ライフサイエンスコーパス: adaptive immune response

1 environmental allergens without altering the adaptive immune response.

2 srupt the normal functions of the innate and adaptive immune response.

3 s and are essential for the initiation of an adaptive immune response.

4 ator of both the size and specificity of the adaptive immune response.

5 aces by CD4(+) T cells, key mediators of the adaptive immune response.

6 -beta, a key mediator between the innate and adaptive immune response.

7 entation and the development of a functional adaptive immune response.

8 nnate immune effectors and initiators of the adaptive immune response.

9 uce type I IFN and bridge between innate and adaptive immune response.

10 subsequently initiating a well-orchestrated adaptive immune response.

11 is a conserved and crucial component of the adaptive immune response.

12 ed with HAI titer, indicating links with the adaptive immune response.

13 uctural predetermination and dynamics of the adaptive immune response.

14 are a key cell type in the initiation of the adaptive immune response.

15 les, initiating target cell death during the adaptive immune response.

16 for normal lymphocyte activation during the adaptive immune response.

17 ed to have synergistic effects on innate and adaptive immune response.

18 te immune properties to limit an exaggerated adaptive immune response.

19 ect in cell to cell communication during the adaptive immune response.

20 e and viral antigen burden with the regional adaptive immune response.

21 n SHRs represent an abnormal proinflammatory adaptive immune response.

22 disease pathology, overriding the protective adaptive immune response.

23 vading pathogens but also for initiating the adaptive immune response.

24 uent T-cell activation are essential for the adaptive immune response.

25 8 mutation in cftr is coupled to an impaired adaptive immune response.

26 criptase, which may restore the HBV-specific adaptive immune response.

27 n of T cell-biased clones consistent with an adaptive immune response.

28 erted, indicating an ability to activate the adaptive immune response.

29 ssociated with suppression of the innate and adaptive immune response.

30 es in innate cellular IL-12 responses on the adaptive immune response.

31 ring development of one arm of the mammalian adaptive immune response.

32 s (APCs) is an essential step in mounting an adaptive immune response.

33 lls are an important link between innate and adaptive immune response.

34 an innate immune pathway that influences the adaptive immune response.

35 ith admixture-enabled selection for enhanced adaptive immune response.

36 D-19 infection can mount SARS-CoV-2-reactive adaptive immune responses.

37 -onset fatal disease prior to development of adaptive immune responses.

38 cal molecular links between innate cells and adaptive immune responses.

39 processes that are important for innate and adaptive immune responses.

40 cing is of major importance in understanding adaptive immune responses.

41 to pathogens and co-ordinate many innate and adaptive immune responses.

42 as potential adjuvants for the induction of adaptive immune responses.

43 HIKV RNA that are not cleared efficiently by adaptive immune responses.

44 microorganisms can modulate both innate and adaptive immune responses.

45 controlled, and organized by both innate and adaptive immune responses.

46 mmed death ligand-1 (PD-L1), which mitigates adaptive immune responses.

47 HD1 can also modulate antibody production in adaptive immune responses.

48 ergic inflammation and bridge the innate and adaptive immune responses.

49 c cytokine which critically links innate and adaptive immune responses.

50 ally required for affinity maturation during adaptive immune responses.

51 een implicated in regulating both innate and adaptive immune responses.

52 d receptor-independent functional innate and adaptive immune responses.

53 T cells contributing to both, the innate and adaptive immune responses.

54 der constant immune surveillance by a host's adaptive immune responses.

55 tching plays an important role in modulating adaptive immune responses.

56 of adaptive immunity or due to pressure from adaptive immune responses.

57 outes and innate signature in the quality of adaptive immune responses.

58 of adaptive immune cells, and CNS-targeting adaptive immune responses.

59 resident gut microbiota is known to license adaptive immune responses.

60 cted cells and by mobilizing both innate and adaptive immune responses.

61 nes associated with inflammatory, innate and adaptive immune responses.

62 vels, thereby presumably fostering efficient adaptive immune responses.

63 apies include activation of either innate or adaptive immune responses.

64 ition receptors might also play key roles in adaptive immune responses.

65 ted because of the insufficient induction of adaptive immune responses.

66 information to generate tailored protective adaptive immune responses.

67 crobiota, leading to dysregulated innate and adaptive immune responses.

68 lso involved in the regulation of innate and adaptive immune responses.

69 e development of inflammation and innate and adaptive immune responses.

70 f importance in generating T helper-1 biased adaptive immune responses.

71 ic injury contributes to impaired innate and adaptive immune responses.

72 rient supply to support clonal expansion and adaptive immune responses.

73 een demonstrated to induce strong innate and adaptive immune responses.

74 ses that modulate malaria-induced innate and adaptive immune responses.

75 ading to perturbation of the host innate and adaptive immune responses.

76 role in DENV-induced cytokine production and adaptive immune responses.

77 xes with their T-cell receptors and initiate adaptive immune responses.

78 ving the complementary actions of innate and adaptive immune responses.

79 ehavior with poorly characterized effects on adaptive immune responses.

80 ical outcomes likely dependent on functional adaptive immune responses.

81 lity to produce antibodies in the context of adaptive immune responses.

82 the initiation and regulation of innate and adaptive immune responses.

83 fects of schistosome infection on innate and adaptive immune responses.

84 and tracking B cell clonal expansions during adaptive immune responses.

85 ctions, both innately and as participants in adaptive immune responses.

86 subjected to the control of host innate and adaptive immune responses.

87 cells as a critical link between innate and adaptive immune responses.

88 stranded RNA fragments to trigger innate and adaptive immune responses.

89 ate cytokine-mediated effects and heightened adaptive immune responses.

90 tolerance, viral infections, and innate and adaptive immune responses.

91 teins that play an important role to develop adaptive immune responses.

92 mplex class I (MHCI) molecules and regulates adaptive immune responses.

93 ls and secosteroids regulate both innate and adaptive immune responses.

94 tory cytokine induction by SVLP(+) DCs, with adaptive immune response activation ex vivo/in vivo.

95 crophage infiltration initiates long-lasting adaptive immune responses after TBI.

96 Th17 cells play a critical role in the adaptive immune response against extracellular bacteria,

97 We discovered that the adaptive immune response against Staphylococcus aureus (

98 d cytotoxic CD8+ T cells are key players for adaptive immune responses against acute infections with

99 Although adaptive immune responses against hepatitis C virus (HCV

100 represents a feature of exacerbated mucosal adaptive immune responses against microbial and/or self-

101 ation is a prerequisite for the induction of adaptive immune responses against pathogens and cancer.

102 dependent cross-priming to bridge innate and adaptive immune responses against the tumor.

103 Additionally, we detected adaptive immune responses against the vector and Cas9 nu

104 Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating

105 mune cells, mechanisms of their synergy with adaptive immune responses against tumors, and discuss re

106 n the role of innate immune cells in priming adaptive immune responses, an improved understanding of

107 ellular stress, cell death, activation of an adaptive immune response and a failure to adapt, with pr

108 Vitamin A regulates the adaptive immune response and a modulatory impact on type

109 arly, CD4(+) T cells are constituents of the adaptive immune response and accumulate within the plaqu

110 DOWN genes) in MDD were associated with the adaptive immune response and included clusters of genes

111 after experimental depletion of cells of the adaptive immune response and is associated with a loss o

112 e the immune system, one associated with the adaptive immune response and T-cell activation, and the

113 that lymphadenectomy impairs acquisition of adaptive immune responses and antibody production in res

114 global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulatio

115 K) plays a major role in inflammation and in adaptive immune responses and could therefore contribute

116 ) and adeno-associated viruses (AAVs) evades adaptive immune responses and enables effective gene edi

117 by which UV radiation can modify innate and adaptive immune responses and how this immunomodulatory

118 hich the goal is the generation of effective adaptive immune responses and long-lasting immune memory

119 (Trm) cells mediate potent local innate and adaptive immune responses and play a central role agains

120 lls (DCs) are at the crossroad of innate and adaptive immune responses and profoundly modulate the de

121 senger donor-strain nT-regs can inhibit host adaptive immune responses and prolong allograft survival

122 tivity of the protease MALT1 is required for adaptive immune responses and regulatory T (Treg)-cell d

123 er, the interaction of human MAIT cells with adaptive immune responses and the role they may play in

124 y members in the orchestration of innate and adaptive immune responses and their diversity and plasti

125 ars to fulfill a role in regulating adequate adaptive immune responses and, hence, may be involved in

126 suppress proliferation of effector T cells (adaptive immune response) and production of IL1B and TNF

127 human ZIKV response, including viremia, the adaptive immune response, and persistent ZIKV in semen.

128 ssive innate immune response, suppresses the adaptive immune response, and reduces circulating IL-1be

129 er dysfunction are modified by genes, innate/adaptive immune responses, and different environmental f

130 and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT functi

131 nicity, allowing staphylococci to evade host adaptive immune responses, and propose to exploit these

132 expanded roles of neutrophils in innate and adaptive immune responses, and summarize current knowled

133 uated airway hyperresponsiveness, innate and adaptive immune responses, and type 2 cytokine productio

134 high-affinity T-cell receptors to deepen the adaptive immune response; and reinvigorating older appro

135 ed inflammatory innate response and impaired adaptive immune response are associated with clinical se

136 It is becoming clear that both innate and adaptive immune responses are active in PD.

137 d that human ILFs are sites where intestinal adaptive immune responses are initiated in an anatomical

138 and discuss the need to study how innate and adaptive immune responses are integrated when they coexi

139 Adaptive immune responses are tailored to different type

140 In patients with CHB, both innate and adaptive immune responses are weak and thus rarely lead

141 recent identification of early HIV-specific adaptive immune responses as novel correlates of HIV res

142 molecular pathways evoked during innate and adaptive immune responses as well as the chronic demyeli

143 er, this therapy recruits both an innate and adaptive immune response, as deficiencies in either arm

144 n of alarmins in the induction of innate and adaptive immune responses, as well as their contribution

145 ization, thereby implicating both innate and adaptive immune responses at the oropharyngeal mucosa.

146 FN response of mice was suppressed, then the adaptive immune responses became critical.

147 This genetic variability is affected by the adaptive immune response but the contribution of other h

148 d Igs can provide valuable insights into the adaptive immune response, but bioinformatics pipelines f

149 or in lymphocytes is a required event during adaptive immune response, but dysregulated activation of

150 th and disease can provide key insights into adaptive immune responses, but the accuracy of current T

151 ty complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens

152 a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its den

153 been exploring novel strategies to shape the adaptive immune response, by targeting innate immune cel

154 More broadly, they suggest that adaptive immune responses can contribute to innate IEL a

155 multifactorial components of the innate and adaptive immune responses, controls parasitemia, and blo

156 re an important site at which the innate and adaptive immune responses converge but their architectur

157 dulate inflammation without compromising the adaptive immune response could be the most effective the

158 e states based on pattern recognition in the adaptive immune response could be used to develop biomar

159 ecruitment, and the initiation of innate and adaptive immune responses culminate in immunothrombosis,

160 Effective adaptive immune responses depend on activation of CD4+ T

161 The adaptive immune response depends on antigen presentation

162 The adaptive immune response depends on antigen presentation

163 piratory syndrome coronavirus 2 (SARS-CoV-2) adaptive immune response despite chronic immunosuppressi

164 is is the eradication of infection before an adaptive immune response develops.

165 C3 serves as a potential target for treating adaptive immune responses driving multiple sclerosis and

166 (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to

167 jor studies have been done to understand the adaptive immune response during KFDV infection in humans

168 estinal bacteria species that induce cognate adaptive immune responses during homeostasis have been i

169 ast the mechanisms initiating and sustaining adaptive immune responses during primary infection with

170 Augmentation of adaptive immune responses during therapy was more impres

171 the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infecti

172 berculosis (TB) is based on the induction of adaptive immune responses endowed with long-term memory

173 r, the existing models cannot support robust adaptive immune responses, especially the generation of

174 to assess whether the carbohydrate-specific adaptive immune response exemplified in our previous stu

175 nsplantation decreases the durability of the adaptive immune response following cART withdrawal and v

176 e requirement for a pre-existing intratumour adaptive immune response for effective immunotherapies,

177 Pursuing the Th2 adaptive immune response further we demonstrate that Cav

178 thma, including several signals in innate or adaptive immune-response genes.

179 tion to the lung and to influence subsequent adaptive immune responses highlights the importance of u

180 ittle is known about the contribution of the adaptive immune response in Alzheimer's disease(2).

181 lations, and to verify the development of an adaptive immune response in infected individuals.METHODS

182 Activation of the adaptive immune response in mice was initiated by macrop

183 pe I IFN response, suggesting a role for the adaptive immune response in resolving infection.

184 These results reveal an adaptive immune response in the blood and cerebrospinal

185 e a complex role in directly influencing the adaptive immune response in the context of development,

186 hat result in the type 2-biased OVA-specific adaptive immune response in the lung were dependent upon

187 ciation between the mutational landscape and adaptive immune responses in adenomatous premalignancy.S

188 ining inflammation and promoting appropriate adaptive immune responses in both humans and mice.

189 nning at 48 h leads to tight control without adaptive immune responses in half of animals.

190 paradigm whereby tissue mechanics fine-tune adaptive immune responses in health and disease.

191 signal transduction required for appropriate adaptive immune responses in humans.

192 le of HIV-specific CD4(+) T cells in shaping adaptive immune responses in individuals infected with c

193 We measured activation of adaptive immune responses in mice with pancreatitis by f

194 y high recurrence rates of UTIs, we examined adaptive immune responses in mouse bladders.

195 L-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.

196 s also capable of modulating host innate and adaptive immune responses in response to sepsis, transpl

197 receptor ALX/FPR2 show defective innate and adaptive immune responses in salivary glands.

198 intestinal barrier function, and innate and adaptive immune responses in the mucosal cells of the in

199 MCG effects on DC functionality and adaptive immune responses in vivo were assessed by combi

200 timulated T and B cells and thereby curtails adaptive immune responses in vivo.

201 r the development of key vitamin A-dependent adaptive immune responses, including CD4(+) T-cell homin

202 NLRP10-deficient mice developed vigorous adaptive immune responses, indicating that there was not

203 Intestinal adaptive immune responses influence host health, yet onl

204 signaling, communication between innate and adaptive immune response, integrin, PTEN and phospholipa

205 ority of patients, indicating that the local adaptive immune response is active during human RUTI.

206 This change in the adaptive immune response is associated with impaired vir

207 1-overexpressing parasites, showing that the adaptive immune response is critical to reducing disease

208 rapeutic use in clinical studies in which an adaptive immune response is desired.

209 Adaptive immune response is part of the dynamic changes

210 The adaptive immune response is regulated primarily by mecha

211 Elucidation of the adaptive immune response is valuable for understanding p

212 Failure to make adaptive immune responses is a hallmark of aging.

213 mma, a critical cytokine for both innate and adaptive immune responses, is also regulated by a super-

214 blishment of an anti-BP CD4 T cell-dependent adaptive immune response leading to anti-drug Abs produc

215 ay, such as an anti-CD40 mAb, suppresses the adaptive immune response, leading to pig kidney graft su

216 ave suppressed type I IFN responses and lack adaptive immune responses, leading to a prolonged infect

217 ttern recognition receptors in informing the adaptive immune response, markedly less attention has be

218 , the memory component of the virus-specific adaptive immune response may improve viral control compa

219 ins are established regulators of innate and adaptive immune responses, microbial populations, and se

220 expression signature or other markers for an adaptive immune response might be of relevance for ident

221 (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of a

222 ggest that undernutrition impairs innate and adaptive immune responses needed to control Mycobacteriu

223 revealed a significant relationship between adaptive immune responses of extracorporeal membrane oxy

224 To this end, we compared innate and adaptive immune responses of moDCs with those that were

225 o allow the pathogen to evade the innate and adaptive immune responses of the host.

226 the outcome of the preferential focus of the adaptive immune response on epithelial repair at the exp

227 of potentially noxious molecules to mount an adaptive immune response or, in the case of autoimmune d

228 n, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation

229 ranscripts encoding components of innate and adaptive immune response pathways.

230 ggest that diverse bacterial species and the adaptive immune response play important roles in RUTI in

231 c targets to control dysregulated innate and adaptive immune responses, promote lymphocyte antitumor

232 Effective adaptive immune responses require a large repertoire of

233 proline-rich peptides trigger the innate and adaptive immune response, resulting in intestinal cell s

234 negatively affected by a range of innate and adaptive immune responses, resulting in alterations in t

235 suppressed kidney damage without augmenting adaptive immune responses, suggesting it might offer a n

236 nic phase, antigen presentation initiates an adaptive immune response targeted to the brain, which ma

237 nt changes to the microbiome, and innate and adaptive immune responses that are critical to the induc

238 Innate and adaptive immune responses that prime myeloid cells, such

239 T cells are vital for adaptive immune responses that protect against pathogens

240 In the absence of innate and adaptive immune responses, the transplanted pig kidneys

241 ization of S aureus modulates the innate and adaptive immune response, thereby predisposing the organ

242 ex (MHC) genes encode proteins that initiate adaptive immune responses through the presentation of fo

243 lso be genetically engineered to control the adaptive immune response, thus enabling exogenous immuno

244 The contribution of the adaptive immune response to CD pathogenesis has been ext

245 ecognition receptors that enhance the skin's adaptive immune response to epicutaneous antigens.

246 ef-induced MHC-I down-regulation restore the adaptive immune response to HIV-infected cells in vitro

247 T cells significantly contribute to the host adaptive immune response to HSV-1 challenge following va

248 cell receptors (TCR) plays a key role in the adaptive immune response to infections.

249 The adaptive immune response to influenza virus infection is

250 B cells are a major part of the adaptive immune response to inhaled HDM allergen, partic

251 rst identified in bacteria and archaea as an adaptive immune response to invading genetic material, h

252 nate immune cells is critical to shaping the adaptive immune response to microbial infection.

253 ough IFNgamma is the central mediator of the adaptive immune response to pathogens, it has been shown

254 the protective efficacy and duration of the adaptive immune response to SARS-CoV-2, as well as its i

255 ion in potentially modulating the innate and adaptive immune response to the SARS-CoV-2 virus or to a

256 lammatory cytokines, which in turn shape the adaptive immune response to the tumor.

257 s approaches to optimize both the innate and adaptive immune response to the tumor.

258 gnant lesions, suggesting the presence of an adaptive immune response to these neoantigens.

259 hysiological factors that mediate innate and adaptive immune response to vaccines.

260 comprehensively assess the acute innate and adaptive immune response to ZIKV infection in ten women

261 rmulations and delivery parameters shape the adaptive immune responses to a toxoid and fimbria-derive

262 We review the innate and adaptive immune responses to acute and chronic HBV infec

263 ommensal microorganisms calibrate innate and adaptive immune responses to affect the activation thres

264 In this review, we examine the innate and adaptive immune responses to avian influenza viruses and

265 re are preexisting humoral and cell-mediated adaptive immune responses to Cas9 in humans, a finding t

266 Studies of adaptive immune responses to CCHFV have been limited due

267 variants required FcRn to induce innate and adaptive immune responses to hIgG1 ICs, which were augme

268 cART, including the possible contribution of adaptive immune responses to HIV-associated neurocogniti

269 ction, including how it regulates innate and adaptive immune responses to infection.

270 uggests that progestins significantly affect adaptive immune responses to influenza A virus infection

271 med a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins follo

272 cells are important effectors of innate and adaptive immune responses to pathogens and NK cell funct

273 licular helper (T(FH)) cells are critical in adaptive immune responses to pathogens and vaccines; how

274 with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.

275 othesized that humans may harbor preexisting adaptive immune responses to the Cas9 orthologs derived

276 ort tumor growth and to convert and suppress adaptive immune responses to the tumor.

277 ll surface proteins that regulate innate and adaptive immune responses to viral infection by engaging

278 odulatory activity that can alter innate and adaptive immune responses to viral infection.

279 y, in modulating host intrinsic, innate, and adaptive immune responses to viral infections in the res

280 that pregnancy results in altered innate and adaptive immune responses to ZIKV infection in the repro

281 ock syndrome, an escalation of the cytotoxic adaptive immune response triggered upon the binding of p

282 RVVC patients show no defective Th-dependent adaptive immune response upon Candida stimulation.

283 nst viral infection and in the activation of adaptive immune response via JAK/STAT signaling.

284 lper cells in antiviral defense, influencing adaptive immune responses via interactions with dendriti

285 apy; however, in a murine model the systemic adaptive immune response was greatest with a single admi

286 A marked adaptive immune response was noted for the up-regulated

287 innate immune rejection and further suppress adaptive immune responses, we expressed the immunomodula

288 Importantly, adaptive immune responses were also necessary for MCMV t

289 Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder di

290 Few differences in adaptive immune responses were observed between the sexe

291 ositioned at the interface of the innate and adaptive immune responses when lymphocytes interact with

292 Viral replication is suppressed by the adaptive immune response; when these immune cells are de

293 mbrane oxygenation also induces CNS-directed adaptive immune responses which may exacerbate extracorp

294 ancreases indicate differences in innate and adaptive immune responses, which highlights differences

295 features of SA-4-1BBL that bridge innate and adaptive immune responses with both preventive and thera

296 and the temporal relationships of innate and adaptive immune responses with neurodegeneration are unk

297 ors play a central role in the initiation of adaptive immune responses with several TLR agonists acti

298 MAIT cells were depleted by the onset of the adaptive immune response, with decreased detection of gr

299 le and emerging PET biomarkers of innate and adaptive immune responses, with mention of exciting futu

300 The adaptive immune response within tumours has previously b