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1 der include: unifying implementation science activities through a single organizational structure, li
2 network models that self-generate irregular activity through a balance of excitation and inhibition.
4 t expression of Mef2c by de-repressing MEF2C activity through a Calmodulin-CamKII-histone deacetylase
6 antimicrobial efficacy and improving in vivo activity through a combination of intracellular delivery
9 hat the IKK regulator NLRC5 shapes NF-kappaB activity through a feedforward loop of NLRC5 ubiquitinat
11 t cytokinin signaling specifies meristematic activity through a graded distribution that influences t
13 ensing by directly inhibiting cGAS enzymatic activity through a mechanism involving both cGAS binding
16 the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus af
18 adults, and that LRF confers its repressive activity through a NuRD repressor complex independent of
19 functions of MMP12, including antimicrobial activity through a peptide within its C-terminal domain
20 q1 also stimulated Pso2 translesion nuclease activity through a site-specific ICL in vitro We noted t
22 suggesting that LINC complexes support RhoA activity through a transcription-independent mechanism.
23 l mechanism for generating constitutive GPCR activity through a transsynaptic Elfn1/mGluR7 structural
24 Tight control of psoriatic arthritis disease activity through a treat-to-target approach significantl
25 R signaling, and, finally, modulation of ATR activity through a variety of post-translational modific
26 roduction is impervious to antiviral RNase L activity, through a mechanism of viral RNA protection th
27 ates thermomorphogenesis by suppressing PIF4 activity, through a reduction in PIF4 protein level.
30 an oral drug stimulating the parasympathetic activity through acetylcholinesterase inhibition, in exp
31 n shown previously to reduce dopamine neuron activity through action on D(2) autoreceptors to produce
32 diomyocytes, STIM1 acts by tuning Akt kinase activity through activation of mTOR complex 2, which fur
33 tor (GEF), Epac, known to down-regulate RhoA activity through activation of Rap1 GTPase activity incr
34 d and periphery, adenosine inhibits neuronal activity through activation of the adenosine A1 receptor
35 tory adaptations which stabilise target cell activity through activity-dependent global scaling have
37 s a multifaceted process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously u
40 ly, pharmacologic modulation of beta-catenin activity through alpha-catenin is a potentially attracti
41 control Smad2 and Smad3 transcription factor activities through alternate Activin type 2 receptors.
42 ouples the NAD(+) synthetase and glutaminase activities through an ammonia tunnel but free ammonia is
43 Ca(2+) regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca(2+)-
44 istent with ATP stimulating guanylyl cyclase activity through an allosteric, phosphorylation-independ
45 ly warm North Atlantic SSTs enhance heatwave activity through an association with drier spring condit
46 ain and triggers activation of its E3 ligase activity through an autocatalytic mechanism that amplifi
47 findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism.
48 ADAM10 negatively regulates its constitutive activity through an ER retention motif but is dispensabl
49 arious stresses, the Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unc
50 hile Usa1 attenuates Ubp1's deubiquitination activity through an inhibitory effect of its UBL domain.
53 dritic MORs in POMC neurons inhibit neuronal activity through at least two effectors with distinct le
55 metastatic melanoma patients show anti-tumor activity through B-cell depletion by anti-CD20 antibody.
56 the UbV interaction, explain its inhibitory activity through binding the surface on the APC2 subunit
58 has focused on the ability to modify neural activity through both local perturbations and changes in
59 roposed that internal Ca(2+) increases TrpV4 activity through Ca(2+)-CaM binding to a C-terminal Ca(2
62 We propose that rapid alteration of PTEN activity through changes in its phosphorylation status c
63 crostructure) of axons affect neural circuit activity through characteristics such as conduction spee
64 arable devices that digitalize physiological activities through chemical information in a trustable m
67 ons are required to achieve full therapeutic activity through clearance of IgG-opsonized virions and
68 s for multidimensional control of functional activities through combinations of orthogonal, drug-tuna
69 t to prevent inappropriate levels of spiking activity through compensatory adjustments in the strengt
72 m channels helps fine-tune long-term channel activity through conformational changes at the selectivi
75 mechanistic link between ongoing and evoked activity through cortical excitability and argue that th
76 natures of criticality in ongoing and evoked activity through cortical excitability, which fills the
78 hip connecting adhesion signaling to YAP/TAZ activity through cytoskeleton dynamics remains poorly un
80 sorders and has been used to modulate neural activity through delivery of electrical stimulation to k
81 receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gbetagamma subuni
82 mechanisms underlying the inhibition of COP1 activity through direct interactions with photoactivated
83 ibutes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition o
87 new insight into how regulation of enhancer activity through DNA methylation can have dramatic conse
88 ss as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase
89 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
90 s pro-inflammatory NF-kappaB transcriptional activity through effects on the cytosolic NADH:NAD(+) ra
94 served ascending system that gates forebrain activity through fast and powerful synaptic inhibition o
96 s been suggested to control its DNA cleavage activity through flexibility of the catalytic HNH domain
98 ial mechanism for cross-regulation of enzyme activity through formation of competitive encounter comp
99 t it serves to curb high levels of courtship activity through functioning as an inhibitory neuromodul
101 ted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms.
102 l programmes, and how misregulation of their activities through genetic abnormalities leads to pathol
105 ical role in DNA binding and transcriptional activity through heterodimeric association with several
106 (PV)-positive interneurons modulate cortical activity through highly specialized connectivity pattern
107 ized and screened for their antiinflammatory activities through in vitro and in vivo experiments.
108 nto the intracellular mechanism of sorafenib activity through in situ kinome profiling identified the
110 mutations confer PLCgamma1 gain-of-function activity through increased inositol phosphate production
112 enhance glycogen synthase kinase (GSK)-3beta activity through increased phosphorylation of Tyr-216 in
113 d, enhanced, and selective antiproliferative activity through inducing cell apoptosis confirmed by nu
114 cultivar and improved the anti-inflammatory activities through inhibiting cyclooxygenase-2 and lipox
115 e antioxidant capacity and anti-inflammatory activities through inhibiting cyclooxygenase-2 and lipox
116 Ci, which positively regulates Hh signaling activity through inhibiting Ci ubiquitination and degrad
117 or of Yes-associated protein (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats
118 etrapyrrole biosynthesis, reduction of GluTR activity through inhibition by tRNA(Glu) precursors caus
121 own to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function.
123 while setting the global level of cerebellar activity through inhibition via rate coding mechanisms.
124 c inhibitory receptor that modulates NK cell activity through interacting with HLA-A and HLA-B allele
125 ibited Npas2 gene transcription and promoter activity through interaction with Rorgamma to repress Ro
126 aNp63 mRNA, protein expression, and promoter activity through interaction with the transcription fact
129 lts show that PGD2 markedly augments disease activity through its ability to enhance the proinflammat
130 B002 or an analog may exert useful antiviral activity through its ability to form high-affinity terna
131 hat ChREBP regulates EtOH metabolism and ADH activity through its direct control of sirtuin 1 express
133 incipal neurons, and orchestrates population activity through its powerful and sustained feedforward
134 This molecule displays trispecific binding activity through its recognition of the CD20 molecule on
136 e emergence and fate of trajectory-dependent activity through learning and mastery of a continuous sp
137 es both in vitro and in vivo and exert their activity through locus-specific alterations of histone a
139 erspecies interactions can impact antibiotic activity through many mechanisms, including alterations
141 urons homeostatically regulate their ongoing activity through mechanisms that link membrane voltage t
142 Pin1 proved to be a main regulator of FOXM1 activity through MEK-dependent physical regulation durin
143 ly held that streptolysin S exerts its lytic activity through membrane disruption, its exact mode of
144 ofactor tissue factor (TF), which stimulates activity through membrane-dependent substrate recognitio
146 including Escherichia coli, stimulated HDAC activity through metabolism of phytate and production of
149 Furthermore, quercetin has anti-obesity activity through mitogen-activated protein kinase and ad
150 plements this process by regulating thalamic activity through modality-specific thalamic reticular nu
151 both muscarinic antagonist and beta2 agonist activities, through modification of the linker motif, to
152 often relies on repurposing cytotoxic T cell activity through modified T cell receptors or chimeric a
154 whether these mAbs could influence enzymatic activity through modulation of TG2 susceptibility to oxi
155 oth lacking extracellular domains and kinase activity, through mRNA degradation to promote immunity.
156 as a preferred location of repeated hominin activity through multiple changes in climate and local e
158 it level requires representation of neuronal activity through multiple recording sites and at high sa
160 documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is kno
161 matory cytokine that exhibits chemokine-like activities through non-cognate interactions with the che
165 memories, we mimicked endogenous oscillatory activity through optogenetic stimulation of parvalbumin-
167 ene but exhibit reduced p53 tumor suppressor activity through overexpression of the negative regulato
168 l protrusions and that H2O2 inhibits cofilin activity through oxidation of cysteines 139 (C139) and 1
169 nd sertraline, directly suppress TIDA neuron activity through parallel effects, independent of 5-HT t
170 increasing dihydrosphingosine activates Mef2 activity through PDK1 in mammalian neuronal cell line su
171 ence on CaM, but also limited maximal enzyme activity through persistence of LAVP-mediated autoinhibi
172 ion of carnitine palmitoyltransferase (CPT)2 activity through pharmacological inhibition or knockout
173 rotein Kinase A (PKA) modulates Hh signaling activity through phosphorylating the transcription facto
175 domain kinase (LIMK), which regulates actin activity through phosphorylation of cofilin, an actin-de
176 t DYRK1A stimulates GLI transcription factor activity through phosphorylation of general nuclear loca
177 contrary to most bacteria that regulate ICDH activity through phosphorylation, Mtb is capable of regu
178 ynthetic scalability and excellent catalytic activity through physical-transformation into 3D structu
179 F-23 promoter and stimulated FGF-23 promoter activity through PLCgamma/calcineurin/NFAT and MAPK path
180 iorating oxidative stress and cell apoptosis activities through positive regulation on superoxidase,
181 h extracts presented significant antioxidant activity through positive interactions with the lipid bi
185 neurons causes a downmodulation of neuronal activity through presynaptic mechanisms and by reducing
186 ative activity of enzymes, (2) alteration of activity through protein or substrate engineering for br
192 , opening the possibility of modifying their activity through rational chemical or genetic approaches
196 ing controls complex functions such as motor activity through regulation of cell firing and heterolog
197 emoglobin subunit beta (HB) exerts antiviral activity through regulation of type I interferon product
200 G-T risk haplotype decreased transcriptional activity through rs7278468, which lies in a consensus bi
201 que peptidoglycan composition and remodeling activity through SagA, which generates smaller muropepti
204 cells restore the majority of these reduced activities through selection of specific genomic mutatio
205 Similarly, reductions in local neuronal activity through sensory deprivation or optogenetic inhi
206 ieved by the induction of its expression and activity through shifting from cytoplasm to the nucleus.
207 that DR enhances both lifespan and physical activity through similar mechanisms, but this has not be
208 dence suggests that UPF3A acquired repressor activity through simple impairment of a critical domain,
209 sts that the antibodies inhibit NA enzymatic activity through steric hindrance, thus limiting NA acce
211 in their lmFG, we found that disrupting lmFG activity through stimulation, and later surgical resecti
213 side studies that attempted to dissect these activities through structural and biochemical characteri
214 zation requires SUMOylated TOP2A CTD binding activity through SUMO-interaction motifs and the phospho
216 ithin the framework of the European Physical Activity through Sustainable Transport Approaches (PASTA
220 harmacological inhibition of viral E3 ligase activity through targeting SOCS box motifs is a putative
221 t, antibodies also exhibit effector-mediated activities through the interaction of the Fc glycan and
222 uring the study of evolution of PaO and RCCR activities through the olive fruits maturation in two va
223 ial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-
224 cholinergic neurons is to inhibit EEG delta activity through the activation of cerebral cortex, rath
225 nt antioxidants and displayed cytoprotective activity through the activation of nuclear factor erythr
226 nuclear localization and its transcriptional activity through the androgen receptor-STK4/MST1-protein
228 of tremor episodes drives tremulous network activity through the basal ganglia or the cerebello-thal
233 12 directly modulates neuromuscular junction activity through the cholecystokinin receptor homolog on
234 ores results in synergistic cardioprotective activity through the combination of both molecular pathw
236 onstrate that increasing cellular proteasome activity through the direct delivery of purified proteas
237 y L. monocytogenes to modulate cytotoxic LLO activity through the enzymatic activity of its PC-PLC.
238 ively cool the body during extreme prolonged activity through the evapotranspiration of water on the
239 reaction, is likely able to achieve its high activity through the formation of an intermetallic phase
240 chia coli class I RNRs, dATP inhibits enzyme activity through the formation of inactive alpha6 and al
242 mor-related neuronal activity) drove network activity through the GPi, which effectively influenced t
243 ote both long-lasting and glucose-responsive activity through the incorporation of an aliphatic domai
244 presses mammalian target of rapamycin (mTOR) activity through the induction of an mTOR inhibitor, DDI
245 -3 of epithelial origin both stimulated MMP9 activity through the induction of IL-1beta secretion by
246 hanism(s) by which HNK exerts its anti-tumor activity through the inhibition of c-Met-Ras-HO-1 axis;
248 information in the form of border modulated activity through the integration of additional sensory m
249 episodes (assessed using EMG) drove network activity through the internal globus pallidus (GPi), ext
251 ly confirmed that these agents trigger their activity through the mitochondria-dependent apoptosis.
253 strategy to selectively block oncogenic KRas activity through the PH domain of Cnk1, which reduces it
254 a model system to demonstrate enhancing OER activity through the promotion of PCET by tuning the cry
255 regulate the aromatase gene transcriptional activity through the recruitment of nuclear receptor cor
256 usion, PGE2 increases both TF expression and activity through the regulation of the EP1/SIRT1 pathway
257 h factor signaling pathways to control TORC1 activity through the regulation of TSC dynamics in HeLa
259 (azocasein) was used to quantify the enzyme activity through the release of a chromogenic product th
261 sponse to redox events by regulating protein activity through the reversible formation of disulfide b
262 new mechanism of E3 ligase control of mTORC1 activity through the RNF186-Sestrin-2 axis, suggesting t
263 ce a coordinated change in Na(+),K(+)-ATPase activity through the signaling of protein kinases such a
264 n the helical core can perturb metalloenzyme activity through the simple expedient of modifying the h
266 opic gold nanocrystals with high chiroptical activity through the templating effect of chiral micelle
267 agation of ascending sensory-evoked afferent activity through the thalamus en route to the cortex.
268 dy uncovers a mechanism for shaping NAc core activity through the transfer of excitatory information
270 ed the role of sumoylation in regulating TDG activity through the use of TDG mutants defective for su
271 iple experiments show that elevating cofilin activity, through the loss of Limk1, results in faster s
272 ruit additional ligand proteins with diverse activities through their dimerization domain, the chromo
273 ungal functional composition and soil enzyme activities through their direct effect on dissolved orga
274 rent extraction methods affected antioxidant activities through their effect on biologically active c
276 s (ROS) in neurons and they control synaptic activity through their roles in energy production and in
277 eceptors (D2R) are major regulators of motor activity through their signaling on striatal projection
278 e receptors (KARs) regulate synaptic network activity through their slow channel kinetics, most promi
279 opposite effects on the brown adipose tissue activity through thermoregulatory nuclei such as the dor
280 -6 signal transducer, gp130, and can mediate activities through these interactions in the endoplasmic
283 cleavage and offer potential ways to inhibit activity through this receptor, which may dampen autoimm
284 Notably, we found that E93 controls enhancer activity through three different modalities, including p
287 ound to negatively regulate the Hh-signaling activity through transcriptional regulation of Ptch1, a
288 Furthermore, the ligands modulate riboswitch activity through transcriptional termination despite no
290 e Ab-sumIL2 significantly enhances antitumor activity through tumor targeting and specific binding to
291 ell as their relationship to changes in drug activity through two algorithms: e-Driver and e-Drug.
292 ements arise from disturbed striatal resting activity through two different population dynamics.
293 ator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or m
295 tivation of GPER/GPR30 further inhibits PMCA activity through tyrosine phosphorylation of the pump.
297 action to achieve delicate control of oxygen activity through uniformly creating oxygen vacancies wit
299 upportive onco-metabolism reveal coordinated activities through which Cav-1 enables rewiring of cance
300 dings support that netrin-1 exerts oncogenic activity through YAP signaling, providing a mechanism co