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1 proliferative responses (referred to as an "activated state").
2 DA release (change in BPND from baseline to activated state).
3 dent transition from the intermediate to the activated state.
4 ng a dynamic switch between a dormant and an activated state.
5 osslinking of these two residues favored the activated state.
6 ce that stabilizes the channel in a pre-open activated state.
7 to lack of high-resolution structures of the activated state.
8 he resting state and others only in the GABA-activated state.
9 andom walk in both the basal and the agonist-activated state.
10 increase in GCLC expression kept HSCs in an activated state.
11 tion, and may cause the channel to be in the activated state.
12 ve coregulators additionally maintains their activated state.
13 tacts leading to stabilization of the GTPase activated state.
14 izing the voltage sensor of domain II in its activated state.
15 cific conformations were unable to reach the activated state.
16 stellate cells (HSC) from a quiescent to an activated state.
17 of activation markers, suggestive of a semi-activated state.
18 nteraction when the AChR is in the closed or activated state.
19 ons sample conformations consistent with the activated state.
20 ed antithrombin that locks the serpin in the activated state.
21 the retention of the entering ligand in the activated state.
22 SC2 phosphorylation and maintains TSC2 in an activated state.
23 present the heterotrimer core of SNF1 in its activated state.
24 play a role in its transcriptionally poised, activated state.
25 en that triggers the reaction, and are in an activated state.
26 suggested that AEA raised the energy of the activated state.
27 the conformational transition of S1P1 to its activated state.
28 pffer cells; only Fzb was expressed in their activated state.
29 is expressed in the nuclear localization and activated state.
30 and VI are only observed in complex with the activated state.
31 id microglia; the latter is indicative of an activated state.
32 the inhibitory segment of TnI in the Ca(2+)-activated state.
33 nteractions within the binding site into the activated state.
34 ose that the open form of SecA represents an activated state.
35 nts with sickle cell disease (SCD) are in an activated state.
36 ilibrium between reactants and a high-energy activated state.
37 rst solution structure of the allosterically activated state.
38 alpha1PI Pittsburgh, even in the nonheparin-activated state.
39 esponse regulator from a phosphorelay in its activated state.
40 shes the uniformity of the transcriptionally activated state.
41 sition to the pore domain in the resting and activated state.
42 rms by ligand binding returns the TSHR to an activated state.
43 nent C1s is present in dog joint fluid in an activated state.
44 mational freedom for the tetrapyrrole in the activated state.
45 VSD activations to the intermediate and then activated state.
46 stabilizing the voltage sensor domain in an activated state.
47 e voltage sensor from the deactivated to the activated state.
48 Immune cells cycle between a resting and an activated state.
49 available for maintaining WM contents in an activated state.
50 eterogeneous dark state to an ordered, light-activated state.
51 nd selectively recruited G proteins in their activated state.
52 uced conversion toward a mature inflammasome-activated state.
53 esponsive genes from a repressed state to an activated state.
54 These motions are moderated in the activated state.
55 rotein to progress from the basal toward the activated state.
56 es of the PH domain in its autoinhibited and activated states.
57 niporter holocomplex in inhibited and Ca(2+)-activated states.
58 egment moves outward to its intermediate and activated states.
59 ein structure in both dark-adapted and light-activated states.
60 alpha1I228C, alpha1Q229C and alpha1L232C in activated states.
61 lls than in naive CD8 T cells at resting and activated states.
62 explain U1-CPAFs' switch from repressive to activated states.
63 d in CD4+ T lymphocytes, both in resting and activated states.
64 r memory or naive cells in their resting and activated states.
65 gment spans the membrane in both resting and activated states.
66 ponses was present during both quiescent and activated states.
67 of human vinculin in its inactive and talin-activated states.
68 ular protein assemblies, including accessing activated states.
69 te the transit of stem cells from dormant to activated states.
70 uce neuromodulator-independent transition to activated states.
71 allosteric activation and suggested multiple activated states.
72 an allosteric equilibrium between native and activated states.
73 tforms assembling ULK1 and Beclin 1 in their activated states.
74 h these proteases in unactivated and heparin-activated states.
75 al networks, called the "desynchronized" or "activated" state.
76 during quiescent states and during aroused (activated) states.
77 low turnover (quiescent) and rapid turnover (activated) states.
78 r either 0 ms (closed state), 1.5 and 10 ms (activated states), 1 s (fast desensitized state), or > o
79 nt exometabolomic profiles in both naive and activated states; 2) approximately 30% of detected metab
80 increased in the resting (37%; P < 0.05) and activated state (26%; P < 0.005) in type 1 diabetic comp
81 the Arf family GTPases, in which a partially activated state, achievable from a receptor-mediated act
84 e, binding protons from the outside until an activated state allows proton transport to the inside.
85 of the TKD-EGFR resides in the cytosol in an activated state, although surface-localized subsets of t
86 n SSc, epidermal cells are in a persistently activated state and are able to promote dermal fibrosis.
87 n of c-Src with the beta3 tail occurs in its activated state and at a site that overlaps with PPII bi
88 he mechanisms that keep myofibroblasts in an activated state and control myofibroblast functions.
89 cling under conditions similar to the stress-activated state and indicate a clathrin/dephosphin-media
91 s, Lyn is constitutively bound to GPVI in an activated state and platelets lacking Lyn exhibit defect
92 and IXa in the native as well as the heparin-activated state and support a new model of allosteric ac
93 he Nox4 DH domain exists in an intrinsically activated state and that electron transfer from NADPH to
94 e GDP-bound inactive state and the GTP-bound activated state and their activation is predominantly me
95 e the energetic cost of attaining the GTPase-activated state and thereby decrease the stringency of d
96 s required to propel the B cell into a fully activated state and thus a normal humoral immune respons
97 ormational equilibrium between inhibited and activated states and that electrostatic interactions inv
100 oth mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-termi
101 animal-derived T lymphocytes were in a more activated state, and RNA sequencing analyses revealed hy
102 onformation for HER2 that resembles a ligand-activated state, and show HER2 poised to interact with o
103 s upon GTP binding, forming tetramers in the activated state, and stimulates the GTPase activity in a
104 e but is released from the core in the fully activated state, and the bulk of allosteric activation h
105 inactive {[Fe4S4]2+ Nip2+ Nid2+} state, the activated state appears to be 2-electrons more reduced,
107 ubiquitination in both the basal and ligand-activated states as well as delayed the processing of li
108 crystal structures of troponin in the Ca(2+)-activated state at 3.0 angstroms resolution and in the C
110 s capable of representing both repressed and activated states at the same time and in the same nucleu
111 h the transition from the unactivated to the activated state being induced by the templated NTP bindi
113 Spider Roll binds to full-length PAK1 in its activated state but does not bind PAK1 when it forms an
114 selectivity filter of KirBac1.1 in the open-activated state but that it may not directly enter the s
115 y associating with closed-resting and closed-activated states but a low affinity interaction with the
116 pping PM H(+)-ATPases in the phosphorylated, activated state, but how SAURs bind PP2C.D proteins and
117 ptured the voltage sensor module (VSM) in an activated state, but structure of the deactivated voltag
118 dendritic cells (FDCs) exist in resting and activated states, but are activated in germinal centers,
119 Leukocytes are thus maintained in a non-activated state by appropriate receptor clustering or re
120 I were examined in the dark and in the light-activated state by fluorescent probes and cysteine cross
121 tion R1441H traps Roc in a more persistently activated state by increasing its affinity for GTP and,
122 number of different stimuli to a chronically activated state by signaling through both purinergic and
123 dynamically converts these complexes to an "activated" state by phosphorylation events, primarily me
125 ate of the active site FeMo-cofactor into an activated state capable of reducing dinitrogen remains e
126 phages revealed markers characteristic of an activated state (CD80, CD86, Ly-6C/G), whereas macrophag
128 and subsequently switches the oxidase to an activated state dependent upon PtdIns(3)P and SH3 domain
132 s of GPCRs that are thought to be in a fully activated state, except that the cytoplasmic end of tran
133 unactivated state or the +2 DNA base in the activated state facilitates translocation via a ratchet
134 The structure of troponin in the Ca(2+)-activated state features a nearly twofold symmetrical as
135 u(2+) mediates the formation of a monomeric, activated state followed by the formation of a discrete
137 that Ror2 expression results in a partially activated state for canonical Wnt signaling through an i
139 odulate a voltage-dependent transition to an activated state from which Cl(-)/H(+) exchange can occur
141 by an unstable converter locus which in its activated state gives rise to a high nornicotine, low ni
142 sal activity, revealing that PDE5 in its non-activated state has low intrinsic catalytic activity.
144 in both unphosphorylated and beryllofluoride-activated states have been determined, revealing a mecha
145 nt of the cNMP/CRP family, which in the cAMP-activated state holds the C-terminal EAL enzyme in a pho
146 ression when the protein is not in its fully activated state; however, saturating levels of the prote
147 bound toxin traps the voltage sensor in the activated state in a voltage-dependent but concentration
152 -type maternal Rasgrf1 allele maintained its activated state in the next generation independently of
154 ate and a low H(+)/ATP coupling ratio and an activated state in which ATP hydrolysis is tightly coupl
155 by rapidly transiting from its resting to an activated state in which it serves as a receptor for lig
157 e them to maintain depolarized, persistently activated states in the absence of sustained input are p
160 adhesion and spreading in both the basal and activated states, increased F-actin content, and increas
161 te significantly impact sensory coding, with activated states increasing the reliability of responses
162 fines the dimer interface in the resting and activated state, indicates how ligand binding is coupled
163 s Xa and IXa in both unactivated and heparin-activated states, indicating that these residues made cr
164 1-layer 2 interactions also destabilize the activated state induced on HIV-1 by treatment with solub
166 xit of a stem cell out of quiescence into an activated state is characterized by major metabolic chan
168 ive-helix bundle protein lambda(6-85), whose activated state is significantly populated during foldin
170 cortical extrasynaptic glutamate during EEG-activated states is counteracted by a decrease during NR
171 that nucleotide release under both basal and activated states is likely an important mechanism for fi
172 Expression of Vav1 Y174F, which mimics its activated state, is a potent inducer of invadopodia form
174 consistent with these cells remaining in an activated state longer and undergoing more rounds of pro
175 isolated in transcriptionally repressed and activated states maintain their characteristic chromatin
176 tion activity varies between deactivated and activated states marked by the presence and absence of s
178 ated in this study that, in both resting and activated states, mouse peripheral CD4(+)CD25(+) T regul
179 With dATP, myosin heads may remain in an activated state near the thin filaments following relaxa
180 is believed to parallel the induction of an activated state observed in pancreatic disease such as c
181 and adopts a conformation distinct from the activated state observed in structures of other voltage-
182 other, with "up" transitions among different activated states occurring exclusively near the mitotic
184 rolyl isomerization not only to generate the activated state of a protein but also to maintain it for
186 e a model explaining how TARPs stabilize the activated state of AMPARs and how the interactions betwe
189 upstream activators: instead of mimicking an activated state of CDC42, EspF(U) mimics an autoinhibito
193 perimentally resolved structures of the Ca2+-activated state of its isolated C2alpha domain, one dete
194 a membrane in response to ATP and during the activated state of microglia that is associated with ner
196 Despite extensive studies on the Ca(2+)-activated state of NCS proteins, little is known about t
197 affinity reagent that selectively binds the activated state of PAK1, we used molecular modeling to r
198 dimer provides a scaffold for assembling the activated state of PARP-1 and suggests a mechanism for c
200 1-yl)ethanone (FLB-12)] that antagonizes the activated state of PXR with limited effects on other rel
202 acterization of soluble mimics for the light-activated state of rhodopsin have shown that grafting de
205 tions investigated increased the GTP-loaded, activated state of RIT1 in vitro, but they could be clas
206 S3 (a talin peptide that mimics a postulated activated state of talin), nor F-actin alone can activat
208 nnabinoid type-2 receptor (CB2R) affects the activated state of the brain endothelium and blood-brain
209 g as an agonist, is insufficient to lock the activated state of the channel for a prolonged duration.
210 each of these four mutations stabilized the activated state of the channel, thereby producing gain-o
213 use AlF4- complexes with GDP to stabilize an activated state of the Galpha subunit, these results sug
215 -I changes the character of MEFs to a highly activated state of the MAPK pathway, indicating the crit
217 mers are formed in the resting state and the activated state of the receptor by different TM interact
223 r and oxygen is the key factor retaining the activated state of the TiO2 powder for a time period.
224 s provide the first structural model for the activated state of the transducin-PDE6 complex during vi
226 the open conformation of the channel and the activated state of the voltage sensors, yet decouples th
228 s on the three-dimensional structure for the activated state of this receptor, metarhodopsin II.
229 64 (77.8% +/- 3.5%, n = 6) was larger in the activated state of TRESK (i.e., after calcineurin-depend
230 raction in living cells under the resting or activated state of TRPV1, as well as in presence of stru
233 GX-936 and related inhibitors bind to the activated state of voltage-sensor domain IV (VSD4), wher
239 l and solution structures of the resting and activated states of the photosensory core of the bacteri
241 uctural models of resting, intermediate, and activated states of the voltage-sensing domain of the ba
243 impact on cAMP observed with the inactive or activated states of wild type Atr1a on function, and not
245 iactivated T cells ready to shift to a fully activated state once a CD3-mediated signal has been rece
247 stabilization of tropomyosin in the "Ca(2+)-activated state" or "C-state." The last 17 amino acids p
251 ent microglial cells in both the resting and activated state produced the protein Ym1, which is a mar
252 presence of alpha(v)beta3 in a functionally activated state provides a unique advantage for circulat
253 neurons gradually increased and, in a fully activated state, reached the same or even higher values
256 where shifting the equilibrium to the fully activated state requires total unclasping of the cytopla
257 onditions are not ultimately in a blocked or activated state, respectively, but rather the combinatio
259 VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO
261 ation, quiescent glial cells converted to an activated state showing a decrease in nuclear chromatin
262 d state to background levels, but the TS2/16-activated state still retained approximately 30% of the
263 ain's tissue macrophages and are found in an activated state surrounding beta-amyloid plaques in the
264 state that catalyzes synthesis slowly and an activated state that catalyzes synthesis rapidly, with t
265 a substrate switches the proteasome into an activated state that persists throughout the degradation
266 ssion of M-CSFR causes microglia to adopt an activated state that results in proliferation, release o
268 a(2)(+) stimulation converts CaMK-II into an activated state that, in the zebrafish, is detected in t
269 gered, the native peptide transiently visits activated states that are very similar to those sampled
274 activates from the intermediate state to the activated state, the VSD-pore coupling has less efficacy
275 onal antibodies were used to achieve uniform activated states, the binding of alpha5beta1 to full-len
276 chanism that could keep infected cells in an activated state, thereby promoting viral replication.
277 to favor the attractive interactions in the activated state through core conformational changes indu
278 , resulting in an apparent reversal of their activated state to a quiescent, nonproliferative state.
279 e mutant synergy site reduced the AG89 (low)-activated state to background levels, but the TS2/16-act
280 studies suggest that vinculin must be in an activated state to bind to alpha-catenin and that this i
281 ormal RAS protein locked in a constitutively activated state to drive malignant transformation and tu
283 resting state to the intermediate state and activated state to trigger pore opening via electro-mech
284 d beta-catenin follicles in both resting and activated states to uncover the discrete set of genes wh
285 ors result in their coordinated shift to the activated state upon being released from inhibition by r
287 and retain the capacity to return to a less activated state, validating the potential for developing
288 inactive state of CB(1) and be broken in the activated state via a chi(1) rotamer switch (F3.36(201)
289 lizes the voltage sensor in domain II in its activated state via a voltage-sensor trapping mechanism.
290 positions of key side chains in resting- and activated-state VS model structures, providing new insig
292 The kinetic constants of these steps of the activated state were similar to those of the unregulated
293 ing distinct native, intermediate, and fully activated states wherein the P14 residue retains an inte
294 glycoprotein alpha(IIb)/beta(3), in a fully activated state, which is critical for thrombus formatio
295 rhodopsins that lead to the formation of the activated state, which is ready to interact with the G p
296 ts with sickle cell disease reveal a basally activated state, which suggests that pathological platel
297 ift in ATM phenotype toward an alternatively activated state, which was accompanied by reduced AT inf
298 cture of the enzyme has been captured in the activated state, with a cyclic tetra-adenylate (cA(4)) m
299 the transition of ECs from a quiescent to an activated state, with higher proliferation rate, upregul