ライフサイエンスコーパス: adamantane

1 gio- and stereoselectivity (3 :2 = 105:1 for adamantane).

2 caffolds of the general structure 1 based on adamantane.

3 esults are seen for the alternate substrate, adamantane.

4 panded tetrahedranes, prismanes, cubanes and adamantanes.

5 le-molecule conductance compared with Si(10) adamantanes.

6 ming by investigating a series of methylated adamantanes.

7 susceptible to neuraminidase inhibitors and adamantanes.

8 The hydrocarbon in-adamantane (1), a high-energy adamantane isomer in which

9 thylbipyridine to a bulky hydrophobic group (adamantane, 1), a heme ligand (imidazole, 2), or F (3).

10 thylidene)cyclooctane (TMCO) from commercial adamantane-1,3-dicarboxylic acid has been developed.

11 antane.ethanolamine complex (8), and (S)-2-[(adamantane-1-carbonyl)amino]-3-phenylpropionic acid (15)

12 A series of eight 4-substituted 1-(adamantane-1-carbonyloxy)pyridine-2(1H)-thiones (1, X =

13 best prodrug 6 (isopropyl 2-(6-acetamido-2-(adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexano

14 e collection led to the identification of 1, adamantane-1-carboxylic acid (3-methyl-3H-benzothiazol-2

15 12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhib

16 n could be reduced by a sEH inhibitor, 12-(3-adamantane-1-yl-ureido)-dodecanoic acid n-butyl ester wa

17 Starting from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (1

18 ge for the formal equilibrium: [13]G-H + 1-X-adamantane [13]G-X + adamantane, where [13]G-H is the C(

19 ,N (CH(3))(2)-Dmt-Tic-OH (1), H-Dmt-Tic-NH-1-adamantane (2), and N,N(CH(3))(2)-Dmt-Tic-NH-1-adamantan

20 opropylphenyl)-1H-pyrazole-3-carbonyl]amino] adamantane-2-carboxylic acid, hydrochloride] blocked inh

21 our novel nanoscale 1,3,5,7-tetrasubstituted adamantanes 22 and 25-27 designed for atomic force micro

22 Adamantanes 22 and 25-27 may also find application as ch

23 amantane (2), and N,N(CH(3))(2)-Dmt-Tic-NH-1-adamantane (3) were determined by X-ray single-crystal a

24 ll-defined tower-shaped 1,3,5-trisubstituted adamantanes 30 and 33 that incorporate a macrocyclic tri

25 series of guests based on 2,6-disubstituted adamantanes, 4,9-disubstituted diamantanes, 1,6-disubsti

26 er mechanical stability (49 pN) than neutral adamantane (44 pN), a trend consistent with the chemical

27 gma-quantum interference (sigma-DQI) in sila-adamantane, a molecule whose cluster core is isostructur

28 PhMe = 4-methylbenzoic acid, and HO2C12H17 = adamantane acetic acid) in a stepwise fashion from S = 4

29 Using the proteasomal inhibitor adamantane-acetyl-(6-aminohexanoyl)3-(leucinyl)3-vinyl-(

30 Adamantanes (amantadine and rimantadine) are one of the

31 The adamantanes, amantadine and rimantadine, have been used

32 s a good structure-function relationship for adamantane amino derivatives inhibiting [(3)H]TCP or [(3

33 upon addition of a competitive binder (e.g., adamantane ammonium (ADA)) for CB[7], (2) by a dual pH-c

34 disubstituted diamantanes, and 1-substituted adamantane ammonium ions by direct and competitive (1)H

35 trated an alarming increase in resistance to adamantanes among influenza A(H3N2) viruses isolated in

36 x), and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperi

37 manifested only with the bulky C-terminal 1-adamantane analogues 2 and 3.

38 rochemical relevance, including naphthalene, adamantane and hexamethylenetetramine.

39 demonstrated that the alkyl chain connecting adamantane and ITC is a crucial determinant for Ad-ITC i

40 -Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-1-adamantane and N,N(Me)2-Dmt-Tic-NH-tBut were highly effe

41 We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 coun

42 ized by hydrophobic interactions between the adamantane and the TM peptide.

43 The angles of the linkers between adamantane and tpy head play a critical role in guiding

44 raise concerns about the appropriate use of adamantanes and draw attention to the importance of trac

45 , and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir.

46 ar acenes, cyclohexane, decalin, triptycene, adamantane, and [2.2]paracyclophane.

47 These anchors include cycloalkanes, adamantanes, and nitrogen heterocycles that compete favo

48 rafts-like alkylation in the synthesis of an adamantane-annulated arene.

49 an alkylative dearomatization/acid-mediated adamantane annulation sequence that allows facile access

50 o oseltamivir and zanamivir and resistant to adamantane antiviral medications.

51 ularity of these agents, cucurbit[7]uril and adamantane are recognized to have high in vivo stability

52 the neuraminidase inhibitors (NAIs) and the adamantanes, are well characterized, as are many mutatio

53 ongest bases are the decalin base 25 and the adamantane base 31.

54 ed first- and second-generation polycationic adamantane-based dendrons via a combined protection/depr

55 ure of the human receptor in complex with an adamantane-based inhibitor, which we leverage, in conjun

56 An adamantane-based NO donor 14 was synthesized and combine

57 ace as a supramolecular host/FRET donor, and adamantane-BHQ2 conjugates were employed as the guest/qu

58 The simulations suggested that the adamantane binds with an average metal-deuterium distanc

59 ifted signal associated with a perdeuterated adamantane bound to CP450cam, while signals presumably a

60 am, while signals presumably associated with adamantane bound to other cavities persisted.

61 angle spinning NMR spectra of perdeuterated adamantane bound to the active site of microcrystalline

62 ng ligand, camphor, was used to displace the adamantane-bound species.

63 sistance to neuraminidase inhibitors and the adamantanes, but the ability of these viruses to replica

64 methylbutane, norbornane, nortricyclene, and adamantane by tritiodeprotonation or deuteriodeprotonati

65 nd vibrational density of states of 1-fluoro-adamantane (C(10)H(15)F), an intriguing molecular crysta

66 Despite its intermediate size, adamantane (C(10)H(16), T(d)()) can enclose a wide varie

67 We employed various spacers between the adamantane cage and a cationic moiety as a tool for tuni

68 as employed because of the resistance of the adamantane cage toward cyclometalation reactions.

69 clodextrin (CD) with the hydrophobic part of adamantane carboxylate (AD) due to added salt or polar (

70 us involving the protonation state change of adamantane carboxylate at pH 5.8, and (3) by a dual pH-p

71 Me)2 = 3,5-dimethylbenzoic acid, HO2C11H15 = adamantane carboxylic acid, HO2C-th = 3-thiophene carbox

72 us substituted aminoquinolines coupled to an adamantane carrier are described.

73 The dosimetry of the cucurbit[7]uril-adamantane (CB7-Adma) pretargeting approach in men was c

74 s a chaperone to assist the formation of the adamantane-CB7 pairs.

75 The adamantane compounds, exemplified by JNJ303, are highly

76 ystal structure of the 1,3,5-tris(pyren-2-yl)adamantane containing chloroform as a guest are also pre

77 (TCG)(4)TTPA with a tetrakis(triazolylphenyl)adamantane core and trimer DNA arms.

78 st synthesis of a tetraradical based upon an adamantane core bearing six equivalent nitroxide-nitroxi

79 four quaternary germanium atoms in the sila-adamantane core, in a cluster analogy to precision germa

80 set the stage for the formation of the dioxa-adamantane core.

81 the tetrakis[4-(resorcin-5-ylethynyl)phenyl]adamantane core.

82 The linker between the adamantane cores is constituted of short ethylene glycol

83 is(methylidene)bicyclo[3.3.1]nonane from the adamantane derivative were optimized, and diadducts of t

84 Memantine, an adamantane derivative, has been used for the treatment o

85 clo[4.3.1.1(3,8)]undecane (1), a benzo-1-aza-adamantane derivative, is described and features a previ

86 ample of an enantiopure 1,2-difunctionalized adamantane derivative, which paves the way for potential

87 The mechanisms by which four adamantane derivatives (IEM-1857, -1592, -1460 and -1754

88 l(3), CD(2)Cl(2), and alcohol solutions with adamantane derivatives 15a,b, quinuclidine 15d, ammonium

89 lues of Ka for the interaction of CB[7] with adamantane derivatives 22-24 exceeds 10(12) M(-1)!

90 Both routes start from arylated adamantane derivatives and give the target compounds 12

91 we provide evidence for the binding site for adamantane derivatives and their putative access pathway

92 The adamantane derivatives have been used in HCV clinical tr

93 ions on the channel-blocking kinetics of the adamantane derivatives IEM-1754 and IEM-1857.

94 A plausible location of neutral and charged adamantane derivatives is shown in a model of the restin

95 We used a series of adamantane derivatives to probe the structure of the phe

96 In the case of the disubstituted adamantane derivatives, two and four conformers, respect

97 s has revolved around the synthesis of novel adamantane derivatives, we have recently found that othe

98 y to accommodate larger guests like cationic adamantane derivatives.

99 mization pathway of chiral 1,2-disubstituted adamantane derivatives.

100 ted cation conductance and its inhibition by adamantane derivatives.

101 The rigid adamantane-derived head unit with a single hydrogen atom

102 e identification of a novel benzylpiperazine adamantane diamide-derived compound that inhibits EboV i

103 ed to the affinity of CB[7].Diam(NMe3)2, the adamantane diammonium ion complexes (e.g., CB[7].2,6-Ad(

104 emonstrate that the dissociation dynamics of adamantane dications takes place in a two-step process:

105 ITC 6 with the longest chain between ITC and adamantane displayed the maximum growth inhibition in p5

106 omplex [(((Ad)ArO)(3)N)U(III)(DME)] (1; Ad = adamantane, DME = 1,2-dimethoxyethane) reacts with the t

107 ing approach where we conceptually pare sila-adamantane down to its bicyclic Si[3.3.1] and linear oli

108 '-dimethylbipyridine to an enzyme substrate (adamantane, F(8)bp-Ad), a heme ligand (imidazole, F(8)bp

109 It is an important target of adamantane-family antiviral drugs, but drug resistance h

110 on chemotype based on a quinoxalone-tethered adamantane framework developed via a metal- and light-fr

111 the synthesis of a sterically congested bis-adamantane framework-based chiral alcohol, (1R,2S,3S,4R)

112 ex that contains a sterically more demanding adamantane functionalized ligand, [((AdArO)3tacn)UIII] (

113 rchical coordination-driven self-assembly of adamantane-functionalized M(12) L(24) MOC (Ada-MOC) and

114 vesicles as supramolecular templates and an adamantane-functionalized poly(acrylic acid) additive an

115 Adamantane functions as a hydride transfer agent and thu

116 ancy disorder in the low-T phase of 1-fluoro-adamantane gives rise to the appearance of low-temperatu

117 t the replacement of a methylene unit of the adamantane group by an oxygen atom increases the solubil

118 but the lipophilicity and metabolism of the adamantane group compromise their overall usefulness.

119 importance of this property for binding the adamantane group.

120 We found that positively charged adamantane guest demonstrated higher mechanical stabilit

121 A cucurbit[7]uril host and an adamantane guest molecule form a high-affinity host-gues

122 Methods: Three (64)Cu-labeled adamantane guest radioligands were developed, and their

123 ribe the functionalization of HA either with adamantanes (guest moieties) via controlled esterificati

124 Me)2-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-1-adamantane and N,N(Me)2-D

125 N,N(Me)2-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-

126 in the United States until susceptibility to adamantanes has been reestablished among circulating inf

127 Adamantanes have been used to treat influenza A virus in

128 side chain binds to either S1 or S2 and the adamantane headgroup binds to S1.

129 egy that harnesses an intramolecular beta-CD/adamantane host-guest interaction to generate a stabiliz

130 blies are instead composed of robust beta-CD/adamantane host/guest interactions.

131 orientation of the C-terminal substituent 1-adamantane in 2 and 3 was affected by differences in the

132 is of an exo-cis-exo stereoisomer containing adamantane in the tether exhibited an unusually close ap

133 exploited to keep the host (CB7) and guest (adamantane) in proximity.

134 in structure from bicyclo[2.2.1] through to adamantane, including some in the top-selling pharmaceut

135 ainst a newly developed isoxazole-conjugated adamantane inhibitor that targets the AM2 S31N channel.

136 lthough resistance arose to these prototypic adamantane inhibitors of the influenza A virus (IAV) M2

137 ltaneous encapsulation of free ferrocene and adamantane inside the 1(2) capsular assembly.

138 gle-molecule junctions of the tricyclic sila-adamantane is 2.7-times lower than their bicyclic Si[3.3

139 hydrocarbon in-adamantane (1), a high-energy adamantane isomer in which one methine hydrogen atom is

140 An adamantane-labeled glutamine analog was selected through

141 ed with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see

142 s such as P4O6 and P4O10 that possess iconic adamantane-like cage structures, highly reactive phospho

143 e IR spectra and normal-mode analysis of the adamantane-like compound [Mn(4)O(6)(bpea)(4)](n+) (bpea

144 O pKa values for a series of rigid tricyclic adamantane-like triols containing 0-3 trifluoromethyl gr

145 These results indicate that adamantane metabolic stabilization sufficient to obtain

146 Rimantadine hydrochloride (alpha-methyl-1-adamantane-methalamine hydrochloride) is a chiral compou

147 thiophenol (74%), adamantamine (91%), and 1-adamantane methanol (75%), respectively.

148 le, 1-adamantane-p-toluenesulfonamide, and 1-adamantane methyl p-toluenesulfonate were reduced with 3

149 (1)H-(1)H NOE cross peaks indicate that the adamantane moiety of the drug is bound in the spacious p

150 be novel NitroMemantine drugs, comprising an adamantane moiety that binds in the NMDAR-associated ion

151 in-binding complex, with a freely accessible adamantane moiety.

152 beric acid, and sclareolide, and substituted adamantane molecules, when catalyst Cu/Au (3:1) or Pd/Au

153 The adamantane nucleus exposes three carboxylic acid groups

154 philic counteranions provided access to sila-adamantane on the gram-scale, enabling us to discover st

155 replacement by a single large molecule (here adamantane or ferrocene) entropically favourable.

156 Active drugs featured phenyl-, adamantane-, or alkyl residues at the methylene bridge.

157 Additionally, the starting racemic material, adamantane-oxazolidine-2-one, was resolved into single e

158 mines and heterocycles by decarboxylation of adamantane-oxazolidine-2-one.

159 Using the same conditions, thioanisole, 1-adamantane-p-toluenesulfonamide, and 1-adamantane methyl

160 The synthesis of the adamantane phenylalkylamines 2a-d, 3a-c, and 4a-e is des

161 Using a silane-functionalized adamantane precursor and a laser-heated diamond anvil ce

162 AdabisGb(3) (two deacyl Gb(3)s linked to adamantane) protects against VT1/VT2 more effectively th

163 ansition from an inactive state (wherein the adamantane protein-binding headgroup is encapsulated) to

164 Results: The adamantane radioligands possessed high in vitro stabilit

165 fic and high tumor uptake of the pretargeted adamantane radioligands provide great potential for the

166 The adamantane radioligands were analyzed for pretargeting u

167 idged 1,2,4,5-tetraoxane characterized by an adamantane residue showed the highest activity (IC(5)(0)

168 ics of 2003, 1951, and 1947; and the rise in adamantane resistance among currently circulating human

169 We sought to assess adamantane resistance among influenza A viruses isolated

170 rculating in the United States demonstrating adamantane resistance highlights the clinical importance

171 eased due to the emergence of near-universal adamantane resistance in influenza A/H3N2 viruses during

172 Adamantane resistance in the A/H3N2 virus samples was 10

173 Adamantane resistance is imparted mainly by a S31N mutat

174 fied version of this method for detection of adamantane resistance mutations.

175 Adamantane resistance was found in only 1.2% of NY and W

176 g, although at a level less significant than adamantane resistance.

177 ) in the M2 gene known to be correlated with adamantane resistance.

178 iruses circulating in the United States were adamantane resistant.

179 ved compounds that inhibit the wild-type and adamantane-resistant forms of the influenza A M2 ion cha

180 clo[2.2.1]heptane, bicyclo[2.2.2]octane, and adamantane, respectively, were determined in the gas pha

181 istic inquiry into the isomerization of sila-adamantane revealed new approaches for installing halide

182 o-, and three-pyrenyl groups attached to the adamantane scaffold are disclosed.

183 at the addition of an aromatic ring into the adamantane scaffold produced conformational rearrangemen

184 that the presence of the oxygen atom on the adamantane scaffold results in active site rearrangement

185 eprotection strategy starting from different adamantane scaffolds.

186 biphenyl]-4-carboxylate ( 27: ) acts both on adamantane-sensitive and a resistant M2 variant encoding

187 we found that a hexyl group adjacent to the adamantane served as a chaperone to assist the formation

188 Whereas the adamantane site binds CB solely via hydrophobic interact

189 the Fe(4)S(4) clusters are bridged with the adamantane [Sn(4)S(10)](4-) linking blocks, the electroc

190 ctrodes align with the long branches of sila-adamantane, strong sigma-DQI interactions occur between

191 Adamantane-substituted donor-acceptor Stenhouse adducts

192 seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses tha

193 dro-5-boraadamantane as well as some related adamantane systems, hitherto unknown as persistent long-

194 re TBA stands for tetrakis(p-hydroxybiphenyl)adamantane that assembles into a material from micromola

195 With the addition of catalytic amounts of adamantane the selectivity of this transformation can be

196 of 2 with C(8) K and liberation of N(2) and adamantane, the two silylene subunits are regenerated to

197 C 1s and S 2p binding energies are lower in adamantane thiol than alkane thiols on gold by 0.67 +/-

198 2''-terpyridine (tpy) ligands constructed on adamantane, three discrete 3D metallo-supramolecular arc

199 This intermediate was then conjugated to adamantane-trimerized GPI (2[(3-amino-3-carboxypropyl)(h

200 In this study, we present an adamantane-trimerized small molecule that has nanomolar

201 oxygen, nitric oxide, nitrous oxide, 1-azido adamantane, trimethylamine n-oxide, and 1,4-benzoquinone

202 chors (a flexible Letsinger type and a rigid adamantane type).

203 than 2 and was most consistent with a Cu4S6 adamantane-type species.

204 in this work suggested that the ferrocene or adamantane unit of the conjugates interacted with the be

205 a photodissociation study of the diamondoid adamantane using extreme ultraviolet femtosecond pulses.

206 The first syntheses of functionalized sila-adamantanes via site-selective reactions are described.

207 droxy, 1-acetyl, 1-carboxy-, and 1-acetamido-adamantane, we demonstrated selective fluorination at th

208 ionalized over bridgehead Si centers in SiGe adamantanes; we use this chemistry in conjunction with s

209 es that confer resistance to oseltamivir and adamantanes were assessed.

210 tert-butyl wheels and another set of larger adamantane wheels on the same car.

211 ilibrium: [13]G-H + 1-X-adamantane [13]G-X + adamantane, where [13]G-H is the C(13)H(22) fragment of

212 strongly perturb optical absorbance in sila-adamantane, whereas substituents at the exocyclic and 2-

213 he opposite is true for the neutral molecule adamantane, which prefers the TID (or barbiturate) locus

214 STM-BJ) measurements to show that Si(8)Ge(2) adamantane wires give a 60% increase in single-molecule

215 nd alkenes (3 degrees :2 degrees = 102:1 for adamantane with the COF film), which is improbable in ho

216 dal building block, 1,3,5-Tris(4-aminophenyl)adamantane, with linear dialdehyde building blocks allow

217 ethylsilylene bridge that is present in sila-adamantane yet absent in Si[3.3.1].

218 sodesmic bond separation scheme to gas-phase adamantane yields a value for Delta(f)H degrees (298) wi