ライフサイエンスコーパス: acyl-CoA oxidase

1 cted based on the structure of a four-domain acyl-CoA oxidase.

2 enhanced expression of a known target gene, acyl-CoA oxidase.

3 n acyl-CoA dehydrogenase and the peroxisomal acyl-CoA oxidase.

4 ability to package catalase, luciferase and acyl-CoA oxidase.

5 rate-limiting enzyme of this cycle is fatty acyl-CoA oxidase.

6 e, we determine the crystal structure of the acyl-CoA oxidase 1 (ACOX-1) homodimer and the ACOX-2 hom

7 ered the expression of 28 transcripts [e.g., acyl-CoA oxidase 1 (ACOX1) and FAT atypical cadherin 1 (

8 oss-of-function mutations in the peroxisomal acyl-CoA oxidase 1 (ACOX1) gene cause neurodegeneration

9 Acyl-CoA oxidase 1 (Acox1), the enzyme that catalyzes th

10 Mice lacking acyl-CoA oxidase 1 (Acox1), the first enzyme of the pero

11 ein 70 (PMP70) (modest down-regulation), and acyl-CoA oxidase 1 (ACOX1).

12 out of the peroxisomal beta-oxidation enzyme acyl-CoA oxidase 1 (Acox1-AKO) was not sufficient to aff

13 ACOX1 (acyl-CoA oxidase 1) encodes the first and rate-limiting

14 biogenesis and metabolism (e.g., PEX13p and acyl-CoA oxidase 1).

15 In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid

16 Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-C

17 A variant (p.Arg225Trp) of peroxisomal acyl-CoA oxidase 2 (ACOX2), involved in bile acid (BA) s

18 BCFAs is mediated by the peroxisomal protein acyl-CoA oxidase 2 (ACOX2).

19 CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme believed to be in

20 nitine palmitoyl transferase-1, (CPT-1), and acyl CoA oxidase (ACO) (p < 0.05).

21 Induction of HSD IV and acyl-CoA oxidase (ACO) proteins in rat liver at differen

22 ssion of the canonical PPARalpha-target gene acyl-CoA-oxidase (ACO) in a PPARalpha-dependent manner i

23 Acyl-CoA oxidase (ACOX) enzymes are central players in p

24 the 5'-flanking region of H202-producing rat acyl-CoA oxidase (ACOX) gene and in other genes inducibl

25 stem, which consists of three enzymes: fatty acyl-CoA oxidase (ACOX), enoyl-CoA hydratase/3-hydroxyac

26 yltransferase (CAT) fusion construct for rat acyl-CoA oxidase (ACOX), the rate-limiting enzyme in the

27 on of fatty acids is catalyzed by the enzyme acyl-CoA oxidase (ACOX), which oxidizes a fatty acyl-CoA

28 oyl-CoA hydratase (HD) and peroxisomal fatty acyl-CoA oxidase (ACOX).

29 ween ibr3 and acx3, which is defective in an acyl-CoA oxidase acting in fatty acid beta-oxidation, ha

30 cluded induction of acetylcholinesterase and acyl CoA oxidase activities and oxidative impairment, wh

31 ve in ACX1, ACX3, or ACX4 have reduced fatty acyl-CoA oxidase activity on specific substrates.

32 ated animals showed significant induction of acyl-CoA oxidase activity, probably caused by PPARalpha

33 Thus, ATP may serve as a regulator of acyl-CoA oxidase activity, thereby directly linking asca

34 sed in Escherichia coli and shown to possess acyl-CoA oxidase activity.

35 rate activation, fatty acids are oxidized by Acyl-CoA Oxidase (ACX) enzymes.

36 The Arabidopsis acyl-CoA oxidase (ACX) family comprises isozymes with di

37 ve in ACX3, two of the six Arabidopsis fatty acyl-CoA oxidase (ACX) genes.

38 henotype results from loss of function of an acyl-CoA oxidase (ACX1A) that catalyzes the first step i

39 0.0001) and increased peroxisomal activity (acyl CoA oxidase and catalase activity) compared to the

40 The final preparation contained an acyl-CoA oxidase and a second protein of the plant nucle

41 fied by peptide sequence analysis, including acyl-CoA oxidase and a trifunctional enzyme of the perox

42 PARalpha and the peroxisome-associated genes acyl-CoA oxidase and catalase.

43 he PPARalpha-responsive genes encoding fatty acyl-CoA oxidase and cytochrome P450 4A1.

44 rate that peroxisomal beta-oxidation enzymes acyl-CoA oxidase and D-bifunctional protein are essentia

45 Acyl-CoA oxidase and peroxisome proliferator-activated r

46 basis for the substrate specificities of the acyl-CoA oxidases and reveal why some of these enzymes h

47 e deficient in PPAR alpha, peroxisomal fatty acyl-CoA oxidase, and some of the other enzymes of the t

48 atabolism (carnitine palmitoyltransferase-I, acyl-CoA oxidase, and uncoupling protein-2) and their co

49 m to long-chain (ACX1) and long-chain (ACX2) acyl-CoA oxidases, and show that the corresponding endog

50 PARalpha (PPARalpha(-/-)), peroxisomal fatty acyl-CoA oxidase (AOX(-/-)), and in both PPARalpha and A

51 ng the PPARalpha-dependent regulation of the acyl-CoA oxidase (AOX) promoter, the rate-limiting step

52 ochrome P450 4A2 (CYP4A2)), and peroxisomal (acyl-CoA oxidase (AOX)) enzymes.

53 The first step of this system, catalyzed by acyl-CoA oxidase (AOX), converts fatty acyl-CoA to 2-tra

54 inding, and import of an oligomeric protein, acyl-CoA oxidase (Aox), into the peroxisome matrix.

55 dation pathway in mice at the level of fatty acyl-CoA oxidase (AOX), the first and rate-limiting enzy

56 We previously generated mice lacking fatty acyl-CoA oxidase (AOX), the first enzyme of the L-hydrox

57 e proliferators, whereas those lacking fatty acyl-CoA oxidase (AOX-/-), the first enzyme of the perox

58 Acyl-CoA dehydrogenases and acyl-CoA oxidases are two closely related FAD-containing

59 xpression of mRNAs for the peroxisomal fatty acyl-CoA oxidase, bifunctional enzyme, or thiolase, whic

60 sappeared; there was increased expression of acyl CoA oxidase, carnitine palmitoyl transferase 1, and

61 nditions for quantitative measurement of the acyl-CoA oxidase-catalyzed reaction are offered.

62 Yeast (Candida tropicalis) acyl-CoA oxidase catalyzes the oxidation of a variety of

63 ected with H2O2-generating peroxisomal fatty acyl-CoA oxidase cDNA, which encodes the first and rate-

64 mitoyltransferase I) and extramitochondrial (acyl-CoA oxidase, cytochrome P450 4A3) enzymes.

65 al beta-oxidation pathway--disorders such as acyl CoA oxidase deficiency and bifunctional protein def

66 Acyl-CoA oxidase-deficient cells accumulated 2-5 times m

67 02 (CrACX2), a gene encoding a member of the acyl-CoA oxidase/dehydrogenase superfamily.

68 utant, which disrupts a putative peroxisomal acyl-CoA oxidase/dehydrogenase, ibr1 and ibr10 display n

69 bidopsis mutant defective in two peroxisomal acyl-CoA oxidases does not metabolize ascr#18 and does n

70 The peroxisomal acyl-CoA oxidase efficiently oxidizes 4-thiaacyl-CoA ana

71 amely acyl-CoA synthetase (acs-1 and acs-2), acyl-CoA oxidase (F08A8.1 and F08A8.2), and stearoyl-CoA

72 Fatty acyl-CoA oxidase (FACO) activity and mRNA were increased

73 anoyl-CoA alpha hydroxylase (PAHX) and fatty acyl-CoA oxidase (FACO) mRNA levels during differentiati

74 t derived from the endogenous PPAR-inducible acyl-CoA oxidase gene promoter.

75 onstitutively active human peroxisomal fatty acyl-CoA oxidase gene promoter.

76 nt (PPRE) found in the promoter of the fatty acyl-CoA oxidase gene.

77 Mutations in the acyl-CoA oxidase genes acox-1, -2, and -3 led to specifi

78 The genes for the two acyl-CoA oxidases have been termed AtACX1 and AtACX2.

79 lone or in pairs and purified, the resulting acyl-CoA oxidase homo- and heterodimers displayed differ

80 In addition, the structure of peroxisomal acyl-CoA oxidase II from rat liver is compared to that o

81 ion of acyl CoA synthetase-2 and peroxisomal acyl CoA oxidase in a time-dependent manner.

82 alpha and of the classical peroxisomal fatty acyl-CoA oxidase in energy metabolism, and in the develo

83 to be made for the roles of uncharacterized acyl-CoA oxidases in C. elegans and in other nematode sp

84 uences share significant homology with known acyl-CoA oxidases, including the conserved CGGHGY motif,

85 catalyzing straight-chain acyl-CoAs by fatty acyl-CoA oxidase, L-bifunctional protein, and thiolase,

86 CoA dehydrogenases) or failed to be induced (acyl-CoA oxidase, liver carnitine palmitoyl-CoA transfer

87 RXRalpha deficiency did not change the basal acyl-CoA oxidase, medium chain acyl-CoA dehydrogenase, a

88 substrate specificities suggest that the two acyl-CoA oxidases might play a general house-keeping rol

89 lpha-mediated responses such as induction of acyl-CoA oxidase mRNA by PPs are present in the MuSHalph

90 Cardiac fatty acyl-CoA oxidase mRNA levels increased at doses in which

91 ls from patients with deficiencies of either acyl-CoA oxidase or D-bifunctional protein, the first tw

92 f the genes encoding the peroxisomal enzymes acyl-CoA oxidase (POX1) and medium-chain acyl-CoA synthe

93 l-branched fatty acyl-CoAs by branched-chain acyl-CoA oxidase (pristanoyl-CoA oxidase/trihydroxycopro

94 AtACX2 are members of a family that includes acyl-CoA oxidases specific for shorter-chain acyl-CoAs.

95 arkably, we show that most of the C. elegans acyl-CoA oxidases that participate in ascaroside biosynt

96 ans-double bond by acyl-CoA dehydrogenase or acyl-CoA oxidase, the resultant 2,5, 7-decatrienoyl-CoA

97 A PPARalpha target gene, acyl CoA oxidase, was decreased by ethanol in wild-type

98 A second PPARalpha-responsive gene, acyl-CoA oxidase, was also induced in rat liver by diabe

99 When the acyl-CoA oxidases were expressed alone or in pairs and p

100 Full-length cDNAs coding for two distinct acyl-CoA oxidases were isolated by screening an Arabidop

101 result demonstrated that CrACX2 is a genuine acyl-CoA oxidase, which is responsible for the first ste

102 Acyl-CoA oxidases, which catalyze the first step in thes

103 Here we show that three acyl-CoA oxidases, which catalyze the first step in thes