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4 ifferentially modifies different oscillatory activities in a widespread network of cortical and subco
7 n a TNF-induced IL-6 mouse model and in vivo activity in a collagen antibody-induced arthritis model,
8 s (HOMs) modulate primary visual cortex (V1) activity in a direction-specific manner that also depend
11 optical method (COSMOS) for tracking neural activity in a largely uncharacterized spatiotemporal reg
13 motor activity and cocaine-induced locomotor activity in a manner indistinguishable from wild-type D2
14 ether POM may indirectly normalize DA neuron activity in a model representative of the hyperdopaminer
15 cell function, we assessed their therapeutic activity in a mouse model of T cell-mediated autoimmunit
23 ls with ASD evince atypical modulation of LC activity in accordance with changes in attentional deman
24 alyst exhibited outstanding oxygen-reduction activity in acidic electrolytes, which was further studi
25 ttribute to an O(2)-independent antisickling activity, in addition to the O(2)-dependent activity.
29 ehabilitation and mobilization, specifically activity in and near the hospital bed, appears safe and
31 ations and pharmacology to inhibit MNK-eIF4E activity in animals with spared nerve injury, a model of
39 n the presence of substrates for ETC and ETC activities in both populations of heart mitochondria in
40 in's structure, dynamics, and ligand-binding activity in both its soluble and membrane-anchored state
41 erlie the drastic reduction in cell division activity in both shoot and root apical meristems observe
42 idence suggests a co-operative role for RAC1 activity in BRAF(V600E)-driven melanoma progression and
44 t express cFos protein, an index of neuronal activity, in brain tissue and benchmarked it against two
47 or reduced methamphetamine-induced locomotor activity in C57BL/6J congenic mice harboring DBA/2J poly
51 ase SEP-1, primarily known for its essential activity in cell division and cortical granule exocytosi
52 ith this, we found decreased 20S proteasomal activity in cells that were exposed to bortezomib and ca
57 R uniquely share the same Delta-14 reductase activity in cholesterol biosynthesis, yet little is know
59 or NTRK1-3 fusions, have shown considerable activity in clinical trials, and larotrectinib, entrecti
61 -based correlations of alkaloid content, OMT activity in crude extracts, and OMT gene expression supp
63 ngle mechanism of surprise best accounts for activity in dACC during a task requiring response invigo
65 ironolactone abolished SIRT2-mediated TC-NER activity in differentiated neuronal cells and protection
72 , which offer a direct measurement of neural activity in functionally well-characterized brain networ
76 ofile with encouraging preliminary antitumor activity in heavily pretreated patients with mesothelin-
77 echanisms contribute to enhanced sympathetic activity in HF, but these pathways are still incompletel
78 neous afferents, whereas LAI and PAS require activity in (higher threshold) afferents activated by th
79 ion.SIGNIFICANCE STATEMENT Patterned network activity in hippocampal networks plays a key role in the
80 ndogenous genomic loci to cellular enzymatic activities in human and mouse cell lines and organoids.
82 probes (AZP) detected dysregulated protease activity in human prostate cancer biopsy samples, enabli
83 We also uncover evidence of ramping cell activity in humans, which represents a complementary typ
85 ffects were associated with increased neural activity in HVC and occurred independently of basal gang
86 l of hyperglycemia-induced renal injury ENaC activity in hyperglycemic animals was elevated in SS but
88 mption of living donor liver transplantation activity in India toward the end of the study period.
89 has remained difficult to manipulate neural activity in individual limbs of freely moving animals.
91 s a previously undescribed suppressor of YAP activity in insulin target cells and provide insight int
92 es include regulation of all mineral-related activities in international waters and protecting the ma
93 sion cap, and increased alkaline phosphatase activity in lesions in the Ahr knockout in comparison wi
95 developed to measure arylsulfatase A (ARSA) activity in leukocytes and dried blood spots (DBS) using
96 tem (MEMS) sensor capable of measuring water activity in liquid, vapor, and semisolid (e.g., hydrogel
98 e hypothesize that, in fM1, SAI is evoked by activity in low threshold, presumably cutaneous afferent
99 er processing levels, as in the human brain, activity in low-level visual areas should encode variati
100 essels, suggesting that basal K(ATP) channel activity in LSM is not an essential component of the lym
106 hibited P-gp and BCRP but not MRP2 transport activities in male and female rat brain capillaries.
112 ntitative methods to measure their enzymatic activities in mice intranasally challenged with a wild-t
115 metabolism and upregulation of mitochondrial activity in mouse adipocytes and fly fat bodies with dow
119 nnels (Na(v) proteins), arresting electrical activity in nerves and muscles and paralyzing would-be p
127 mP and PrU cells have multipotent progenitor activity in organoid formation and tissue reconstitution
129 dy of one ISG (CCDC92) that shows anti-Ebola activity in our screen reveals that CCDC92 can inhibit v
130 o investigate the role of neuronal NF-kappaB activity in pathogenesis of amyotrophic lateral sclerosi
131 ntitatively detect such pathological seeding activities in patient biosamples, e.g. cerebrospinal flu
134 Noninvasive tests to measure endoscopic activity in patients with Crohn's disease (CD) have limi
135 inexor combined with dexamethasone has shown activity in patients with heavily pre-treated multiple m
137 k-benefit profile and encouraging antitumour activity in patients with MET-amplified, EGFR mutation-p
138 or (CAR) T-cell therapy has shown remarkable activity in patients with refractory or relapsed acute l
139 that has shown preclinical and single-agent activity in patients with relapsed or refractory B-cell
140 I/T/DIN/GM-CSF has significant antitumor activity in patients with relapsed/refractory neuroblast
141 n deficient lysosomal acid-alpha-glucosidase activity in patients, and a progressive decline in mobil
144 uculline methiodide while recording cellular activity in PFC of male rhesus monkeys performing a dela
146 ne time, biotransformation was a descriptive activity in pharmaceutical development, viewed simply as
148 on may play a role in the regulation of HPR1 activity in planta, although it was not required for gro
149 n-OPC switch by controlling the level of Shh activity in pMN progenitors, and also regulates the allo
151 (low glycaemic index (GI) diet plus physical activity) in pregnant women with obesity (294 contol, 26
152 rikingly, these supramodal patterns included activity in primary sensory regions not directly relevan
155 ATP, which in turn modulates afferent nerve activity in response to bladder filling during the urina
156 nocrystals demonstrated robust remyelinating activity in response to demyelinating agents in both chr
157 of 94.66%, and we investigated the cortical activity in response to sensory stimuli in these conditi
159 in hRIPK1 in regulating its pro-death kinase activity in response to TNFalpha and pro-survival activi
160 ry neurotransmitter GABA in regulating delay activity in rhesus monkeys performing a delayed decision
163 nd positive correlation with gamma-secretase activity in samples from patients with late-onset Alzhei
164 pression and increase in Nox4 expression and activity in SCs and peripheral nerves, which were furthe
165 em to simultaneously monitor CDK4/6 and CDK2 activities in single cells and found that CDK4/6 activit
168 ing our assay, we have compared synaptotoxic activities in size-exclusion chromatography fractioned p
169 mulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting in improved mic
173 extracellular levels of dopamine and net PKA activity in spiny projection neurons in the nucleus accu
174 elf-similar) fluctuations in ongoing spiking activity in subcortical (lateral geniculate nucleus, LGN
176 a key role for mitochondrial morphology and activity in supporting the morphogenetic events that dri
177 ns with sex- and reproductive state-specific activity in sustaining the increased food intake of moth
180 cate immunostimulatory and immunosuppressive activity, in that opioid users have elevated infection r
181 for a completely distinct layer of networked activities in the brain-the gene regulatory network (GRN
183 tor to the nucleus results in nuclear mTORC1 activity in the absence of growth factor stimulation.
186 ried with changes in prestimulus oscillatory activity in the alpha band (8-13 Hz), we establish a mec
187 presence of bursts of local field potential activity in the alpha, and even more so, in the beta fre
190 mented the importance of direction-selective activity in the areas that are active during memory-guid
191 an open, large-scale physiological survey of activity in the awake mouse visual cortex: the Allen Bra
194 Our findings reveal increased oscillatory activity in the beta band (~20 Hz) at triplet transition
196 Here we report that the integrity of CA activity in the brain is necessary for the consolidation
199 n nucleus [6], we assessed the effects of NE activity in the CeA on behavioral expression using recep
200 nd-gated ion channels that regulate synaptic activity in the central and peripheral nervous system, p
203 Participants in the MT group showed lower activity in the cognitive control network (CCN) during t
204 gand, a canonical cA4-activated ribonuclease activity in the Csx1 domain and a potent cA4 ring nuclea
205 Nedd4-2 regulates Kir4.1/Kir5.1 expression/activity in the DCT and modulates NCC expression by Kir4
207 ts the importance of mitochondrial aconitase activity in the development of advanced metastatic prost
208 firmed the chemogenetically induced cellular activity in the DMS astrocytes using calcium imaging.
209 ) imaging showed that patterns of multivoxel activity in the dorsal anterior cingulate cortex (dACC),
211 xposed to + Nic exhibited elevated locomotor activity in the elevated plus maze and altered stress-co
214 g as a sensory network, they detect neuronal activity in the form of elevated extracellular K(+) and
215 ting was pursued subsequently by testing C2C activity in the formalin inflammatory mouse pain model.
217 PD), but few studies have characterized beta activity in the globus pallidus internus (GPi), another
220 subjects suggested that high-frequency gamma activity in the insula positively correlates with physio
221 sical visual SL task, divergent rhythmic EEG activity in the interstimulus delay periods within patte
223 was not sufficient to induce detectable HIF activity in the kidney endothelium, in vitro experiments
225 cific CatA overexpression and increased CatA activity in the LV of transgenic mice (CatA-TG) reduced
228 we detected evoked and spontaneous neuronal activity in the mouse visual cortex, with fluorescence c
233 test these hypotheses, we recorded neuronal activity in the orbitofrontal and anterior cingulate cor
234 visual threats and that low-frequency theta activity in the orbitofrontal cortex (OFC) negatively co
235 muli (F(1,125) = 4.94, p = .028) and greater activity in the portion of the IFG specific to the VAN (
238 Compound 16 had no significant off-target activity in the protein kinome and only weak activity ve
240 results demonstrate a requirement for dnmt1 activity in the regulation of RSC proliferation, gene ex
241 hat REDD1 ablation enhances Nrf2 DNA-binding activity in the retina and that the suppressive effect o
243 uced BrS, the CineECG localized the late QRS activity in the RVOT, a phenomenon never observed in nor
245 Cyp1a1 displayed increased CYP1A1 enzymatic activity in the skin, which resulted in exacerbated immu
246 lectrocorticogram to record neuronal network activity in the somatosensory cortex during sensory stim
247 activation, and exhibited potent adjunctive activity in the standard mouse model of TB chemotherapy
249 , the stronger the unexpected action-related activity in the STN region was the more detrimental was
250 also found that unlike in other systems, Rpf activity in the streptomycetes is not correlated with pe
251 g of precisely patterned neural time-keeping activity in the supplementary motor area (SMA), orchestr
252 olorectal cancer, it remains unclear whether activity in the tumor-associated stroma contributes to m
253 Feature selectivity and identity-sensitive activity in the two regions was coincident, and they exh
254 ve-driven gambles is accompanied by enhanced activity in the ventral striatum when curiosity or hunge
256 eflecting transient suppressions of neuronal activity-in the area surrounding focal cortical injuries
257 rgence of sensory experience and the role of activity in their integration into cortical networks, th
260 The SAR findings and the enhanced allosteric activity in this class of allosteric modulators were acc
261 frequency, and due to network interactions, activity in this excited frequency band propagates to ne
264 ory integration can alter patterns of neural activity in time, and even coordinate activity among pop
265 presence of excess neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chron
268 , commonly considered a measure of metabolic activity in tumors, is also in this cohort a measure of
270 Here, we engineer inducible nitrogenase activity in two cereal endophytes (Azorhizobium caulinod
271 ongenetic, light-induced control of cellular activity in two-dimensional (2D) and three-dimensional (
274 directly relevant to the task (e.g., neural activity in visual cortex predicting conscious perceptio
276 th favorable brain permeability and multiple activities in vitro (acetylcholinesterase, butyrylcholin
278 nhanced version of Rep) display G4 unwinding activities in vitro that are significantly higher than t
279 B763), a compound with partial FXR agonistic activity in vitro and FXR-dependent gene modulation in v
281 strate that CERBERUS has auto-ubiquitination activity in vitro and is localized within distinct motil
282 odies enhance alternative pathway convertase activity in vitro, confirming their pathogenic effect.
290 raries of synthetic genes, and test them for activity in vivo using a quantitative complementation as
292 le oral pharmacokinetic properties, displays activity in vivo, and is projected to have a low human e
293 rsely, these Tregs display potent regulatory activity in vivo, promoting long-term skin allograft sur
296 ibited excellent HOO(*) and NO(2) scavenging activity in water (k(overall)(HOO(*)) = 1.53 x 10(8) M(-
298 propose a model for tissue-specific enhancer activity in which an HDAC-associated GLI repression comp