ライフサイエンスコーパス: activity

1 tion and chemogenetic inhibition of neuronal activity.

2 r2c-containing Pp2a complex to reduce Erk1/2 activity.

3 a dimeric BRAF(KD) assembly to increase BRAF activity.

4 nds with relevant antioxidant and anticancer activity.

5 rom the histone "tails," which modulate gene activity.

6 nflammatory cytokine secretion and cytotoxic activity.

7 s, mostly in areas with a high anthropogenic activity.

8 suggesting a non-genetic basis for enhanced activity.

9 it exhibits oncogenic Ras-like transforming activity.

10 zed in high radiochemical yield and specific activity.

11 ength and exhibited potent antiproliferative activity.

12 in providing the necessary metabolic network activity.

13 idues that play a critical role in catalytic activity.

14 ated gene repression requires PRC1 catalytic activity.

15 ediated interactions influence Hippo pathway activity.

16 ssociation in the circulation inhibits PCSK9 activity.

17 GDH stability, oligomerization, or enzymatic activity.

18 ep against a backdrop of overall reduced ABN activity.

19 play in determining the timing of biological activity.

20 as variations in duration or time-integrated activity.

21 us potentially attributable to increased PKA activity.

22 resting flow that is linked to enhanced NOS activity.

23 duces mitochondrial electron transport chain activity.

24 delivery while preserving its full enzymatic activity.

25 pensable for both HSP90 interaction and PDE6 activity.

26 n integrating spontaneous and sensory-driven activity.

27 expression without affecting canonical HIF1a activity.

28 regulation of OAT1 expression and transport activity.

29 technical hurdles in reliably measuring its activity.

30 h alanine or methionine also increased basal activity.

31 ns in its backbone and maintained biological activity.

32 oxide perovskite catalysts with improved OER activity.

33 ng to the down-regulation of LINE-1 promoter activity.

34 ain centers involved in regulating sleep and activity.

35 s itaconate, a metabolite with antimicrobial activity.

36 t for selected derivatives, showing moderate activity.

37 tion of GAs, but was lacking the 3-oxidation activity.

38 ly associated with a decreased antimicrobial activity.

39 th a single cofilin having filament-severing activity.

40 entral regulator of RNA polymerase (Pol) III activity.

41 essing Pb emissions directly linked to human activities.

42 -obesity drugs by inhibiting its DNA-binding activities.

43 binding sites important for these allosteric activities.

44 ase (PAL) and lower polyphenol oxidase (PPO) activities.

45 ammaRs), which confer pleiotropic biological activities.

46 lution and potential to exert specific toxic activities.

47 l D,D-endopeptidase and D,D-carboxypeptidase activities.

48 nt alkyltransferase or reductive elimination activities.

49 A high mass activity (1.946 A mg(-1) at 0.45 V) of Pd(delta+)-OCNT i

50 and increased sodium/calcium exchanger (NCX) activity (~52%).

51 m 14 loci displaying allelic transcriptional activity, a subset of which corroborates four colocalizi

52 th cells, indicative of differential network activity across cell types.

53 inflammation but it has no direct antiviral activity against ECTV.

54 e considered adequate for redirected killing activity against Env-expressing target cells but began t

55 topiperazines (ETPs) and evaluation of their activity against five human cancer cell lines.

56 C, which has been shown to have anti-tumour activity against NTRK gene fusion-positive solid tumours

57 d donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes

58 One of these analogues has excellent activity against several streptogramin-resistant strains

59 Investigations of antiviral activity against the human respiratory syncytial virus w

60 NVS-CECR2-1 exhibits cytotoxic activity against various human cancer cells, killing SW4

61 etabolism, energy expenditure, and locomotor activity, along with increased body temperature and BAT

62 es, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hep

63 The activity analysis included all patients who completed at

64 ogical state, and (3) C15:0 has demonstrated activities and efficacy that parallel associated health

65 citly includes the combined effects of human activities and fire regimes.

66 Here, we report on the diversity, activity and adaptations of fungal communities in the de

67 ecise cell types whose loss of mitochondrial activity and altered mtDNA copy number that result in or

68 , an inhibitor of glycolysis, augmented AMPK activity and attenuated ZIKV replication.

69 perties, as a result, enhances the intrinsic activity and availability of surface iridium sites, whil

70 Simultaneous optical monitoring of CaCC activity and Ca(2+) dynamics revealed that the TRPV1 lig

71 relationship between bioelectric ion channel activity and calcium, finding that cell hyperpolarizatio

72 The transform between neural activity and calcium-related fluorescence involves nonli

73 t mice, this mutant restored basal locomotor activity and cocaine-induced locomotor activity in a man

74 e has been a lack of information about Gdf15 activity and effects in normal kidney and in AKI.

75 al cytoplasmic regulatory domain impair NHE6 activity and endosomal function are poorly understood.

76 lacental glutamine and glutamate transporter activity and expression, and propose the mammalian targe

77 hat this ELANE mutation diminishes enzymatic activity and granulocytic differentiation without signif

78 thelial inflammation adversely impacts niche activity and HSC function which is reversible upon suppr

79 d in lower PTEN antigen levels, enhanced Akt activity and increased rate of cell proliferation.

80 lone is necessary for ZNF165 transcriptional activity and is required for TNBC tumor growth in vivo u

81 pe, which is associated with reduced mitotic activity and lower expression of PLETHORA 1 (PLT1)/PLT2

82 mpact of gold nanoparticles on the metabolic activity and morphology of human pulmonary endothelial c

83 dine uptake, system L amino acid transporter activity and Na(+) K(+) -ATPase activity using sarcolemm

84 nd constrain computational models with brain activity and pushes our understanding of human brain fun

85 ive single-atom catalysts, and it has a high activity and selectivity for electrochemical CO(2) reduc

86 n starting and ending values of plasma renin activity and serum aldosterone were 6.8 vs. 5.5 ng/mL/h

87 cts of single amino acid variation on enzyme activity and steady-state cellular abundance with a larg

88 Mechanistically, we observed elevated AMPK activity and the AMPKbeta1 abundance in the liver of E4b

89 equired calcium ion for both the hydrolyzing activity and the antioxidant effect.

90 ucidate the underpinnings of both actomyosin activity and the dynamics of microtubule/motor assemblie

91 inhibiting beta-catenin translation and mTOR activity and thereby reduces HCC cell survival.

92 ic activity was independent of motor-related activity and thus tracked specifically the learning of r

93 aits, identifying cultivars with antioxidant activity and total anthocyanins content closest to those

94 Fatty acid oxidation activity and tricarboxylic acid (TCA) cycle metabolites

95 mory in a similar manner to rodent grid-cell activity and, therefore, strengthen the putative link be

96 lity, brain microstructure, functional brain activity, and alpha-syn pathology by longitudinally cond

97 me, administered antibody, antibody specific-activity, and antigen-site density most impacted median

98 teraction data for ligands with antimalarial activity, and establishes curation of data from screenin

99 total running, appropriate food anticipatory activity, and increased consumption, thereby achieving s

100 ogical conditions to control the production, activity, and movement of these organelles.

101 of key coordinating residues for transporter activity, and provide a structural explanation for varie

102 localization and interference with cI(VP882) activities are separable.

103 ATPases associated with various cellular activity are a set of protein assemblies that function a

104 t of separate regularly spaced "nodes" of TP activity around the division site of predivisional cells

105 idated by mitochondrial respirometry, enzyme activity assays and gene expression analyses.

106 and R loops and showed a potent cell killing activity associated with the formation of micronuclei, a

107 onstrate the applicability of an untargeted, activity-based approach for SCRA detection in OF.

108 argets have found widespread applications as activity-based probes and as irreversibly binding drugs.

109 The absence of PlexA1, neuronal activity, Bax and Bak, or caspase-9 leads to the mainten

110 ition, virus-encoded VP3 antagonizes RNase L activity both in vitro and in vivo These studies highlig

111 symbiont's sRNAs not only to control its own activities but also to trigger critical responses promot

112 nce pathway that amplifies noncanonical Gli1 activity, but characteristics and drivers of the nMRTF c

113 chemistry (cleavable versus stable) altered activity, but not accumulation.

114 ion of Trpm7 and inhibition of TRPM7 channel activity by the FDA-approved drug FTY720 increased the s

115 cosylase activity (C146 and C255), (2) lyase activity (C140S, C163, C241, and C253), and (3) structur

116 those that are necessary for (1) glycosylase activity (C146 and C255), (2) lyase activity (C140S, C16

117 ap of eRNA loci through which super-enhancer activities can be quantified by RNA-seq and a user-frien

118 Aberrant ferroportin activity can lead to diseases of iron overload, such as

119 Besides its antiviral activity, chloroquine might also mitigate the cytokine s

120 e AHR pathway and increased CYP1A1 enzymatic activity compared with healthy donors, suggesting that d

121 ly free of tumors and had normal phospho-ERK activity compared with Nf1(flox/flox);PostnCre(+) mice.

122 , where it showed a markedly higher specific activity compared with PLD4.

123 ities of RuBisCO and PPDK but decreased PEPc activity compared with warm-grown plants.

124 , disrupting the correlations between neural activities decreased decoding performance, mostly in CA1

125 ites with known or suspected neuromodulatory activity, define mechanisms of signalling pathways from

126 ion for women and the three outcomes: sexual activity, demand for contraception, and modern contracep

127 s and show that Zn(2+) inhibits AMPARs in an activity-dependent manner, opening up this pathway as a

128 HVDAS is caused by mutations in activity-dependent neuroprotective protein (ADNP).

129 Within mammalian brain circuits, activity-dependent synaptic adaptations, such as synapti

130 icates dynamic functions for various MAPs in activity-dependent synaptic plasticity.

131 In this study, we used an activity-dependent tagging system in mice to determine t

132 Although inhibition of PDE3A catalytic activity did not account for DNMDP sensitivity, we found

133 gions and their interactions with brain-wide activity drive action selection is less understood.

134 fusion-positive solid tumours, including CNS activity due to its ability to penetrate the blood-brain

135 thin the TMJ superficial niche exhibit Notch activity during TMJ morphogenesis.

136 Because the frequency content of nerve activity falls in a higher frequency range than that of

137 learn network similarity and shared pathway activity for groups of cancers with related origins repr

138 the capacity of our model to uncover in vivo activity for the biotin biosynthesis inhibitor MAC13772.

139 ng ROI-based fMRI analysis, we measured fMRI activity for valid and invalid trials (target at cued/un

140 de voltage modulation of ligand-induced GPCR activity has been reported for several GPCRs.

141 Such activity has typically been observed and interpreted in

142 been classically developed to inhibit enzyme activity; however, new classes of small molecules that e

143 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21-1.94).

144 anding of all processes leading to catalytic activity, i.e., light absorption, charge separation, tra

145 motor activity and cocaine-induced locomotor activity in a manner indistinguishable from wild-type D2

146 cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunit

147 ntion to salient stimuli, as well as greater activity in attention-related brain networks.

148 anti-fungal drug itraconazole abolishes NPC1 activity in cells.

149 valent Bruton tyrosine-kinase inhibitor with activity in chronic lymphocytic leukaemia.

150 GPIHBP1 fusion protein exhibited high enzyme activity in in vitro assays.

151 er processing levels, as in the human brain, activity in low-level visual areas should encode variati

152 ral cereblon-modulating agent with promising activity in non-Hodgkin lymphoma.

153 ained points and rewards for engaging in any activity in or out of school.

154 ght be used in practice to assess endoscopic activity in patients with CD.

155 Our findings reveal increased oscillatory activity in the beta band (~20 Hz) at triplet transition

156 Participants in the MT group showed lower activity in the cognitive control network (CCN) during t

157 such as synaptic scaling, stabilize neuronal activity in the face of perturbations.

158 s of sensory-driven versus choice-correlated activity in the low-dimensional population code.

159 test these hypotheses, we recorded neuronal activity in the orbitofrontal and anterior cingulate cor

160 The role of CCC1 ion transporter activity in the regulation of plant immunity is corrobor

161 results demonstrate a requirement for dnmt1 activity in the regulation of RSC proliferation, gene ex

162 Virulence inhibitory activity in the RND-negative background resulted from Om

163 olorectal cancer, it remains unclear whether activity in the tumor-associated stroma contributes to m

164 strate that CERBERUS has auto-ubiquitination activity in vitro and is localized within distinct motil

165 This BTC demonstrated potent antitumor activity in vivo but was poorly tolerated, which was hyp

166 Z)/MEK inhibitor combination showed enhanced activity in vivo specifically in CA-NRAS models.

167 e., the spectroscopic evidence of biological activity) in exoplanets.

168 Barrel activity increased significantly within 500 ms of whiske

169 pes of tumors, report a promising anticancer activity induced by CB2R agonists due to their ability t

170 ittle is known about the detailed electrical activity inside the cell.

171 ckpoint serves as an exemplar, whereby CTLA4 activity is blocked by antibodies in cancer immunotherap

172 Their activity is frequently deregulated in disease and target

173 In contrast, we find that Rca activity is highly sensitive to truncations and mutation

174 ring a murine model of sepsis, P2X7 receptor activity is important for maintaining elevated levels of

175 Collectively, our data suggest that mTOR activity is linked to T-bet in Ag-expCD4(+) T cells but

176 The intrinsic lymphatic contractile activity is necessary for proper lymph transport.

177 , but the molecular basis for this increased activity is not known.

178 Continuous activation of MYC activity is potentially lethal.

179 thesis of heparan sulfate, we show that this activity is required for efficient infection by SBV.

180 e extend this paradigm to measuring proteome activity landscapes by acquiring and integrating quantit

181 nate precipitation (MICP) in which microbial activity leads to the formation of calcium carbonate pre

182 causal relationship between higher physical activity levels and lower risks of breast cancer and col

183 comotor pattern and spinal locomotor network activity, likely resulting from defective survival of a

184 dence for the persistence of germinal center activity long after the period of active viral replicati

185 expCD4(+) T cells but that reduction in mTOR activity may not directly underpin Ag-expTh1 cell loss a

186 Microbial activity mediates the fluxes of greenhouse gases.

187 ocol, including virtual reality video games, activity monitors, and handheld computer devices for 6 m

188 local field potentials (LFP) and multi-unit activity (MUA) in the cortex in response to repeated bri

189 Treatment induced recovery of respiratory activity normalized these effects, increasing oxygen sup

190 Cyclin/Cdk1 activity normally declines in tight association with inc

191 ment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, wh

192 d-grown Miscanthus plants increased in vitro activities of RuBisCO and PPDK but decreased PEPc activi

193 he phospholipid-scrambling or ion conduction activities of the dual-functional TMEM16F.

194 homogeneous and heterogeneous photocatalytic activities of the TBPCExBox(4+) , for the elimination of

195 The median injected activity of (18)F-rhPSMA-7 was 327 MBq (range, 132-410 M

196 Here, we assess the splicing activity of 34 inteins (both uncharacterized and known)

197 eta-catenin while increasing the phosphatase activity of a Ppp2r2c-containing Pp2a complex to reduce

198 ncreased cell concentrations demonstrate the activity of acetate-degrading hyperthermophiles.

199 vo studies demonstrated that 20 restored the activity of beta-lactam antibiotics against carbapenem-r

200 Changing activity of cardiac Ca(V)1.2 channels under basal condit

201 xplored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells.

202 first time that PA influences the biological activity of chitosans, which can now be recognized as bo

203 elease has been causally associated with the activity of cholinergic interneurons.

204 Furthermore, the activity of CX-6258 was validated in several Ewing sarco

205 The expression and activity of deubiquitinases are critical for physiology

206 ion for EphA2, we compared the EphA2 binding activity of EBV gH/gL and the EBV gH/gL-N(69)L/S(71)V mu

207 ing methods to predict the likely biological activity of encoded molecules.

208 The aim of the study was to evaluate the activity of FAP via FAPI-positron emission tomography-co

209 ructure, stability and intercellular channel activity of gap junctions; however, the molecular basis

210 r pharmacological abolition of the catalytic activity of HDAC3.

211 in (CTD) that modulates the Zn(2+) transport activity of HsZnT8; and two adjacent sites buried in the

212 via angiogenesis inhibition may augment the activity of immune checkpoint inhibitors.

213 ur approach is capable of monitoring in-situ activity of LAP in live cells.

214 Our results on the structure and activity of Lpg2603 reveal a unique mode of regulation o

215 served molecular chaperone important for the activity of many client proteins.

216 The activity of many enzymes is regulated by associative pro

217 pathology of all fibrotic conditions is the activity of myofibroblasts.

218 In this study, we examined the antiviral activity of natural compounds against the following infl

219 Here, we monitor the enzymatic activity of p97 in real time via an NMR-based approach t

220 n the inflamed pancreas and may suppress the activity of pancreas autoreactive T cells in newly hyper

221 ental and reproductive cues that repress the activity of proteostasis-related pathways in early adult

222 mined by a lumenal pH of ~5.0, including the activity of resident acid-activated hydrolases.

223 In embryos, the heat-induced activity of SfHsp20.71 and SfHsp70D promoters outperform

224 n resistance through reduced tyrosine kinase activity of the insulin receptor; however, its impact on

225 ngly activated outside of lethargus, altered activity of the locomotion interneurons during lethargus

226 acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) iso

227 ns had opposite effects on the RNA-unwinding activity of the N-terminal cassette, with one configurat

228 ular functions, such as vesicle trafficking, activity of the Rab3 and Rab27 small GTPases, tumour nec

229 thmic Purkinje cell firing, which alters the activity of their target cerebellar nuclei cells.

230 How the combined activity of these different components is spatiotemporal

231 lished mechanism, we compare and analyze the activity of these two superbases.

232 s in zebrafish embryos to assess their joint activities on physiology and transcriptional alterations

233 monstrated that DspB has increased catalytic activity on de-N-acetylated PNAG oligosaccharides, but t

234 ctually retains substantial H3K4 demethylase activity on nucleosome substrates.

235 gue 2-fluoro-ATP, and to confirm its agonist activity on rat P2X2 receptors expressed in human cells.

236 proach for the clinical assessment of lesion activity on root surfaces.

237 d by Rac1, with decreased and increased Rac1 activities opening and closing, respectively, the silent

238 s and particles and are appropriate for this activity owing to their biocompatibility and ability to

239 ion with fMRI at a coarse spatial scale, the activity patterns for flexion and extension of the same

240 hythms in behaviors and show a wide range of activity patterns.

241 Local M2 neural activity precedes local M1 activity, supporting top-down

242 nt and the target of 90% of the neutralizing activity present in SARS-CoV-2 immune sera.

243 used devices to target mobility and physical activity problems, individually prescribed by a physioth

244 levant proteins have unknown or inaccessible activity profiles and so cannot be targeted by such stra

245 e molecular libraries for studying structure-activity profiles.

246 Leg muscle activity reduced, and postural sway increased after HDBR

247 -SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation.

248 However, how neuronal activity regulates synaptic vesicle recycling is largely

249 , previous studies focus on changes in brain activity related to motor execution.

250 The structure-activity relationship (SAR) trends identified were subst

251 on the scaffold revealed a dynamic structure activity relationship and delivered analogues with nanom

252 ew is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and

253 c reaction pathways, for affording structure-activity relationships.

254 4 in biological fluids and a decrease in its activity results in higher bacterial load and exacerbate

255 ratio greater than 61 for both mean Nursing Activities Score per nurse ratio as well as Nursing Acti

256 adjustment the association between a Nursing Activities Score per nurse ratio greater than 61 for bot

257 ies Score per nurse ratio as well as Nursing Activities Score per nurse ratio on day 1 and in-hospita

258 96; P = .036) and a reduced risk of an NAFLD activity score of 4 or higher (ADH1B*2: OR, 0.83; P = .0

259 This study shows that suboptimal anti-A3G activity shapes viral fitness and drives viral evolution

260 olved in antimicrobial and anti-inflammatory activities, showed a twofold increase in vaginal deliver

261 piking during mnemonic periods interact with activity-silent mechanisms in the prefrontal cortex (PFC

262 Rv0891c had very low adenylyl cyclase activity so it could represent a pseudoenzyme.

263 the other sites only inhibits Katanin ATPase activity stimulated by MTs.

264 aptic input to single neurons and population activity strongly tracked visual cues in one environment

265 ion (in micro- vs. mesopores), and catalytic activity suggest nearly invariant structure and function

266 Local M2 neural activity precedes local M1 activity, supporting top-down hierarchy between the regi

267 f all six compounds showed greater arrestant activity than 2-phenylundecane alone.

268 c kinase and histone acetyltransferase (HAT) activities that activates transcription of key protoonco

269 tection of oxygen-dependent changes in COX-2 activity that are independent of protein expression with

270 Lastly, patterns of cortical activity that discriminated between tones became increas

271 clear contribution of androgen receptor (AR) activity that has been established in preclinical models

272 A methylation result from opposing enzymatic activities, the rates of which remain largely unknown.

273 Here, we report that octopamine activity through the beta-adrenergic-like receptor Octbe

274 K10 in the regulation of p53 transcriptional activity through tyrosine phosphorylation.

275 HBECs that activate low levels of telomerase activity to maintain short telomeres.

276 a-secretase complex as well as its catalytic activity toward its substrate Notch, a critical regulato

277 luation of the Au@Pt/Au NPs electrocatalytic activity toward WOR.

278 reported by Solomon et al. that hippocampal activity tracks distance in semantic space during recall

279 osture-dependence of extrinsic finger muscle activity using bipolar fine-wire electrodes inserted int

280 transporter activity and Na(+) K(+) -ATPase activity using sarcolemmal membranes isolated from hindl

281 supporting that E4BP4 may suppress the AMPK activity via promoting the AMPKbeta1 ubiquitination and

282 that the dimensionality of neural population activity was higher across blocks in which animals learn

283 The anti-acetylcholinesterase activity was higher in butanol extract, whereas the ethy

284 This cue-specific activity was independent of motor-related activity and t

285 A clone encoding carboxymethyl cellulase activity was isolated during functional screening of a h

286 FVIII activity was measured at baseline and weekly thereafter.

287 OsNLA1 promoter activity was observed in roots, ligules, leaves, sheaths

288 Antimicrobial activities were also promising, especially against Salmo

289 ition and metalloproteinase 2 and 9 (MMP2-9) activity were compared to tropifexor and selonsertib.

290 ll responses with S protein-specific killing activity were detected.

291 Some ISGs have specific antiviral activity, whereas others regulate the cellular response.

292 ence, without inducing alcohol dehydrogenase activity, which suggests that coated fruit did not ferme

293 was no evidence for associations of physical activity with histologic types and lung cancer in ever a

294 esponded to lithium; they featured sustained activity with large current injections and a large, fast

295 f visual moving dots, while recording neural activity with millisecond resolution using magnetoenceph

296 nd MeOH extracts presented higher inhibitory activity with respect to alpha-amylase and tyrosinase.

297 through an unbalanced control of kallikrein activity, with bradykinin as most likely mediator.

298 have negative short-run effects on economic activity, with losses likely concentrated in coastal low

299 dies suggest that CD39 and CD73 nucleotidase activity within junctional spaces can exploit their conf

300 horter duration or, alternatively, with less activity, without a compromise in image quality.