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2 confirm that 3-MPA inhibited PEPCK-M enzyme activity as 3-MPA interfered with the PEPCK enzyme assay
6 us harbors two distinct noncoding regulatory activities, as a cis-DNA repressor that regulates neighb
7 lation of GABA availability by mitochondrial activity as a biologically relevant mechanism and demons
8 erall, this study suggests assessment of SYK activity as a biomarker for metastatic disease and the u
9 ith pericyte maturation and uncover PI3Kbeta activity as a checkpoint to ensure appropriate vessel fo
11 ly interfere with P-glycoprotein drug efflux activity as a consequence of carbonic anhydrase XII (CA
12 . identify enhanced electron transport chain activity as a critical determinant of this process, esta
13 In this study, we identify CYP1A1 enzymatic activity as a critical regulator of beneficial AHR signa
17 the germline, pointing to paternal physical activity as a direct factor driving offspring's brain ph
20 od allows for a systematic study of catalyst activity as a function of particle composition for vario
21 We found that subsets of neurons shifted activity as a function of the changing expected delay an
22 an important trade-off between stability and activity as a function of this decrease in structural dy
28 Gaussian process models highlighted calpain activity as a key event during primary rod photoreceptor
31 triggers a functional switch between UgpB's activity as a molecular chaperone and its activity as a
32 revious in vitro studies implicated PLP2/DUB activity as a negative regulator of the host interferon
33 ormer is confirmed, this would mark physical activity as a novel modifiable risk factor for preventin
34 ze this transcription factor and promote its activity as a positive regulator for leaf senescence und
35 , our results support impaired TRN-PV neuron activity as a potential cause of schizophrenia-linked ab
36 d depression incidence and assessed physical activity as a potential effect modifier and mediator.
37 ic validation for inhibition of LRRK2 kinase activity as a potential means of affecting disease progr
38 e change and added a parallel screen of SOD1 activity as a potential proxy for compound toxicity.
39 s led to the identification of ORF37's DNase activity as a potential target for antiviral therapeutic
41 ci, which suggests targeting of gap junction activity as a preventive strategy for obesity-associated
42 These findings identify enhancement of NAMPT activity as a promising new therapeutic strategy to prot
44 Interestingly, when we used prion conversion activity as a readout in real-time quaking-induced conve
46 mutant proteins have increased nucleotidase activity as a result of altered activating and autoregul
47 contributes to enhancement of cGAS enzymatic activity as a result of DNA-induced liquid-phase condens
48 found that may have contributed to increased activity as a result of greater Shannon entropy in RRE s
51 localized mostly in the nucleus and has low activity as a result of tight nuclear tethering(14-18).
52 ome T-cell ALLs (T-ALLs), predicting in vivo activity as a single agent and in combination with dexam
53 ent of the B-cell receptor, has demonstrated activity as a single agent and in combination with ritux
54 together with signs of clinical and biologic activity as a single agent in patients with R/R AML.
56 oparticles leads to their improved catalytic activity as a solid oxide fuel cell electrode and in the
58 g System (IRAMS) to measure murine locomotor activity as a surrogate measure of disease severity and
59 cytokine profile, immunogenicity (using IDO activity as a surrogate), and downstream T cell polariza
61 difications of efavirenz to modulate CYP46A1 activity as a therapeutic target of brain disorders such
64 ys for the inhibition of hypothalamic neuron activity, as alcohol signals hypothalamic neurons in a v
65 GPR158 is expected to prolong the betagamma activity, as also observed with some activators of G-pro
66 tudies distinguish between two separable EMC activities, as an insertase regulating tail-anchored pro
71 endothelial cells promotes disease, but its activity as an extracellular molecule is incompletely de
72 s on distinct cell populations poses MMP-2,9 activity as an important mediator and contributor in her
73 resequences, MPP exhibits a second conserved activity as an internal processing peptidase for complex
75 of free GMT upon hydrolysis, with biological activity as assessed by cytotoxicity assays performed in
77 sue injury and was independent of blood pool activity as assessed by quantitative positron emission t
79 tibular-induced eye movements, and hair-cell activity as assessed with FM dye labeling and microphoni
81 M203 mRNA levels are associated with disease activity, as assessed by serum levels of the complement
82 24 levels showed an association with disease activity, as assessed by the urticaria activity score an
83 Considering only 32 scans of the highest activity as categorized by a visual scoring strategy, we
85 h 100% selectivity and 9-fold increased mass activity as compared to a more traditional aluminosilica
87 h and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, ind
88 activity, as well as robust endonucleolytic activity as compared to its bacterial homolog RNase J1 o
90 T/F/M substitutions impaired PA endonuclease activity as compared to that of wild-type (I38-WT) PA.
91 kind and has displayed superior anti-cancer activity as compared to the current first line drug gemc
92 -LCD sites and had decreased home ranges and activity as compared to wolves without LCDs in their hom
95 y improved hydrogen evolution reaction (HER) activity, as compared to the unsubstituted Mo(2)CT(x) ca
96 ncreased circularly polarized emission (CPL) activity, as compared to their parent chiral models lack
97 ace oxygen, and therefore lower CO oxidation activity, as compared to uniformly distributed nanoparti
99 (M1) are essential for performing daily life activities, as damage to these pathways can result in fa
100 ith UGT76E1 contributing a major in vivo UGT activity, as deduced from Arabidopsis mutants with aboli
102 xcitatory synapse formation elevates network activity, as demonstrated by microelectrode array analys
103 cinnamic acids, affording strong antioxidant activity, as detected by the protection of membrane lipi
104 a differential reduction in Galphai protein activity as determined by cellular dielectric spectrosco
105 ow that the seasonal onset of photosynthetic activity as determined by PRI time series was significan
107 to the 18S rRNA markedly reduced TriMV IRES activity, as did the delivery of antisense oligonucleoti
109 ty control, and once released, exosomes have activities as diverse as remodeling the extracellular ma
110 eliable methods are needed to determine MGMT activity as DNA methylation, the current standard, does
113 the subcellular locations of endogenous PLD activity as elicited by physiological agonists of G prot
114 odel integrates the impact of diurnal neural activity as emanated from circadian regulation to predic
115 decreased intracellular ATP levels and AMPK activity, as evaluated by its phosphorylation at threoni
116 duction in CVB3-induced NLRP3 expression and activity as evidenced by lower ASC (apoptosis-associated
117 small, physiologic changes in glucocorticoid activity, as evidenced by the lack of circadian rhythmic
119 gricultural weeds can adapt rapidly to human activities as exemplified by the evolution of resistance
120 ic effects in improving the electrocatalytic activity, as exemplified by the oxygen evolution reactio
121 ratrol displayed significant anti-adipogenic activities as exhibited by the ability to antagonize PPA
123 lent photochemical properties and biological activity as fluorination of the azobenzene core alters n
124 stained asynchronous activity, we summarized activity as functional graphs where edges between units
126 ate of LbCas12a-mediated collateral cleavage activity as high as 3.5-fold compared to the wild-type c
128 generation critically requires normal GTPase activity, as hypothesis-testing mutations that increase
129 udies identify E2, esr2b, and downstream BMP activity as important regulators of hepatobiliary fate d
130 ave responded to the extent of inducible CCM activity, as indicated by changes in inorganic carbon up
131 usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from
134 s, are insensitive to alterations in area 14 activity as is the extinction of conditioned threat resp
135 identity of the sugar group is important for activity, as is the position of a number of hydroxyl gro
136 s are mostly confined to modulating cortical activity, as is typical with transcranial magnetic or tr
137 and define energy algorithms during physical activity as it relates to strength and movement strategy
138 , a key feature determining their biological activity, as it affects the affinity of the pyrrolobenzo
141 rties of these molecules and their catalytic activity as ligands in copper-catalyzed azide and alkyne
142 le to instability, which can lead to runaway activity, as manifested in pathological regimes such as
143 erlying DNA sequences and divergent enhancer activity as marked by histone 3 containing the acetylate
144 ary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-gluco
145 asured the relative amount of chronic lesion activity as measured by change in T1 volume and intensit
146 hibited normal synaptic density and neuronal activity as measured by density of VGLUT2(+) puncta and
148 okine structure but diminished CXCR4 agonist activity as measured by ERK phosphorylation, chemotaxis,
149 ed in 47 (40.2%) and correlated with disease activity as measured by total BPDAI (r = 0.918; P = .06)
150 een looking behaviors and neurophysiological activity, as measured by EEG, are different for children
154 Cu(++) ions as inhibitors of H. pylori HtrA activity, as monitored by in vitro cleavage experiments
157 his regulated turnover is essential for IRF1 activity, as mutation of T181 results in an improperly s
158 to virulence is due to their role in urease activity, as neither mutant exhibited a fitness defect w
163 ies that enhance PP2A and inhibit proteasome activity as novel therapeutic strategies for asthma.
166 y meprin beta caused increased ADAM protease activities, as observed by peptide-based cleavage assays
167 e partition enhances proximal Zdbf2 promoter activity, as observed during differentiation or with gen
170 policymakers should further promote physical activity as one of the most recommended effective strate
171 nduced a functional reorganization of neural activity as optogenetic activation could elicit avoidanc
173 N-tre is only partially dependent on its GAP activity as overexpression of constitutively active Rabs
174 ary biological evaluations indicate improved activity as P-selectin antagonists for the axially confi
175 s mitochondrial respiratory complex assembly/activity as part of the mitochondrial respiratory comple
176 erstood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar
179 alized the epitopes, and measured functional activities as potency in inhibition of hemagglutination
180 luated for MAO-A, MAO-B, and AChE inhibitory activities as potential drug candidates for the treatmen
181 ify microbial strains with GLP-1 stimulatory activity as potential metabolic disease therapeutics.
182 ship between network interactions and cortex activity, as predicted by a branching process, is missin
186 conditions and of an increase in monitoring activities as primary drivers for such patterns, particu
187 s kinase inhibition and modulation of GTPase activity as promising disease-modifying therapeutic targ
188 n this essay, the authors note that defining activities as public health surveillance has important i
189 available person-knowledge, showing greater activity as ratings for likability based on body of work
194 ) catalyst shows an extremely high intrinsic activity as reflected from its high turnover frequency,
195 P1;3 in liposomes demonstrated water channel activity, as revealed by stopped-flow light scattering.
196 that excess levels of s-Opa1 inhibit fusion activity, as seen under conditions of altered proteostas
197 of unfrozen water favoured various enzymatic activities as shown by a pH decrease, indicating protein
198 s flexibility allows facile evolution of new activities, as shown by reinvention of function between
199 of ZmC(4)-NADP-ME drastically decreases its activity as shown by the low residual activity of the re
203 d in COS-1 cells demonstrated beta-glucanase activity, as shown by degradation of the cell wall of Pn
204 kinetic trap retains native-like functional activity, as shown by the preserved ability to bind its
206 aphy in humans to record changes in neuronal activity as subthreshold rhythmic stimuli gradually beca
207 is gap by explicitly interpreting population activity as the aggregate response of many single neuron
210 tuations in default mode and control network activity as the primary driver of resting-state function
211 widespread operation that describes neuronal activity as the ratio of a numerator (representing the e
212 ncertainty is encoded in cortical population activity as the width of a probability distribution, a h
213 use in this decision is represented in brain activity as the width of a probability distribution, pro
214 te mechanism is atypical locus ceruleus (LC) activity, as the LC plays a critical role in attentional
215 tatistical regularities, and we modeled this activity as theoretical surprise levels using several le
216 p mature feedforward control of ankle muscle activity as they age, such that at age 10-12 years there
218 have retained integrity and gene expression activity as they traveled within white clover from their
220 This appears to result from diminished agr activity, as transcriptional analysis revealed significa
221 /CD4-cre(tg/wt) mice had similar suppressive activity as Tregs from CD83(flox/flox)/CD4-cre(wt/wt) wi
222 nder conditions of chronic myelin phagocytic activity, as TREM2 LOF causes pathogenic lipid accumulat
223 of the anticancer leads, indicated by their activity as tubulin-polymerization inhibitors, represent
224 peptide-caged liposomes that treat protease activity as two-valued (i.e., signal is 0 or 1) operatio
225 ound to be associated with decreased uveitis activity, as was sun exposure in those with vitamin D de
226 munology approaches further diversified SMOC activities, as we created interferon- or necroptosis-ind
228 biomarkers for tomatoes and their biological activities as well as metabolic fate should be investiga
229 nickel homeostasis and formate dehydrogenase activities as well as molybdopterin and selenocysteine b
230 ive class II activities, including two novel activities, as well as a spectrum of class I activities.
231 e correlation between lichenase and xylanase activities, as well as a weaker relationship between lic
232 anodrugs that display enhanced antibacterial activities, as well as aggregation-induced emission (AIE
233 robial, anti-inflammation, and anti-diabetic activities, as well as antioxidant and antinitrosant pro
234 ency leads to the suppression of PKC isoform activities, as well as inhibition of the downstream targ
235 gratory, vasculoprotective, and housekeeping activities, as well as profound suppression of genes rel
236 s, promoting both invasive and proliferative activities, as well as therapeutic resistance to irradia
237 en AR and SLIRP was disrupted by Ack1 kinase activity as well as androgen or heregulin treatment.
238 l connectivity arise from residual vasomotor activity as well as arteriole dynamics driven by self-ge
241 6 isoforms that differ in terms of catalytic activity as well as cellular and tissue distribution.
242 BII and BL6, were assessed for antimicrobial activity as well as correlated dodecylphosphocholine (DP
244 skeletal muscle tissue for analyses of SERCA activity as well as gene expression of SERCA1a and sarco
245 1 expression is inversely proportional to AR activity as well as HOXB13, a known interacting protein
248 PLD1 inhibitor, VU0155069, shows anti-septic activity as well as inflammasome-inhibiting effects.
249 nd quantitatively analyse the ictal striatum activity as well as its synchronization with cerebral co
255 previously uncharacterized behavior-related activity as well as patterns of spontaneous voltage acti
256 iple repressors with SigB-dependent promoter activity as well as post-transcriptional mechanisms ensu
257 ng the initiation factors implicated in this activity as well as review different mechanisms by which
258 ic physicochemical properties, antioxidative activity as well as subjected to the quantitative and qu
259 t of calcium indicators that report neuronal activity as well as surgical protocols, head fixation ap
261 hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnem
262 Arf6 silencing concomitantly decreased PLD activity as well as the levels of PA found on phagosomes
265 egies aimed at interfering with its biologic activity as well as their potential in a precision medic
266 racted maps of spatially distinct sources of activity as well as their time series using principal co
267 ough the manipulation of auxin and cytokinin activity as well as through the activation of energy sig
268 els incorporating local STP predicted neural activity as well or better than LN and global STP models
270 ations in the active site that abolished CAD activity, as well as a variant (Asn152Ser) that increase
271 led changes in spontaneous and evoked neural activity, as well as activation of non-neuronal cells, i
272 resulting from compromised phosphodiesterase activity, as well as alterations in receptor-coupled G-p
273 selectively enhanced 5alphaR expression and activity, as well as AP levels, in the prefrontal cortex
274 R1a signaling by inhibiting its constitutive activity, as well as by enhancing its G protein-dependen
275 ma expression, indicating enhanced cytolytic activity, as well as decreased expression of exhaustion
276 air function of EXO5 due to loss of nuclease activity, as well as failure of nuclear localization.
277 plications for moderate to vigorous physical activity, as well as high-volume, high-intensity exercis
278 ic mechanisms regulate hypothalamic neuronal activity, as well as how changes in the interaction amon
279 ed both wakefulness and cortical delta/gamma activity, as well as impaired the 40 Hz auditory steady-
280 gly altered copper binding and the enzymatic activity, as well as intracellular Cu(1+) abundance and
281 (OEG(2))(2)-IP4, displays increased in vitro activity, as well as more favorable pharmacokinetic and
282 tion stress, but the dependence on high CDK2 activity, as well as MRE11, contradicts this hypothesis.
283 ons had higher levels of neutrophil elastase activity, as well as myeloperoxidase levels compared to
284 as lipid phosphatase and protein phosphatase activity, as well as other functions in the nucleus.
285 oscopy), total phenolic content, antioxidant activity, as well as phenolic profiles (before and after
286 Compositional changes related to microbial activity, as well as proteolytic and lipolytic phenomena
287 m context-dependent modulation of excitatory activity, as well as regulate experience-dependent plast
288 nputs effectively timed the principal neuron activity, as well as regulated distinct CA1 interneuron
290 ic RNAs, displays both 5'->3' exonucleolytic activity, as well as robust endonucleolytic activity as
291 ific serum antibodies with high neutralizing activity, as well as significantly higher titers of RSV-
292 precise and rapid switching ON or OFF sgRNA activity, as well as switching OVER to secondary sgRNAs.
293 AR1 binding behaviors related to its editing activity, as well as the antagonizing effect of RBP bind
294 ed the overall levels of expression, protein activity, as well as the bio distribution of the firefly
295 pha-induced increase in IkappaB kinase (IKK) activity, as well as the expression of NF-kappaB target
296 degree of intratumoral heterogeneity in EGFR activity, as well as the pharmacodynamic effect of a rad
297 levance of SIRT5 in cellular desuccinylation activity, as well as the presence of other NAD(+)-depend
298 d that the Arkadia W972A mutant has the same activity as wild-type (WT) Arkadia in enhancing TGF-beta