily o

274 smit signals spontaneously or in response to action potentials, they differ from excitatory synapses

275 calcium ion flux indicating occurrence of an action potential, this paper demonstrates that an applic

276 Neurons from knockout mice had a higher action potential threshold and a more depolarized membra

277 nels open at voltages more negative than the action potential threshold and are thus termed subthresh

278 dependent and associated with a reduction in action potential threshold.

279 sts, associated with a depolarizing shift in action potential threshold.

280 s, accompanied by a hyperpolarizing shift in action potential threshold; and 2) a transient depolariz

281 ecreased the current required to generate an action potential through PAR(2) Inhibitors of adenylyl c

282 In failing heart cells, restoration of the action potential to a nonfailing phase 1 configuration i

283 Modification of the action potential to include steps to different potential

284 quires axons not only to faithfully transfer action potentials to distant synaptic regions but also t

285 est no change in sensory transduction but in action potential transformation and conduction.

286 n effect that has been visualized during the action potential using quantitative phase imaging.

287 lular Ca(2+) measurements were combined with action potential voltage clamp techniques in a physiolog

288 studies consistently show marked changes in action potential waveform during epileptic discharges, b

289 itic release was independent of a particular action potential waveform, firing pattern evoked, or a m

290 The first two alter the action potential waveform, whereas the third increases t

291 ostatic changes and the interaction with the action potential we consider the somewhat artificial con

292 With bursts of action potentials, we found that calcium responses have

293 nsible for depolarizing and repolarizing the action potential were tightly coexpressed, and their abs

294 Brief action potentials were in turn maintained by ultra-rapid

295 ith chronic MI (6 weeks), in vivo monophasic action potentials were simultaneously recorded in the pe

296 SNc DaNs engage calcium channels to generate action potentials, which lead to oxidant stress by yet u

297 amplitude of action potentials, and narrowed action potential width.

298 We recorded action potentials with peak-to-peak amplitudes of 15.1-9

299 nfarct region have more DADs and spontaneous action potentials, with spontaneous Ca(2+) release, unde

300 cts support such coordination since incoming action potentials would depolarize the dendrite at multi