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1 ely facilitates interaction with the agonist-activated form of a G-protein-coupled receptor (R*) and
2 ing CDX activity by ectopic expression of an activated form of a Xenopus Cdx gene (XcadVP16) in the h
6 ng antibodies recognizing the phosphorylated/activated form of AKT kinases, we observed elevated phos
7 nsgenic mice expressing a membrane-targeted, activated form of Akt under control of the 2',3'-cyclic
9 characterized by combined overexpression of activated forms of AKT and neuroblastoma Ras viral oncog
11 ells ectopically expressing a constitutively activated form of Akt3 or endogenously expressing mutant
12 the TGF-beta signaling pathway by expressing activated forms of ALK-1 and ALK-5, type I receptors for
16 precursor cells, we conditionally express an activated form of an FGF receptor or delete the FGF rece
17 compound failed to significantly suppress an activated form of another RTK, the Drosophila epidermal
18 Moreover, the co-expression of Cat-1 and an activated form of Arf6 in fibroblasts was sufficient to
19 phila Arfaptin protein directly binds to the activated forms of Arf6 and Rac1 GTPases, and mutants in
20 Studies in Drosophila have revealed that an activated form of Armadillo, the effector of Wnt signall
25 sponse, characterized by the accumulation of activated forms of ATM and Chk2 as well as nuclear foci
27 In converse, conditional expression of an activated form of beta-Catenin leads to expansion of Nkx
29 encoding either a stabilized, constitutively activated form of beta-catenin or a dominant negative fo
31 gene transfer to force the expression of an activated form of beta-catenin that should constitutivel
32 mportance, we have targeted expression of an activated form of beta-catenin to the urothelium of tran
35 etroviral transduction of the constitutively activated forms of both GTPases into primary murine macr
36 d in mice through the combined expression of activated forms of both KRas and Akt in glial progenitor
37 (RCAS)/TVA system to transfer genes encoding activated forms of BRAF, KRas, Akt and Cre to nestin-exp
38 ion has attracted considerable interest, and activated forms of BRAF, such as BRAF(V600E), have becom
40 to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a membe
42 gle-molecule level: C3b, the proteolytically activated form of C3, and factor H (FH), the surface-sen
46 o the cytoplasm and the nucleus, whereas the activated forms of calpain-7 and -10 are found only in t
47 tion, whereas expression of a constitutively activated form of CaMKII mimicked the effects of morphin
48 nogenic soft agar assay and detection of the activated form of caspase-3 and cleavage of poly(ADP-rib
52 genesis of C431 resulted in a constitutively activated form of CBS that could not be further activate
53 Cat-1 from NIH3T3 fibroblasts expressing an activated form of Cdc42 (Cdc42 F28L), or from the human
54 sed an assay in yeast where expression of an activated form of Cdc42, a Rho-type guanosine triphospha
56 Da protein that formed a stable complex with activated forms of Cdc42 and thereby showed characterist
58 We demonstrate that CRL4(CDT2) targets the activated form of CHK1 for destruction in the nucleoplas
59 ocalization of the phosphorylated, therefore activated, form of cJun, a JNK target in dorsal root gan
62 nesis and lipolysis, forced expression of an activated form of CREBH protein in the liver significant
65 uorescein, fluorescein and resorufin with an activated form of cyclic trimetaphosphate to give interm
66 clease-coupled DNA methylation assay with an activated form of Dnmt1 engineered to lack the replicati
68 three-dimensional structures of the apo and activated forms of DtxR show conformational changes in t
69 ratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that
70 tudies, the effects of a novel conditionally activated form of EGF-R, v-ErbB:ER, on the morphological
72 somal maturation assay and observed that the activated form of EhRab35 significantly increased the ra
73 ther contexts, and MsEphrin colocalizes with activated forms of endogenous Src in the leading process
74 xide synthase (r(part) = 0.46, P = 0.02), an activated form of endothelial nitric oxide synthase.
75 gested that evaluation of the phosphorylated/activated form of ErbB-2 might be more precise in defini
76 etastases of uveal melanoma patients express activated forms of ERBB2 (the coreceptor for ERBB3) and
80 Mutant tibiae have increased levels of the activated form of ERK1/2, consistent with the idea that
82 y, FHL2 interacted more efficiently with the activated form of ERK2 than with the dephosphorylated fo
83 partate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase
86 veral multiple myeloma cell lines expressing activated forms of FGFR3, NDGA generally resulted in a d
87 efects are associated with low levels of the activated forms of focal adhesion kinase (FAK) and extra
91 ed receptor kinases (GRKs) phosphorylate the activated form of G protein-coupled receptors leading to
92 alian cells that these RhoGEFs interact with activated forms of G alpha 12 or G alpha 13 through thei
93 ounced with the mutationally or functionally activated form of Galpha(13) compared to that of wild-ty
99 ounced with the mutationally or functionally activated form of Galpha13 as compared with the wild-typ
102 Conversely, expression of a constitutively activated form of GSK3beta sensitized cancer cells to mT
103 he global gene expression pattern induced by activated forms of H-Ras, RhoA, Rac1 and Cdc42 using cDN
104 e report that expression of a constitutively activated form of HIF2alpha (P405A, P530A, and N851A, na
105 of inhibitors shows higher affinity for the activated form of Hsp90 compared to our earlier 8-sulfan
109 NSP1 can induce degradation of inactive and activated forms of IAD-containing IRF proteins (IRF3 to
111 We investigated whether mice that express an activated form of IKKbeta in the esophageal epithelia de
112 uced platelet aggregation, expression of the activated form of integrin alphaIIbbeta3, and exposure o
113 ells engineered to express human SERT and an activated form of integrin beta3 exhibited enhanced SERT
114 the structural features associated with the activated form of Itk, we have solved the NMR structure
120 umors that developed in mice that express an activated form of Kras (Kras(LSL-G12D/+);Ptf1a(Cre/+) mi
122 m with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreati
123 2H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pa
124 ic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, a
126 some detail in bacteria and plants, but the activated form of l-Rha and the corresponding biosynthet
127 tact, TCR microclusters are colocalized with activated forms of Lck, ZAP-70, and the linker for activ
128 rved following overexpression of Pitx2 or an activated form of Lef1, suggesting an effect on cell pro
130 nonical Wnt signaling stimulated by Wnt1 and activated forms of LRP5 (low density lipoprotein recepto
132 ferentially interact with the phosphorylated/activated form of MAD, and Nup93 acts to recruit the imp
133 defects due to loss of Msk are rescued by an activated form of MAPK or the secreted epidermal growth
137 xpressed dominant-negative or constitutively activated form of MEK5 to inhibit or activate the MEK5-E
138 lls with CP-654577 reduces the levels of the activated form of mitogen-activated protein kinase, incr
139 lpha/beta activity, and the expression of an activated form of MKK6 (an immediate upstream activator
141 edium, is between the intermediate and fully activated forms of MMP-2 induced by membrane type 1-MMP.
143 ction in myogenic processes, we expressed an activated form of mouse calcineurin A in Drosophila and
144 ncogenic stress and that the phosphorylated (activated) form of MSK1 is significantly increased in th
145 rmined by analysis of the phosphorylated and activated forms of mTORC1 signaling proteins in the pref
146 yzed hydroacylation between aldehydes and an activated form of N=N bond was achieved under mild condi
149 MM cells from all the patients expressed the activated forms of NF-kappaB and STAT3 but to a variable
150 marrow of 22 MM patients and checked for the activated forms of NF-kappaB and STAT3 by immunocytochem
157 -inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like
158 l of Notch1 in solid tumors, we expressed an activated form of Notch1 (N1ICD) in the developing mouse
161 :nicd1a transgenic embryos overexpressing an activated form of notch1, nicd1a, displayed increased cp
162 ferent studies of transgenic mice expressing activated forms of Notch1 (Notch1IC) led to conflicting
163 and brain, we injected retroviruses encoding activated forms of Notch1, Notch2, or Notch3 into embryo
164 n this study, we show that the effects of an activated form of Notch2 (N2IC) on the T-cell lineage ar
165 the effects of conditional expression of an activated form of NOTCH2 (pL2.Lgr5.N2IC), conditional de
167 conclude that there is no accumulation of an activated form of O2 before C-H abstraction in the Dbeta
169 nhibition induced apoptosis, as evidenced by activated form of PARP, caspases-3 and was suppressed by
172 e-introducing expression constructs encoding activated forms of phosphoinositide 3-kinase, Akt, or Ak
173 Subsequent studies demonstrated that an activated form of PI 3-kinase restored Rac GTP loading i
174 , but not HIV infection alone, contained the activated form of PKR, which localized predominantly to
175 dy specific for the tyrosine-phosphorylated, activated form of PLCgamma1, we now show that chronic mo
176 ing SKN-1, the MEDs, PAL-1, and the Wnt/MAPK-activated form of POP-1, are responsible for activating
177 cretion by strains containing a mutationally activated form of prfA, the key regulator of L. monocyto
178 t that hES cells localize a conformationally activated form of proapoptotic BAX to the trans Golgi ne
179 on of 3'-phosphoinositol lipids (PI3Ps), the activated form of Rac, a small GTPase, and F-actin.
183 We investigated whether expression of the activated form of Ras in gastric chief cells of mice lea
188 arily muscle-forming mesoderm, and expressed activated forms of Ras or Notch to induce FC or FCM fate
190 We show that, in Dictyostelium discoideum, activated forms of RasC prolong the time course of TORC2
196 This phenotype can be recapitulated using an activated form of RhoA and rescued by inhibiting Rho-kin
198 solid tumors, we established a conditionally activated form of ROCK II by fusing the kinase domain to
200 luble guanylyl cyclase (sGC) itself, the NO -activated form of sGC, and phosphodiesterase(s) (PDE).
201 re known mutations predicted to result in an activated form of Shp2, whereas six are new mutations.
202 In this study, the biosynthesis of this activated form of sialic acid completely from endogenous
203 antibody specific for the phosphorylated and activated form of Smad1 to examine endogenous patterns o
210 ached high levels in the mother cell; (2) an activated form of Spo0A impaired sporulation when produc
213 -Tyr containing proteins, an antibody to the activated form of Src-family PTKs was used to localize a
214 othelial cell-specific overexpression of the activated form of SREBP2 synergized with hyperlipidemia
215 Stat3 protein levels and the levels of the activated form of Stat3 (pStat3) at P12, P15, P18, and P
217 pression were increased by overexpressing an activated form of Stat3 but decreased by attenuation of
218 , while the introduction of a constitutively activated form of Stat3 into immortalized human breast e
219 ereas the overexpression of a constitutively activated form of STAT3 promoted HSC senescence through
220 correlation between increased levels of the activated form of Stat3, phosphorylated-Stat3, and incre
221 igodendrocytes; (2) the overexpression of an activated form of STAT5 prevents alpha-amino-3-hydroxy-5
222 Transgenic mice expressing a constitutively activated form of STAT5b have been shown previously to c
224 n addition, we demonstrate expression of the activated form of STAT6, a mediator of IL-4 signaling, b
226 fonyl transfer, and nodPQ, which produce the activated form of sulfate, 3'-phosphoadenosine-5'-phosph
227 These enzymes function together to produce activated forms of sulphate, APS and PAPS (3'-phosphoade
229 the embryo and antagonizes the ability of an activated form of Tar/Acvr1b to induce endoderm at the a
230 misexpressing dominant-negative and dominant-activated forms of Tbx5 in the chick wing we provide evi
231 C-893 selectively killed cells expressing an activated form of the anabolic oncogene Ras in vitro and
232 gulated by the polarized distribution of the activated form of the Cdc42 protein, rather than by the
233 Transgenic mice expressing a constitutively activated form of the cellular homologue Akt2 specifical
234 ate that albicin specifically recognizes the activated form of the complex, allowing more efficient i
235 neered to inducibly express a constitutively activated form of the cyclic AMP-dependent protein kinas
236 Conversely, expressing a constitutively activated form of the Drosophila JAK kinase (hop(Tum-l))
238 is required to stabilize the lifetime of the activated form of the enzyme against reoxidation of Fe(H
239 ss spectrometry data show that the TIH-bound activated form of the enzyme closely resembles the inhib
240 )(III) couple), the kinetic stability of the activated form of the enzyme has been greatly diminished
242 hat while the thermodynamic stability of the activated form of the enzyme is unchanged (characterized
246 ) to the Golgi complex is initiated when the activated form of the GTPase Sar1p recruits the Sec23p-S
247 ted cells is rescued by the expression of an activated form of the immediate upstream p38-activating
249 d levels of expression of fibronectin and an activated form of the integrin alphavbeta3, which coordi
250 Here, we describe a mouse line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1),
251 ctive form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin, determined
252 ne to enforce expression of a constitutively activated form of the Notch 4 receptor, we show that sig
253 wo known clock components [Lfng mRNA and the activated form of the Notch receptor (cleaved Notch intr
254 g the number of polar cells by expressing an activated form of the Notch receptor increases the numbe
255 ory progenitors, we transiently expressed an activated form of the Notch1 receptor (NICD) using a com
258 dose-dependent manner by coexpression of an activated form of the nuclear kinase Sik/BRK that hyperp
260 inant antibody (scFvSCE5), which targets the activated form of the platelet-integrin glycoprotein IIb
261 s a crucial factor for stabilizing the light activated form of the protein, and have been used to pro
265 he intracellular domain of Notch, a dominant activated form of the receptor, is sufficient to prevent
267 steady-state level of the phosphorylated or activated form of the response regulator CheY dictates t
270 ted with high levels of immunoreactivity for activated forms of the BDNF receptor TrkB and beta1-inte
271 We also show that senescent cells contain activated forms of the DNA damage checkpoint kinases CHK
272 IB point mutations also disrupt signaling by activated forms of the kinase cascade scaffold protein S
274 tromal tumors (GISTs) express constitutively activated forms of the KIT receptor tyrosine kinase prot
275 ption factor lhx1a, and forced expression of activated forms of the lhx1a gene product rescued nephri
279 Cell type- or region-specific expression of activated forms of the oncoproteins Harvey-Ras and AKT i
281 asses of FLT3 mutations cause constitutively activated forms of the receptor that are found in signif
285 Arrestins selectively bind to phosphorylated activated forms of their cognate G protein-coupled recep
286 bstrates and by detection of proteolytically activated forms of these caspases by Western immunoblott
287 unt of PKMzeta protein and the amount of the activated form of this kinase, phospho-PKMzeta (p-PKMzet
291 L-cmk decreased the nuclear content of SKI-1-activated forms of transcription factors SREBP-1, SREBP-
292 isplay substantially increased levels of the activated form of transforming growth factor beta, a pot
293 GF treatment results in the translocation of activated forms of TrkA to lipid rafts, and this localiz
295 Furthermore, selective expression of an activated form of UNC-43 in ADF neurons is sufficient to
297 sformed by IL-27R contain elevated levels of activated forms of various signaling proteins, including
299 nic mice that overexpressed a constitutively activated form of YAP (YAP(S127A)), and measured protein