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1 r extraction in the presence of overwhelming activities of (137)Cs via the autodepostion of silver on
3 .17 or 0.19 mol/kg lactose with an enzymatic activity of 2.0 or 2.8 mukat/kg for acid (pH 4.4) or swe
6 y yields of 21 +/- 5 and 23 +/- 4% and molar activities of 25-40 and 200-300 GBq/mumol, respectively.
11 udy provides novel information regarding the activity of a large set of progestins on human and zebra
13 eta-catenin while increasing the phosphatase activity of a Ppp2r2c-containing Pp2a complex to reduce
14 hages and indicate that 5-HT potentiates the activity of a transcription factor (AhR) that regulates
17 ment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, wh
19 nent for index finger muscles, while the EMG activity of all finger extensor muscles were modulated i
21 IL1beta significantly enhanced the antitumor activity of alpha-PD-1 and was accompanied by increased
22 receptor (EGFR) antibodies and find that the activity of antibody mixtures can be predicted without p
24 cal purity of approximately 90%, and a molar activity of approximately 1.5 MBq nmol(-1) Reaction opti
26 an in LC3 lipidation brings this "secondary" activity of ATG16L1 in full light and emphasizes its imp
27 f this study is to evaluate the pre-clinical activity of ATR inhibition in soft tissue sarcomas (STS)
28 AUX/IAA proteins, which normally repress the activity of auxin response transcription factors (ARFs).
32 vo studies demonstrated that 20 restored the activity of beta-lactam antibiotics against carbapenem-r
34 or suppressor function changes the metabolic activity of cancer cells to drive unrestricted prolifera
36 ned models were parameterised using in vitro activities of carbonic anhydrase (CA), pyruvate, phospha
38 cardiomyocytes, and that cyclic contractile activity of cardiomyocytes accelerates TT diffusion dyna
41 stress in the form of altered nutrition, and activity of certain AL local interneurons affect the mag
42 xplored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells.
44 first time that PA influences the biological activity of chitosans, which can now be recognized as bo
46 te and long-term effects of manipulating the activity of circuits involved in opioid-mediated physiol
48 represents a unique case of stereoselective activity of cis/trans isomers that can discriminate betw
49 lasses and, though the regulated transporter activity of class I proteins is becoming better understo
51 trategy aims to suppress the development and activity of corrosion-inducing microorganisms with the a
55 hough a mutation that regulates constitutive activity of CXCR4 also results in monomerization of the
56 PTBP1 ensures precise synchronisation of the activity of cyclin dependent kinases at distinct stages
57 evated 7-ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 enzymes and continuous accum
60 3.2 times the odds of impaired instrumental activities of daily living (95% CI: 1.6-6.3) compared to
61 gical disability, functional independence in activities of daily living, excellent functional outcome
64 liary bile salt hydrophobicity, or increased activity of dedicated cholesterol and phospholipid trans
67 he REV-ERB agonist SR9009 inhibited promoter activity of diverse HIV-subtypes and HIV-1 replication i
68 ribosome biogenesis that require the kinase activity of DNA-PKcs and its phosphorylation at the T260
71 us to target the guanine nucleotide exchange activity of DOCK5, which is essential for bone resorptio
72 sensors, we show for the first time that the activity of dopamine neurons precisely represents the im
75 esize instead that changes in the functional activity of E-cadherin expressed on tumor cells in respo
76 ion for EphA2, we compared the EphA2 binding activity of EBV gH/gL and the EBV gH/gL-N(69)L/S(71)V mu
81 -responsive genes revealed that the combined activity of ERF102 and ERF103 is also required for a ful
83 w a pivotal role for ESRRB in regulating the activity of ESC-specific enhancer units and propose that
84 has been postulated to be important for the activity of EV-carried miRNA in modulating gene expressi
87 The aim of the study was to evaluate the activity of FAP via FAPI-positron emission tomography-co
88 lrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C) through destabilization of heptameri
89 ally, the SNP treated fruit exhibited lesser activities of fruit softening enzymes like pectin methyl
92 ructure, stability and intercellular channel activity of gap junctions; however, the molecular basis
93 ter mouse lines to assess the spatiotemporal activity of Gdf5 regulatory sequences in experimental OA
94 role for genomic sequences, as the relative activities of genomic sequences are best explained by th
95 ffect of these differences on the anticancer activity of ginger by performing efficacy-based fingerpr
100 odel that provides insights into the limited activity of HDACi in clinical trials and offers directio
101 armaceutical strategy based on modifying the activity of heparan sulfate, an important regulator of a
102 egulated by G-protein-coupled receptors, the activity of heterotrimeric G proteins is modulated by ma
106 mechanism underlying the intriguing clinical activity of HMAs in AML/MDS patients with chromosome 7 d
108 in (CTD) that modulates the Zn(2+) transport activity of HsZnT8; and two adjacent sites buried in the
109 n, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and s
110 rine model, the serum level and anaphylactic activity of IgE may be downregulated by glycan-specific
111 As compared with WT mice, we show that the activity of IL-13 is dramatically augmented in SP-A(-/-)
113 ze ring assembly, DNA binding, and unwinding activity of individual Twinkle hexamers at the single-mo
117 rtance of electrostatic interactions for the activity of INPs from the bacterium Pseudomonas syringae
118 based tool to evaluate the immunosuppressive activity of intratumoral T(R)(eg) cells; they may also a
120 tasis with low levels of liver iron, reduced activity of iron enzymes, and misregulation of the cell-
124 6 WT and AD-associated mutants on the enzyme activities of KLK5 and KLK7 were compared using fluoroge
125 t a role for altered neuronal expression and activity of KPNA7 in a rare type of pediatric epilepsy.
127 rmatitis (AD) affect the protease inhibitory activity of LEKTI or its susceptibility to mesotrypsin d
130 that abolishing/reducing the deISGylase/DUB activity of Lpro causes viral attenuation independently
131 ortical structures, we recorded CDh neuronal activity of macaque monkeys before and during unilateral
132 nd quantitative assay to monitor dynamic FAO activities of mammalian cells in physiologically relevan
135 ate the safety, tolerability, and antitumour activity of margetuximab plus pembrolizumab (an anti-PD-
138 novel therapeutic approaches to control the activity of metabolic enzymes in T cell subsets represen
139 ht an important, but unrecognized, catalytic activity of mineral nanoparticles produced by fungal-min
143 ivating HF stem cells and by influencing the activities of multiple signaling pathways that are known
144 We then consider mechanisms by which the activity of multiple niche cell types may be coordinated
146 as to quantify how much the primary afferent activity of muscle spindles can contribute to shaping mu
149 In this study, we examined the antiviral activity of natural compounds against the following infl
152 ning task for head-fixed mice, monitored the activity of neurons of the lateral OFC using two-photon
153 M) representations are encoded by population activity of neurons with distributed tuning across the s
154 along sloppy dimensions associated with the activity of neurons with low centrality and displaying l
155 ransmitters signal through GPCRs to modulate activity of neurons, and changes in such signaling can u
157 r to USP14 block, AKT inhibition rescued the activity of NHEJ-DDR proteins in autophagy- and PTEN-def
159 fined the structure of DDM and evaluated the activity of novel congeners in triple negative breast an
161 algorithms trained to predict the regulatory activity of nucleic acid sequences have revealed princip
162 f tert-butyl alcohol (TBA) used to probe the activities of OH groups of Zr(6)O(8) nodes in the MOFs U
164 have been employed to improve the anticancer activities of oncolytic PVs, including development of se
171 n the inflamed pancreas and may suppress the activity of pancreas autoreactive T cells in newly hyper
173 he role of NAAA in controlling the signaling activity of PEA; the structural bases for NAAA function
174 in a phase II study to evaluate the clinical activity of pembrolizumab 200 mg every 3 weeks, without
175 bacterial ABC transporter that regulates the activity of periplasmic peptidoglycan amidases via its i
177 ken together, our study reveals an antitumor activity of phenformin to promote keratinocyte different
178 that Zip14 ablation coincides with sustained activity of phosphorylated components of signaling pathw
179 ted each variant's effect on the 5' nuclease activity of PLD3, finding that some variants lead to red
180 der these conditions even when the levels or activities of PP1 and PP2A are strongly inhibited at kin
182 ircuits.SIGNIFICANCE STATEMENT Ongoing delay activity of prefrontal neurons constitutes a neuronal co
183 ental and reproductive cues that repress the activity of proteostasis-related pathways in early adult
184 , most strikingly, that small changes in the activity of PTP1B can cause large shifts in the phosphor
185 cordings in adult female mice to monitor the activity of putative pyramidal and inhibitory neurons lo
187 rallel, EA treatments further suppressed the activities of pyramidal neurons in PrL, suggesting that
193 d-grown Miscanthus plants increased in vitro activities of RuBisCO and PPDK but decreased PEPc activi
196 egulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factor
197 ogic for many human diseases, and modulating activity of signaling pathways is often the preferred th
198 was done to assess the long-term safety and activity of siltuximab over up to 6 years of treatment.
199 nhistone substrates and additional catalytic activities of SIRT6, including long-chain deacylation an
205 regulates both kinase and phosphatase enzyme activity of SrrB and present the structure of the DHp-CA
207 s are also critical for the localization and activity of synaptic neurotransmitter receptors and ion
208 ssion systems, we demonstrate the anti-HSV-1 activity of TDRD7 in multiple human and mouse cell types
210 , phenolics profile by HPLC, and antioxidant activity of ten fruit beer produced adding fruits during
211 We show genetically that the antibacterial activities of the compounds against efflux-deficient Esc
216 homogeneous and heterogeneous photocatalytic activities of the TBPCExBox(4+) , for the elimination of
217 earlier work, we discovered that through the activities of the viral protein kinase conserved across
218 the Val617Phe mutation in JH2 stimulates the activity of the adjacent kinase domain (JH1) resulting i
219 formational heterogeneity in determining the activity of the C-terminal domain of bacterial Enzyme I
220 ic studies to analyze the components and the activity of the CD5 signaling machinery in primary T cel
221 ulated by the membrane environment, with the activity of the channel determined by the local concentr
223 n, for over six weeks in vivo, the localized activity of the clinically licensed growth factor BMP-2.
224 (DENV2proHeLa) was employed to determine the activity of the compounds in a cellular environment.
225 ratory motor potential amplitude, electrical activity of the diaphragm, pressure output of the diaphr
226 f the CB1r agonist (CP55940) on the balanced activity of the direct/indirect pathways in the SNr and
227 heavily on the delicate balance between the activity of the donor immune system against malignant an
233 n resistance through reduced tyrosine kinase activity of the insulin receptor; however, its impact on
234 AK (HTB), from Capsella rubella controls the activity of the key regulator of fruit development, INDE
236 ngly activated outside of lethargus, altered activity of the locomotion interneurons during lethargus
237 acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) iso
241 ns had opposite effects on the RNA-unwinding activity of the N-terminal cassette, with one configurat
242 pressor reflex in PAD and a reduction in the activity of the P2X receptor pathway is probably a part
243 lls was active against cancer cells and that activity of the parental clone, or functional avidity of
246 apoptosis, which was mediated by the reduced activity of the prosurvival transcriptional regulator Ye
247 ular functions, such as vesicle trafficking, activity of the Rab3 and Rab27 small GTPases, tumour nec
250 is critically determined by the coordinated activity of the renin-angiotensin system (RAS), includin
252 ating this further, we observed that the low activity of the SF gate appears to arise from the ineffi
253 targeting the hippocampal network increased activity of the targeted (left) hippocampus during scene
254 st of transposition is likely related to the activity of the TNP2-like transposase genes as the expre
256 Each of the drugs affected expression or activity of their predicted target in the network, and d
259 C-C formation is restricted by the intrinsic activity of these catalysts often being comparable to po
260 was also effective in vivo and improved the activity of these compounds compared to that of the indi
262 l, and voglibose are used for inhibiting the activity of these enzymes, however, alternative solution
268 vestigate MEK5 and ERK5 in SCLC, linking the activity of these two kinases to the control of cell sur
270 ism in which the protein disulfide reductase activity of thioredoxins (TRXs) plays a central role.
271 in that chamber, stress increases persistent activity of this projection, which correlates with entri
272 ry protein Nef can antagonize this antiviral activity of TIM-1 while host restriction factors such as
273 fully functional.Conclusions: Enhancing the activity of TMEM16A increases epithelial fluid secretion
274 at 220 degrees C, 3.3 times higher than the activity of traditional Cu/ZrO(2) catalysts (159 g(MeOH)
276 association with pol II or by modulating the activity of transcription or RNA processing factors, the
277 int mutagenesis campaigns: while the average activity of TRIAD variants is more compromised, a larger
278 mine the effects of epileptic seizure on the activity of trigeminovascular Adelta-, C-, wide-dynamic
281 TIDC were required to license the cytotoxic activity of tumor CD8(+) T cells, and in their absence,
283 ors to simultaneously measure changes in the activity of two cell signaling pathways in the same livi
284 fructose concentration as well as enzymatic activity of two commercially available beta-galactosidas
285 mical analysis revealed that the DNA-binding activity of UAF1 is indispensable for enhanced RAD51 rec
290 0.003 mug/mL (0.007 muM)] that surpassed the activity of vancomycin against C. difficile clinical iso
293 cularly coronaviruses, suggests that low DUB activities of viral PRO/DUBs may generally be fine-tuned
294 th salient visual stimuli, we found that the activity of visually responsive neurons in the central b
296 p.Y783 residue is essential for the proximal activity of wild-type PLCgamma1, but we provide evidence
297 While p44 is known to regulate the helicase activity of XPD during NER, p62 is thought to be purely
298 Here, we tracked the microtubule end-binding activity of yeast kinesin-8, Kip3, under varying loads a
299 bute to the pathogenesis of KSHV-MCD and the activity of zidovudine and valganciclovir in this diseas