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1 ormationally restricted form that is readily activatable.
2 whereas Stx2, Stx2c, Stx2e and Stx1 are not activatable.
3 in the cardiac lymph remained latent but was activatable.
10 osteogenesis in vivo, we coadministered catS-activatable and calcification-targeted molecular imaging
11 l at the site of target expression but shows activatable and differential contrast depending on their
13 gments and nontraditional binding scaffolds, activatable antibodies, bispecific antibodies, immunocyt
15 has tremendous therapeutic potential as H2O2-activatable antioxidant prodrug for the treatment of I/R
17 We propose that synthetic biological light-activatable arrays, produced with soft materials, might
19 ious than ACh, and shows that ACR-8 can form activatable binding-sites, thus opening doors for elucid
20 work, we describe in situ polymerization of activatable biorthogonal small molecules in response to
21 h submicron resolution, we developed a force-activatable biosensor named integrative tension sensor (
22 derate bone-binding drug risedronate to a pH-activatable BODIPY fluorophore enables the probe to pene
23 Conversely, inhibitors that do not orient an activatable bond in this manner, such as glutarate and c
25 cent years have seen the development of PPGs activatable by biologically and chemically benign visibl
26 a1(II) promoter an inert form of Cre that is activatable by exogenous tamoxifen (TM); TM administrati
29 med the jump muscle to be moderately stretch-activatable by replacing its myosin isoform with an embr
30 nt pathogenic clones frequently express TCRs activatable by ubiquitous autoantigens presented by clas
33 V-Cre or WAP-Cre in combination with the Cre-activatable CAG-CAT-EGFP construct, we find stronger exp
39 ct apoptosis in vivo, a novel cell-permeable activatable caspase substrate, TcapQ647, was synthesized
41 nce of dendrimeric nanoparticles coated with activatable cell penetrating peptides (ACPPs), labeled w
44 be selectively delivered to tumors using an activatable cell-penetrating peptide targeting matrix me
45 get, proteolytic enzyme MMP-2, the probe, an activatable cell-penetrating peptide, Ceeee[Ahx]PLGLAGrr
47 hod to visualize tumors during surgery using activatable cell-penetrating peptides (ACPPs), in which
48 nds (i.e., EGFR-specific GE11 peptide), acid-activatable cell-penetrating peptides (i.e., TH peptide)
51 such as the modified Volvox carteri ChR1 red-activatable channelrhodopsin ("ReaChR," lambdamax = 527
52 Here we show that a recently described red activatable channelrhodopsin (ReaChR) permits control of
53 ort the novel chemical design of fluorescent activatable chemokines as highly specific functional pro
56 Taken together, the results suggest that activatable chemotherapy can enhance adjuvant immunother
57 We engineered a variant of ChR, denoted red-activatable ChR (ReaChR), that is optimally excited with
61 and its subsequent inactivation by thrombin-activatable CPB (generating OPN-L) occurs locally within
66 ations ranging from the development of light-activatable cysteine-containing peptides to the developm
68 bstitution of Tyr(B16) by an isosteric photo-activatable derivative (para-azido-phenylalanine) enable
70 intermediate complexity harboring weak, but activatable, electrophiles are matched with the protein(
71 cellular force imaging, we developed a force-activatable emitter reporting single-molecular tension e
72 by targeted integration of a Cre recombinase-activatable expression cassette driven by the cytomegalo
73 gregates and competitively inhibits thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2)
74 r (TFPI) and reduction in levels of thrombin activatable fibrinolysis inhibitor (TAFI) and fibrinogen
76 ediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby he
78 n, and inhibiting thrombomodulin or thrombin-activatable fibrinolysis inhibitor (TAFI) normalized PG,
79 ced fibrinolysis secondary to lower thrombin activatable fibrinolysis inhibitor (TAFI) production.
80 te the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated
84 I)-deficient plasma by an activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-dependent mec
87 entage of white cells with LAS, and thrombin-activatable fibrinolysis inhibitor activation peptide an
88 omplications of VTE, attenuation of thrombin activatable fibrinolysis inhibitor activity is under inv
89 nhibitor 1, and decreased levels of thrombin-activatable fibrinolysis inhibitor and alpha2-antiplasmi
90 in degradation product D-dimer, and thrombin-activatable fibrinolysis inhibitor by ELISA in 118 monoz
91 lasminogen activator inhibitor-1 or thrombin-activatable fibrinolysis inhibitor display modest phenot
92 % heritability, and that of zymogen thrombin-activatable fibrinolysis inhibitor showed a very strong
93 asminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor succumb to yersiniosi
94 fibronectin binding protein A, and thrombin-activatable fibrinolysis inhibitor were examined directl
95 asmin-antiplasmin complex, D-dimer, thrombin activatable fibrinolysis inhibitor, and lipoprotein(a) f
96 ce deficient in alpha2-antiplasmin, thrombin-activatable fibrinolysis inhibitor, or fibronectin, indi
97 rboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-termin
100 hesis of a folate-doxorubicin conjugate with activatable fluorescence and activatable cytotoxicity.
101 imultaneous injections with Prosense-680, an activatable fluorescence sensor reporting on cathepsin a
103 esolution intravital microscopy with a photo-activatable fluorescent albumin marker to simultaneously
106 al for clinical implementation of a nuclease-activatable fluorescent probe for early diagnosis of SAB
107 escence molecular tomography and a cathepsin-activatable fluorochrome to image autophagy in the heart
113 neutravidin-biotin binding with an attached activatable fluorophore) could be useful in tumor-specif
115 oading cells with a cell-permeable and photo-activatable fluorophore, NPE-HCCC2/AM (acetoxymethyl est
117 innovative structural design translates into activatable fluorophores with excellent photochemical an
118 ate this issue further, we have expressed an activatable form of hepsin, and have generated a set of
120 approach to quantify and predict the loss of activatable GABA(A) receptors due to desensitization in
121 agnetic resonance imaging of MPO with an MPO-activatable Gd-chelate revealed a spatially defined T1-w
125 1, was reported, which complements the photo-activatable GFP by providing a red super-resolution colo
129 framework of a genetically encodable, light-activatable heterodimerizer system, the actin-remodellin
131 rter tool is reported that can be used as an activatable imaging agent to monitor macrophage immunoth
132 ational design and screening of targeted and activatable imaging reporter agents to sense fundamental
133 In conjunction with the cysteine protease-activatable imaging reporter Prosense VM110 (VisEn Medic
136 vesicle to stratify radiotherapy response by activatable inflammation magnetic resonance imaging (aiM
137 nt manner through activation of the thrombin activatable inhibitor of fibrinolysis, and in a thrombin
140 to model this event, we crossed conditional activatable K-ras(G12D/WT) mice with the prostate condit
142 f the assay allowed the determination of the activatable levels of TAFI in human and other animal pla
146 ral crosstalk between Dr-Trks and blue-light-activatable LOV-domain-based translocation system enable
147 n anti-alphaIIbbeta3 mAb fused to a thrombin-activatable, low-molecular-weight pro-uPA (PLT/uPA-T).
149 delivery have taken inspiration from natural activatable materials like zymogens, membrane proteins,
151 we demonstrate that alpha-catenin is a force-activatable mechanotransducer at cell-cell junctions by
152 nted herein is the design of a redox stimuli activatable metal-free photosensitizer (aPS), also funct
153 gy based on systemic administration of tumor-activatable minicircles that use the pan-tumor-specific
157 hina et al. intravitreally deliver the light-activatable molecule acrylamide-azobenzene-quaternary am
158 ethods for targeting the expression of light-activatable molecules to specific cell types, under gene
159 rofiles, suggest potential of the iRGD-based activatable monolithic peptide probe as a promising imag
160 her conjugation, the dye/quencher-conjugated activatable monolithic peptide probe visualized tumor re
161 consists of purified microtubules and light-activatable motor proteins that crosslink and organize t
163 performed after intravenous injection of the activatable MPO sensor (bis-5-hydroxytryptamide-diethyle
165 We report here that a functional, enzyme-activatable MRI agent can accurately track the oxidative
167 eport the development of "opto-MOR," a light-activatable mu opioid receptor (MOR) chimera that can be
168 neral strategy to produce pH-tunable, highly activatable multicolored fluorescent nanoparticles using
173 om simple inert carriers of radioactivity to activatable nanomaterials for both diagnostic and therap
174 has been recent growth in the development of activatable near-infrared (NIR) fluorescent probes for m
175 rly in living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far
176 optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) probe can
178 mouse model of ovarian carcinoma with enzyme-activatable near-infrared probes sensitive to tumoral pr
179 ed a NAD(P)H quinone oxidoreductase 1 (NQO1)-activatable NIR fluorescent probe (NIR-ASM) by conjugati
186 received an injection of a cysteine protease-activatable NIRF imaging agent (Prosense750; excitation/
188 -mediated activation of a pyrophosphorolysis-activatable oligonucleotide (P*) followed by extension o
194 ions were incubated for 1 h with the "smart" activatable P2&3TT probe, the total assay time being les
195 ntrol, demonstrating the first aptamer-based activatable PA probe for advanced molecular imaging in l
196 MMP-positive MDA-MB-231 tumor tissue by MMP-activatable PA-L1 (5.98 +/- 0.62 %ID/g) but not by furin
197 ion sequence, DEVD, and a flanking optically activatable pair comprising a far-red quencher, QSY 21,
200 compare the efficiency of other fluorescent activatable phospholipase probes as suitable molecular i
204 monstrate these concepts of "tumor-targeted, activatable photoimmunotherapy" in a mouse model of peri
209 This study represents the first hypoxia-activatable phototherapeutic polymeric prodrug system wi
210 l in rat hippocampal neurons created a light-activatable PIRK switch for suppressing neuronal firing.
211 plex revealed a significant increase of cAMP-activatable PKA activity that was associated with a sign
212 f coagulation required the presence of fully activatable platelets and was not ascribable to platelet
213 y (PDT), we designed a smart plasma membrane-activatable polymeric nanodrug by conjugating the photos
216 ribe the design and synthesis of a targeted, activatable probe for photoacoustic imaging, which is re
217 the design, synthesis, and evaluation of an activatable probe that shows great promise for enabling
218 at all tumors were visible with the protease-activatable probe, even when they were not readily appar
221 The utility of SPNs for designing smart activatable probes for real-time in vivo imaging is also
223 lular biomarkers, if and only if there exist activatable probes that appropriately respond to the bio
224 k of previously uncharacterized targeted and activatable probes that are excited by a nuclear decay-d
225 c probes is dependent on the availability of activatable probes that respond rapidly and selectively
227 Several targeting moieties, including enzyme-activatable probes, antibodies, peptides, and lectins, h
230 it and the cytotoxic doxorubicin, a targeted activatable prodrug is obtained that becomes activated (
231 hese problems, we prepared the far-red light-activatable prodrug of PTX by conjugating photosensitize
232 vivo efficacy of the novel low-energy-light-activatable prodrug using the photo-unclick chemistry.
234 anhydrides) showed the most promise as acid-activatable prodrugs under mildly acidic conditions foun
236 in the putative TetD binding site of a TetD-activatable promoter and a mutation in the protein's N-t
238 The recent development of synthetic photo-activatable proteins designed using the light-oxygen-vol
242 Using these progenitors and a conditionally activatable PU.1 protein, we show that PU.1 can negative
243 ting, phosphorylated Raf-1, representing the activatable Raf-1 pool, is the Raf-1 subpopulation targe
244 to their cell and organelle permeability and activatable reactivity, could be considered for the deve
245 demonstrate their translatability using a NE-activatable reagent to evaluate inflammation in DSS mice
247 stasis-related genes, including the thrombin-activatable receptor PAR-1 (protease-activated receptor-
249 approximately 60% or the fraction of Ca(2+)-activatable regulatory units was reduced to approximatel
251 endogenous SM22alpha locus combined with Cre-activatable reporter genes that were integrated into the
253 Using QCM-D crystals modified with a photo-activatable RGD peptide, the time point of presentation
254 ity was also observed in rods containing non-activatable rhodopsin, ruling out transactivation of rho
256 Herein we describe a quantitative redox-activatable sensor (qRAS) for the real-time monitoring o
257 have used a small-molecule, gadolinium-based activatable sensor for magnetic resonance imaging of MPO
258 that alpha-catenin is a reversible, stretch-activatable sensor that mechanically links cadherin comp
259 , we report the construction of fluorescence-activatable sensors to detect the activities of flavivir
261 maging microcatheters combined with protease-activatable smart probes results in a beacon effect that
262 asms after the intravenous administration of activatable "smart" probes that increase in NIR fluoresc
264 cle AChR macroscopic currents in the resting/activatable state with approximately 100-fold higher pot
270 arries two functional alleles for the potent activatable Stx2 variant toxin, Stx2d, for the presence
274 endothelial NO synthase, which serve as PKA-activatable substrates, inhibits the tube formation, whe
275 se VEGF receptors, but these were not active/activatable suggesting that inherent differences between
278 me catabolism) as well as establishing tumor-activatable systems for cancer imaging and drug delivery
280 sonance tuning (TMRET) nanoprobe with dually activatable T(1) and T(2) magnetic resonance signals tha
282 Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar a
284 arent association between the level of Stx2d-activatable toxin produced by an STEC strain and the sev
285 efficiently quenched by it being bound to an activatable trigger group through a novel self-immolativ
289 rough the use of cell-penetrable, bioanalyte-activatable, turn-on probes is dependent on the presence
290 investigate potential use as an acoustically activatable ultrasound contrast agent, with the hypothes
291 n vitro cross-linking experiments with photo-activatable unnatural amino acids, we show that full-len
292 This suggests that Hsp27, which is otherwise activatable upon heat shock, remains inactive in the R6/
293 H21 strain B2F1, an isolate that produces an activatable variant of Stx2 (Stx2d) and is lethal to mic
297 tions, we show here for the widely used, red-activatable Volvox carteri channelrhodopsin-1 derivate R
298 hea, but isolates containing stx2c or stx(2d-activatable) were recovered more often from patients who