ライフサイエンスコーパス: actionable

1 hat are sufficiently precise and practically actionable.

2 hemotherapeutic, this approach is clinically actionable.

3 n several cancers, may be prognostic and are actionable.

4 t these mutations remain therapeutically non-actionable.

5 45 alarms among 100 children, 50 (0.5%) were actionable.

6 BrM-acquired alterations that are clinically actionable.

7 ry bone cancer metastasis that is clinically actionable.

8 icts conversion to exAMD within a clinically actionable 6-month time window, achieving a per-volumetr

9 Patients with tumors harboring actionable aberration(s) in fibroblast growth factor rec

10 aling axis that regulates HMGCR, defining an actionable addiction in that leads to MESN-subtype-depen

11 low or no clinical actionability, clinically actionable adult-onset conditions, and carrier status fo

12 nGS also revealed actionable adult-onset disease risk in 3/85 (3.5%) newbo

13 Here we present childhood-onset and actionable adult-onset disease risk, carrier status, and

14 ivided into 2 groups; group 1, patients with actionable alarms (AA) and group 2, patients with non-AA

15 ost individuals had at least one potentially actionable alteration (94.7%), with the median number of

16 An actionable alteration was found in 37.6%.

17 we review the biology of infrequent genomic actionable alterations in NSCLC as well as the current a

18 nation therapeutic strategies, we identified actionable alterations in signaling that underlie adapti

19 c profiling has revealed several potentially actionable alterations in small subsets of patients and

20 4.7%), with the median number of potentially actionable alterations per patient being 2 (range, 0-13)

21 increasingly used for the identification of actionable alterations that are critical to cancer care.

22 tatistical analyses-all aspiring to identify actionable alterations, and thus molecular targets, in a

23 nique somatic profile with pharmacologically actionable alterations, justifying the inclusion of noni

24 parisons and identify potentially clinically actionable alterations.

25 field of research, the goal will be to find actionable and clinical interventions to identify at-ris

26 r signaling, we examined the relationship of actionable and incidental (non-actionable) MRI findings

27 Analysis of these complex data to produce actionable and replicable health and disease categories

28 t cancer with a P/LP variant with clinically actionable and/or management guidelines in development a

29 e setting, it would be considered clinically actionable, and has been actioned in relatives ascertain

30 Our results suggest a quickly actionable approach to supporting conventional therapies

31 ence, cost, and the clinical implications of actionable arrhythmia alarms on telemetry monitoring fol

32 s for each other as investigators search for actionable, biological underpinnings of disease.

33 ted information about molecular subtypes and actionable biomarkers.

34 clinical workflows, and have rarely produced actionable biometric data for healthcare providers.

35 priateness of Inpatient Antibiotics was made actionable by an expert antibiotic stewardship panel and

36 We make this observation actionable by developing a conditional independence test

37 ant detection performance in 59 genes deemed actionable by the American College of Medical Genetics a

38 ndency on autophagy creates new, potentially actionable cancer cell susceptibilities.

39 n Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, a hybridization capture-based

40 acidosis induces potentially therapeutically actionable changes to alternative splicing.

41 HBs harbor multiple SSTR subtypes that offer actionable chemo-therapeutic strategy for management of

42 igning observational research so it delivers actionable clinical or population health evidence.

43 sarcoma and more importantly that SEMA4C has actionable clinical potential.

44 health informatics, disease-risk prediction, actionable clinical recommendations, and precision medic

45 esearch is not consistently translating into actionable clinical trial (CT) outcomes.

46 eting a set of limited eligibility criteria (actionable cohort).

47 39 (68.9%) patients met the criteria for the actionable cohort.

48 ohort, and 33.1% (95% CI, 32.3-33.9) for the actionable cohort.

49 ohort, and 32.2% (95% CI, 31.4-33.0) for the actionable cohort.

50 ll HFrEF with ADHF, PIONEER-HF eligible, and actionable cohorts using linked Medicare claims data.

51 nners which translates modeling results into actionable control advice adaptable to system-specific d

52 Thus, TRX1 is an actionable CRPC therapeutic target through its protectio

53 Our analysis provides exploratory actionable data on the overall effect sizes and strength

54 ironmental sampling as a tool for generating actionable data that can inform public health responses

55 les to PROMs use include failure to generate actionable data, implementation obstacles, and inappropr

56 her, our data indicate that SCLC displays an actionable dependence on ATR/CHK1-mediated cell cycle ch

57 he vitamin B6 pathway as a pharmacologically actionable dependency in AML.

58 ropriate adoption of this test could provide actionable diagnostic information that is anticipated to

59 34 (1.6%) had genetic findings for medically actionable disorders that, although unrelated to their n

60 paper presents 10 principles to put machine-actionable DMPs (maDMPs) into practice and realize their

61 'nDRIVE revealed many potentially clinically actionable driver genes.

62 h might be improved by the identification of actionable driver mutations.

63 share common molecular subtypes with similar actionable drivers to improve precision therapy.

64 ghting the potential of YAP/TEAD as possible actionable drug targets for ERalpha(+) breast cancer.

65 Detection of actionable drug targets in cell-free DNA, more comprehen

66 In particular, discovery of actionable drug targets is critical to developing target

67 Moreover, QMAP-Seq reveals clinically actionable drug vulnerabilities and functional relations

68 and that thermodynamic poise information is actionable during network reconciliation.

69 cy-makers and the public with meaningful and actionable environmentally-informed COVID-19 risk estima

70 social and economic health disparities, and actionable epidemiologic evidence is needed to identify

71 In addition, actionable estimates of excess mortality will require ti

72 ically and empirically ill-suited to provide actionable, evidence-based recommendations for reducing

73 ns for their breast cancer patients based on actionable, evidence-based results.

74 hat extent drug costs, which are potentially actionable factors, contribute to medication nonadherenc

75 itoring of the skin microbiome could provide actionable findings about the pathogenesis of SSIs.

76 We discovered actionable findings in four participants that would not

77 ates some challenges around communication of actionable findings in research participants in this con

78 RRS-LS) are designed to identify potentially actionable findings to inform the Army's suicide prevent

79 d a program of research designed to deliver "actionable" findings-genomic results that 1) reveal fund

80 Thus, PAK4 may be therapeutically actionable for a subset of MIBC patients with amplified

81 ility, but predictions are small and not yet actionable for individuals.

82 lly valuable' findings even if not medically actionable-for instance, findings that help corroborate

83 al conditions, we should also acquire highly actionable functional information by perturbing-for exam

84 Therapeutically actionable fusions involving RAF1, BRD4 and ROS1 were ve

85 ients, 92% harbored at least one potentially actionable GA, which was identified in TP53/cell cycle p

86 658 (86.6%) had at least 1 actionable GA.

87 nonpapillary origin, focusing on potentially actionable GAs described to predict response to approved

88 e sensitive and robust methods for detecting actionable gene fusions in lung cancer and could provide

89 BRCA2 is a clinically actionable gene implicated in breast and ovarian cancer

90 ing their target genes, including clinically actionable genes and immune checkpoints.

91 or likely pathogenic, particularly among the actionable genes associated with cardiovascular disease.

92 n changes (<2-fold or >2-fold) in clinically actionable genes including gains of FGFR4 (n = 6 [30%]),

93 ve been missed by WES and SNP arrays in many actionable genes such as PIK3CA, EGFR, AKT3, FGFR1, ERBB

94 iant interpretation in many other clinically actionable genes, in any relevant cell type.

95 nVar-curated missense variants in clinically actionable genes, we evaluated the accuracy and yield of

96 and shows their connections with clinically actionable genes.

97 lioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted th

98 Actionable genetic alterations included 25 EGFR mutation

99 based on family history may miss clinically actionable genetic changes with established implications

100 om white patients with respect to clinically actionable genomic alterations and suggest that clinical

101 atients with metastatic PSCC have clinically actionable genomic alterations in mechanistic target of

102 cations in mTORC2-specific genes as the only actionable genomic alterations, suggesting a distinct ro

103 mber of PDACs to assess the full spectrum of actionable genomic alterations.

104 lation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNST

105 lly valid, medically important and medically actionable genomic findings (for example, pathogenic var

106 We evaluated actionable genomic findings in community-based participa

107 Proportion of clinically actionable germline mutations detected by universal tumo

108 ce analysis using a multigene panel detected actionable germline variants in 6 patients (5%).

109 in TNNT2 or TNNI3 but exhibit few clinically actionable HCM variants overall.

110 To generate actionable health and demographic data to prevent child

111 We discovered more than 67 clinically actionable health discoveries and identified multiple mo

112 that deep longitudinal profiling can lead to actionable health discoveries and provide relevant infor

113 stance tests that are able to provide timely actionable HIV resistance data at individual, population

114 es from human biological samples to generate actionable hypotheses.

115 Molecular alterations were potentially actionable in 28 of 135 patients (21%).

116 e features of tumorigenesis have been highly actionable in kidney cancer treatments, and will likely

117 iant of cardiovascular relevance, these were actionable in only 14% (95% CI, 7-26.2).

118 lorectal cancer/polyp (CRC/P)-associated and actionable incidental findings genes.

119 ty from NCDs is a robust, comprehensive, and actionable indicator for quantifying and monitoring glob

120 aling pathway, since they provide clinically actionable information as negative predictors of benefit

121 oint-of-care (POC) diagnostics provide rapid actionable information for patient care at the time and

122 n of humanized animal antibodies and provide actionable information for use in vaccine studies.

123 ng the course of the pandemic and to provide actionable information highlighting advantages and drawb

124 e first two coding-complete genomes provided actionable information in real-time for the deployment o

125 gnosis of neurologic infections and provided actionable information in some cases.

126 ed with other related analyses, will provide actionable information that will shape policy makers' th

127 tery (PA) pressures provides clinicians with actionable information to help further optimize medicati

128 rovide caregivers with reliable, immediately actionable information to identify whether there is a ne

129 er, centralization may delay the delivery of actionable information to the bedside, particularly in t

130 ies could decode genetic risk into medically actionable information, thereby improving genetic diagno

131 pared to previous samples, can generate more actionable information.

132 ed efforts to translate sequencing data into actionable information.

133 Patients with clinically actionable inherited mutations whose genetic test result

134 However, despite the clear need to develop actionable insights for improving the resilience of crit

135 b application that can help researchers gain actionable insights from gene-sets.

136 help uncover novel biological and clinically actionable insights into carcinogenesis.

137 These results provide actionable insights that can be rapidly translated into

138 method that uses proteomics data to produce actionable insights to increase biofuel production.

139 on disease, and the automated derivation of actionable insights.

140 tium to highlight key gaps, unmet needs, and actionable issues.

141 f primary importance, the Taskforce outlined actionable items regarding 1) the creation of a standard

142 This essay also provides actionable items that the cell biology community can imp

143 e strategy that innovates the exploration of actionable kinases for precision medicine.

144 undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising

145 s, providing medulloblastoma pathology in an actionable manner during surgery.

146 results communicated in a clear, timely, and actionable manner to strengthen public health responses.

147 sequencing identified TORC1 signaling as an actionable mechanism of drug resistance.

148 tilization of metabotypes of ASD can lead to actionable metabolic tests that support early diagnosis

149 ion and potentially identify therapeutically actionable, metastasis-specific genomic aberrations.

150 ns acquired in BrM could identify clinically actionable metastatic dependencies.

151 Our new approach provides quantitative, actionable MIC results within just 5 h because it measur

152 ite-focused research has identified multiple actionable microbial targets that are relevant for host

153 lura-seq's utility in identifying clinically actionable microenvironmental adaptations in early metas

154 evance and therapeutic potential of a novel, actionable miR/RBP axis in tumor angiogenesis and metast

155 oupled clinical decision support to identify actionable modifications for improvement.

156 This actionable molecular addiction to functional PARP1 signa

157 al than the 488 patients who did not have an actionable molecular alteration (2.58 years [95% CI 2.39

158 eived unmatched therapy and those without an actionable molecular alteration (HR 0.82 [95% CI 0.64-1.

159 ncreatic cancer whose tumours harboured such actionable molecular alterations and who received molecu

160 Therapeutically actionable molecular alterations are widely distributed

161 Actionable molecular alterations were identified in 282

162 383 days (IQR 214-588), those patients with actionable molecular alterations who received a matched

163 About 25% of pancreatic cancers harbour actionable molecular alterations, defined as molecular a

164 Feasibility, the frequency of actionable molecular alterations, the effect on decision

165 ts for whom outcomes were available, 189 had actionable molecular alterations.

166 confidence that CD157 is an authentic and/or actionable molecular participant in OT-dependent social

167 S) as a biologically distinct and clinically actionable molecular subset of SCCs that are uniquely am

168 ion in DIPG and ERK5 as a novel, immediately actionable molecular target.

169 athways that interact with them, and discuss actionable molecular targets, therapeutic agents in clin

170 rofiling of tumours can identify potentially actionable molecular variants for which approved antican

171 r-related deaths in China due to the lack of actionable molecules.

172 ropose that the application of smarter, more actionable monitoring and decision support systems and a

173 lationship of actionable and incidental (non-actionable) MRI findings and NDD diagnoses together with

174 A locally actionable mutation (i.e., available targeted treatment

175 However, the same 'actionable mutation' impacts distinct context-specific g

176 y of targeted therapies showed theoretically actionable mutations (i.e., mutations for which targeted

177 equent in GBC and associated with coexisting actionable mutations and a high TMB.

178 ermine the concordance in the frequencies of actionable mutations and copy number alterations/aberrat

179 quences of somatic mutations and identifying actionable mutations and the related drug responses curr

180 anticancer agents, but the identification of actionable mutations are often constrained by the incomp

181 ugs include (1) the timely identification of actionable mutations at diagnosis and at relapse; (2) de

182 (17.5%; 95% CI, 15.3%-19.9%) had clinically actionable mutations conferring cancer susceptibility, i

183 gest the identification of these potentially actionable mutations could have clinical significance fo

184 l cell lung cancer (NSCLC), SCLC harbors few actionable mutations for therapeutic intervention.

185 DCs can partially recapture the tumor tissue actionable mutations from 161 patients with ESCC.

186 Identifying actionable mutations has led to potential new targets, w

187 used widely as a diagnostic tool to identify actionable mutations in cancer patients.

188 ct targeted drug sensitivity associated with actionable mutations in ESCC.

189 Although panel sequencing for actionable mutations in plasma is moving towards the cli

190 studies were performed to identify potential actionable mutations predictive of drug response, which

191 psy specimen revealed adenocarcinoma with no actionable mutations present.

192 ealed that most medulloblastomas do not have actionable mutations that point to effective therapies.

193 er pharmacogenomics (KNMPx), for identifying actionable mutations that rewired signaling networks and

194 llele frequency (VAF) threshold was applied, actionable mutations were identified in 41 of 100 patien

195 red median overall survival in patients with actionable mutations who were treated with a matched the

196 Most melanomas had potentially actionable mutations, most in components of the mitogen-

197 ore, it may not define sufficiently accurate actionable mutations, neglecting those that are rare.

198 acilitated the development of therapies with actionable mutations.

199 nerability for TNBCs lacking therapeutically actionable mutations.

200 Integration of these two fields into actionable new concepts in the timing of food intake has

201 ormation can potentially be used to identify actionable nodes for targeting TNBC, a breast cancer sub

202 ions across the spectrum of this disease are actionable; not the absence of actionable variables them

203 Multiple actionable or resistance-conferring tumor mutations were

204 r human microbiome studies to translate into actionable outcomes for health, meta-analysis of reprodu

205 provide evidence for KDR being a clinically actionable PAH gene and further support the central role

206 We identified actionable pathogenic variants in 8 known hereditary can

207 , diverse states had 8% to 15% prevalence of actionable pathogenic variants.

208 e pivotal switch of a novel broad-acting and actionable pathway controlling EGFR signaling, and drivi

209 ecule Nrp2 as the pivotal switch of a novel, actionable pathway driving EGFR upregulation and resista

210 ce, the Nek6-Hsp72 module represents a novel actionable pathway for selective targeting of cancer cel

211 Here we identify a pharmacologically actionable pathway that controls cellular clearance via

212 y, recent studies have uncovered potentially actionable pathways, which support the prediction that f

213 vention; (2) a web-based dashboard providing actionable, patient-level feedback; and (3) pharmacists

214 Our IBD analyses reveal actionable patterns, including isolated parasite populat

215 In addition, we find potentially clinically actionable PI3K signalling mutations in 16% of cases.

216 s of the scientific crowd into practice with actionable plans.

217 gulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 axis.

218 tablished and proceeded to conduct concrete, actionable problem solving in 4 high-impact areas in car

219 ection and structured peer review leading to actionable quality interventions.

220 entability-score-statistics') identified Six-Actionable Recommendation Themes (SART) as a framework t

221 We also propose guidelines for practical, actionable recommendations for the deployment of managem

222 cape of GM scholarship in Africa and propose actionable recommendations to improve research capacity

223 luate the certainty in evidence and generate actionable recommendations.

224 inase (RTK) fusions have emerged as rare but actionable resistance mechanisms.

225 wabs have a significantly shorter time to an actionable result than bulk fecal specimens (median, 67.

226 mmon blood pathogens, and enables clinically actionable results to be released much earlier than with

227 which are challenging to synthesize down to actionable results with a clear interpretation.

228 Background Identifying actionable resuscitation practices that vary across hosp

229 that the DMP can have more thematic, machine-actionable richness with added value for all stakeholder

230 This study expands the landscape of actionable RNF43 mutations, extending the benefit of the

231 Yet, the goal of developing actionable, robust, and reproducible predictive signatur

232 WBC and PLT counts were the most actionable routine tests for excluding anaplasmosis.

233 proach can be used by nonstate actors to set actionable scope 3 targets and to build climate-compatib

234 therefore, most likely to be therapeutically actionable.See related article by Hanrahan et al., p.

235 d in vivo analyses, we identify a simple and actionable set of 'rules'.

236 Here, we report on the discovery of an actionable signaling pathway utilized by metastatic tumo

237 for molecular analyses, thereby identifying actionable somatic alterations in more patients.

238 Actionable somatic alterations were detected in 73% of t

239 Actionable somatic alterations were identified.

240 e to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors(2,3).

241 resistance to immunotherapy are elucidated, actionable strategies to prevent or treat them may be de

242 is regimen in vivo and identify a clinically actionable strategy to combat drug resistance.

243 tely stratify mCRPC patients into clinically actionable subgroups.

244 oach, we devise a general workflow to define actionable subtypes in human cancers.

245 earch and our ability to identify clinically actionable subtypes of disease.

246 We conclude with actionable suggestions for cultivating a more prosocial

247 de important functional information to guide actionable target and biomarker discovery.

248 The identification of an actionable target downstream of RB1, inactivated in SCLC

249 mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy.

250 this variation and represents an immediately actionable target for increased cost efficiency.

251 remodeling and represents pharmacologically actionable target for the inhibition of aggressive mesen

252 Our data highlight a downstream actionable target in RB1-deficient cancers, for which th

253 f the upper pilosebaceous unit and may be an actionable target in the treatment of acne.

254 These data reveal a potential actionable target that may be exploited for efficient re

255 evel ITH in ESCC, identify several potential actionable targets and may provide novel insight into ES

256 t into host-pathogen dialog that may furnish actionable targets for antiparasite therapies or vaccine

257 ive rise to oncogenic gene fusions can offer actionable targets for cancer therapy.

258 elop immune memory to infection, pointing to actionable targets for immunotherapy.

259 s and stratification, as well as to identify actionable targets for informing molecularly guided ther

260 and its signaling pathway may serve as novel actionable targets for PEL management.

261 stage approach, this study validates several actionable targets for preventing depression.

262 t for building this CMBCD model is to expose actionable targets for prevention to achieve optimal car

263 h the genomic landscape of ASCP and identify actionable targets for this lethal cancer, we applied DN

264 Actionable targets found in a single MB biopsy were seld

265 Thus, identifying actionable targets in treatment-naive and chemoresistant

266 We identified therapeutically actionable targets including kinesin spindle protein (KS

267 l conditions for which the identification of actionable targets is urgently needed.

268 identified practical diagnostic markers and actionable targets of the failed immune response.

269 Potentially actionable targets to disrupt this RAS-dependent nutrien

270 deficiency in NEPC, which offers potentially actionable targets to prevent therapy resistance in PCa.

271 esistant prostate cancer (CRPC), identifying actionable targets, and emerging resistance mechanisms.

272 ling pathway and are candidate drug targets (actionable targets, n = 132; 4%), as well as gene fusion

273 bona fide cancer drivers and therapeutically actionable targets, requires functional testing.

274 rations that include previously undiscovered actionable targets.

275 ing tumor biology and identifying clinically actionable targets.

276 ple condense general physical knowledge into actionable, task-specific plans to achieve flexible and

277 ultiplex respiratory panel with a clinically actionable TAT is associated with reduced hospital admis

278 at TGFbeta/SMAD3 inhibition may represent an actionable therapeutic approach for a subset of aggressi

279 least sensitive, these findings may lead to actionable therapeutic strategies that consider SCLC int

280 serving as both a trackable biomarker and an actionable therapeutic target for breast cancer.

281 the HuR-IDH1 regulatory axis as a critical, actionable therapeutic target in pancreatic cancer.

282 mitochondrial OXPHOS pathways could offer an actionable therapeutic target in the clinic.

283 ciated with these alterations that represent actionable therapeutic targets are less well established

284 These findings reveal a new arsenal of actionable therapeutic targets to drive clinically relev

285 n of driver mutations, and identification of actionable therapeutic targets, as well as a clearer pic

286 In summary, BRAF fusions are actionable therapeutic targets, however there are signif

287 rofiling to guide prognosis and selection of actionable therapeutic targets.

288 ic landscape of sRCC and uncover potentially actionable therapeutic targets.

289 BTC include a significant number of putative actionable therapeutic targets.

290 However, stroke risk crossed an actionable threshold defined as >1%/y in patients with a

291 toward a shared goal of making DMPs machine-actionable to improve the experience for all involved by

292 er, there is a paucity of readily available, actionable tools capable of predicting IH occurrence at

293 PRT is shown to generate a pharmacologically actionable tumour cell dependence for survival.

294 s disease are actionable; not the absence of actionable variables themselves.

295 w that 2% of this population has a medically actionable variant.

296 pies, and have malignancies with potentially actionable variants for which no approved anticancer dru

297 te that a significant fraction of clinically actionable variants have low VAFs, often due to low tumo

298 In the absence of other actionable variants the patient was administered MEK inh

299 antly accelerate the discovery of clinically actionable variants.

300 nsitivity since the IPO4-CEBPD-PRKDC axis is actionable via NU7026 (PRKDC inhibitor) or targeting IPO