ライフサイエンスコーパス: acyltransferase

1 ransporters, cytochrome P450 enzymes, and an acyltransferase.

2 ul for mode of action studies on the PORCN O-acyltransferase.

3 fatty acid synthase and glycerol-3-phosphate acyltransferase.

4 sphotransferase, and lysophosphatidylcholine acyltransferase.

5 ty acid biosynthetic enzymes and specialized acyltransferases.

6 tain their side activity as lysophospholipid acyltransferases.

7 ckground by each of the CyaC, HlyC, and RtxC acyltransferases.

8 a series of reactions catalyzed by acylsugar acyltransferases.

9 ng to a clade separate from most anthocyanin acyltransferases.

10 ne residues by co-expressed toxin-activating acyltransferases.

11 linkage glucan synthase and hydroxycinnamate acyltransferases.

12 of integral membrane proteins known as DHHC acyltransferases.

13 ivity that target LpxA and potentially other acyltransferases.

14 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol

15 The ER enzyme sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholestero

16 and co-expression of FUS3 and diacylglycerol acyltransferase 1 (DGAT1) further increased TAG levels t

17 iated with fat content, the Diacylglycerol O-Acyltransferase 1 (DGAT1) gene turned out to be a functi

18 Diacylglycerol acyltransferase 1 (DGAT1) is an integral membrane enzyme

19 The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy

20 Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides

21 ental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with

22 or overexpression of lysophosphatidycholine acyltransferase 1 (LPCAT1), two key enzymes of Lands' cy

23 aturated phosphatidylcholine (PC) by lyso-PC acyltransferase 1 (LPCAT1).

24 lyc12g006330--or S. lycopersicum acylsucrose acyltransferase 1 (Sl-ASAT1)--and Solyc04g012020 (Sl-ASA

25 We identified sterol O-acyltransferase 1 (SOAT1) as a key player in sustaining

26 Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (E

27 duced cholesterol esterification by sterol-O-acyltransferase 1 (SOAT1).

28 pin subspecies and preserved lysocardiolipin acyltransferase 1 expression in db/db mice.

29 argely via the enzyme DGAT (diacylglycerol O-acyltransferase 1) and degrade LD via ATGL (adipocyte tr

30 Acyl-CoA:cholesterol acyltransferases 1 and 2 (ACAT1/2) convert cholesterol i

31 presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, a

32 auveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are en

33 cell lines, mediated by acyl-CoA cholesterol acyltransferase-1 (ACAT-1) enzyme.

34 of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme that catalyzes trig

35 s well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of su

36 Overexpressing glycerol-3-phosphate acyltransferase-1 or -4 inhibited insulin signaling and

37 the genetic deletion of Acyl-CoA:wax alcohol acyltransferase 2 (AWAT2) causes the obstruction of MGs

38 opyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.

39 , that the inducible lysophosphatidylcholine acyltransferase 2 (LPCAT2) plays a key role in macrophag

40 Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in tri

41 id remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of

42 Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylch

43 Monoacylglycerol acyltransferase 3 (MGAT3) is an integral membrane enzyme

44 Glycerol-3-phosphate acyltransferase-4 (GPAT4) null pups grew poorly during t

45 y of pathogen-inducible GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 6 (GPAT6) in controlling pathogen entry

46 on our data, we propose the name of NatA (N-acyltransferase A) in lieu of YiaC to reflect the functi

47 matic activity of a ripening-related alcohol acyltransferase (AAT1).

48 ive lipase, and 1-acylglycerol-3-phosphate O-acyltransferase ABHD5.

49 Acyl-CoA:cholesterol acyltransferase (ACAT) mediates cellular cholesterol est

50 -mediated activation of acyl-CoA:cholesterol acyltransferase (ACAT) triggered rapid internalization o

51 vating the ER-localized acyl-CoA:cholesterol acyltransferase (ACAT) which leads to the depletion of a

52 the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related enzyme (Are)2p, with 2 pl

53 terifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-cholesterol ac

54 se 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-chain fatty aci

55 ) enzyme family, acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyse the transfer of an acy

56 -esterification to the sn-2 position by sn-2 acyltransferase activity (i.e. the Lands cycle).

57 The N-terminal domain is not necessary for acyltransferase activity and is composed of an intrinsic

58 emonstrated the high selectivity of the sn-1 acyltransferase activity for saturated acyl-CoA species.

59 sn-1 acyltransferase activity in murine liver microsomes ster

60 cation of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G(0)

61 and LPCAT2 encode the major lysophospholipid acyltransferase activity of the chloroplast, and it is p

62 ibition of ER-localized glycerol-3-phosphate acyltransferase activity protected from all aspects of l

63 DGAT1 acyltransferase activity sequesters retinol in ester for

64 cystis The recombinant slr2103 enzyme showed acyltransferase activity with phytol and diacylglycerol,

65 to hepatocytes, support lecithin:cholesterol acyltransferase activity, and suppress inflammation.

66 ols than controls but similar diacylglycerol acyltransferase activity, triacylglycerol secretion, and

67 production, in addition to lysophospholipid acyltransferase activity.

68 ine, are taken up by LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on

69 iency to generate triacylated cardiolipin by acyltransferase/acyl-acyl carrier protein synthetase, de

70 "Late" acyltransferases add secondary acyl chains to lipid A af

71 yltransferases (GPATs), acylglycerophosphate acyltransferases (AGPATs), lipid phosphate phosphohydrol

72 n be converted to PC by the lysophospholipid acyltransferase Ale1.

73 The acyltransferase also selects whether both or only one of

74 Protein S-acyltransferases, also known as palmitoyltransferases (P

75 ber of amino acid changes in two acylsucrose acyltransferases alter their acyl acceptor preferences,

76 tochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase and an increase in serine palmitoyl tran

77 ecreased expression of sn-1,2 diacylglycerol acyltransferase and mitochondrial acyl-CoA:glycerol-sn-3

78 laria involves specific activities of a BAHD acyltransferase and two cytochrome P450 hydroxylases.

79 ase motifs that are present in other studied acyltransferases and transacylases.

80 hyde 2,1-aminomutase, anthocyanin 5-aromatic acyltransferase, and eugenol synthase 1) and enzymes inv

81 The activity of Dga1p, a diacylglycerol acyltransferase, and TG accumulation were both 30-35% lo

82 zDHHC S-acyltransferases are enzymes catalyzing protein S-acylat

83 idues of arabinoxylan (AX), and certain BAHD acyltransferases are involved in their addition.

84 Acyltransferases are key contributors to triacylglycerol

85 The two mammalian AR-containing S-acyltransferases are the Golgi-localized zDHHC17 and zDH

86 Are2p, Aus1p, and Pdr11p, unlike the minor acyltransferase, Are1p, colocalize to sterol and sphingo

87 tion of a member of the BAHD family of plant acyltransferases as cocaine synthase.

88 , acylsugar assembly requires four acylsugar acyltransferases (ASATs) of the BAHD superfamily.

89 tion, differential scanning calorimetry, and acyltransferase assays, we determined that PlsX binds di

90 the first example of reconstituting a trans-acyltransferase assembly line PKS in vitro and of using

91 udies, we observe that inactivation of a cis-acyltransferase (AT) domain to circumvent its native ext

92 lly been done by focusing on engineering the acyltransferase (AT) domains of polyketide synthases (PK

93 We identified recently a large trans-acyltransferase (AT) polyketide synthase gene cluster re

94 xtensions in FAS and PKS are initiated by an acyltransferase (AT), which loads monomer units onto acy

95 ybrid nonribosomal peptide synthetase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PK

96 Acyltransferase (AT)-less type I polyketide synthases (P

97 Acyltransferase (AT)-less type I polyketide synthases (P

98 AG biosynthesis by expression of Arabidopsis acyltransferases AtDGAT1 and AtDGAT2, as well as the DGA

99 (in which phosphatidylcholine:diacylglycerol acyltransferase (AtPDAT1) is the major TAG biosynthetic

100 interestingly B. mori glycerol-3-phosphate O-acyltransferase (BmGPAT) was found to be expressed durin

101 An acyltransferase, called PE, subsequently catalyzes the t

102 ain with significant homology to carnitine O-acyltransferase (cAT).

103 Additional expression of the montbretia acyltransferase CcAT1 led to detectable levels of mini-M

104 The late acyltransferases controlling the acylation of lipid A ha

105 The broad substrate specificity of acyltransferase CT775 provides C.t. with the capacity to

106 esis is catalysed by acyl-CoA diacylglycerol acyltransferase (DGAT) enzymes(2-4), the structures and

107 utionarily unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, are the

108 ) synthesized by two acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes.

109 Kinetically improved diacylglycerol acyltransferase (DGAT) variants were created to favorabl

110 ltransferase (GPAT), acyl-CoA:diacylglycerol acyltransferase (DGAT), and phospholipid:diacylglycerol

111 these PUFAs available for the diacylglycerol acyltransferase (DGAT)-catalyzed reaction for TAG produc

112 genetic approaches to disrupt diacylglycerol acyltransferase (DGAT)-dependent LD biogenesis, we provi

113 the integral membrane enzyme diacylglycerol acyltransferase (DGAT).

114 2-diacylglycerol catalyzed by diacylglycerol acyltransferase (DGAT, EC 2.3.1.20).

115 Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step

116 d acyltransferases (LPAT) and diacylglycerol acyltransferases (DGAT) that are required for successive

117 ptimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors.

118 ipid biosynthesis, two type-1 diacylglycerol acyltransferases (DGAT1) from rice were characterized fo

119 G synthesis by deleting neuronal diglyceride acyltransferases (DGATs) and enhancing PL synthesis thro

120 Diacylglycerol acyltransferases (DGATs) catalyze a rate-limiting step o

121 phosphohydrolases (LPINs) and diacylglycerol acyltransferases (DGATs), are involved in the glyceropho

122 ree out of five putative type II diglyceride acyltransferases (DGATs), the enzymes that catalyze TAG

123 egral membrane enzymes known as DHHC protein acyltransferases (DHHC-PATs).

124 at the recycling endosome-resident palmitoyl acyltransferase DHHC2 interacts with and palmitoylates A

125 fied the plasma membrane-localized palmitoyl acyltransferase DHHC5 as an important mediator of the st

126 etion of the primary murine monoacylglycerol acyltransferase does not quantitatively affect lipid abs

127 that the L142 protein contains an N-terminal acyltransferase domain and a predicted C-terminal glycos

128 main containing 3), MBOAT7 (membrane bound O-acyltransferase domain containing 7), TM6SF2 (transmembr

129 ane 6 superfamily member 2, membrane-bound O-acyltransferase domain containing 7, glucokinase regulat

130 erfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing (MBOAT), and glucokina

131 738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transme

132 Recently, the rs641738 membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) polymorphis

133 the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also c

134 translational modification mediated by the O-acyltransferase encoded by the Drosophila porcupine homo

135 These are type I/IV trichome-expressed BAHD acyltransferases encoded by Solyc12g006330--or S. lycope

136 ree mass spectrometric assay to characterize acyltransferase enzymatic activity.

137 date employ a separate thioesterase (TE) or acyltransferase enzyme for product release.

138 (palmitate) to lipid A by the outer membrane acyltransferase enzyme PagP occurs in immunostimulatory

139 f such substrates, we expressed three castor acyltransferase enzymes that incorporate HFA at each ste

140 slational modification mediated by palmitoyl acyltransferase enzymes, a group of Zn(2+)-finger DHHC-d

141 pharmacological inhibition of Porcupine, an acyltransferase essential for Wnt secretion, alleviates

142 The human zDHHC S-acyltransferase family comprises 23 enzymes that mediate

143 Moreover, we discovered that EPS1, a BAHD acyltransferase-family protein with a previously implica

144 thesis locus shares similarity with LpxL, an acyltransferase from lipid A biosynthesis.

145 The slr2103 protein sequence is unrelated to acyltransferases from bacteria (AtfA) or plants (DGAT1,

146 amoyl transferase, lysine decarboxylase, and acyltransferase gene families.

147 s UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase genes (la0512 and la4326 [lpxD1 and lpxD

148 evere iron overload had glyceronephosphate O-acyltransferase (GNPAT) polymorphism p.D519G (rs11558492

149 alogen synthetic enzyme glyceronephosphate O-acyltransferase (GNPAT) recapitulated the effects of Pex

150 t of knockout of the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acyla

151 e-bound O-acyltransferase (MBOAT), ghrelin O-acyltransferase (GOAT), which modifies the metabolism-re

152 study, we targeted the glycerol-3-phosphate acyltransferase GPAM along with choline kinase-alpha (CH

153 ding those that encoded glycerol-3-phosphate acyltransferase (GPAT), acyl-CoA:diacylglycerol acyltran

154 Two genes encoding glycerol-3-phosphate acyltransferase (GPAT), the first committed enzyme for T

155 erols is catalyzed by a glycerol-3-phosphate acyltransferase (GPAT).

156 The expression of glycerol-3-phosphate acyltransferase (GPAT3) was examined throughout the smal

157 ; the wild type and the GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE [GPAT6] and CUTIN SYNTHASE [CUS1] mutant

158 ene families, including the glycerophosphate acyltransferases (GPATs), acylglycerophosphate acyltrans

159 n be reacylated by the glycerophosphocholine acyltransferase Gpc1, which produces lysophosphatidylcho

160 ding the enzyme, named glycerophosphocholine acyltransferase (GPCAT).

161 Tissue transglutaminase (tTG) is an acyltransferase/GTP-binding protein that contributes to

162 The results indicate each acyltransferase has a unique effect on seed oil composit

163 Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzy

164 Hedgehog acyltransferase (HHAT) is the enzyme in the endoplasmic

165 Here, we show that Hedgehog acyltransferase (Hhat), the enzyme responsible for the a

166 ide-by-side comparison of PORCN and Hedgehog acyltransferase (HHAT), two enzymes that attach 16-carbo

167 Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis

168 p-coumaroylation of AX promoted by SvBAHD05 acyltransferase in the cell wall of the model grass S. v

169 Furthermore, in vitro assays of acyltransferases in microsomal fractions prepared from d

170 in vivo activities of type-2 diacylglycerol acyltransferases in Nannochloropsis oceanica (NoDGAT2s o

171 tablished the role of C. trachomatis-encoded acyltransferases in producing the new disaturated molecu

172 les of different classes of TAG biosynthetic acyltransferases in seed oil biosynthesis, we utilized t

173 PCAT with castor phospholipid:diacylglycerol acyltransferase increased novel FA and total oil content

174 or with palmitate with or without carnitine acyltransferase inhibition by mildronate.

175 Incubation with the acyltransferase inhibitor 2-bromopalmitate (25 mum for 1

176 almitoylproteomes, identified as a zDHHC20 S-acyltransferase interactor, and annotated as a potential

177 enzymes and spatial separation of different acyltransferases into separate metabolons affect efficie

178 PatA is an essential membrane associated acyltransferase involved in the biosynthesis of mycobact

179 The acyltransferase involved in the formation of these conju

180 y impacted by the substrate specificities of acyltransferases involved in lipid synthesis, such as th

181 stablishes an independent group of bacterial acyltransferases involved in triacylglycerol and wax est

182 ubstrate for a cAMP-regulated protein lysine acyltransferase (KATms; MSMEG_5458).

183 LBC agar, named choA, was identified as an N-acyltransferase known to produce an acylated glycine mol

184 reviously reported that lecithin:cholesterol acyltransferase (LCAT) and LDL receptor double knock-out

185 holipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharac

186 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse chole

187 is closely regulated by lecithin-cholesterol acyltransferase (LCAT) which is produced in the liver.

188 The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I)

189 homologue of mammalian lecithin:cholesterol acyltransferase (LCAT), a key enzyme that produces chole

190 ferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from humans in ret

191 ng a circulating enzyme lecithin cholesterol acyltransferase (LCAT).

192 tional protein alpha), a monolysocardiolipin acyltransferase-like enzyme, is required for fatty acid

193 work, the functions of lecithin:cholesterol acyltransferase-like PLAs (LCAT-PLAs) in HFA biosynthesi

194 n avocado (Persea americana) mesocarp and no acyltransferase/lipase motifs in most oleosins.

195 Finally, apolipoprotein N-acyltransferase (Lnt) catalyzes the transfer of the sn-1

196 a-amino terminus by the enzyme lipoprotein N-acyltransferase (Lnt), using an active-site cysteine thi

197 last enzyme in the pathway, apolipoprotein N-acyltransferase, Lnt, responsible for adding a third acy

198 ct 4-aa motif necessary for the LPA-specific acyltransferase (LPAAT) activity impaired G0S2's ability

199 Lysophosphatidate acyltransferase (LPAAT) catalyses the second step of the

200 Lysophosphatidic acid acyltransferase (LPAT) catalyzes acylation of the sn-2 p

201 The CT775 gene encodes an acyltransferase (LpaT) that selectively transfers fatty

202 isoform of the enzyme lysophosphatidic acid acyltransferase (LPAT) to the endoplasmic reticulum so t

203 These include lysophosphatidic acid acyltransferases (LPAT) and diacylglycerol acyltransfera

204 C transport requires lysophosphatidylcholine acyltransferase (LPCAT) activity at the chloroplast to f

205 e action of acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) can transfer PUFAs on PC directl

206 In Arabidopsis, lysophosphatidic acid acyltransferase (LPCAT) cycles FA to and from PC for mod

207 transferase (LPEAT), lysophosphatidylcholine acyltransferase (LPCAT), and lysophospholipase (LYPLA) c

208 rapamycin (mTOR) and lysophosphatidylcholine acyltransferase (LPCAT1)-mediated epigenetic changes.

209 ve demonstrated that lysophosphatidylcholine acyltransferases (LPCATs), which catalyze the incorporat

210 y phospholipase A2 (sPLA2), lysophospholipid acyltransferase (LPEAT), lysophosphatidylcholine acyltra

211 in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1).

212 rmacologically relevant lysophosphospholipid acyltransferase (LPLAT) superfamily.

213 rfamily of enzymes known as lysophospholipid acyltransferases (LPLATs), which are present in all doma

214 Both chains are attached by the acyltransferase LpxA, the first enzyme in the lipid A bi

215 lecule inhibitors (compounds 1 and 2) of the acyltransferase LpxA, the first enzyme in the lipopolysa

216 UDP-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes the first step of lipid

217 report that B. cenocepacia has only one late acyltransferase, LpxL (BCAL0508), which adds a myristoyl

218 tinoid isomerase (RPE65) or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis

219 Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis

220 evel is highly regulated by lecithin:retinol acyltransferase (LRAT) enzyme.

221 Lecithin:retinol acyltransferase (LRAT) is the enzyme that traps vitamin

222 olocalization of RPE65 with lecithin:retinol acyltransferase (LRAT) that provides the hydrophobic sub

223 Lecithin-retinol acyltransferase (LRAT)-deficient mice and P23H mutant mi

224 transgenic mice expressing lecithin retinol acyltransferase (Lrat)-driven Cre and maintained on stan

225 Lysocardiolipin acyltransferase (LYCAT), a cardiolipin (CL)-remodeling e

226 c reticulum, and that certain diacylglycerol acyltransferases may be the candidate enzymes catalyzing

227 DHHC-type protein acyltransferases may regulate the localization, stabilit

228 As members of the membrane-bound O-acyltransferase (MBOAT) enzyme family, acyl-coenzyme A:c

229 uman DGAT1, a member of the membrane-bound O-acyltransferase (MBOAT) family, by cryo-electron microsc

230 enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family.

231 ved Asp residues within the membrane-bound O-acyltransferase (MBOAT) homology domain are segregated o

232 DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which ar

233 tural model of a eukaryotic membrane-bound O-acyltransferase (MBOAT), ghrelin O-acyltransferase (GOAT

234 t-specific subfamily of the membrane bound O-acyltransferases (MBOAT) that acylate different lipid su

235 marrow FGF23 production through local G-3-P acyltransferase-mediated (GPAT-mediated) lysophosphatidi

236 cological inhibition of acyl-CoA:cholesterol acyltransferase-mediated cholesterol esterification, in

237 Lpp activates Toll-like receptor 2, the MsbB acyltransferase modifies lipopolysaccharide.

238 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, wit

239 Mutations in predicted catalytic and acyltransferase motifs do not influence TAG levels, sugg

240 g genes encoding Braun lipoprotein (Lpp) and acyltransferase (MsbB), the latter of which modifies lip

241 dopsis (Arabidopsis thaliana) diacylglycerol acyltransferase mutant dgat1-1 (in which phosphatidylcho

242 Here we demonstrate that the protein acyltransferase Pat regulates genes on Salmonella Pathog

243 Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse.

244 lation, we set out to identify the palmitoyl acyltransferase (PAT) involved.

245 The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the

246 esults also suggest that zDHHC3, a palmitoyl acyltransferase (PAT), catalyzes the palmitoylation of P

247 Expression of a complete acyltransferase pathway to efficiently process HFA estab

248 novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflamm

249 fied on over half of the family of palmitoyl-acyltransferases (PATs) that mediate protein palmitoylat

250 knowledge of the roles of specific palmitoyl acyltransferases (PATs), which catalyze palmitoylation,

251 ce at membranes and is mediated by palmitoyl acyltransferases (PATs).

252 PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) is an enzyme that catalyzes the t

253 RASE1 (DGAT1) or PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) on seed lipid composition were as

254 rase (DGAT), and phospholipid:diacylglycerol acyltransferase (PDAT), were strengthened asynchronously

255 DGAT1 activity, phospholipid:diacylglycerol acyltransferase (PDAT1) plays an important role in TAG s

256 s C466 and C473 by the DHHC family palmitoyl acyltransferase Pfa4.

257 H0-ACP motif is present in 98% of type I cis-acyltransferase PKS chain-extension modules.

258 The phospholipase A and acyltransferase (PLAAT) family of cysteine hydrolases co

259 ion of Wnt3 by Porcupine, a membrane-bound O-acyltransferase, plays a significant role in the intrace

260 s in turn utilized by the polytopic membrane acyltransferase PlsY on the pathway of bacterial phospho

261 Porcupine O-acyltransferase (PORCN) is considered essential for Wnt

262 ally accepted that lipidation of WNTs by the acyltransferase Porcupine (PORCN) and their subsequent r

263 Small molecules that disable the Wnt acyltransferase Porcupine (Porcn) are candidate anticanc

264 ion of the endoplasmic reticulum-localized O-acyltransferase porcupine (PORCN), which is necessary fo

265 ted fatty acid, to a conserved serine by the acyltransferase Porcupine (PORCN).

266 ''-O-ACYLTRANSFERASE (Vv3AT), encodes a BAHD acyltransferase protein (named after the first letter of

267 ber of a small subfamily of membrane-bound O-acyltransferase proteins that acylate secreted proteins,

268 pected that one of the genes might encode an acyltransferase, providing directions to our functional

269 ion and catalysis for an important family of acyltransferases, providing exciting possibilities for i

270 pid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1.

271 and Ale1 are the major cellular GPC and LPC acyltransferases, respectively.

272 ated acyl-CoA selectivity of microsomal sn-1 acyltransferase(s) and reveal its participation in a pre

273 lysophospholipids by acyl-CoA-dependent sn-1 acyltransferase(s).

274 We also noted that the acyltransferase selects from the bacterial pool of acyl-

275 s of an insertional mutant revealed that the acyltransferase slr2103, with sequence similarity to pla

276 tion of sterols with fatty acids by sterol O-acyltransferases (SOATs).

277 enables the interrogation of other bacterial acyltransferases' structure-mechanism relationships, and

278 d, demonstrating that other lysophospholipid acyltransferases than the two LPEATs could acylate LPE T

279 PlsX is a peripheral membrane acyltransferase that catalyzes the conversion of acyl-AC

280 T3 was shown to encode an acyl-CoA-dependent acyltransferase that catalyzes the transfer of short (fo

281 Here, we show that Lro1, an acyltransferase that generates TGs from phospholipid-der

282 eages by targeting Porcn, a membrane-bound O-acyltransferase that is indispensable for the activity a

283 Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is

284 We further identified ZDHHC19 as a palmitoyl acyltransferase that regulates STAT3.

285 Porcupine is an O-acyltransferase that regulates Wnt secretion.

286 is catalyzed by a family of transmembrane S-acyltransferases that contain a conserved zinc finger DH

287 an 'acetyltransferase' rather than an as an 'acyltransferase'; this has now been corrected in five in

288 conjunction with the enzyme lecithin:retinol acyltransferase to facilitate retinol uptake in some cel

289 concert with two previously identified BAHD acyltransferases--to reconstruct the entire cultivated t

290 ller of the two chromosomes, encodes a trans-acyltransferase (trans-AT) polyketide synthase (PKS) mul

291 ng to enable the functional expression of an acyltransferase via trafficking to the vacuole, heterolo

292 ulated gene, ANTHOCYANIN 3-O-GLUCOSIDE-6''-O-ACYLTRANSFERASE (Vv3AT), encodes a BAHD acyltransferase

293 We found that diacylglycerol acyltransferases, which catalyze the final reaction in a

294 ty acids to glycerol by glycerol-3-phosphate acyltransferases, which facilitate their transport to th

295 in of zDHHC17 (HIP14) and zDHHC13 (HIP14L) S-acyltransferases, which is involved in both substrate re

296 7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmit

297 and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylation

298 mosome 11 locus containing a cluster of BAHD acyltransferases with one gene (named Sl-ASAT3) expresse

299 Here, we report on a plant xanthophyll acyltransferase (XAT) that is both necessary and suffici

300 ice with a genetic deletion of the palmitoyl acyltransferase (Zdhhc23) that controls S-acylation of t