ライフサイエンスコーパス: active site

1 effect on restructuring water network in the active site.

2 -phosphatase with a trapped substrate in its active site.

3 AcCYP51 inactivation than only blocking the active site.

4 propagation from the allosteric site to the active site.

5 destabilizing the closed conformation of the active site.

6 idge helix, a flexible element of the Pol II active site.

7 brane bilayer, providing lipid access to the active site.

8 binds the PRPP binding motif within the XPRT active site.

9 ns cluster near loops that lay on top of the active site.

10 icrobial oligopeptide inhibitor, in the CatD active site.

11 to recognize epitopes in proximity to RTA's active site.

12 ranslationally modified amino acids near the active site.

13 ansition-state analog moiety targeted to the active site.

14 -dependent kinase (AncMsPFK) with F6P at its active site.

15 that this antibody interacts with the MMP10 active site.

16 the binding of its peptides to the target's active site.

17 ds are also able to efficiently bind the COX active site.

18 o HydG forms an ethyl radical trapped in the active site.

19 e the three-dimensional nature of the kinase active site.

20 Omega, 240, and 270 loops, which border the active site.

21 pshot of a human PIKK with a substrate-bound active site.

22 d the structural composition of the involved active site.

23 ing the RNA-DNA hybrid product distal to the active site.

24 ween flavin and substrate within the protein active site.

25 work of interactions to place H3K27 into the active site.

26 by blocking the access of substrates to the active site.

27 but differs in the residues constituting the active site.

28 terization and mapping of the 70S ribosome's active site.

29 ostridioides difficile with Hyp bound in the active site.

30 activity aided by two metal cofactors at the active site.

31 a polyubiquitin chain attached to the UBE2K active site.

32 gion that extends up to 28 angstrom from the active site.

33 laced by detergent from the highly protected active site.

34 nd with the alphaC helix swung away from the active site.

35 e exhibits fructose-6-phosphate (F6P) at the active site.

36 al activity reduction without distorting the active site.

37 rophobic and hydrophilic halves of the CA II active site.

38 g the scissile phosphate into the rearranged active site.

39 ts that displaces nucleotide from the kinase active site.

40 is a distinct loop structure adjacent to the active site.

41 oA (SCoA) cosubstrate is bound at the MmOGOR active site.

42 log (an irreversible inhibitor) bound in the active site.

43 ion metal, either vanadium or iron, at their active sites.

44 heterostructures ensures the ready access of active sites.

45 zyme whose activities arise through distinct active sites.

46 to the involvement of different receptors or active sites.

47 ail in moving the cobalamin cofactor between active sites.

48 and to monitor protein events in hydroxylase active sites.

49 ence of nitrogen-coordinated, single Ni atom active sites.

50 formance, it is crucial to identify the most active sites.

51 protons, and reactants toward catalytically active sites.

52 tations can locate at functional (binding or active) sites.

53 ity to DNMDP, and substitutions in the PDE3A active site abolish compound binding.

54 uence on the kinase domain conformations and active site accessibility.

55 tes broadly and for understanding how copper active sites achieve activation of strong C-H bonds.

56 s) with closely-placed graphitic nitrogen as active sites, achieving dihydrogen dissociation and subs

57 In this work, we identify two consensus active site acidic (a) and basic (b) motifs shared acros

58 Furthermore, kinetic analysis of active site alanine mutants indicates that carbapenem hy

59 the position of each pocket relative to the active site also appeared to be important for polymer el

60 Site-specific replacement of active-site amino acids revealed the presence of a water

61 SDMD N- and C-domain linker by the caspase-1 active site, an anti-parallel beta sheet at the caspase-

62 lic scaffold that binds proximal to the Gna1 active site and can be optimized to a selective submicro

63 modification and molecules that bind at its active site and elsewhere.

64 ions leads to increased accessibility of the active site and higher catalyst turnover frequency.

65 he donor and acceptor substrates bind in the active site and how ethambutol inhibits arabinosyltransf

66 ntify potential catalytic amino acids in the active site and tested these by mutagenesis and in plant

67 , revealing the ligand-free structure of the active site and the conformation of the catalytic site c

68 t into the binding of inhibitors at the CDK7 active site and to aid in the rational design of therape

69 inhibitor to this pocket collapsed the MKP5 active site and was predicted to limit MAPK binding.

70 neous catalysts, revealing the nature of the active sites and establishing links between structural m

71 A careful balance between active-site and exosite contributions is critically impo

72 -specific binding pocket located outside the active site, and a side chain crafted to act as a latch

73 sign assesses the relationship between metal active site architecture and catalytic reactivity.

74 ntration, quaternary structure, and distinct active site architecture despite overall structural simi

75 ves the spatial organization of the nuclease active site, arguing that OLD proteins use a conserved c

76 l movement of amino acid residues within the active site as the substrate binds.

77 scale spatial resolution for visualizing HER active sites as electrochemical images.

78 the importance to control the catalytically active sites at the atomic level.

79 he electrocatalytic function of MOF-anchored active sites at the molecular level.

80 When comparing the number of active sites available, FeS(s)(m) was found to have a hi

81 The active-site belongs to the 'PD-D/EXK' superfamily of nuc

82 Serine active-site beta-lactamases hydrolyze beta-lactam antibi

83 ethoxy-2-nitrobenzyl-l-serine as a transient active-site block, and its subsequent deprotection with

84 Domains I and III form the MenD active site, but no function has yet been ascribed to do

85 ubstrate peptide, and glutamine bound in the active site, but too far away from SAM to be methylated.

86 g enzyme group, due to a different number of active sites, C and N terminal locations and arrangement

87 highlight how small changes in the integrase active site can have notable implications for drug bindi

88 hibit turnover by fastening down the SULT1A3 active-site cap.

89 lar-level insights into the structure of the active sites, catalytic mechanisms, and the long-term cy

90 The structure of NdCCD revealed a tapered active site cavity markedly different from the broad act

91 ionizable residues in the substrate-binding active-site cavity are; resolving this point would help

92 s fully retracted, which leaves space in the active-site cavity for RNA elongation.

93 ocated on opposite sides of the murine Esco2 active site cleft, are critical for catalysis.

94 hange as the substrate moves deeper into the active site cleft.

95 te of [NiFe] hydrogenase and the nitrogenase active site cluster FeMoco.

96 d density functional theory studies on large active site cluster models.

97 how that the low reduction potentials of the active site cofactors are optimized for fast elimination

98 s due to differences in the structure of the active site compared with other zinc-dependent nucleotid

99 he resting state structure reveals a new out active site conformation characterized by large rotation

100 The active site consists of a mononuclear iron coordinated b

101 Here we conducted an alanine scan of active site constituents that engage the ATP phosphates

102 igh affinity for both HLA-B*08 and the ERAP1 active site could not promote the formation of a ternary

103 Other than its unique tetranuclear active site Cu(Z), the binuclear electron entry point Cu

104 ns a cyanimide reactive moiety, binds to the active-site cysteine residue of UCHL1 in an activity-dep

105 QOR revealed a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration.

106 tricate coupling between the dynamics of the active-site cysteines and of the cap loop which modulate

107 The assembly of the active site defies common chemical convention by contrad

108 in improving intrinsic activity, increasing active site density, and attaining optimal porous struct

109 suggest that the three lysines in the lyase active site destabilize pol beta when bound to DNA nonsp

110 in component tuning, morphology control, and active site determination.

111 cupation of the substrate-binding site by an active site-directed inhibitor.

112 vantage of this technique for development of active site-directed ligand evolution of peptides, where

113 e between the most conserved MMP pair via an active site-directed mechanism of inhibition reported he

114 enesis analyses confirmed these compounds as active site-directed reversible inhibitors of mPTPB.

115 product binding and the architecture of the active sites, disclosing important structural informatio

116 MOF-525-J33 with 15.6 angstrom inter active-site distance and 33 % vacancies exhibited unprec

117 talytic activity and the reciprocal of inter active-site distance; a smaller distance led to higher a

118 Understanding the dynamic changes at the active site during catalysis is a fundamental challenge

119 dispersed surface MO(x) sites, nature of the active sites during MDA, reaction mechanisms, rate-deter

120 Protonation and active site dynamics induced by the first step of splici

121 perform sequence and structural alignments, active-site elements were identified, showing divergence

122 rporation of orthogonal Lewis acid and Pd NP active sites endowed 1-OTf-Pd(NP) with outstanding catal

123 mAbs inserted long CDR-H3 loops into the NA active site, engaging residues highly conserved among IB

124 ) triggered adverse secondary changes in the active site entailing dislocations of the ATP phosphates

125 ence that a DNA polymerase can configure its active site entirely differently in human cells than in

126 eading postulate is that the iron-containing active sites exist primarily in a pyridinic Fe-N(4) liga

127 e accessibility method and revealed that the active site faces the cytosol.

128 helical DNA substrate, positioning the DNase active site for first-strand cleavage.

129 g by aiding template strand alignment in the active site for high-affinity binding of the initiating

130 such as steric fit and H-bonding within the active site for proper alignment with MutY catalytic res

131 iently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer.

132 ry (DFT) calculations predisposes the copper active site for the formation of a stable Cu-O(2) interm

133 at another copy, LeuRS-F, contains canonical active sites for aminoacylation and editing.

134 However, the atomic-scale regulation of such active sites for NRR catalysis remains challenging becau

135 s an alpha(2)beta(2) heterotetramer with two active sites for substrate reduction.

136 yano substituents at the vinylene linkage as active sites for the evolution of H(2) .

137 nd defects have been intensively explored as active sites for the hydrogen evolution reaction (HER) t

138 umerous catalysts, including NiO, that offer active sites for water dissociation have been extensivel

139 Active-site forces induce a JT distortion that localizes

140 y affected by strain leading to preferential active sites formation.

141 pathway featured by electron transfer at the active site from Fe(3+) -O...Ir(2+) -O(vac) to Fe(2+) -O

142 Active-site function of IXa was assessed with a tripepti

143 istribution of four proteases with different active site geometries in three cell lines and periphera

144 recently characterized hydride state of the active site (H-cluster).

145 ancestral RNA polymerase catalytic core, its active site has evolved the ability to discriminate agai

146 assures a proper actin-binding interface and active site have formed before producing a power stroke.

147 Atomically dispersed FeN(4) active sites have exhibited exceptional catalytic activi

148 With three synergistic active sites, Hf(12) -Ru-Co-OTf competently catalyzed de

149 binding of the conjugates at the polymerase active site, however, in different modes in the presence

150 In conclusion, the location of the Opi3 active site identified here is consistent with the propo

151 a unique conformation, positioning the MTase active site immediately above the poly-ribonucleotidyltr

152 ic amino acid substitutions distant from the active site in a Klentaq DNA polymerase variant (ZP Klen

153 ere we show the enzyme PanD binds POA in its active site in a manner consistent with competitive inhi

154 Substrates entering the active site in a partially oxidized state form cysteine

155 etric ensemble, thus clearly identifying the active site in alkene combustion catalysts.

156 lating bases in the gap are ushered into the active site in an ordered manner.

157 minate a surprising plasticity of the ligase active site in its interactions with ATP and metals.

158 tam antibiotic now is enabled to bind to the active site in its mechanism of action.

159 subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open

160 The active site in the quaternary Pol mu complex is poised f

161 n about the role of key elements of the RNAP active site in translesion transcription.

162 rformance properties, ranging from occupying active sites in catalytic reactions to co-adsorbing at t

163 The maximum concentration of free active sites in the C8-SCX fiber and the adsorption equi

164 l theory to cluster models of the bimetallic active sites in the heme-copper oxidases are reviewed.

165 ction with methanol to form esters, interior active sites in UiO-66 become accessible for the reactio

166 The active sites in Y-DeAlBEA are 70 times more active than

167 groups, and are 7 times more active than the active sites in Zn-DeAlBEA.

168 The active site-incapacitated variant FXII-W268R/S544A revea

169 accompanied by conformational changes in the active site, including the translation of an alpha-helix

170 thiol dioxygenases, closer inspection of the active site indicates that other catalytic features are

171 Furthermore, four types of promising active site inhibitors of plasmin have been developed: t

172 cts in full-length BTK induced by a panel of active site inhibitors, including large-scale shifts in

173 Pchlide binding to one BchNB active site initiates ET from the pre-reduced [4Fe-4S] c

174 sitions of the metal ions that perverted the active sites into off-pathway states incompatible with l

175 the trigger loop, a flexible element of the active site involved in nucleotide addition, can stimula

176 The product-bound active site is almost identical to that of the substrate

177 Often, the active site is formed by an ensemble of atoms, thus intr

178 The active site is formed by four catalytic motifs that are

179 Pchlide binding in one active site is recognized in trans by an Asp-274 from th

180 tiates V(D)J recombination, we find that the active site is reconfigured for the two consecutive reac

181 organometallic chemistry feature of the NiFe active site is that the iron atom is co-coordinated by t

182 the current knowledge about electrocatalytic active sites is briefly summarized.

183 its indoline ring situating adjacent to the active site, its sulfonyl group adopting a sharp kink, a

184 e with high affinity for the MIF tautomerase active site (K(i) = 18 +/- 1 nM) that binds with concomi

185 nd HER2 mediate specific binding by the SHP2 active site, leading to blockade of RasGAP binding and o

186 Two active site loops undergo large conformational excursion

187 ranslationally controlled by acylation of an active-site lysine.

188 form this reaction, culminating at the FeMco active site (M = Mo, V, Fe), which is capable of binding

189 apoenzyme that reveals the positions of two active site metals in the FEN/EXO domain.

190 uct the first putative nucleotide bound PolD active site model and provide structural and functional

191 tic interactions of the base within the MutY active site modulate the lability of the N-glycosidic bo

192 forces and interactions that allow and limit active-site motions.

193 ther deleted for bioZ or which encode a BioZ active site mutant are biotin auxotrophs, as are strains

194 exes were compared with kinetic data on FUT8 active site mutants and with specificity data from a lib

195 A single active site mutation further enhances the rate of NP-DNA

196 f complete peptidyl transferase center (PTC) active site mutational analyses to inform design.

197 ed the effects of homologous and orthologous active-site mutations on both stability and transferase

198 ite cavity markedly different from the broad active site observed for the retinal-forming Synechocyst

199 known about the bioassembly of the binuclear active site of [NiFe] hydrogenase and the nitrogenase ac

200 sly undescribed copper center that forms the active site of a copper-containing enzyme thiocyanate de

201 form and B-form DNA duplexes, and within the active site of a DNA polymerase lambda variant.

202 nation of a high-definition structure of the active site of a metalloprotein from a powder sample, by

203 at variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp(105), Val(120), an

204 fied to restrict any substrate access to the active site of CYP2J2.

205 re that activating MVCs bind adjacent to the active site of Ddl from Thermus thermophilus and used a

206 e sulfonyl piperazine compounds occupies the active site of LpxH, foretelling a straightforward path

207 drogen bonding, Bronsted acid/base) near the active site of metal-containing catalysts is an effectiv

208 e docked bioactive molecules of tea onto the active site of Nsp15.

209 longation prior to the sequence entering the active site of Pol I both in vivo and in vitro.

210 etitive interaction of CO(2) and O(2) at the active site of ribulose-1,5-bisphosphate carboxylase/oxy

211 modification prior to incorporation into the active site of spliceosomes.

212 an auto-inhibitory linker that occludes the active site of the enzyme is required and sufficient to

213 cose at 3.9 angstrom resolution revealed the active site of the enzyme.

214 The active site of the nitrogenase MoFe protein corresponds

215 Docking was used to explore the active site of the out conformation.

216 he Ig3-protease interaction surface, and the active site of the protease domain.

217 he structure of PAICS with CAIR bound in the active sites of both domains and SAICAR bound in one of

218 How the 12 ATPase active sites of ClpA, 6 in the D1 ring and 6 in the D2 r

219 -planar geometry that strongly resembles the active sites of molecular metal-porphyrin catalysts.

220 The active sites of RFC are fully bound to adenosine 5'-trip

221 accelerated mass diffusion and more exposed active sites of this design, HP-MOFs exhibited an enhanc

222 he structural impact of the formation of the active site on RNP architecture.

223 sed on atomically dispersed rhenium (ReO(4)) active sites on an inert support (SiO(2)) for the halide

224 However, the lowest overpotential active sites on these three crystallographic facets oper

225 To this end, we model various active sites on these two facets using hybrid density fu

226 ases the oxygen vacancies and exposes more W active sites, optimizes the nitrogen adsorption energy,

227 s by blocking substrate access by binding to active sites or exosites or by allosteric modulation.

228 nism by which unconventional RBDs containing active sites or molecule-binding pockets could interact

229 nce that a conserved serine residue near the active site participates in the catalytic activity of Cd

230 The high active sites per mass ratio of such hollow HEA nanoparti

231 ect and indirect demethylases, highlight the active-site plasticity of these Fe(II) /alpha-ketoglutar

232 ndent of its lipid phosphatase function, the active site plays a role in the Fab1-Vac14-Fig4 complex.

233 support, the confinement experienced by the active site plays an important role for the catalytic ac

234 that Asn-169, a conserved residue in the AAG active-site pocket, contributes to discrimination agains

235 stidine involved in zinc coordination at the active site reacted slower than what was expected by its

236 e apo-form and when bound to IP6 revealed an active-site rearrangement that allows for ATP binding an

237 r without PQQ, both with La(3+) bound in the active-site region and coordinated by Asp(320) Using con

238 )N(2))Fe is a more effective model of Fe-N-C active sites relative to the pyrrolic iron macrocycles,

239 (a) of 8.7 +/- 0.05 that we attributed to an active-site residue involved in deprotonating bound subs

240 DNA polymerase activity depends on conserved active site residues and propose a likely mechanism for

241 The study identifies the roles of the active site residues and the Mg(2+) ions in catalyzing t

242 d gain-of-function mutations of the putative active site residues correspondingly altered copper bind

243 Pol beta Asn279 and Arg283 are the critical active site residues for the differentiation of an incom

244 the larger substrate is accommodated and how active site residues have changed to recognize N-citrylo

245 hroughout its catalytic cycle and mapped the active site residues responsible for nucleoside selectio

246 ternal glutamates, and we find that the same active-site residues discriminate between initiase and e

247 s was utilized to assess the role individual active-site residues play in guiding selective DKP dimer

248 dral intermediate analogs that delineate key active-site residues that make this enzyme an elongase.

249 signment of the catalytic roles of conserved active-site residues.

250 o family anchor the loop's N-terminus to the active site Ser-Cys-Thr-Sec sequence.

251 iate revealed that avibactam is bound to the active-site serine in two orientations ~180 degrees to e

252 ubstrate transmembrane domain and engage the active site should provide important tools for structura

253 dividual protocols based on the 'masking' of active sites should be elaborated for each enzyme.

254 ucture of RiCE17 with a mannopentaose in the active site shows that the CBM35 domain of RiCE17 forms

255 Our studies indicate that active-site shuttling occurs at a high frequency, and we

256 The combination of a functionalized active site, size-selective reactivity, and multistep ac

257 c14 family and comparing the conservation of active site structure and specificity among a sampling o

258 ogen Candida albicans have revealed that the active-site structure and Cu binding of SOD5 strongly de

259 reaction (ORR) in fuel cells; however, their active site structures remain poorly understood.

260 Although the active site subsites are well defined for a few model LP

261 itioned at the periphery with outward-facing active sites suggesting that the complex may target mult

262 The proximity of the EF domain to the active site suggests that Ca(2+) binding is relevant to

263 A bifunctional active site that is distinct from its methyltransferase

264 WA domain initiates a signal toward the CbbQ active site that is propagated via elements that include

265 U6 folds with U2 snRNA into an RNA-based active site that positions the 5'SS at two catalytic met

266 cooperative reaction mechanism involving an active site that spans the interface between two dimers,

267 By mutations of critical residues at the active site, the modified local structures become looser

268 he other side, with the multiple Pt adjacent active sites, the cluster and nanoparticle Pt/CeO(2) sam

269 action for steric hindrance around the metal active site to achieve stronger asymmetric induction.

270 17A) in the conserved switch I region of the active site to examine how myosin couples structural cha

271 he loosely bound 3TC-TP is misaligned at the active site to prevent a steric clash with the side chai

272 to bind cA(4) specifically, and a conserved active site to rapidly cleave this signalling molecule,

273 bromoethoxy analogue was used to explore the active site topography; and deuterium isotope effects on

274 e membrane in an orientation that places the active site toward the membrane.

275 g isoprene chain extends beyond the enzyme's active site tunnel, and an insert within the alpha3 heli

276 contact the same region at the bottom of the active site tunnel, which undergoes conformational chang

277 nvolving a specific and crucial role for the active site tyrosine, conserved in all CcOs, is suggeste

278 lex show that CO and Trp remain bound in the active site under comparable X-ray illumination, indicat

279 in vivo indicate that the PaClpP2 peptidase active site uniquely contributes to biofilm development.

280 hermodynamics of TM ion binding to a protein active site unlike extant models.

281 Here, we engineered active-site variants to switch the SETD3 target specific

282 ed structural changes that are linked to the active site via ATPase motif VI.

283 o acids jointly communicate occupancy to the active site via subtle changes in dynamics, enabling exq

284 Initially, a conserved glutamate at the active site was believed to generate the nucleophile nec

285 n of (dis)similarities between the target CA active sites was planned with benzenesulfonamide derivat

286 ng mutations and a caged lysine blocking the active site, we can rapidly switch on catalytic activity

287 molecule of alpha-naphthoflavone in a closed active site, we observed that subtle amino acid substitu

288 These dispersed active sites were investigated by hard and soft X-ray sp

289 cts McrC binding so that it engages a single active site, where it then uses an arginine/lysine-media

290 dation overpotential of bimetallic Ni and Co active sites (whereas Ni(2+) can be more easily activate

291 protein (PBP)2a, resulting in opening of the active site, whereby the beta-lactam antibiotic now is e

292 able topologies, and defined catalytic/redox-active sites), which have motivated increasing efforts t

293 itively charged cavities directly around the active site, which are expanded as the enzyme evolved wi

294 in the ancestor CYP1B enzyme yielded an open active site with four ligand copies.

295 As HPF1 forms a joint active site with PARP1 or PARP2, our data implicate HPF1

296 led turnover or provide an ET pathway to the active site with substrate bound.

297 f a coordinatively-unsaturated metalloenzyme active site, with utility for selecting compounds with m

298 lity in acid can be constructed by embedding active sites within an acid-stable metal-oxide framework

299 s and a hydrophobic interface, with putative active sites within the membrane region.

300 es a TPN orientation that coordinates to the active-site Zn(II) ions via a CN and that maximizes a pa