ライフサイエンスコーパス: activity-dependent

1 during development and is in many instances activity dependent.

2 e; and (iv) systems that are neither age nor activity dependent.

3 regeneration are not static and are largely activity dependent.

4 a-MSH on MC3R neuron firing rate is probably activity-dependent.

5 drial DNA (mtDNA) damage and is LRRK2 kinase activity-dependent.

6 al stimulation of neuronal circuits leads to activity - dependent acceleration of amyloid production,

7 Microneurography revealed initial activity-dependent acceleration of conduction velocity u

8 Here, we show that activity-dependent accumulation of Msp300 in the postsyn

9 While the influence of activity-dependent actin remodeling in these phenomena h

10 ic accessory protein required for efficient, activity-dependent AMPAR endocytosis.

11 ase mutant variants, we define the catalytic activity-dependent and catalytic activity-independent co

12 cing events, suggesting both JMJD6 enzymatic activity-dependent and independent control of alternativ

13 PR/Cas9 genome editing to separate catalytic activity-dependent and independent functions of Mll3 (Km

14 To examine the contributions of activity-dependent and independent processes to excitato

15 m of regulation is metaplasticity (i.e., the activity-dependent and long-lasting changes in neuronal

16 Long-term potentiation (LTP) is an activity-dependent and persistent increase in synaptic t

17 on of cell type-specific, circuit-selective, activity-dependent and spatiotemporally resolved transge

18 rease in MC3R neuron firing rate is probably activity-dependent, and was independent of fast synaptic

19 This neurotransmitter plasticity is activity-dependent, as was revealed by chemogenetic mani

20 This work demonstrates the presence of activity-dependent associative and non-associative reorg

21 However, activity-dependent augmentation of synaptic vesicle pool

22 alpha(2)delta-3 promotes the function of an activity-dependent autocrine Bone Morphogenetic Protein

23 establish a transcriptional requirement for activity-dependent, autocrine BMP signaling in determini

24 We propose that activity-dependent, autocrine signals provide neurons wi

25 We further show that mice that lack the activity-dependent Bax/Bak pathway or caspase-9 similarl

26 ilateral CS projections, suggesting that the activity-dependent Bax/Bak-caspase-9 pathway is essentia

27 The results identify an essential role for activity-dependent BDNF release in the rapid antidepress

28 Here we tested the hypothesis that activity-dependent BDNF release within the mPFC is neces

29 ngs indicate that regulation of GR-PO(4) via activity-dependent BDNF signaling is important for the f

30 Together, our data show that activity-dependent brain-derived neurotrophic factor rel

31 Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture

32 e been discovered, ultrafast endocytosis and activity-dependent bulk endocytosis, in which SVs are re

33 ndocytosis in Myo5b KO enterocytes resembles activity-dependent bulk endocytosis, the primary mechani

34 the Q-system of binary expression to enable activity-dependent Ca(2+) imaging in olfactory neurons o

35 ory glutamate-gated channels and a source of activity-dependent Ca(2+) influx.

36 tatory refinement and shortens the period of activity-dependent calcium signaling around hearing onse

37 oxide, modulate AMPAR transport by modifying activity-dependent calcium signaling.

38 c AMPAR transport and delivery by modulating activity-dependent calcium signaling.

39 emory engrams adds an important dimension of activity-dependent cellular states to existing brain tax

40 Synaptic plasticity, the activity-dependent change in neuronal connection strengt

41 nization and examine the impact of adaptive, activity-dependent changes in conduction velocity on the

42 n brain.SIGNIFICANCE STATEMENT In the brain, activity-dependent changes in gene expression are requir

43 lking at different speeds and compared it to activity-dependent changes in HMP.

44 membrane to the nucleus that is required for activity-dependent changes in neuronal gene expression d

45 Activity-dependent changes in protein complexes were con

46 t the solubility of individual proteins, but activity-dependent changes in protein interactions, when

47 th young and mature synapses exhibit similar activity-dependent changes in short-term depression.

48 However, detection of activity-dependent changes is more or less feasible in d

49 Accordingly, activity-dependent changes of the membrane potential are

50 ulated facilitation mechanisms operating via activity-dependent changes of vesicular release probabil

51 the wealth of knowledge about all aspects of activity-dependent circuit development and plasticity in

52 xtrusion capacity was further exacerbated by activity-dependent Cl- loading, resulting in a persisten

53 es this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synapti

54 al conditions, receptors and G proteins form activity-dependent complexes that last for around one se

55 ements, involves both guidance molecule- and activity-dependent components during development.

56 Our results reveal an activity-dependent conduit by which the reproductive sys

57 ate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adu

58 endothelial cells, which in turn mediate the activity-dependent control of BBB efflux transport.

59 ein binding that modulate calcium signaling, activity-dependent critical period development, and the

60 ence, en passant boutons act as hotspots for activity-dependent de novo MT nucleation, which controls

61 at gamma-tubulin and augmin are required for activity-dependent de novo nucleation of uniformly dista

62 the metabolic support function of myelin to activity-dependent demand and also represents a novel me

63 cells to enable the measurement and study of activity-dependent dendritic release of vasopressin (VP)

64 axis in spinal dorsal horn neurons prevented activity-dependent dendritic spine remodeling and signif

65 ignals from GluN2A-containing NMDARs control activity-dependent DNA-methylation involved in memory fo

66 ty, as determined by using the mitochondrial activity-dependent dye Mitotracker CM-H2TMRosa, is highe

67 Thus, activity-dependent dynamic [Ca(2+)](mito)-to-[Ca(2+)](cy

68 Activity-dependent ECS alpha variations may represent a

69 Conclusion: (225)Ac-L1 demonstrated activity-dependent efficacy with minimal treatment-relat

70 ectional Hebbian plasticity and learning via activity-dependent endocannabinoid signaling.

71 IEGs Fos and Arc connect to activity-dependent enhancers via singular short-range lo

72 sults link short-term effects of exercise to activity-dependent expression of Mtss1L, which we propos

73 kinesis defects and cell death in a protease activity-dependent fashion.

74 and RAN translation in regulating basal and activity-dependent FMRP synthesis, and they demonstrate

75 promote actomyosin ring assembly and a motor activity-dependent form that supports ring contraction.

76 Three new studies show that activity-dependent formation of myelin contributes to me

77 s commonly thought to reflect the outcome of activity-dependent forms of synaptic plasticity, yet act

78 cell sequencing analysis revealed an axis of activity-dependent gene expression amongst a subset of t

79 atory elements maintains temporal control of activity-dependent gene expression and scales somatic in

80 methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons.

81 Mechanisms of activity-dependent gene expression including alterations

82 Activity-dependent gene expression is integral to the sy

83 involved in signaling pathways that underlie activity-dependent gene expression, such as CaMKII, Shan

84 hes, we demonstrated that unique patterns of activity-dependent gene transcription associated with br

85 tion promotes coupling of Cav1.2 channels to activity-dependent gene transcription.

86 Glutamate-receptor signaling initiates the activity-dependent generation of Nrxn-CTF, which accumul

87 The consequences of aberrant induction of activity-dependent genes on neuronal physiology are not

88 sults in deficits in promoter methylation of activity-dependent genes, as well as synaptic plasticity

89 Using a new knock-in mouse for activity-dependent genetic labeling (TRAP2), we demonstr

90 onse, we used an intersectional approach and activity-dependent GFP reconstitution across synaptic pa

91 nervous system as a whole, we tested whether activity-dependent global scaling could also manifest wi

92 which stabilise target cell activity through activity-dependent global scaling have been observed onl

93 Activity-dependent global scaling therefore operates on

94 Using the activity-dependent GRASP and trans-Tango techniques, we

95 cialized for neurotransmitter signaling, yet activity-dependent growth factor release also plays crit

96 thought to mature during development through activity-dependent Hebbian plasticity(1), whereby simila

97 Slc26a6(-/-) mice also showed activity-dependent hypertension that was unaffected by d

98 We found that activity-dependent immediate early gene H1a is critical

99 Here we report a novel role of an activity-dependent immediate early gene Homer1a (H1a) in

100 the neuropathic pain condition, Homer1a, an activity-dependent immediate early gene product, disrupt

101 city phosphatase 1 (DUSP1); both known to be activity-dependent immediate early genes that respond to

102 these results show that Ca(2+) flux produces activity-dependent inactivation for both GluN2A and GluN

103 esynaptic downscaling was associated with an activity-dependent increase in Drosophila vesicular glut

104 al layer 1 lacking principal neurons with an activity-dependent increase of extracellular potassium.

105 We propose activity-dependent inhibition of vesicle un-priming or r

106 (2+)-dependent inactivation (CDI), a type of activity-dependent inhibition that requires intracellula

107 Activity-dependent interdomain dynamics may enable allos

108 evealed augmented cytosolic steady state and activity-dependent intra-terminal calcium levels prefere

109 yer five pyramidal neuron axon we found that activity-dependent intracellular calcium concentration (

110 Finally, we describe a novel form of activity-dependent intrinsic plasticity that persistentl

111 Using activity-dependent labeling and gene expression profilin

112 s, identified by 2-photon Ca(2+) imaging and activity-dependent labeling to recruit the relevant neur

113 NMDARs allows to implement synapse-specific, activity-dependent lateral inhibition, and thus could pr

114 suggest a novel mechanistic link between an activity-dependent long non-coding RNA and epilepsy.

115 This glycine receptor activity inhibits an activity-dependent long-lasting potentiation of glutamat

116 dentified a crucial role for this pathway in activity-dependent long-term depression (LTD) at hippoca

117 nia are colocalized with distinct classes of activity-dependent, looped enhancers.

118 ILPs are released from BAGs themselves in an activity-dependent manner during development, indicating

119 dulating spontaneous neurotransmission in an activity-dependent manner, but not for viability.

120 sicles recycle via the plasma membrane in an activity-dependent manner, but their exocytosis is slow

121 s and show that Zn(2+) inhibits AMPARs in an activity-dependent manner, opening up this pathway as a

122 essed PTEN expression in a methyltransferase activity-dependent manner, resulting in increased AKT an

123 ed, Rac1, gene expression in a CB1R and CDK5 activity-dependent manner, which persisted to adulthood.

124 rate that NLK lowers mHTT levels in a kinase activity-dependent manner, while having no significant e

125 connexin36/35-containing gap junctions in an activity-dependent manner.

126 be, which binds to neutrophil elastase in an activity-dependent manner.

127 es GluN2A-type NMDA receptor responses in an activity-dependent manner.

128 ions to the spinal cord are eliminated in an activity-dependent manner.

129 -called enhancer RNA (eRNA) and occurs in an activity-dependent manner.

130 ppresses the SIAH2 protein level in a kinase activity-dependent manner.

131 active-site cysteine residue of UCHL1 in an activity-dependent manner.

132 cuits underlying memory and navigation; this activity-dependent maturation occurs sequentially along

133 In all, we identify a neural substrate and activity-dependent mechanism by which social context can

134 o focus on the synapse, where well-described activity-dependent mechanisms are known to play a key ro

135 ators of deterministic genetic programs with activity-dependent mechanisms during neurodevelopment.

136 modulatory tone may select a subset of rapid activity-dependent mechanisms from a larger menu to achi

137 owever, whether these guidance molecule- and activity-dependent mechanisms interact with one another

138 d to give rise to broad "proto-regions," and activity-dependent mechanisms lead to progressive refine

139 ect axon growth and cell specification, with activity-dependent mechanisms.

140 al recipients of thalamic inputs and undergo activity-dependent migration arrest, wiring, and program

141 of cortical interneurons encounters several activity-dependent milestones.

142 Our findings elucidate an activity-dependent miRNA-mediated mechanism for regulati

143 ists and for studies on brain plasticity and activity-dependent modeling of brain circuits.

144 porally overlapping activity-independent and activity-dependent modes of myelination are beginning to

145 Here we investigated the activity-dependent modification of these connections dur

146 that it is a presynaptic regulator of rapid activity-dependent modifications in synaptic structure.

147 Learning is primarily mediated by activity-dependent modifications of synaptic strength wi

148 neural circuits, undergo remarkably similar activity-dependent modulation manifesting as epochs of e

149 it would provide for an additional layer of activity-dependent modulation of neurotransmission.

150 Activity-dependent modulation of vesicle mobility may re

151 se sites in small central synapses and their activity-dependent modulation.

152 Although the activity-dependent molecular mechanism of neurotransmitt

153 However, the activity-dependent molecular mechanisms remain incomplet

154 Activity-dependent molecular mechanisms, including, but

155 Activity-dependent myelination is thought to contribute

156 s vulnerable to damage and degeneration, and activity-dependent myelination may represent an endogeno

157 nf-TrkB signaling is a required component of activity-dependent myelination.

158 roles including axonal metabolic support and activity-dependent myelination.

159 ptic lobe neuroepithelial cells through aPKC activity-dependent myosin II regulation.

160 We used activity-dependent neural tagging to investigate represe

161 The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range in

162 females.SIGNIFICANCE STATEMENT Chemical- and activity-dependent neuromodulation alters synaptic stren

163 (required for Pc-ODP).SIGNIFICANCE STATEMENT Activity-dependent neuronal plasticity is the cellular b

164 e Met allele, which is linked with decreased activity-dependent neuroplasticity.

165 ctual disabilities (ID) causing mutations is activity-dependent neuroprotective protein (ADNP), with

166 HVDAS is caused by mutations in activity-dependent neuroprotective protein (ADNP).

167 de NAPVSIPQ (NAP), an active fragment of the activity-dependent neuroprotective protein (ADNP).

168 privation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox Protein (ADNP

169 P2 is essential for vesicular exocytosis and activity-dependent neurotransmitter release.

170 hat this synaptic rearrangement requires the activity-dependent, non-apoptotic Bax/Bak-caspase signal

171 ity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell death.

172 ach the age of the normal critical period of activity-dependent ocular dominance (OD) plasticity.

173 dehydrogenase (RDH) activity, with enzymatic activity dependent on lipid droplet targeting and cofact

174 and temporal control of phosphorylation, and activity dependent on proximity (i.e., linker length).

175 CD40(+) endothelial cells and anti-T. gondii activity dependent on ULK1 and beclin 1.

176 Using activity-dependent optogenetic manipulations of natively

177 In contrast to theoretical studies on activity-dependent outgrowth but consistent with predict

178 es encourages a reassessment of the scope of activity-dependent pH influences on neurotransmission an

179 ity, increasing evidence supports a role for activity-dependent, plastic changes in myelin-forming ce

180 apses, Cx36-containing gap junctions undergo activity-dependent plasticity and complex regulation.

181 accompanying electrophysiological changes to activity-dependent plasticity and we report on novel mec

182 superficial dorsal horn (SDH), and modifies activity-dependent plasticity at sensory synapses onto t

183 Synaptic connections undergo activity-dependent plasticity during development and lea

184 suggested to shape synaptic transmission and activity-dependent plasticity in endbulb-bushy cell syna

185 By inducing activity-dependent plasticity in the visual cortex of ad

186 Activity-dependent plasticity of intrinsic excitability,

187 t the FTD-causing V337M tau mutation impairs activity-dependent plasticity of the cytoskeleton in the

188 h neurons induce a second critical period of activity-dependent plasticity when they reach the approp

189 Despite the growing interest in activity-dependent plasticity, it is still unclear wheth

190 ers of the cortex that can account for rapid activity-dependent plasticity.

191 r circuits that do not require task-specific activity-dependent plasticity.

192 le neural circuit function in light of rapid activity-dependent plasticity.

193 tential new mechanisms for the initiation of activity-dependent plasticity.

194 te-and-fire based model modified to simulate activity-dependent post-spike changes in neuronal excita

195 Neuronal activity also evokes non-synaptic activity-dependent potassium currents that are amplified

196 ignaling that underlies estrogen-induced and activity-dependent potentiation of excitatory synapses i

197 Cortical development is an activity-dependent process [1-3].

198 The notion of sleep as a local, activity-dependent process suggests that activity histor

199 eak, FLARE should be useful for the study of activity-dependent processes in neurons and other cells

200 diversify glutamatergic synaptic sizes, with activity-dependent processes primarily setting the scale

201 tory synapse sizes is commonly attributed to activity-dependent processes that drive synaptic growth

202 T: Synaptic refinement and strengthening are activity-dependent processes that establish orderly arra

203 Here, we tested how activity-dependent processing during sleep might differe

204 Taken together, our study reveals a novel activity-dependent programmed cell death process require

205 ciated proteins complicates studies of these activity-dependent protein interaction networks, because

206 commonly used to study synaptic proteins on activity-dependent protein interactions.

207 Application of this method, activity-dependent proximity ligation (ADPL), to serine

208 elop and apply a method that we call soluble activity-dependent proximity ligation (sADPL), which har

209 Activity-dependent pruning also occurs at embryonic Dros

210 s1L, which we propose as a novel effector of activity-dependent rearrangement of synapses.

211 refore, channel clustering can influence the activity-dependent reduction in NMDA receptor currents.S

212 SVZ-derived neurogenesis after stroke is activity-dependent, region-specific, and sensitive to mo

213 Thus, the potentially activity-dependent regulation of A-type VGKCs, controlli

214 erneurons (PVs) in the dentate gyrus provide activity-dependent regulation of adult neurogenesis as w

215 ent, or if they reflect acute differences in activity-dependent regulation of critical genes is curre

216 ng, and that spillover transmission mediates activity-dependent regulation of early events in adult n

217 rapid changes in ECS alpha and indicate that activity-dependent regulation of extracellular space may

218 synaptic transmission, hormone secretion and activity-dependent regulation of gene expression.

219 -dependent SUMOylation to permit and prevent activity-dependent regulation of I(h) and I(A), respecti

220 These results suggest that the activity-dependent regulation of Kv2.1 channel kinetics

221 show that, in mixed neuron glia co-cultures, activity-dependent regulation of metabolic gene expressi

222 that downregulation of active transporters (activity-dependent regulation) is a simple and biologica

223 As in specific subtypes of neurons and their activity-dependent regulation, these results suggest tha

224 s introduce Syp as an important early acting activity-dependent regulator of a plasticity gene that i

225 R2 co-repressor complex to suppress neuronal activity-dependent regulatory elements and maintain low

226 Thus, the interplay of bHLH-PAS complexes at activity-dependent regulatory elements maintains tempora

227 e neuronal-specific bHLH-PAS factor NPAS4 to activity-dependent regulatory elements to induce transcr

228 , acting thus as a gating mechanism by which activity-dependent release from these two neuronal compa

229 MDARs may act as a gating mechanism by which activity-dependent release from these two neuronal compa

230 The underlying signalling mechanism involves activity-dependent release of ATP triggering bicarbonate

231 extracellular pH homeostasis via a neuronal activity-dependent release of bicarbonate.

232 Still, the precise mechanisms underlying activity-dependent release of dendritic signals, and how

233 tiation of synaptic transmission mediated by activity-dependent release of lipids was abolished.

234 tes, and shed light into mechanisms by which activity-dependent release of neuronal signals from axon

235 nts, and shed light into mechanisms by which activity-dependent release of neuronal signals from axon

236 Neurons communicate by the activity-dependent release of small-molecule neurotransm

237 S-STD component with a scaling effect (i.e., activity-dependent release sites inactivation), extendin

238 ce to glutamatergic neurotransmission in the activity-dependent remodeling of brain neural circuitry

239 tract fibres and spinal motoneurones undergo activity-dependent reorganization.

240 The activity-dependent rules that govern the wiring of GABAe

241 sights into the molecular pathway underlying activity-dependent Sema4D-induced synapse formation and

242 competitive manner and that preventing such activity-dependent shaping of corticospinal circuits lim

243 onal conductance, thus demonstrating spiking activity-dependent short-term plasticity of electrical s

244 ervous system, this work has investigated an activity-dependent signaling mechanism in the peripheral

245 These activity-dependent signals act during a defined period o

246 ed by internal Ca(++) stores; (5) respond to activity-dependent signals that regulate spine density.

247 C fibers display activity-dependent slowing (ADS), whereby repetitive sti

248 reasing sympathetic outflow and by measuring activity-dependent slowing at 2 Hz stimulation.

249 specific firing patterns and frequencies on activity-dependent somatodendritic release of vasopressi

250 R2 lacking AMPAR-mediated influx as the only activity-dependent source in adulthood.

251 Treatment studies of (225)Ac-L1 demonstrated activity-dependent, specific inhibition of tumor growth

252 ied that DIP2A interacted with cortactin, an activity-dependent spine remodeling protein.

253 Accordingly, activity-dependent structural abnormalities are likely t

254 s required to form novel memory by promoting activity-dependent structural and functional synaptic pl

255 Third, DA-gated, activity-dependent SUMOylation contributed to a feedback

256 These results suggest that activity-dependent SUMOylation of FOXP1 may be an import

257 Second, tonic 5 nm dopamine (DA) gated activity-dependent SUMOylation to permit and prevent act

258 ally, model RT neurons are predisposed to an activity-dependent switch from GABA-mediated inhibition

259 Within mammalian brain circuits, activity-dependent synaptic adaptations, such as synapti

260 Metaplasticity represents activity-dependent synaptic changes that modulate the ab

261 Activity-dependent synaptic depression and gradual recov

262 FMRP-null PNs lose activity-dependent synaptic modulation, with impairments

263 ural and electrophysiological changes during activity-dependent synaptic plasticity at the Drosophila

264 nisms and suggests that MAP2 participates in activity-dependent synaptic plasticity in mature hippoca

265 By modifying rules that govern activity-dependent synaptic plasticity, addictive drugs

266 ortant for cognitive performance by altering activity-dependent synaptic plasticity.

267 icates dynamic functions for various MAPs in activity-dependent synaptic plasticity.

268 tion of Arc, a gene known to be critical for activity-dependent synaptic plasticity.

269 rimental results, the effect of detergent on activity-dependent synaptic protein complexes has not be

270 s of an RNA-binding translation regulator of activity-dependent synaptic refinement.

271 Activity-dependent synaptic remodeling occurs during ear

272 Using activity-dependent tagging combined with neural manipula

273 We then utilized an activity-dependent tagging murine line, the ArcCreER(T2)

274 In this study, we used an activity-dependent tagging system in mice to determine t

275 Activity-dependent tangential migration of GABAergic cor

276 Using a novel activity-dependent technology called CANE developed in o

277 ) there are two cleavage pathways; basal and activity-dependent that produce the mitogenic form of ne

278 rescue reduced expression and dysfunctional activity-dependent trafficking of Syt1 in the absence of

279 he plasma membrane, but had no effect on its activity-dependent trafficking.

280 ice disrupts enhancer-promoter interactions, activity-dependent transcription and motor learning.

281 In neurons, regulation of activity-dependent transcription by the nuclear factor o

282 Neuronal-activity-dependent transcription couples sensory experie

283 oop accrues with abstinence and, through the activity-dependent transcription factor CREB2, drives th

284 onically image in vivo signaling of CREB, an activity-dependent transcription factor important for sy

285 mutant mice exhibit impaired global neuronal activity-dependent transcription in response to fear con

286 adult mice, FLARE also gave light- and motor-activity-dependent transcription in the cortex.

287 Neuronal activity-dependent transcription is tuned to ensure prec

288 brain function, and that defective neuronal activity-dependent transcription may be a mechanism by w

289 fications of neuronal circuits by modulating activity-dependent transcription programs that are vital

290 Activity-dependent translation requires the transport of

291 eparation as a general mechanism controlling activity-dependent translation.

292 This neuronal mechanism usually involves activity-dependent translocation of synaptonuclear facto

293 ly, we show that a system that utilizes both activity-dependent transporter downregulation and regula

294 cribe a long-duration ( approximately 60 s), activity-dependent, TTX- and ouabain-sensitive, hyperpol

295 It remains unclear whether activity-dependent uniform scaling also operates within

296 Activity-dependent uniform scaling can therefore manifes

297 Measurements of the water activity-dependent viscosity of aerosol particles from t

298 approaches for the predictions of the water activity-dependent viscosity of these ternary systems ar

299 r properties have been shown to change in an activity-dependent way through learning and behavior-a p

300 98 and can be regulated by LRRK2 in a kinase activity-dependent way.