ライフサイエンスコーパス: active

1 , P1 neurons themselves are not persistently active.

2 for which MET inhibition with crizotinib is active.

3 oter, we can determine when the promoter was active.

4 GAS from oligomerizing into the functionally active 2:2 cGAS-dsDNA state.

5 rvation require the organism to be awake and active(4), the ability to switch to a memory consolidati

6 ophagic degradation of mitochondria) is also active after myotube formation.

7 cologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hy

8 vator and "seed" for further translationally active aggregation.

9 ryogenic-electron microscopy structure of an active alpha(2)beta(2) complex are performed to examine

10 . colorata might support a similarly broadly active ancestral ABCE model of floral organ determinatio

11 Finally, two of them (TNFAIP6 for active and CXCL6 for chronic) were confirmed in the urin

12 and facilitate rapid proton transfer between active and dormant chains.

13 precursors and metabolites, are biologically active and important for proper brain function.

14 iable method for the differentiation between active and inactive bacteria at single cell level is urg

15 contrasts between 2,3,5,6TMP-TQS isomers and active and inactive enantiomers of other TQS-related com

16 nt forms of uPlm that are both catalytically active and insensitive to alpha2-AP inhibition.

17 iological transporter GBIHBP1 that is highly active and largely resistant to physiological inhibitors

18 prove the efficacy of deltamethrin, the most active and most commonly used pyrethroid, by more than 1

19 rsity of HIV-1 is a major challenge for both active and passive immunization.

20 ce that facultatively aerobic SUP05 are more active and respire nitrate when oxygen becomes available

21 splitter neurons were more likely to remain active and retained more consistent spatial information

22 In addition, we find that germline-active and soma-specific promoters have distinct feature

23 ently, there is an unequivocal need for more active and specialised metrics for reliably identifying

24 The need for active and stable oxidation catalysts is driven by the d

25 controlling this bistable switch between non-active and transfer competent cells have long remained e

26 o had the option of using at least one fully active, approved antiretroviral drug in at least one but

27 the ability of seven microorganisms encoding active ArsM enzymes to methylate As.

28 of the obtained compounds were proven to be active as inhibitors of PDE1 isoforms, with IC(50) value

29 tudy provides evidence that acalabrutinib is active as single-agent therapy with a manageable safety

30 Venetoclax is highly active at achieving deep remission for most treated pati

31 numerical analysis revealed that the maximum active attenuation potential outperforms the perfect aco

32 rve, possibly due to a reduced population of active auditory nerve fibers, which will be of importanc

33 Thus, SNr may regulate the active avoidance movement in downstream areas that media

34 has an essential role driving or regulating active avoidance responses is unknown.

35 understand the contribution of metabolically active bacteria in fundamental processes triggering envi

36 patoma cells showed high level expression of active beta-catenin, alpha-fetoprotein, and SOX9, sugges

37 copy with endoscopic treatment of sites with active bleeding or high-risk stigmata for rebleeding.

38 nflicting perspectives, assessing whether co-active brain regions during task states tend to increase

39 We found that active, but not sham rTMS elicited (1) an increase in dl

40 ous organic compounds by exploiting their pH-active carboxylic acid groups.

41 mathematical modeling analyses suggest that active cargo loading reduces non-specific encapsulation

42 g (TUNEL) assay and immunohistochemistry for active caspase-3.

43 l the evolution pathway of precursors to ORR-active catalyst comprised exclusively of single-atom Fe(

44 sphorus, as a new ligand that forms a highly active catalyst for hydroboration of unactivated 1,2-dis

45 Applying harsh conditions, highly active catalysts or highly reactive bonding groups, as i

46 Patients (N = 1817) with untreated, active choroidal neovascularization due to age-related m

47 We identified that open and active chromatin at the major translocation cluster locu

48 tivity and selectivity of hearing require an active cochlea.

49 20, which subsequently spread locally before active community surveillance was implemented.

50 ing to S. elongatus-E. coli K-12 as the most active community.

51 fically, the discovery of an intracellularly active complement system-the complosome-and its key role

52 ants by capsaicin, allicin and sanshool, the active components of chili pepper, garlic and mountain p

53 by TPA diffusion, whereas transport of other active components was rendered nonessential either by th

54 rk, we investigate the adsorption of surface-active compounds at the water-oil interface subjected to

55 n and bioavailability of a broad spectrum of active compounds upon mucosal administration, mucus-pene

56 ounds, which increased the identification of active compounds, while decreasing screening time and re

57 ducts are an important class of biologically active compounds.

58 terials, agrochemicals, and pharmaceutically active compounds.

59 endent by positioning the CDK7 T-loop in its active conformation.

60 ole for the ArpC3 subunit in stabilizing the active conformation.

61 confidence interval [CI] -1.02 to -0.63) and active control (k-9; n = 662; SMD = -0.35, 95% CI -0.56

62 In this randomized, active-controlled, double-blinded trial, 444 adults 60 t

63 ectrodeposition process for creating a redox-active crystalline layer (denoted as RZx) on pyrolytic g

64 bacteria and an essential cofactor for redox-active cuproenzymes.

65 Mechanical instabilities in the active cytoskeleton network and feedback loops in the bi

66 en-vacancy coordination remains a subject of active debate.

67 Optically active defects in wide band gap materials, for instance,

68 argo, and Advanced-InSAR analysis highlights active deformation in the MS.

69 as arrested, and lesion areas identified as active, demonstrating that thermal imaging is a promisin

70 al ability of soft-membraned eggs undergoing active development.

71 esional skin and especially in patients with active disease.

72 f nerve fiber layer phagocytosis in areas of active disease.

73 the change in (64)Cu-ATSM signal after redox-active drug treatment.

74 work, we hypothesized that 12/15-LOX is also active during invasive aspergillosis.

75 st, although many individual M1 neurons were active during observation, M1 population activity was di

76 ophagocytic lymphohistiocytosis, and chronic active EBV disease.

77 act RNA and identify genes that characterize active (endocapillary-extracapillary proliferations) and

78 Our results reveal an active, energy-driven mechanism that reactivates backtra

79 We show that active enhancer units are precisely delineated by active

80 ional silencers that we identified were also active enhancers in other cellular contexts.

81 Mutations can render the receptor active even in the absence of light.

82 bdominal expiratory pattern formation during active expiration observed during hypercapnia or after t

83 However, only RTN triggers active expiration, presumably because RTN, unlike C1, ha

84 orination as no growth of Dehalococcoides or active expression of Dehalococcoides-reductive dehalogen

85 region that encompasses the trace of nearby active faults.

86 tion of optical fibre was integrated into an active fibre ring cavity with optical gain and interroga

87 way for efficient exploration of additional active flow control strategies in other complex fluid me

88 mposite chitosan films may be considered for active food packaging applications.

89 nt for adjacent modules in either ring to be active for efficient enzyme function.

90 hat the sensitivity of the electrode remains active for several runs of the analysis.

91 jury causes upregulation of a constitutively active form of acetylcholine-dependent K(+) current (I(K

92 Here, we report that an active form of the ESCRT-associated protein ALIX efficie

93 closed conformation of E2~Ub represents the active form that mediates ubiquitin transfer has yet to

94 the metabolic proteome mass fraction and the active fraction of ribosomes.

95 (NMR) spectroscopy and mass spectrometry of active fractions led to the identification of phosphatid

96 energy, contain the same distribution of IR-active functional groups.

97 athway in 10403S strains expressing the more active GcpE allele.

98 ilise the auto-inhibited state to promote an active GEF.

99 tions with histone modifications that typify active genes and enhancer elements.

100 ates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor to act o

101 ay on select sites such as transcriptionally active genes.

102 those isolated from other areas showed that active genetic reassortment occurred in IDV and that fiv

103 A meteoric origin of the OFG and active groundwater migration from onshore are inferred.

104 Response rates were 41.7% in the active group and 36.4% in the sham group (P = 0.6).

105 Of these, 18 events were reported in the active group and 8 in the control group.

106 Although beneficial for plant survival, active growth inhibition is often undesirable for crop p

107 s on extracellular matrix gene promoters and active H3K4me3 marks on interleukin, defensin, and chemo

108 Patients with active hematologic or lung malignancies, peri-COVID-19 l

109 le of forming co-gels with the catalytically active hexameric compounds.

110 ium vivax (Pv-M17) function as catalytically active hexamers to generate free amino acids from human

111 Wetlands are common sites of active Hg methylation by anaerobic microbes; however, th

112 topologies increases in the vicinity of the active hot and cold walls for all cases considered here.

113 the phantom study, the diameter of the most active hot spot was reduced by 24% in the dual gated ima

114 The most active hybrid displayed over threefold and 10-fold highe

115 m the inefficiency of K(+) in stabilizing an active (i.e. conductive) SF conformation.

116 erum levels, protected mice from passive and active IgE sensitization, and resulted in cross-protecti

117 Genetic induction of active IL1beta or pharmacologic inflammasome stimulation

118 Of 30 patients completing DAA therapy with active illicit opioid use at intake, 14 (46.4%) engaged

119 Lipoprotein lipase (LPL) is active in capillaries, where it plays a crucial role in

120 egulatory elements (FMREs) were ubiquitously active in human tissues, showed long-range chromatin int

121 uercetin, dexamethasone and apomorphine were active in models of AD and PD.

122 The Ocn-Cre(+) dDG neurons were highly active in response to anxiogenic environment but had low

123 P387 TSP4 was more active in supporting adhesion of cultured human and mous

124 of biosecurity measures by all stakeholders active in the APR, including surveillance for species su

125 (CDIs), a class of antibiotics that are only active in the presence of copper ions, are effective bac

126 (DSB) repair and Fanconi anemia (FA) factors active in the S/G2 phase as potent inhibitors and regula

127 l AIG1/ADTRP inhibitor, ABD-110207, which is active in vivo Acute treatment of WT mice with ABD-11020

128 The enhancer was active independently of orientation and whether located

129 Finally, we show that active inference agents learn models that are parsimonio

130 ermine the systemic absorption of additional active ingredients and how quickly systemic exposure exc

131 Sunscreen products contain UV filters as active ingredients for the protection of the skin agains

132 rated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to det

133 si-experimental study included patients with active injection drug use and definite IE from January 2

134 er nonlinear coefficients and convenience in active integration, they have suffered from high wavegui

135 Previously, we showed that active K-Ras4B dimerizes in silico and in vitro through

136 d to partially replace polymer donors in the active layer of PBDB-T/Y1.

137 -channel transistors in a common quantum dot active layer.

138 e traditional lecturing with evidence-based, active-learning course designs across the STEM disciplin

139 Immunopattern II early active lesions contain 64% more iron (95% confidence int

140 ere they could press an inactive lever or an active lever that produced CS presentation, without wate

141 ng how strong trans effect ligands and redox-active ligands work together to enable rapid electrochem

142 ct effect of fecal microbiota independent of active liver inflammation or injury.

143 type 2 (AT2) cells represent a metabolically active lung cell population important for surfactant bio

144 Active maintenance of beta-cell identity through fine-tu

145 who were COVID-19 positive, of whom 117 had active malignancy, defined as those receiving cancer-dir

146 Chemical tools that detect active MALT1 have been reported, but suffer from poor ce

147 Culex are able to locate and land on surface-active manatees, and at minimum, penetrate and probe man

148 Eumelanin is also a promising redox-active material for energy conversion and storage, but t

149 degradation processes of the photocatalytic active material.

150 While redox-active materials based on conducting and semiconducting

151 reduction processes of positive and negative active materials.

152 cular scale, creating a fascinating type of "active matter".

153 Active matter, both synthetic and biological, demonstrat

154 se(s) underlying the loss of melanogenically-active melanocytes from the anagen hair bulbs of affecte

155 ; P=0.47), despite yielding higher prasugrel active metabolite concentration (ng/mL; 62.3+/-82.6 vers

156 d with chewed prasugrel, which led to higher active metabolite concentration but not greater IPA comp

157 omics results helped to prioritize potential active metabolites that modulated the hypothermic respon

158 ed as the parent oxide, and Ir serves as the active metal species that produces the ex-solved metalli

159 atalyzed protocol using 2-bromoaldehydes and active methylene group containing substrates that afford

160 ble-blind trial of SER-287 in 58 adults with active mild-to-moderate UC (modified Mayo scores 4-10, e

161 482) will develop symptoms after 14 days of active monitoring or quarantine.

162 n measured leg muscles (p >= 0.146)), soleus active muscle volume (p = 0.538; d = 0.241), or aerobic

163 sider the integration of synthetic optically active nanocomponents into organized hierarchical biopol

164 t facilitate voltammetric detection of redox active neurochemicals in a multianalyte solution.

165 itions in C. elegans, sleep requires a sleep-active neuron called RIS.

166 Active non-muscle myosin II (NMII) enables migratory cel

167 assays to demonstrate that the expression of active noncanonical EphA2-S897E in melanoma cells led to

168 itional overexpression of the constitutively active NOTCH intracellular domain in CD11c-expressing ce

169 nation of DFT theory, solvent model, and NMR-active nuclei, using both user-selected reference compou

170 We showed that the enzyme was active on Galalpha1-3Gal but not the blood group B antig

171 systems, with the latter proposed to be the active oxidant for most of these systems.

172 of mixed-valence interactions between redox-active, pai-conjugated scaffolds is of interest when dev

173 ods lead to higher parasitism rates by a day-active parasitoid on its host using a laboratory experim

174 cell wall, outside of the cell itself, is an active participant in shaping plant cells.

175 /cost-offsetting models, and ultimately, the active participation of pathologists to encourage buy-in

176 ed toward integrating these data to identify active pathways or modules under certain experimental co

177 Pore formation by membrane-active peptides, naturally encountered in innate immunit

178 pports a wide range of metal and metal oxide active phases.

179 n tyrosine phosphorylation by competing with active phosphatases for the binding of substrates.

180 The DeltaCytM strain maintained active photosynthesis over the 3-d period, demonstrated

181 to demonstrate the induction of functionally active polyclonal antibody responses as measured in the

182 In this study, we describe an active poultry surveillance system established in Vietna

183 d the biophysical consequences of ATP-fueled active processes acting on chromatin.

184 tazoans that incorporates cell-type-specific active processes.

185 The synergy depends on the presence of the active promoter/origin.

186 tronics research has mainly focused on redox-active proteins because of their role in biological char

187 hese interactions resulted in constitutively active proteins, freed from autoinhibition and no longer

188 lation, 108 cases presented HRCT features of active PTB and the remaining cases were negative but had

189 Features of active PTB were centrilobular nodules, 'tree-in-bud' pat

190 cient cells and restored by a constitutively active Rab7.

191 iation in ultraviolet and photosynthetically active radiation, and relative supplies of resources (e.

192 id aneuploidy, and we previously showed that active Ran coordinates ring positioning with chromatin.

193 le patients were allocated to one of these 2 active regimens.

194 The ability to identify active regulons within a specific cell type, i.e., cell-

195 tment of depression (discovery sample, N=30; active replication sample, N=81; sham replication sample

196 Among these, the most active representatives combined submicromolar cellular p

197 However, the effects of long-term active restoration of extremely degraded grassland on so

198 ptimization strategy culminated with in vivo active RO7101556 (18B) having excellent properties and b

199 o the growing body of evidence supporting an active role of astrocytes in brain information processin

200 a normal microenvironment, thus proving the active role of the BM stroma.

201 and offers an ideal cell model to study the active role of YAP1 in maintenance of the adult epitheli

202 ession (DAT-HT) were hypersensitive to short active (SA; 19:5 L:D) photoperiod exposure versus their

203 liminate these limitations by introducing an active scatterer in a mechanical meta-layer that exploit

204 Regional epidemiology and level of active screening (AS) both influenced the predicted time

205 on of the competitive hierarchy is caused by active segregation and spatial exclusion within the patc

206 o a combination of passive body dynamics and active sensorimotor control.

207 lipidome approach for the identification of active SHs, and thus for deciphering the role of lipid h

208 Our work provides a structural basis for active single- and double-ring complexes coexisting in t

209 ity to DNMDP, and substitutions in the PDE3A active site abolish compound binding.

210 the position of each pocket relative to the active site also appeared to be important for polymer el

211 he donor and acceptor substrates bind in the active site and how ethambutol inhibits arabinosyltransf

212 ocated on opposite sides of the murine Esco2 active site cleft, are critical for catalysis.

213 how that the low reduction potentials of the active site cofactors are optimized for fast elimination

214 s due to differences in the structure of the active site compared with other zinc-dependent nucleotid

215 The active site consists of a mononuclear iron coordinated b

216 Here we conducted an alanine scan of active site constituents that engage the ATP phosphates

217 QOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration.

218 istribution of four proteases with different active site geometries in three cell lines and periphera

219 assures a proper actin-binding interface and active site have formed before producing a power stroke.

220 n about the role of key elements of the RNAP active site in translesion transcription.

221 the trigger loop, a flexible element of the active site involved in nucleotide addition, can stimula

222 The product-bound active site is almost identical to that of the substrate

223 tiates V(D)J recombination, we find that the active site is reconfigured for the two consecutive reac

224 drogen bonding, Bronsted acid/base) near the active site of metal-containing catalysts is an effectiv

225 the larger substrate is accommodated and how active site residues have changed to recognize N-citrylo

226 hroughout its catalytic cycle and mapped the active site residues responsible for nucleoside selectio

227 c14 family and comparing the conservation of active site structure and specificity among a sampling o

228 o acids jointly communicate occupancy to the active site via subtle changes in dynamics, enabling exq

229 binding of the conjugates at the polymerase active site, however, in different modes in the presence

230 accompanied by conformational changes in the active site, including the translation of an alpha-helix

231 nd HER2 mediate specific binding by the SHP2 active site, leading to blockade of RasGAP binding and o

232 enesis analyses confirmed these compounds as active site-directed reversible inhibitors of mPTPB.

233 gion that extends up to 28 angstrom from the active site.

234 laced by detergent from the highly protected active site.

235 a polyubiquitin chain attached to the UBE2K active site.

236 oA (SCoA) cosubstrate is bound at the MmOGOR active site.

237 -phosphatase with a trapped substrate in its active site.

238 propagation from the allosteric site to the active site.

239 Site-specific replacement of active-site amino acids revealed the presence of a water

240 A careful balance between active-site and exosite contributions is critically impo

241 tricate coupling between the dynamics of the active-site cysteines and of the cap loop which modulate

242 forces and interactions that allow and limit active-site motions.

243 that Asn-169, a conserved residue in the AAG active-site pocket, contributes to discrimination agains

244 tes broadly and for understanding how copper active sites achieve activation of strong C-H bonds.

245 The active sites in Y-DeAlBEA are 70 times more active than

246 groups, and are 7 times more active than the active sites in Zn-DeAlBEA.

247 The active sites of RFC are fully bound to adenosine 5'-trip

248 sed on atomically dispersed rhenium (ReO(4)) active sites on an inert support (SiO(2)) for the halide

249 The high active sites per mass ratio of such hollow HEA nanoparti

250 ail in moving the cobalamin cofactor between active sites.

251 ence of nitrogen-coordinated, single Ni atom active sites.

252 forms into the amorphous phase, acting as an active species to facilitate the interaction of gas reac

253 ymphatic vessels in the donor lung exhibited active sprouting toward the host at the anastomosis with

254 Subsequently, active STAT3 resulted in the induction of IkappaBzeta, w

255 First, we validated the crucial role of active STAT5 as a survival factor for functionally diffe

256 n light absorption to form a solvent-swollen active state.

257 via two conformations, an "unconstrained pre-active" state that contributes to fast synaptic events a

258 fast synaptic events and a "constrained pre-active" state that does not.

259 putational models show that the inactive and active states differ by small changes in a regulatory re

260 PCRs provide snapshots of their inactive and active states, but poorly describe the conformational dy

261 Gamma irradiation showed >98% active structures of melatonin encapsulated in PolyRads.

262 The clinical sensitivity in detecting active subarachnoid or ventricular disease in symptomati

263 ent association of GPS with AP after initial active surveillance was not statistically significant, a

264 e receiving cancer-directed therapy or under active surveillance within 6 months of admission.

265 omarkers geared toward patient selection for active surveillance, identification of clinically signif

266 th pregnen-20-carboxaldehyde, a biologically active synthetic steroid, by using a 1,3-dipolar cycload

267 ly infected household contacts who developed active TB up to 5.25 years later, as an indication of ba

268 ne of the 3 groups: MTB uninfected, LTBI, or active TB.

269 The extremely active TC activity and northward shift of TC genesis dur

270 the ability to interact with TGFbeta-1, and active TGFbeta-1 did not bind fibrillin in the absence o

271 jacent hydroxyl groups, and are 7 times more active than the active sites in Zn-DeAlBEA.

272 We found one compound, 7I, that is more active than the parent compound, LQZ-7, and when given o

273 active sites in Y-DeAlBEA are 70 times more active than the Y sites supported on silica, for which t

274 hydrido-carbonyl catalysts that are far more active than traditional neutral cobalt(I) catalysts and

275 ncentration of volatile anesthetic, fatigue, active time, and respiratory function.

276 to assess the prevalence and associations of active trachoma among rural preschool children in Wadla

277 e enhancer units are precisely delineated by active transcription start sites, validate that these bo

278 h DNA demethylation takes place to allow for active transcription.

279 Active transportation policies should operate at 3 level

280 No difference was noted between any active treatment and placebo in PBVC (amiloride vs place

281 f patients with malignancy who are receiving active treatment and up to 33% of patients during surviv

282 Five (25%) patients under active treatment developed serious infectious events, an

283 signed to focused ultrasound subthalamotomy (active treatment) and 13 to the sham procedure (control)

284 rom the site of stimulation, such that after active treatment, the dlPFC appeared better able to enga

285 that this RdRp efficiently incorporates the active triphosphate form of RDV (RDV-TP) into RNA.

286 Diagnosis of active tuberculosis (ATB) currently relies on detection

287 Sexually active unvaccinated women and men aged 16 to 25 years ol

288 n with no need to postulate the existence of active uptake processes.

289 Rats pressed more on the active versus inactive lever, and pairing CS presentatio

290 By modifying and calibrating an active vertex model to experiments, we have simulated nu

291 nal center activity long after the period of active viral replication in peripheral blood.

292 While the Argus II device was active, walking speed increased from baseline to immedia

293 of the Type 1 conjugates were catalytically active, whereas all Type 2 conjugates cleaved RNA target

294 Lip fusion of mouse lipin-2 is catalytically active, which suggests mammalian lipins function with th

295 ity with SAC; however, the enzyme was highly active with l-cysteine, N-acetyl-l-cysteine, and allyl m

296 ells by VSV-EBOVDeltaMLD, the virus remained active within the SCID mouse brain and showed widespread

297 eness of our data, and our defining sexually active women as those who have ever had sex.

298 whereas cells overexpressing constitutively active YAP were able to travel through this capillary pl

299 on the cytoskeleton arrangement, both at the active zone-related with exocytosis-as well as at the en

300 How functional assembly of presynaptic active zones is controlled via trans-synaptic interactio