ライフサイエンスコーパス: adaptive immune system

1 B lymphocytes are important players of the adaptive immune system.

2 phagy/autophagy, dopamine metabolism and the adaptive immune system.

3 ession is modulated by interactions with the adaptive immune system.

4 J recombination ensures the diversity of the adaptive immune system.

5 d DNA-nuclease that is part of the bacterial adaptive immune system.

6 some 6, which plays an important role in the adaptive immune system.

7 ter infection prior to the activation of the adaptive immune system.

8 lopment of T helper 17 (T(h)17) cells of the adaptive immune system.

9 , delta-opioid receptors, and T cells of the adaptive immune system.

10 play important roles both in the innate and adaptive immune system.

11 e human leukocyte antigen (HLA) genes of the adaptive immune system.

12 are orchestrated by both the innate and the adaptive immune system.

13 ed for up to 15 d yet was independent of the adaptive immune system.

14 well described stimulators of the innate and adaptive immune system.

15 ry pathways that involve both the innate and adaptive immune system.

16 ted to allow the virus to be masked from the adaptive immune system.

17 been given to their impact on the developing adaptive immune system.

18 egulation of innate immunity by cells of the adaptive immune system.

19 heterogeneity is an essential feature of the adaptive immune system.

20 mote tumor suppression via activation of the adaptive immune system.

21 tion of infectious and sterile agents to the adaptive immune system.

22 sequencing is a powerful tool to analyze the adaptive immune system.

23 he interface between the circulation and the adaptive immune system.

24 nally been regarded as a unique trait of the adaptive immune system.

25 fects on B cells, the other component of the adaptive immune system.

26 ant in lineage decision-making events in the adaptive immune system.

27 in protospacer integration by the CRISPR-Cas adaptive immune system.

28 igands, marking cells for recognition by the adaptive immune system.

29 correct defects in this important arm of the adaptive immune system.

30 by defects in the innate mucosal barrier and adaptive immune system.

31 r organisms and invertebrates, which lack an adaptive immune system.

32 e T-cell receptor (TCR) is a hallmark of the adaptive immune system.

33 the absence of Bach2 was dependent upon the adaptive immune system.

34 memory is a central feature of the mammalian adaptive immune system.

35 iota effects, or tumoricidal activity by the adaptive immune system.

36 D)J recombination to ensure diversity of the adaptive immune system.

37 is of many diseases due to their role in the adaptive immune system.

38 ecific lymphocytes required for an efficient adaptive immune system.

39 have been found that inhibit the CRISPR-Cas adaptive immune system.

40 way is central for proper development of the adaptive immune system.

41 egnancy coincided with a modification of the adaptive immune system.

42 s and apoptotic cells and stimulation of the adaptive immune system.

43 Vitamin D can modulate the innate and adaptive immune system.

44 detections and the activations of innate and adaptive immune system.

45 an immune-evasive cancer population and the adaptive immune system.

46 ould in turn impinge upon the priming of the adaptive immune system.

47 t detailed AIRR data for the analysis of the adaptive immune system.

48 e and are critical for the activation of the adaptive immune system.

49 and natural killer cells, and recruiting the adaptive immune system.

50 ategies currently being developed engage the adaptive immune system.

51 Memory and specificity are hallmarks of the adaptive immune system.

52 s constitute an essential compartment of the adaptive immune system.

53 is an essential component of the innate and adaptive immune system.

54 unomodulator influencing both the innate and adaptive immune system.

55 ic antigens that trigger both the innate and adaptive immune systems.

56 evolutionary relationship between innate and adaptive immune systems.

57 ays an important role in both the innate and adaptive immune systems.

58 and IL-13 from cells of both the innate and adaptive immune systems.

59 veillance by interacting with the innate and adaptive immune systems.

60 ays an important role in both the innate and adaptive immune systems.

61 ial roles in both prokaryotic and vertebrate adaptive immune systems.

62 ls, B cells, or other cells of the innate or adaptive immune systems.

63 ning regulatory mechanisms of the innate and adaptive immune systems.

64 ly understood role in linking the innate and adaptive immune systems.

65 ace would be devoted by prokaryotes to their adaptive immune systems.

66 all proteins secreted by cells in innate and adaptive immune systems.

67 stem initially identified from the microbial adaptive immune systems.

68 aced short palindromic repeats)-Cas-mediated adaptive immune systems.

69 ted immunomodulation affects both innate and adaptive immune systems.

70 nterspaced short palindromic repeat (CRISPR) adaptive immune systems.

71 of unwanted cells does not always require an adaptive immune system(1,2).

72 f of all bacteria carry genes for CRISPR-Cas adaptive immune systems(1), which provide immunological

73 ed immune response involving both innate and adaptive immune systems accompanies a transition to chro

74 Such drivers include adaptive immune system activation, mesenchymal tissue pr

75 The innate and adaptive immune systems actively participate in this sur

76 (CRISPR-associated) operon form an RNA-based adaptive immune system against foreign genetic elements

77 (CRISPR)-Cas loci guard their hosts with an adaptive immune system against foreign nucleic acids.

78 Cas loci encode proteins that function as an adaptive immune system against infectious viruses and pl

79 eration between the innate immune system and adaptive immune system, an event facilitated by activati

80 T cells represent a crucial component of the adaptive immune system and are thought to mediate anti-t

81 fects of the anti-CCR4 antibody required the adaptive immune system and CD4+ T cells.

82 odel glycoconjugate vaccine can activate the adaptive immune system and demonstrated that the mammali

83 microbiota and maturation of the innate and adaptive immune system and discuss examples of early-lif

84 disease in BPSM1 mice is independent of the adaptive immune system and does not appear to involve in

85 ires reveal insights into the biology of the adaptive immune system and empower diagnostics and thera

86 ial methylation in the crosstalk between the adaptive immune system and glucose homeostasis.

87 B cells are essential components of the adaptive immune system and have important roles in the p

88 the central role that antibodies play in the adaptive immune system and in biotechnology, much remain

89 dependent on the presence of the functional adaptive immune system and independent of TLR4 signaling

90 teins with essential roles in regulating the adaptive immune system and maintaining the extracellular

91 atS) allows for a specific modulation of the adaptive immune system and many major diseases.

92 Emergence of an adaptive immune system and more complex neural systems p

93 g-induced allergic hepatitis mediated by the adaptive immune system and suggest that impaired liver t

94 mus is critical for the establishment of the adaptive immune system and the development of a diverse

95 between the antigen recognition role of the adaptive immune system and the effector functions of mas

96 ations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells

97 They bridge the innate and adaptive immune systems and mediate strong and rapid res

98 e ability to measure critical aspects of the adaptive immune system, and can be readily used for stud

99 s, cavefish shifted immune investment to the adaptive immune system, and here, mainly towards specifi

100 of PLZF as a critical regulator in the human adaptive immune system, and identify a novel, essential

101 cell death, non-canonical NF-kappaB and the adaptive immune system, and might therefore represent a

102 nificantly reduced on cells from the newborn adaptive immune system, and neonatal antigen presenting

103 gration is essential for the function of the adaptive immune system, and regulation of T cell entry i

104 ct with and regulate cells of the innate and adaptive immune systems, and contribute to the resolutio

105 ll, gut microbiome, hypothalamus, innate and adaptive immune systems, and insulin-sensitive tissues.

106 C pathway since early diversification of the adaptive immune system approximately 500 Mya.

107 stnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored.

108 ys used by symbionts to communicate with the adaptive immune system are poorly understood.

109 trate that cell types of both the innate and adaptive immune system are present in the cochlea.

110 CRISPR-Cas adaptive immune systems are used by prokaryotes to defen

111 In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery t

112 The data identify the peripheral adaptive immune system as putatively involved in the mec

113 can elicit direct suppressive effects on the adaptive immune system, as serum from stroke patients in

114 ed cytokines and chemokines, and finally the adaptive immune system, as well as eosinophils as newly

115 re the oldest jawed vertebrates that have an adaptive immune system based on the MHC and Ig superfami

116 complex (PLC) is a cornerstone of the human adaptive immune system, being responsible for processing

117 ractions between molecules of the innate and adaptive immune systems bridge these two arms of immunit

118 ne therapies target single mechanisms in the adaptive immune system but not innate immunity.

119 ous and cyclic stimulation of the innate and adaptive immune system by endogenous nucleic acids relea

120 , suggesting that optimal stimulation of the adaptive immune system by the microbiota might be needed

121 Cardiopulmonary bypass strongly impairs the adaptive immune system by triggering the accumulation of

122 mation phenomena and can link the innate and adaptive immune systems by enhancing graft immunogenicit

123 ) play a central role in both the innate and adaptive immune systems by recognizing pathogen-associat

124 ay bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adju

125 Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide

126 e EMBO Journal, Labzin et al reveal that the adaptive immune system can instruct the innate response

127 The adaptive immune system cannot generally employ this stra

128 ceptors (TCRs) are critical molecules of the adaptive immune system, capable of recognizing diverse a

129 CRISPR-Cas adaptive immune systems capture DNA fragments from invad

130 nes are known to result in impairment of the adaptive immune system, causing a group of disorders col

131 rface fish invest evenly into the innate and adaptive immune systems, cavefish shifted immune investm

132 gy for the generation of mice with humanized adaptive immune systems, complete with tissue engraftmen

133 Recently discovered bacteria and archaea adaptive immune system consisting of clustered regularly

134 t that chronic stress-induced changes in the adaptive immune system, contrary to conferring anxiety a

135 Thus, cells of both the innate and adaptive immune system contribute to end-organ damage an

136 The innate and adaptive immune systems control the spread of virus, for

137 C) lineages, it is clear that the innate and adaptive immune systems converge into 3 major kinds of c

138 enesis of CAV, cells from the innate and the adaptive immune system cooperate to reject the foreign h

139 The microbial adaptive immune system CRISPR mediates defense against f

140 The bacterial adaptive immune system CRISPR-Cas9 has been appropriated

141 epeats (CRISPR) and associated protein (Cas) adaptive immune system (CRISPR-Cas).

142 As a heritable sequence-specific adaptive immune system, CRISPR-Cas is a powerful force s

143 Derived from the bacterial adaptive immune system, CRISPR-Cas9 has been coopted and

144 stem acts as a bridge between the innate and adaptive immune systems critical for establishing a humo

145 CRISPR-Cas adaptive immune systems defend microbes against foreign

146 epeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign

147 functional interactions between ILCs and the adaptive immune system, discuss limitations and future a

148 SCID mice, which lack an adaptive immune system due to the absence of T and B lym

149 n at steady state, while the presence of the adaptive immune system elevates their activation state.

150 The involvement of innate and adaptive immune systems elicit strong and long lasting a

151 Bacteria use adaptive immune systems encoded by CRISPR and Cas genes

152 icient to drive beiging independently of the adaptive immune system, eosinophils or IL-4 receptor sig

153 n pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation o

154 ptor genes in one person-the 'genome' of the adaptive immune system-exceeds the size of the human gen

155 This critical arm of the adaptive immune system facilitates the eradication of pa

156 The innate and adaptive immune systems fail to control HCV infection in

157 arp1(-/-) mice, highlighting the role of the adaptive immune system for full protection.

158 PR-associated (Cas) proteins, function as an adaptive immune system for prokaryotes, protecting them

159 Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infect

160 spaced short palindromic repeats) RNA-guided adaptive immune systems for targeted elimination of fore

161 vities, attempting to exploit the innate and adaptive immune systems for therapeutic gain, are well e

162 CRISPR-Cas adaptive immune systems function to protect bacteria fro

163 ir role in specific activation of the CTL of adaptive immune system, function also as the main ligand

164 onsible for the activation of the innate and adaptive immune system, further accentuating inflammatio

165 Although most prokaryotic adaptive immune systems generally target DNA substrates,

166 tions between an evolving malignancy and the adaptive immune system generate diverse evolutionary tra

167 of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and a

168 The adaptive immune system has been considered to play a min

169 Historically, only cells of the adaptive immune system have been considered capable of r

170 (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnologi

171 -Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend

172 ts-CRISPR-associated genes (CRISPR-Cas), the adaptive immune system in bacteria, limits genetic diver

173 Therefore, the activated adaptive immune system in cancer induces emergency myelo

174 We detect different clonal expansion of the adaptive immune system in distant regions of the same tu

175 g a possible shift towards senescence of the adaptive immune system in DLB.

176 ecombinase(2), an essential component of the adaptive immune system in jawed vertebrates(3).

177 oncomitant activation of 3 components of the adaptive immune system in MS, with a notable contributio

178 ies examine the activation of the innate and adaptive immune system in obesity; inflammation within d

179 trates for the first time alterations in the adaptive immune system in patients with autoinflammatory

180 R and associated Cas proteins function as an adaptive immune system in prokaryotes to combat bacterio

181 The type I-F CRISPR adaptive immune system in Pseudomonas aeruginosa (PA14)

182 The adaptive immune system in Pseudomonas aeruginosa (type I

183 rug-induced liver injury are mediated by the adaptive immune system in response to hepatic drug-prote

184 ) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolate

185 gs further demonstrate the importance of the adaptive immune system in the efficacy of trastuzumab-co

186 solated from patients support a role for the adaptive immune system in the pathogenesis of IADRs.

187 e I CRISPR-Cas systems are the most abundant adaptive immune systems in bacteria and archaea(1,2).

188 ISPR-Cas systems are abundant and widespread adaptive immune systems in bacteria and can greatly enha

189 of the biological function of CRISPR-Cas as adaptive immune systems in bacteria.

190 Adaptive immune systems in prokaryotes and animals give

191 CRISPR-Cas adaptive immune systems in prokaryotes boast a diversity

192 R-associated (cas) genes make up RNA-guided, adaptive immune systems in prokaryotes whose effector pr

193 CRISPR-Cas systems comprise diverse adaptive immune systems in prokaryotes whose RNA-directe

194 integrating signals from the innate and the adaptive immune systems in the control of the B-cell imm

195 understanding of the role of the innate and adaptive immune systems in the pathogenesis of heart fai

196 immunotherapies by activating the innate and adaptive immune systems in tumor microenvironment.

197 any cell types of the innate, as well as the adaptive immune system, including natural killer (NK) an

198 m, coupled with relative inactivation of the adaptive immune system, indicating the potential of tran

199 Prokaryotic CRISPR-Cas adaptive immune systems insert spacers derived from viru

200 Activation of cells in the adaptive immune system is a highly orchestrated process

201 The organizational integrity of the adaptive immune system is determined by functionally dis

202 tivity of NK cells to these signals from the adaptive immune system is heterogeneous and influenced b

203 e.g., during vaccination) independent of the adaptive immune system is mediated in part by macrophage

204 ost remarkable innovations of the vertebrate adaptive immune system is the progressive organization o

205 An essential feature of the adaptive immune system is the proliferation of antigen-s

206 One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of indi

207 Our knowledge about an involvement of the adaptive immune system is very limited.

208 Coordination of the innate and adaptive immune systems is paramount to the development

209 obial repeat sequence; its recognition as an adaptive immune system; its biological characterization;

210 Many archaea and bacteria have an adaptive immune system known as CRISPR which allows them

211 Protein-based therapeutics can activate the adaptive immune system, leading to the production of neu

212 The B and T cells of the human adaptive immune system leverage a highly diverse reperto

213 a role in a range of diseases involving the adaptive immune system like multiple sclerosis, rheumati

214 injury had a delayed onset suggests that the adaptive immune system may be involved in the pathogenes

215 rimental data support that the modulation of adaptive immune system may be used for treating and prev

216 provide new insights into how the innate and adaptive immune system may interact during allogeneic en

217 hat IGHV1-69 and IGHV4-39, while part of the adaptive immune system, may have evolved under selection

218 n DNA for destruction as part of a bacterial adaptive immune system mediated by clustered regularly i

219 Adaptive immune systems must accurately distinguish betw

220 ed that dysregulation of both the innate and adaptive immune systems occur in depressed patients and

221 The adaptive immune system of all jawed vertebrates relies o

222 lity Complex (MHC) is a key component of the adaptive immune system of all vertebrates and consists o

223 CRISPR-Cas systems constitute the adaptive immune system of bacteria and archaea, as a seq

224 volution has been invoked to explain how the adaptive immune system of jawed vertebrates arose from c

225 was a pivotal event in the evolution of the adaptive immune system of jawed vertebrates.

226 the absence of transmission, influences the adaptive immune system of the unborn child.

227 olecular functionality from the well-studied adaptive immune system of vertebrates.

228 the effect of aging on cells of the (mostly adaptive) immune system, on soluble molecules that guide

229 st-stroke autoimmune complications driven by adaptive immune system overactivation, and that CD163 is

230 between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimul

231 CRISPR-Cas adaptive immune systems protect bacteria and archaea aga

232 CRISPR-Cas adaptive immune systems protect bacteria and archaea aga

233 he repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse p

234 CRISPR-Cas adaptive immune systems provide prokaryotes with defense

235 ibodies are critical components of the human adaptive immune system, providing versatile scaffolds to

236 The adaptive immune system relies on the diversity of recept

237 is host-microorganism biliary network on the adaptive immune system remains poorly characterized.

238 The enteric microbiota and the innate and adaptive immune system represent prime candidates that i

239 ty tuning was part of the alterations to the adaptive immune system required for placental gestation.

240 Cells of both the innate and adaptive immune system residing in adipose tissues, as w

241 The adaptive immune system responds to pathogens by selectin

242 form in-depth systems analysis of innate and adaptive immune system responses to implanted biomateria

243 d the cellular composition of the innate and adaptive immune systems, resulted in global changes in b

244 ectious agents, might disrupt control of the adaptive immune system resulting in serious pathologies.

245 We examined whether cells of the adaptive immune system retain the memory of psychosocial

246 The adaptive immune system's capability to protect the body

247 Thus, the interplay of the innate and adaptive immune system selectively targets virulent C. r

248 ated inflammation, telomere dysfunction, and adaptive immune system senescence may also contribute to

249 , blood metabolites, and both the innate and adaptive immune system show evidence of admixture-enable

250 ln+/-; Rag1-/- mice, which lack a functional adaptive immune system, showed improvement in cardiovasc

251 nce to a much more complex one involving the adaptive immune system, similarly to what occurs in usua

252 the context of airway mucus obstruction, the adaptive immune system suppresses antibacterial macropha

253 163 as a possible effector of stroke-induced adaptive immune system suppression.

254 their associated endonucleases (Cas) are an adaptive immune system that exists to protect bacteria a

255 CRISPR-Cas is a prokaryotic adaptive immune system that functions by incorporating f

256 s proteins comprise a prokaryotic RNA-guided adaptive immune system that interferes with mobile genet

257 f the collection of antigen receptors of the adaptive immune system that is generated by the recombin

258 CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archae

259 CRISPR-Cas is an adaptive immune system that protects prokaryotes against

260 i and their associated (cas) genes encode an adaptive immune system that protects prokaryotes from vi

261 om the finding of the CRISPR system being an adaptive immune system that protects the prokaryotes aga

262 CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacte

263 Prokaryotic cells possess CRISPR-mediated adaptive immune systems that protect them from foreign g

264 CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against

265 teria and archaea have evolved sophisticated adaptive immune systems that rely on CRISPR RNA (crRNA)-

266 teria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a

267 RISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-RNA complex,

268 diverse biological processes, including the adaptive immune system, the development of neoplasms, an

269 nication between cells of the innate and the adaptive immune systems, the role of resident cells as w

270 mutations that eliminated a major arm of the adaptive immune system-the MHC II pathway of antigen pre

271 esent a fingerprint of their proteome to the adaptive immune system through the display of endogenous

272 ight an underappreciated contribution of the adaptive immune system to anti-CD47 adjuvant therapy and

273 ors could be used to suppress the CRISPR-Cas adaptive immune system to enhance medical applications,

274 ty of leveraging a patient's coordinated and adaptive immune system to fight the patient's unique tum

275 g antibodies may therefore be easier for the adaptive immune system to generate than previously thoug

276 also functions intrinsically in cells of the adaptive immune system to inhibit proliferation.

277 events responsible for the inability of the adaptive immune system to mount an efficient antitumor r

278 Immunologic memory is the ability of adaptive immune system to quickly and specifically recog

279 The ability of the adaptive immune system to respond to arbitrary pathogens

280 the specific contributions of the innate and adaptive immune system to the generation of pain during

281 explore the contributions of the innate and adaptive immune systems to both viral control as well as

282 s, bacteria and archaea have both innate and adaptive immune systems to defend against infection by v

283 Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infect

284 tic fibrin gel 'awakens' the host innate and adaptive immune systems to inhibit both local tumour rec

285 sensing of foreign agents by the innate and adaptive immune system triggers complex signal transduct

286 Prokaryotic adaptive immune systems use Clustered Regularly Interspa

287 Bacterial adaptive immune systems use CRISPRs (clustered regularly

288 ms, the most widespread and diverse of these adaptive immune systems, use an RNA-guided multiprotein

289 In humans, the adaptive immune system uses the exchange of information

290 Manipulating the adaptive immune system using biomaterials engineering ma

291 We hypothesized that an assessment of the adaptive immune system, using CD4+ T-lymphocyte transcri

292 Prokaryotic CRISPR-Cas adaptive immune systems utilize sequence-specific RNA-gu

293 e-wide association data identified increased adaptive immune system variant burden among genes associ

294 ate immune cells and the cellular arm of the adaptive immune system, via effects on antigen presentat

295 However, the adaptive immune system was required for protection since

296 In addition, a crucial role for the adaptive immune system was shown on concomitant DEP+HDM

297 Antibody class switching is a feature of the adaptive immune system which enables diversification of

298 tight interaction between the innate and the adaptive immune system, which should be considered for t

299 metabolites interacting with the innate and adaptive immune system, which would set the basis for pr

300 nvolve activation of cells of the innate and adaptive immune systems, with pivotal roles for pro-infl