ライフサイエンスコーパス: adaptive immunity

1 l parenchyma lacking leukocyte infiltration (adaptive immunity).

2 DNA (ssDNA) and play key roles in innate and adaptive immunity.

3 hinery moonlighting in support of CRISPR-Cas adaptive immunity.

4 tation of exogenous antigens and to regulate adaptive immunity.

5 tion which can also shape the development of adaptive immunity.

6 n receptor (AgR) diversity that is vital for adaptive immunity.

7 gnaling molecules regulating both innate and adaptive immunity.

8 itical determinant of T cell homeostasis and adaptive immunity.

9 t cytokines, that collectively contribute to adaptive immunity.

10 innate sensing that is critical to activate adaptive immunity.

11 lymphocytes that is critical for modulating adaptive immunity.

12 itical to disease development and subsequent adaptive immunity.

13 preferential expansion, is a key feature of adaptive immunity.

14 to anti-PD-1 treatment in mice, depending on adaptive immunity.

15 cells (DCs) play a critical role in shaping adaptive immunity.

16 ed tissue samples, we could quantify in situ adaptive immunity.

17 d as an active nexus interlinking innate and adaptive immunity.

18 gnate pMHCs to initiate T cell signaling and adaptive immunity.

19 luding chemotaxis, platelet aggregation, and adaptive immunity.

20 immune response to infection and in shaping adaptive immunity.

21 , activate innate immune cells, and regulate adaptive immunity.

22 es to their cognate antigen as a hallmark of adaptive immunity.

23 lecules that recruit and activate innate and adaptive immunity.

24 (-/-) littermate mice, which completely lack adaptive immunity.

25 th other effector systems in both innate and adaptive immunity.

26 hat are distinct from, even if connected to, adaptive immunity.

27 proliferative activities, and stimulation of adaptive immunity.

28 rucial for the regulation of both innate and adaptive immunity.

29 activation is critical to the initiation of adaptive immunity.

30 r (NK) cells are critical to both innate and adaptive immunity.

31 tionally considered an exclusive hallmark of adaptive immunity.

32 be viewed as translators between innate and adaptive immunity.

33 viral persistence and generates long-lasting adaptive immunity.

34 mation; and lack interference with innate or adaptive immunity.

35 B cell clonal expansion is vital for adaptive immunity.

36 are produced, establishing sequence-specific adaptive immunity.

37 ing neoplastic growth in mice lacking intact adaptive immunity.

38 th CnB-deficient leukemia, suggesting robust adaptive immunity.

39 flammatory response that involves innate and adaptive immunity.

40 hogenesis of atherosclerosis with a focus on adaptive immunity.

41 ed DNA lesions, with particular relevance to adaptive immunity.

42 PEM) has revolutionized the understanding of adaptive immunity.

43 lls, O. tsutsugamushi has evolved to counter adaptive immunity.

44 ncogenic signaling and suppresses innate and adaptive immunity.

45 re be expected to have significant levels of adaptive immunity.

46 lity class I (MHC-I) molecules and regulates adaptive immunity.

47 s that revealed the organizing principles of adaptive immunity.

48 IFN-gamma is a key cytokine of innate and adaptive immunity.

49 reviously unconnected critical attributes of adaptive immunity.

50 AML may therefore reflect the price for adaptive immunity.

51 2, are essential for V(D)J recombination and adaptive immunity.

52 s neuronal circuits that regulate innate and adaptive immunity.

53 s, leading to frequent anaemia and decreased adaptive immunity.

54 ietic cells initiate and maintain innate and adaptive immunity.

55 ts operating reflexively regulate innate and adaptive immunity.

56 te immune system, and how this may influence adaptive immunity.

57 tes and is essential for T cell function and adaptive immunity.

58 hich enables disease to progress unabated by adaptive immunity.

59 in Down syndrome, suggesting abnormality of adaptive immunity.

60 centre (GC) response is a pivotal process in adaptive immunity.

61 timicrobial responses, and directly regulate adaptive immunity.

62 nce of myeloid malignancies and a decline in adaptive immunity.

63 lls that activate T cells, linking innate to adaptive immunity.

64 Toll-like receptor signaling, which initiate adaptive immunity.

65 ection, tumor immune evasion and likely also adaptive immunity.

66 hese cells with potent aptitude to stimulate adaptive immunity.

67 und, and sustained suppression of innate and adaptive immunity.

68 minate LXRalphabeta's indispensable roles in adaptive immunity.

69 B lymphocytes play a critical role in adaptive immunity.

70 sm, and the influence of these activities on adaptive immunity.

71 5 (IRF5) is a central mediator of innate and adaptive immunity.

72 eals essential molecular programs of humoral adaptive immunity.

73 ria have emerged as key actors of innate and adaptive immunity.

74 defense against pathogens, and generation of adaptive immunity.

75 heckpoint in the development and severity of adaptive immunity.

76 the activation and regulation of innate and adaptive immunity.

77 tes they produce, act to modulate intestinal adaptive immunity.

78 larval zebrafish that have not yet developed adaptive immunity.

79 ribonuclease III for bacterial RNA-mediated adaptive immunity.

80 ts and by eliminating suppressive effects on adaptive immunity.

81 tion of genes associated with cell cycle and adaptive immunity.

82 R) repertoire is an important determinant of adaptive immunity.

83 ells versus plasma cells is a major quest of adaptive immunity.

84 ammatory stimuli, innate lymphoid cells, and adaptive immunity.

85 gulated and deployed in the race to overcome adaptive immunity.

86 en receptor genes, the hallmark of canonical adaptive immunity.

87 ph nodes is essential for the development of adaptive immunity.

88 of innate immunity and alphabeta T cells of adaptive immunity.

89 tinel cells specialized in the regulation of adaptive immunity.

90 r cascades and cross-talk between innate and adaptive immunity.

91 cing act and lie on a spectrum of innate and adaptive immunity?

92 ture B lymphocytes are crucial components of adaptive immunity, a system essential for the evolutiona

93 Adaptive immunity, addressed here, integrates the activi

94 sigmodontis as a vaccine strategy to induce adaptive immunity against a foreign, crosslinked protein

95 (crRNA) and subsequently promotes CRISPR-Cas adaptive immunity against bacteriophage invasion.

96 rovide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA.

97 iated (Cas) proteins Cas9 and Cas12a provide adaptive immunity against invading nucleic acids, and fu

98 The CRISPR system provides adaptive immunity against mobile genetic elements (MGE)

99 The CRISPR system provides adaptive immunity against mobile genetic elements in pro

100 ISPR system in bacteria and archaea provides adaptive immunity against mobile genetic elements.

101 PA production even in mice with pre-existing adaptive immunity against PEG.

102 ecific CD4 TRM cells play a critical role in adaptive immunity against reinfection and memory induced

103 COVID-19) pandemic hinges on the dynamics of adaptive immunity against severe acute respiratory syndr

104 isogenic KRAS(G12D) tumours, which suggests adaptive immunity against shared antigens.

105 model of malaria which demonstrates that if adaptive immunity against the most virulent effects of m

106 nd widely in prokaryotes, where they provide adaptive immunity against virus infection and plasmid tr

107 CRISPR-Cas systems provide bacteria with adaptive immunity against viruses.

108 ed on the CRISPR-Cas mechanism, that confers adaptive immunity against viruses.

109 to animals lacking cGAS, IRF3/IRF7, IFNAR1, adaptive immunity, alphabeta T cells, and mature B cells

110 have existed long before the development of adaptive immunity, although they have been given differe

111 ons to microbial pathogens to development of adaptive immunity and allergies.

112 in immunoregulation by connecting innate and adaptive immunity and are emerging therapeutic targets.

113 (TLRs) are the key regulators of innate and adaptive immunity and are highly expressed during sepsis

114 s on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies tha

115 ic and led to establishment of HAdV-specific adaptive immunity and expression of early viral genes ex

116 ptors (gammadelta T cells) bridge innate and adaptive immunity and facilitate barrier responses to pa

117 to impair the development of anti-S. aureus adaptive immunity and facilitate reinfection is unclear.

118 cells are important regulators of mammalian adaptive immunity and have relevance for infection, auto

119 act of CD39 enzymatic function on innate and adaptive immunity and how therapeutic modulation of this

120 red broader functions of T-bet in innate and adaptive immunity and in the development of the effector

121 scriptional profile showed downregulation of adaptive immunity and induction of programs related to i

122 ar how pharmacological fine-tuning of innate/adaptive immunity and its combination with DDR inhibitor

123 Given this role in adaptive immunity and its highly monomorphic nature in t

124 al role of checkpoint pathways in regulating adaptive immunity and preventing autoimmunity.

125 CRISPR-Cas systems enable microbial adaptive immunity and provide eukaryotic genome editing

126 reness of the function of RNA methylation in adaptive immunity and provide METTL3 and METTL14 as pote

127 mes can mediate crosstalk between innate and adaptive immunity and regulate cancer progression and me

128 olecular behavior, and its role in bacterial adaptive immunity and RNA-targeting applications.

129 tion of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is de

130 yte development and selection are central to adaptive immunity and self-tolerance.

131 antigen presentation, chemotaxis, innate and adaptive immunity and their regulation.

132 stablishment of chronicity is independent of adaptive immunity and therefore different from the mecha

133 SC) cells that share the ability to suppress adaptive immunity and to hinder the effectiveness of ant

134 also promotes blood brain barrier integrity, adaptive immunity, and activation of microglia/macrophag

135 t the critical balance between tolerance and adaptive immunity, and consider the implications of thes

136 CD8(+) T cells are critical mediators of adaptive immunity, and enhancing their function can prom

137 senses dietary vitamin A status to regulate adaptive immunity, and highlight the role of epithelial

138 duced neuroinvasiveness, induction of strong adaptive immunity, and protection of mice from wild-type

139 or CD8(+) T cells are important mediators of adaptive immunity, and receptor-ligand interactions that

140 ine balance between smoldering inflammation, adaptive immunity, and somatic mutations in promoting or

141 tinct strategies, including innate immunity; adaptive immunity; and dormancy induction, or programmed

142 Both innate and adaptive immunities are involved.

143 The coordinated activities of innate and adaptive immunity are critical for effective protection

144 fundamental principles of innate control of adaptive immunity are well established, it is not fully

145 in inflamed organs, while maintaining active adaptive immunity, as evidenced by full-strength immune

146 eptibility of cancer cells toward innate and adaptive immunity, as well as direct impacts on immune c

147 uch cohorts points to features of innate and adaptive immunity, as well as environmental differences

148 g regulates critical processes in innate and adaptive immunity, as well as parenchymal cells.

149 ombined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD

150 Antibodies are critical components of adaptive immunity, binding with high affinity to pathoge

151 w approach with which to study human in situ adaptive immunity broadly applicable to autoimmunity, in

152 common fungi, this work illuminates not only adaptive immunity, but also innate immune responses to d

153 amma) is a central coordinator of innate and adaptive immunity, but its highly pleiotropic actions ha

154 rtant roles in regulation of both innate and adaptive immunity, but whether and how mTOR modulates hu

155 tice, we show that MCs may directly modulate adaptive immunity by acting as APCs in atherosclerosis.

156 Lymph nodes (LNs) play critical roles in adaptive immunity by concentrating in one location the a

157 HIV-associated dysregulation of adaptive immunity by depletion of CD4 Th cells most like

158 CRISPR-Cas systems provide microbes with adaptive immunity by employing short DNA sequences, term

159 Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells

160 ombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in de

161 he coordinated activation of both innate and adaptive immunity can effectively reduce the risk of tum

162 Immunologic function in innate and adaptive immunity changes with the ageing process.

163 ntrolled inflammatory response, dysregulated adaptive immunity, coagulation abnormalities, hemorrhage

164 ication, virus-induced lung inflammation, or adaptive immunity compared to C57BL/6 (B6) controls.

165 ve overturned two long-held dogmas: (1) only adaptive immunity confers immunological memory; and, (2)

166 ld be ideal if specific innate correlates of adaptive immunity could be identified to set a universal

167 Finally, depletion of NK1.1(+) cells from adaptive immunity-deficient mice both significantly redu

168 ntibody-mediated depletion of IFN-gamma from adaptive immunity-deficient mice significantly compromis

169 ceptor common gamma chain (IL-2Rgammac) from adaptive immunity-deficient mice significantly compromis

170 improvement reflected reduced production of adaptive immunity-derived IL-10 and, in turn, increased

171 ction compared with a first, suggesting that adaptive immunity develops to eliminate the pathogens.

172 line of defense might ensure survival until adaptive immunity develops.

173 CD8(+) T cells play a critical role in adaptive immunity, differentiating into CD8(+) memory T

174 Specific markers of innate and adaptive immunity distinguish CDI from all other groups,

175 those infected with Ab4 but mounted similar adaptive immunity dominated by antibody responses.

176 quires the sequential activity of innate and adaptive immunity effectors.

177 accine and revertant growth, plus innate and adaptive immunity elicited during the course of infectio

178 This defect in adaptive immunity following skin infection was associate

179 munity, the first and, to date, only form of adaptive immunity found in prokaryotes, represents a fle

180 erves a critical role in bridging innate and adaptive immunity from lung mucosa to lymph nodes to pro

181 tion of the p110delta catalytic 21 domain in adaptive immunity function in a patient with expression

182 IL-6) is a cytokine with critical innate and adaptive immunity functions.

183 mmation is a complex construct of innate and adaptive immunity gene expression networks that are vari

184 that have been identified include innate and adaptive immunity genes that contribute to host defense

185 ene 1 (Rag1)(-/-) STING N153S mice that lack adaptive immunity had no lung disease, and T-cell recept

186 In anglerfishes, coevolution of innate and adaptive immunity has been disentangled, implying that a

187 The influence of cell death on adaptive immunity has been studied for decades.

188 NA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast

189 Neutrophils can shape adaptive immunity; however, their role in vaccine-induce

190 elated subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them

191 ess this, we evaluated markers of innate and adaptive immunity in adult inpatients with CDI (diagnose

192 nvestigate the effect of IL-10 on innate and adaptive immunity in an in vitro human observational coh

193 Cas systems has established a novel means of adaptive immunity in bacteria and archaea and deepened o

194 ive bridge between dendritic cells (DCs) and adaptive immunity in cancer.

195 The role of the host adaptive immunity in control or contribution to the seve

196 We profiled adaptive immunity in COVID-19 patients with active infec

197 Human T cells coordinate adaptive immunity in diverse anatomic compartments throu

198 The role of adaptive immunity in early cancer development is controv

199 host microbiome, their effect on innate and adaptive immunity in health and disease with a special f

200 but does not have an effect on Th2-mediated adaptive immunity in lung or gut.

201 her neural functions, induce both innate and adaptive immunity in NTNBC.

202 s I HLA variants are novel as they implicate adaptive immunity in post-traumatic sepsis.

203 models for COVID-19 involving disruption of adaptive immunity in Syrian hamsters.

204 type I interferon signaling irrespective of adaptive immunity in the host.

205 (HDM) effectively activates both innate and adaptive immunity in the lung mucosa.

206 upports a critical role for inflammation and adaptive immunity in the onset of cancer and in shaping

207 RNA-guided nucleases that enforce CRISPR-Cas adaptive immunity in their bacterial hosts.

208 ral crest formation are predicted to enhance adaptive immunity in TNBC while glia development, along

209 ediate proinflammatory responses and trigger adaptive immunity in transplantation through antigen pre

210 xidative response in bridging the innate and adaptive immunity in tumor radiotherapy.

211 How innate immunity gave rise to adaptive immunity in vertebrates remains unknown.

212 This signaling is pivotal for activating adaptive immunity in vertebrates, suggesting a close evo

213 ivirals may benefit from enhanced innate and adaptive immunity in vivo.

214 t of innate immunity but possess features of adaptive immunity, including clonal expansion and establ

215 Given the broad changes in adaptive immunity, including memory T-cell expansion, an

216 te inflammatory innate reactions and complex adaptive immunity, including the pathogenesis of allergi

217 ed in all mice with or without deficiency in adaptive immunity, indicating a critical role for innate

218 vely, these findings provide a mechanism for adaptive immunity involvement in the kidney defect in so

219 Activation of adaptive immunity is a complex process coordinated at mu

220 This cardinal feature of adaptive immunity is achieved by the assembly of a funct

221 The induction of adaptive immunity is dependent on the structural organiz

222 Adaptive immunity is driven by the expansion, somatic hy

223 te immune system appears more activated, the adaptive immunity is in a hyporesponsive state reflected

224 Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of in

225 ficial or adverse effects on vaccine-induced adaptive immunity is not known.

226 A defining feature of adaptive immunity is the development of long-lived memor

227 al transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellul

228 L-36 signaling pathway integrates innate and adaptive immunity leading to host defense against entero

229 atibility complex (MHC) has implications for adaptive immunity, mate choice, and social signalling, h

230 splant provides important information on how adaptive immunity may contribute and modulate graft reje

231 tween gut microbiota, dietary tryptophan and adaptive immunity may help to develop therapeutic strate

232 ction, suggesting that NK cells, but not HCV adaptive immunity, may contribute to HCV viral control f

233 een the primary function of CRISPR-Cas as an adaptive immunity mechanism and these other roles define

234 rsistence even in the presence of innate and adaptive immunity-mediated clearance.

235 sing cells contingent to the preservation of adaptive immunity might be effective in the treatment of

236 gration, eosinophil recruitment, humoral and adaptive immunity, neutrophil activation, and cachexia.

237 tified are neither associated with innate or adaptive immunity nor associated with any antiviral acti

238 Using our experimental model, impact of adaptive immunity on S. aureus colonisation could be ass

239 Both innate and adaptive immunity operate sequentially, and the specific

240 shared germline genetic background, whereas adaptive immunity operates through only 3 main cell type

241 replicative fitness either in the absence of adaptive immunity or due to pressure from adaptive immun

242 is is known to produce antigenic peptides in adaptive immunity, our findings demonstrate its new role

243 candidates for adjuvants to boost innate and adaptive immunity, our understanding of the effect of Cp

244 ripheral MCs to affect lymphoid tissue-borne adaptive immunity over distance by modifying DC function

245 thelial-mesenchymal transition to innate and adaptive immunity pathways and, finally, on the role of

246 CRISPR adaptive immunity pathways protect prokaryotic cells aga

247 of B cell activation, as it links innate and adaptive immunity, promoting potent B cell responses.

248 ted, while proteins implicated in innate and adaptive immunity, proteostasis, and alternative splicin

249 rtebrate class, the cartilaginous fish, with adaptive immunity provided via Ig and TCR lineages, and

250 Adaptive immunity provides life-long protection by gener

251 tion time changes at 24-48 h and the ensuing adaptive immunity (R = 0.9831) at day 5 and the tumor in

252 In turn, adaptive immunity reciprocally regulates ILCs, which ind

253 ng enzymes, and a wide variety of innate and adaptive immunity-related proteins.

254 that CD4(+) T cells, a critical regulator of adaptive immunity, release extracellular threads of DNA

255 R array expansion at the origin of bacterial adaptive immunity relies on recognition of sequence-depe

256 The fundamental process of adaptive immunity relies on the differentiation of self

257 CRISPR-Cas-mediated adaptive immunity relies on the insertion of short DNA s

258 Jawed vertebrate adaptive immunity relies on the RAG1/RAG2 (RAG) recombin

259 the acquisition of a complex microbiota and adaptive immunity, supporting that host-microbiota symbi

260 pathogen induces generally stronger mucosal adaptive immunity than the exposure to an avirulent stra

261 known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membran

262 ical and/or functional lesions in innate and adaptive immunity that increase the host's susceptibilit

263 predicted to perform functions distinct from adaptive immunity that remain to be characterized experi

264 ing evidence for a critical effect of MCs on adaptive immunity, the underlying mechanisms are poorly

265 including the activation of both innate and adaptive immunity, thereby serving as a potent antimicro

266 and how Nod1 and Nod2 proteins contribute to adaptive immunity, this study investigated their role in

267 iral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circl

268 the central role of Cas9 in CRISPR-mediated adaptive immunity to contemporary efforts aimed at devel

269 n unclear, for instance, how RHV evades host adaptive immunity to establish persistent infection.

270 okaryotes deploy CRISPR-Cas-based RNA-guided adaptive immunity to fend off mobile genetic elements su

271 inhibitor RXDX-106 activates both innate and adaptive immunity to inhibit tumor growth and progressio

272 ses that has an essential role in innate and adaptive immunity to intracellular bacteria.

273 nodes (gLNs) are key sites for orchestrating adaptive immunity to luminal perturbations(5-7).

274 ent of the mucosal immune system that confer adaptive immunity to mucosal pathogens.

275 enables lung epithelial cells to escape from adaptive immunity to promote tumorigenesis, and AhR pred

276 clearance and prevents development of potent adaptive immunity to reinfection.

277 ), H-2(k), and H-2(u) molecules to influence adaptive immunity to Salmonella in MHC congenic mice.

278 Understanding adaptive immunity to SARS-CoV-2 is important for vaccine

279 Our data provide fundamental insight into adaptive immunity to SARS-CoV-2 with the actively update

280 Cas (CRISPR-associated) systems as a type of adaptive immunity to target and degrade foreign nucleic

281 city for IgG antibodies to induce protective adaptive immunity to viral infection when they selective

282 raits - to induce PMN inflammation and avoid adaptive immunity - to allow efficient sexual transmissi

283 s, and nanosponges, and the emerging role of adaptive immunity underlying DNAzyme inhibition of cance

284 s) and proinflammatory cytokines and promote adaptive immunity upon viral infection.

285 Adaptive immunity vitally depends on major histocompatib

286 activation of gene networks associated with adaptive immunity was linked to the suppression of netwo

287 Concerning their cross-talk with the adaptive immunity, we found no direct inhibitory effect

288 nitrosourea-induced mutations for defects in adaptive immunity, we identified animals within a single

289 To allow unbridled replication without adaptive immunity, we simultaneously ablated CD8(+) and

290 Although RV clearance typically requires adaptive immunity, we unintentionally generated RV-resis

291 nes involved in metabolism, coagulation, and adaptive immunity were downregulated, while inflammation

292 and activates innate immunity to orchestrate adaptive immunity when synergized with an anti-PD-L1 imm

293 t the combined activation of both innate and adaptive immunity will result in better antitumor effica

294 ortant driver of the evolution of CRISPR-Cas adaptive immunity, with key implications for bacterial f

295 IL-21 is a key player of adaptive immunity, with well-established roles in B-cell

296 with immunogenic reprogramming of innate and adaptive immunity within the TME.

297 ercise may promote more efficient innate and adaptive immunity within the tumor.

298 y functions as a key modulator of innate and adaptive immunity within the tumour microenvironment.

299 ve a reduced innate immune response and lack adaptive immunity, would be susceptible to the infection

300 ntigenic properties fast enough to evade the adaptive immunity, yet they rarely split into diverging