ライフサイエンスコーパス: active form

1 regulating the quantities of the drug in its active form.

2 esting it has difficulty in switching to the active form.

3 ed fatty acids (PUFAs) into their long-chain active form.

4 ed', non-transcribed rDNA chromatin into its active form.

5 ergoes proteolytic activation to generate an active form.

6 e to the switch from the inactive to a fully active form.

7 ynthetic Abeta into a potent in vivo seeding-active form.

8 we suggest might be related to its membrane-active form.

9 but also can metabolize it to its hormonally active form.

10 uantities and in a biologically relevant and active form.

11 d mature into a nitric oxide (NO)-responsive active form.

12 n population of inactive conformation to the active form.

13 of proinflammatory mediator IL-1beta into an active form.

14 ransforms the proenzyme into a catalytically active form.

15 e from ABI5, thereby maintaining ABI5 in its active form.

16 uring maturation of sGC to its NO-responsive active form.

17 ng assay and of the crystal structure in its active form.

18 lubilising membrane-embedded receptors in an active form.

19 ing 3 (NLRP3) inflammasome into a mature and active form.

20 ver insulin to CNS targets in a biologically active form.

21 talytic activity by populating only the most active form.

22 6S proteasomes in the cytosol must assume an active form.

23 ner membrane, and we detected (Fe-S)(int) in active form.

24 enzyme that converts the prodrug INH to its active form.

25 are released into the extracellular space in active form.

26 the autoactivation of SOS to populate their active form.

27 -1beta and pro-IL-18 into their biologically active form.

28 folate pathway that hinder conversion to its active form.

29 -1beta and pro-IL-18 into their biologically active forms.

30 fficient reserves of their transcriptionally-active forms.

31 e subsequently converted to the biologically active forms.

32 cts the processing of the protoxins to their active forms.

33 indole-3,2'-pyrrolidines] in their optically active forms.

34 nergy to mold these catalysts into stiff and active forms.

35 s subsequently metabolized to its hormonally active form, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), by

36 TI triphosphates (NRTI-TP), the biologically active forms, act as chain terminators of viral DNA synt

37 -(thio)triphosphate (GTPgammaS)-loaded ARF6 (active form) added to permeabilized sperm induces acroso

38 We examined processing of the nuclear active form and identified a motif around S87-S90 with h

39 um knowlesi can be purified in a soluble and active form and the recent development of a fluorescence

40 f bivalent histone modifications toward more active forms and induced KSHV reactivation in naturally

41 transcribe different gene subsets, and whose active forms are contained in supramolecular complexes k

42 of [4]:[Cu(2)(+)] at (s)(s)pH 7.9, where the active forms are Cu(II):4:((-)OCH(3)).

43 Here we report that the active forms are the trivalent arsenic-containing specie

44 patible electrodes could hold bacteria in an active form at the anode allowing chemical oxidation of

45 as well by converting gemcitabine to a less active form, both leading to its increased intracellular

46 usly expressed VcrA was reconstituted to its active form by addition of hydroxocobalamin/adenosylcoba

47 Da pro-IL-1beta is processed into the 17-kDa active form by caspase-1-activating inflammasomes.

48 mutants-V14I, T58I, and G60E-populate their active form by deregulation of the previously documented

49 inactive IL-1beta precursor is processed to active form by inflammasomes, multi-protein complexes ac

50 RNAs and undergo conversion to catalytically active forms, by the same polymerization chemistry used

51 D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27

52 that contains enzymes in their catalytically active form can be interrogated by using probes targeted

53 Accordingly, molecular imaging of the MMP-12 active form can inform of the pathogenic process in aneu

54 roximity and reassembled into a biologically active form capable of activating T cell response.

55 signaling pathway, by expression of the XBP1-active form, compromised GCB DLBCL tumor growth in a mou

56 o convert the AhR into its transcriptionally active form, deciphering the AhR:ARNT dimerization mode

57 tion that prevents conversion of EDN3 to its active form (Edn3(ls)).

58 isomerization to a structure similar to its active form, exposing a large hydrophobic surface that f

59 esponsible for phosphorylating FTY720 to its active form, FTY720-P.

60 hain zymogen and a two-chain proteolytically active form, generated by matriptase-dependent activatio

61 t concentration of DE-117 and its hydrolyzed active form (hDE-117) was maintained in the aqueous humo

62 ates and the conditioned media in a dimeric, active form in both compartments.

63 stabilizes SANT1 and transiently samples its active form in solution.

64 IL-1beta produced is processed to its mature active form in the LPS-rich CF lung by the NLRP3 inflamm

65 t in the cytoplasm with stabilization of the active form in the nucleus.

66 cally facilitate ZEITLUPE maturation into an active form in vitro and in planta.

67 two intermediate agonist-bound forms and an active form in which the heterodimer is bound to an agon

68 ibrium between two inactive states and a pre-active form, increasingly populated with higher ligand e

69 rsion of latent TGF-beta to its biologically active form is a major regulatory node controlling its a

70 The proposed transition into the active form is based on a concerted structural rearrange

71 ve conformations, and conversion to the open active form is promoted by binding to PAT-4 (ILK).

72 owth promoter for poultry and swine, and its active form is the trivalent species Rox(III).

73 from these virus particles in enzymatically active form; it is still not clear why it fails to induc

74 the kinase is generated in a constitutively active form, its expression levels are restricted by a v

75 Mcc(ia)), and a soluble, protease-sensitive, active form (Mcc(a)).

76 ermine the structures of this constitutively active form (Mec1(F2244L)-Ddc2) at 2.8 angstrom and the

77 The front accumulates high levels of the active form of a polarity-determining Rho-family GTPase

78 Overexpression of a myristoylated and active form of A. stephensi and Ae. aegypti Akt in the f

79 mical and cellular levels, by binding to the active form of ABL1(T315I) in a mutation-selective bindi

80 jury causes upregulation of a constitutively active form of acetylcholine-dependent K(+) current (I(K

81 We now report prevalence of an active form of ADAM10 in tumors compared with normal tis

82 Expression of a constitutively active form of AKT1 restored proliferation to tumor cell

83 vered a transposon encoding a constitutively active form of Akt2 (myrAkt2).

84 reported to act as a receptor binding to the active form of alpha(2)-macroglobulin (alpha(2)M*), acti

85 rs, or forced expression of a constitutively active form of AMPK, results in polarization to an anti-

86 e novel complex drug, consisting of released-active form of antibodies to S-100 protein, tumor necros

87 erated transgenic mice expressing a dominant active form of ARL3 (ARL3-Q71L) under a rod-specific pro

88 PK activators, metformin and salicylate (the active form of aspirin).

89 his effect is rescued by an shATF4-resistant active form of ATF4, but not by a mutant that lacks tran

90 n of acetylated p53 and the conformationally active form of Bax were found to be significantly higher

91 type-specific expression of a constitutively active form of BZR1 confirms that the high and low level

92 y through overexpression of a constitutively active form of c-Raf (ca-Raf) inhibits progenitor popula

93 However, the active form of CAPS bound to PC12 cell membranes or to l

94 alleviated by expression of a constitutively active form of CelR, suggesting that DivK acts upstream

95 The active form of clavatol, ortho-quinone methide, can be g

96 ere increased; however, elevations in the de-active form of complex I were observed in CAD.

97 (Cul3KO) cells resulted in a decrease in the active form of Cul3WT.

98 enzyme kinetic analyses in solution that the active form of DAPDC from Bacillus anthracis, Escherichi

99 The active form of E. coli Ia RNR is composed of two homodim

100 The active form of FGFR3 bound to and phosphorylated the reg

101 There remains considerable debate over the active form of gold under operating conditions of a rece

102 ssion in the IGF-I-ir neurons belongs to the active form of GSK3beta known to exert neuroinflammatory

103 factors via transgenic overexpression of the active form of HB-EGF.

104 Here, we report the structure of the active form of human ORC determined by X-ray crystallogr

105 ds with high affinity and specificity to the active form of human PAI-1.

106 rt the crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated

107 onic liver-specific expression of a dominant-active form of IDOL in mice.

108 ines expressing an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key k

109 a, leading to expression of a constitutively active form of IKKbeta (IKKbetaca) in epithelial cells b

110 The secreted active form of IL-16 has been detected at sites of TH1-m

111 oB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, an

112 ally, N(pro) interacts with a constitutively active form of IRF3 bound to its transcriptional cofacto

113 IRF3, since N(pro) binds to a constitutively active form of IRF3 in the presence of its transcription

114 The ability of SN22 vs. SN38 (the active form of irinotecan/CPT-11) to overcome efflux pum

115 o the electrochemical oxidation of Ir to the active form of IrO(x) .

116 mediated through increased expression of the active form of its ligand, GAS6, that also served to sta

117 ctively and irreversibly binding to the free active form of KDM1A.

118 rasG12D mice, which express a constitutively active form of KRAS after Cre recombination.

119 2D)Tg/+ (Mist1-Kras) mice, which express the active form of Kras in chief cells on tamoxifen exposure

120 Expression of the constitutive active form of KRAS in this system led to activation of

121 or lipoamide, we identified the biologically active form of LA, R-LA, to be the physiological substra

122 im-3 interacts with Lck, but not the phospho-active form of Lck.

123 re we show that Tfh cells expressed a highly active form of leukocyte function-associated antigen-1 (

124 Our data suggest that the active form of MAP kinase interacts with gamma-tubulin o

125 It was the active form of MAP kinase that was enriched with microtu

126 A constitutively active form of mDia2 rescues the defect in new CENP-A lo

127 By contrast, the constitutively active form of Mek1 stimulated Erk1 even in the presence

128 was suggested that these copolymers are the active form of MinC/MinD.

129 In conclusion, the active form of MMP-12 can be detected by optical imaging

130 ive MMP-12 inhibitor, RXP470.1 to target the active form of MMP-12.

131 However, the biologically active form of MT2 and, importantly, the contributions o

132 n and ectopic expression of a constitutively active form of NFkappaB-p65 (S536E-NFkappaB-p65) signifi

133 Misexpression of the constitutively active form of Notch, a suppressor of neural induction,

134 diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the catalytic sit

135 Here, we report that the active form of PaClpP2 is a part of a heteromeric PaClpP

136 Glyco(Hi) mice constitutively express an active form of phosphofructokinase-2, resulting in eleva

137 Co-electroporation with a constitutively active form of PI3K rescued migration.

138 The expression of this dominantly active form of PI3K results in hyperplasia and invasive

139 ell-intrinsic expression of a constitutively active form of PI3K-P110alpha by high-avidity autoreacti

140 ia and dysfunction in mice that expressed an active form of PIK3CA (His1047Arg) in their lymphatics.

141 Here, we overexpressed an active form of PKMzeta in rat hippocampus, a structure h

142 ults in mislocalization of the catalytically active form of Polo.

143 Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the

144 Overexpression of an active form of Rab5 in strip-mutant neurons suppresses t

145 Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosph

146 Expression of a constitutively active form of RAC1 (RACV12) in mice resulted in the dev

147 The active form of RAD51 is a nucleoprotein filament that as

148 tein SYX-5 colocalizes with a constitutively active form of RAL-1 at the plasma membrane, and MVBs ac

149 t and may be initiated by the constitutively active form of RAS.

150 The transition from the autoinhibited to the active form of RasGRP1 involves the rearrangement of an

151 ssion of wild type (WT) and a constitutively active form of RNase L (NDelta385), but not a catalytica

152 hip to T-cell antigen receptor (TCR) and the active form of Src kinase p56lck (Lck) using single and

153 clear translocation of the transcriptionally active form of SREBP1.

154 A constitutively active form of SRF/Mkl1 was not sufficient to induce foc

155 hat the risk allele increased binding to the active form of STAT1.

156 tion or overexpression of the constitutively active form of STAT3 decreased SOX11 expression.

157 ption 3 inhibitor NSC74859; a constitutively active form of STAT3 was expressed in colon and lung can

158 we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) with mice in which a mu

159 ng, while overexpression of a constitutively active form of STAT5 partially ameliorates Treg cell dys

160 ty and prolonged T2 relaxation indicating an active form of TAO.

161 ulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo

162 ells lacking YaeL accumulate a truncated yet active form of TcpP termed TcpP*.

163 While transport of the active form of TH (T3) across the blood-brain barrier is

164 T8 was necessary for polarized influx of the active form of TH across the BBB.

165 re viable and express a stable but minimally active form of the AADC protein.

166 lly, we describe a method to purify a highly active form of the Bam complex that should facilitate th

167 nhanced in lines expressing a constitutively active form of the BR signaling component BZR1, further

168 localizes with PIP(2) and the phosphorylated active form of the clathrin adaptor protein 2 (AP2) at c

169 We propose that the most active form of the cytokinetic RhoGEF involves complex f

170 is of thyroid eye disease and to predict the active form of the disease.

171 -opts the guanosine triphosphate (GTP)-bound active form of the endosomal Rab5 small GTPase via direc

172 al efforts have been described targeting the active form of the enzyme, FXIa.

173 Here, we report that an active form of the ESCRT-associated protein ALIX efficie

174 etermine whether expressing a constitutively active form of the GTPase Rheb (caRheb) in adult neurons

175 Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by th

176 leus into the bud during anaphase causes the active form of the MEN GTPase Tem1 to accumulate at the

177 synthesis of (-)-myrocin G (4), the putative active form of the metabolite myrocin C (1), that featur

178 P(c) from human astrocytes by increasing the active form of the metalloprotease ADAM10.

179 and show that introducing the constitutively active form of the mTORC1 regulator, Rheb, into HD mouse

180 of its instability: the concentration of the active form of the mutant is 3-fold lower than WT.

181 report the atomic-resolution structure of an active form of the OCP consisting of the N-terminal doma

182 enhanced expression of the transcriptionally active form of the p65 (acetylated on lysine 310) subuni

183 sm similar to shade, as both destabilize the active form of the photoreceptor and thermosensor phytoc

184 e Mediator-induced repression to generate an active form of the PIC.

185 dy termed U33 that selectively inhibited the active form of the protease urokinase plasminogen activa

186 e free ferrous deoxy-NGB, which is the redox active form of the protein in contrast to oxy-NGB.

187 ay be truncated to generate a constitutively active form of the receptor called EGFRvIII.

188 thereby shifting the equilibrium toward the active form of the receptor to trigger defense signaling

189 state, which is thought to correspond to the active form of the receptor, we have identified further

190 these proteins to GPCRs usually requires the active form of the receptors plus their phosphorylation

191 of phosphorylated OmpR, i.e. the presumably active form of the regulator.

192 unoassay that cannot distinguish between the active form of the toxin, which poses a threat to life,

193 the monomer is the genuine, physiologically active form of the toxin.

194 Expression of the spliced and active form of the UPR(ER) transcription factor XBP-1, X

195 inducing the expression of a constitutively active form of the upstream activator IkappaB kinase bet

196 to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicated in numer

197 lial-specific expression of a constitutively active form of the WNK1 substrate protein kinase OSR1 (o

198 We present evidence that the active form of these molecules is the initially released

199 phaS does not result from a particularly ROS-active form of these peptides, but rather from either a

200 Thiamin pyrophosphate (ThDP), the active form of thiamin (vitamin B1), is believed to be a

201 t skin mast cells and fibroblasts secrete an active form of this enzyme.

202 valent of alpha-tocopherol known as the most active form of this lipophilic vitamin.

203 villin-TLR4 mice, carrying a constitutively active form of TLR4, their littermates, and villin-TLR4

204 Levels of the cleaved active form of TSLP were increased in nasal polyps from

205 The active form of U7 snRNP contains the HLB component FLASH

206 A soluble, active form of UGM from Mycobacterium tuberculosis (MtUG

207 Generally, the active form of vanadium remains elusive, although studie

208 ridoxal 5'-phosphate (PLP), the biologically active form of VB6 and involved in the synthesis of neur

209 oxidized to retinoic acid, the biologically active form of vitamin A that acts as a transcription fa

210 Retinol, the most biologically active form of vitamin A, may influence cancer-related b

211 Retinol, the most biologically active form of vitamin A, might influence cancer-related

212 Thiamin pyrophosphate (TPP) is the active form of vitamin B(1) and works as an essential co

213 idoxal 5'-phosphate (PLP), the catalytically active form of vitamin B(6), takes place through the so-

214 yridoxal 5'-phosphate (PLP; the biologically active form of vitamin B-6), and vitamin B-12 and breast

215 PDXK), which catalyzes the production of the active form of vitamin B6 (also known as pyridoxal 5'-ph

216 f inflammasomes and the observation that the active form of vitamin B6 (pyridoxal phosphate, P5P) mod

217 ependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse c

218 in production of pyridoxal 5'-phosphate (the active form of Vitamin B6), which we validate experiment

219 Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in hu

220 The active form of vitamin D (calcitriol) restored the SLE M

221 The active form of vitamin D [1,25(OH)2D] regulates B cells

222 sion of 25-hydroxyvitamin D (25[OH]D) to the active form of vitamin D occurs primarily in the kidney.

223 1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(

224 In contrast, the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25

225 The ability of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25

226 In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calc

227 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25

228 CYP24A1, which initiates degradation of the active form of vitamin D, ameliorates skeletal abnormali

229 nappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities.

230 of vitamin D emerges, 1alpha,25(OH)2D3, the active form of vitamin D, has been applied in anti-cance

231 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has been documented in vitro.

232 ihydroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promisi

233 Vitamin D3, the active form of vitamin D, may counteract intracellular c

234 ied outcomes and 1,25-dihydoxyvitamin D, the active form of vitamin D, the study was underpowered to

235 ing the antitumor effects of calcitriol, the active form of vitamin D.

236 a is excessive production of calcitriol, the active form of vitamin D.

237 Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differen

238 demonstrate that calcitriol, the hormonally active form of vitamin D3, is an excellent candidate for

239 The active form of VWF bound to vimentin, and the purified A

240 s also demonstrate that overexpression of an active form of XBP1 caused atrophy in cultured myotubes.

241 sues from mice that express a constitutively active form of YAP (YAP(S127A)) and analyzed gene expres

242 nic mice that overexpressed a constitutively active form of YAP in the dental epithelium.

243 We found that the active form of YAP1 (nuclear YAP1) was predominantly exp

244 ymogen proteolytically processes itself into active forms of 48, 37, and 33 kDa via sequential trunca

245 Moreover, expression of constitutively active forms of Akt1 and Akt2 restores the anchorage-ind

246 rostate cancer, generation of constitutively active forms of androgen receptor (AR) variants includin

247 We overexpressed FAK alone, constitutively active forms of beta-catenin (CAT) alone, or a combinati

248 This latter phenotype is rescued by active forms of beta-catenin at central and caudal but n

249 tation bzr1-1D, which causes accumulation of active forms of BZR1 [12].

250 Both full-length and constitutively active forms of CREB3L1 (CREB3L1CA) induce the expressio

251 s associated with membranes of metabolically active forms of Ct throughout development.

252 to other systems, by which the formation of active forms of drugs can be catalytically assembled rem

253 t converts inactive cytokine precursors into active forms of IL-1beta and IL-18.

254 than mutants null for VacA or producing more active forms of it, providing the first evidence of a po

255 We previously identified two active forms of matrix metalloproteinases (MMPs), MMP-8

256 Overexpression of active forms of MYRF is sufficient to accelerate synapti

257 developmental transcription factors such as active forms of Notch can directly stimulate transcripti

258 s indicated interactions between TBC1D8B and active forms of RAB11.

259 alters the balance between the inactive and active forms of RasGRP1.

260 In addition, active forms of RNA polymerase-II also colocalized in th

261 n perform a variety of different passive and active forms of synaptic integration on their inputs.

262 evels of PLP and PM phosphate (PMP), the two active forms of the AGT coenzyme, are found.

263 The ligands preferentially engage the active forms of the integrins and trigger signaling casc

264 n phosphorylated/inactive and phosphorylated/active forms of the kinase.

265 alyst furnish the product and regenerate the active forms of the photocatalyst and base.

266 n by limiting accumulation of phosphorylated active forms of the stress kinase JNK.

267 elicobacter pylori virulence gene, cagA, and active forms of the vacuolating cytotoxin gene, vacA, ar

268 Furthermore, constitutively active forms of Yap or Taz were sufficient to stimulate

269 FKBP65 PPIase activity reduced the dimeric (active) form of LH2 but did not affect the binding of mo

270 icant decrease of the phosphorylated, likely active, forms of FoxM1.

271 metabolizing enzymes, was immobilized in its active form on graphene oxide (GO) for enhanced electroc

272 of ascorbate, were quickly reduced to their active form, oxaliplatin, when co-incubated with a macro

273 ferences in the dynamics of the inactive and active forms, particularly in the "insert region" (resid

274 inase 2 (ERK2) or its doubly phosphorylated (active) form (pERK2).

275 FXII undergo reciprocal conversion to their active forms (PKa and FXIIa) by a process that is accele

276 e the transformation of plasminogen into its active form (plasmin), which degrades fibrin and extrace

277 uPA cleaves the zymogen plasminogen into the active form (plasmin), which then degrades the fibrin cl

278 Plasminogen and its active form, plasmin, have diverse functions related to

279 tfB readily binds to C. albicans cells in an active form, producing glucans locally that provide enha

280 es vitamin B6 phosphorylation, producing the active form pyridoxal 5'-phosphate, which regulates two

281 By controlling the reaction conditions, the active form responsible for 4-aminophenol (4-AP) oxidase

282 In the brain, T4 is converted to the active form T3 by type 2 deiodinase (D2).

283 ative state, which is likely to resemble the active form that binds to the Kv1.3 channel.

284 nds RNA with high affinity in a functionally active form that is capable of immediately unwinding RNA

285 Mss51 was enriched in a translationally active form that maintains full Cox1 synthesis even if C

286 closed conformation of E2~Ub represents the active form that mediates ubiquitin transfer has yet to

287 w forms oligomers that are converted into an active form that promotes the translation of target mRNA

288 lular phosphorylation into their antivirally active form, the triphosphorylated nucleoside analogue m

289 thylenimine make the Dopa transforms into an active form (transferred Dopa) that strongly absorbs lig

290 in free Ca2+, resulting in a constitutively active form under physiological Ca2+-concentration, show

291 r to be involved in the stabilization of the active form upon phosphorylation and is not essential in

292 ve prodrugs are typically converted to their active forms using short-wavelength irradiation, which d

293 en the allosterically inhibited form and the active form, we predict a discrete sequence of domain mo

294 onversion of the inactive form of Rho to the active form, we show mathematically that this active reg

295 these transcriptionally inactive AR-Vs into active forms, we identified the two separate elements th

296 by directed evolution, reconstitute into an active form when driven together by an intercellular PPI

297 apable of activating known prodrugs to their active form, which suggests a possible treatment route f

298 ent to convert the inactive holoenzyme to an active form, while hydrolysis per se is required for nuc

299 idate the conformation of the peptide in its active form within silica sheets by interface-specific v

300 ive unspliced form [XBP1(U)] and the spliced active form [XBP1(S)], is a key UPR component mediating