ライフサイエンスコーパス: adaptor complex

1 system, suggesting they form a novel type IV adaptor complex.

2 n shown previously to interact with the AP-3 adaptor complex.

3 proteins is orchestrated by the AP2 clathrin adaptor complex.

4 ived endosome marker (caveolin) and the AP-2 adaptor complex.

5 eceptor 1 or its associated intracytoplasmic adaptor complex.

6 first brain-specific function for a neuronal adaptor complex.

7 1 encodes a mu1 subunit of the AP-1 clathrin adaptor complex.

8 -binding sites for the heterotetrameric AP-1 adaptor complex.

9 identified as the beta3A subunit of the AP-3 adaptor complex.

10 affinity membrane-binding sites for the AP-1 adaptor complex.

11 ing further evidence that AP-1 is a clathrin adaptor complex.

12 TGN (trans-Golgi network)-specific clathrin adaptor complex.

13 the existence of a physiologically relevant adaptor complex.

14 yeast GCN5 (yGCN5), components of a putative adaptor complex.

15 PDCD10, non-homologous proteins that form an adaptor complex.

16 -facing in the open form of the AP2 clathrin adaptor complex.

17 ton), a component of the mitochondrial motor-adaptor complex.

18 RF3/ARF4) small GTPases and the AP3 clathrin adaptor complex.

19 rylation-dependent interaction with the AP-1 adaptor complex.

20 trafficking, but significantly not the AP-2 adaptor complex.

21 mbling the motile dynein-dynactin-activating adaptor complex.

22 he AMPAR GluR2 subunit with the AP2 clathrin adaptor complex.

23 related endogenous beta1 subunit of the AP-1 adaptor complex.

24 ytic sites on the plasma membrane by the AP2 adaptor complex.

25 t epithelial cells contain two AP-1 clathrin adaptor complexes.

26 n protein degradation by utilizing differing adaptor complexes.

27 by the cytoskeleton, across ligand-integrin-adaptor complexes.

28 tides containing the YDSI motif and purified adaptor complexes.

29 interaction of PACS-1 with heterotetrameric adaptor complexes.

30 cluster motifs on cargo proteins but not to adaptor complexes.

31 regulation and for interaction with clathrin adaptor complexes.

32 xes are bona fide native Ada-transcriptional adaptor complexes.

33 s, sigma1 and sigma2, of clathrin-associated adaptor complexes.

34 d pits in vivo, probably via plasma membrane adaptor complexes.

35 n their interaction with clathrin-associated adaptor complexes.

36 (IFT) of cargos assisted by IFT-B and IFT-A adaptor complexes.

37 yers of functional interaction with clathrin adaptor complexes.

38 n-rich core via functionally conserved motor-adaptor complexes.

39 es Lis1-mediated assembly of dynein-dynactin adaptor complexes.

40 ersify the functional repertoire of clathrin adaptor complexes.

41 cessory proteins that interact with clathrin adaptor complexes.

42 lathrin and the assembly polypeptide 2 (AP2) adaptor complexes.

43 The heterotetrameric adaptor complex 1 (AP-1) and the monomeric Golgi-localiz

44 TP-binding protein, Arfrp1, and the clathrin adaptor complex 1 (AP-1) are required for Vangl2 transpo

45 pairs the dynamics of intracellular clathrin/adaptor complex 1 (AP-1)- or GGA (Golgi-localized, gamma

46 In cells deficient for both the clathrin adaptor complex 1 and Chs6p, where Chs3p is transported

47 verning the assembly of the heterotetrameric adaptor complexes 1 and 2 (AP1 and AP2) involved in clat

48 We ruled out the involvement of adaptor complex 1B (AP1B) in the basolateral trafficking

49 s depleted of clathrin or its major clathrin adaptor complex 2 (AP-2), a phenotype mimicked by applic

50 vesicle transport, including members of the adaptor complex 2.

51 The adaptor complex 3 (AP-3) targets membrane proteins from

52 -2) have mutations in the beta 3A subunit of adaptor complex-3 (AP-3) and functional deficiency of th

53 n (GD) to bind the sigma2 subunit of the AP2 adaptor complex, a central player in membrane traffickin

54 chanistic insight into how an NPC-associated adaptor complex accesses the core transcription machiner

55 and BLOC-2, together with the AP-3 clathrin adaptor complex, act at early endosomes to sort componen

56 ubdomains (1-40 and 40-83) require the yeast adaptor complex ADA2/ADA3/GCN5 for transcriptional activ

57 The AP2 adaptor complex (alpha, beta2, sigma2, and mu2 subunits)

58 proteins interact with clathrin and the AP2 adaptor complex and also bind to the phosphoinositide-co

59 We describe the AP-1 adaptor complex and Arf1 as major regulators of PCP prot

60 ISG, which may be mediated by the AP-1 type adaptor complex and clathrin-coated vesicles, occurs dur

61 between the mu2 subunit of the AP-2 clathrin adaptor complex and ITIM tyrosine residues in the cytopl

62 show that BRAG2 binds clathrin and the AP-2 adaptor complex and that both BRAG2 and Arf5 localize to

63 atypical binding motif for the clathrin AP2 adaptor complex and the major PKA phosphorylation sites

64 he vacuole requires the function of the AP-3 adaptor complex and Vps41p.

65 Cytosolic coat proteins such as clathrin and adaptor complexes and coat protein complex I (COPI) and

66 Heterotetrameric adaptor complexes and SNAREs play key roles in the speci

67 a are necessary for in vitro binding to both adaptor complexes and that Tyr72 has an important role i

68 partners, such as the AP-1 and AP-2 sorting adaptor complexes and the nonvisual arrestins.

69 sis, cooperates with the Ufd1-Npl4 ubiquitin-adaptor complex, and specifically targets Ku80 that is m

70 olgi network and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p.

71 tudy, we demonstrate binding of the clathrin adaptor complex AP-1 with the GVYVKM motif of the cytopl

72 Ap1b1 is a subunit of the adaptor complex AP-1, which has been implicated in the t

73 ind AP-2 but did not bind the Golgi-specific adaptor complex AP-1.

74 ) and endosomes that depends on the clathrin adaptor complex AP-1.

75 The epithelial cell-specific clathrin adaptor complex AP-1B facilitates the sorting of various

76 The epithelial cell-specific adaptor complex AP-1B is crucial for correct delivery of

77 he epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for the polarized dist

78 findings of Eps15 association with clathrin adaptor complex AP-2 and its localization in clathrin-co

79 e-based signals with the clathrin-associated adaptor complex AP-2 at the plasma membrane, whereas lys

80 The mu 2 chain of the clathrin-associated adaptor complex AP-2 is a member of the adaptor medium c

81 The adaptor complex AP-2 is the major clathrin-associated ad

82 The adaptor complex AP-2 plays an important role in cargo se

83 ent-protein-tagged beta2 subunit of clathrin adaptor complex AP-2 revealed that EGFR mutants lacking

84 ion signal that interacts with the endocytic adaptor complex AP-2 to facilitate efficient entry of CF

85 phorylation of the beta2 subunit of clathrin adaptor complex AP-2 was detected in three types of cell

86 of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein, and thre

87 was distinct from labeling for the endocytic adaptor complex AP-2.

88 ed endocytosis signals are recognized by the adaptor complex AP-2.

89 that full-length CFTR binds to the endocytic adaptor complex AP-2.

90 n, two of the four subunits of the endocytic adaptor complex AP-2.

91 ssociation with the plasma membrane clathrin adaptor complex AP-2.

92 icles is mediated by the clathrin-associated adaptor complex AP-2.

93 ce co-receptor CD4 by hijacking the clathrin adaptor complex AP-2.

94 ocytic machinery, including clathrin and the adaptor complex AP-2.

95 adaptor positioning and in regulation of the adaptor complex AP-3.

96 tween intermediate filament proteins and the adaptor complex AP-3.

97 n at least 4 distinct protein complexes: the adaptor complex AP-3; biogenesis of lysosome-related org

98 f at least 3 distinct protein complexes: the adaptor complex AP-3; the HPS1/HPS4 complex; and BLOC-1

99 Irc6 and p34 bind to clathrin adaptor complexes AP-1 and AP-2 and are members of a con

100 -adaptin subunits of the clathrin-associated adaptor complexes AP-1 and AP-2, respectively.

101 to the beta-adaptin subunit of the clathrin adaptor complexes AP-1 and AP-2, which are responsible f

102 Nef, which mediates binding to the clathrin adaptor complexes AP-1, AP-2, and AP-3.

103 which interacts with the endocytic clathrin adaptor complex, AP-2, and is required for its efficient

104 and as a membrane receptor for the clathrin adaptor complex, AP-2, during endocytosis.

105 ractions between CD4, Nef, and the endocytic adaptor complex, AP-2, have been reported.

106 hrin assembled into cages with the endocytic adaptor complex, AP-2.

107 e mu-subunits of plant or mammalian clathrin adaptor complex AP1 and plant AP4 but not that of plant

108 , the involvement of the clathrin-associated adaptor complex AP2 and the identity of the AP2 subunit

109 The clathrin adaptor complex AP2 is thought to be an obligate heterot

110 results suggest that AP50 and the coated pit adaptor complex AP2 may play an important role in regula

111 endocytosis through recruiting the clathrin adaptor complex AP2 to IR.

112 5 and intersectin, which in turn engaged the adaptor complex AP2.

113 endosomes that requires the heterotetrameric adaptor complex AP3.

114 e show that in the absence of AP-2, the AP-1 adaptor complex appears to functionally substitute for A

115 ctor of the adaptor protein-1 (AP1) clathrin adaptor complex, as a novel player in dynein-dynactin fu

116 ciple coat components, clathrin and the AP-2 adaptor complex, assemble a polyhedral lattice at plasma

117 ndosomes requires the phosphorylation of the adaptor complex at a step during or after AP-3 recruitme

118 ule to co-localize the Nef protein with AP-2 adaptor complexes at the cell margin.

119 Accordingly, the heterotetrameric AP-2 adaptor complex binds not only to clathrin and select ca

120 nese through a mechanism involving the Rsp5p adaptor complex Bsd2p/Tre1p/Tre2p.

121 CHC22 associates with the AP1 and AP3 adaptor complexes but not with AP2.

122 W domain, binds to the heterotetrameric AP-2 adaptor complex by associating directly with the globula

123 An exosome adaptor complex called NEXT (nuclear exosome targeting)

124 t the PM-anchored Rsp5/Rcr1 ubiquitin ligase-adaptor complex can provide an acute response to degrade

125 In the absence of a heterooligomeric adaptor complex composed of FCHO, Eps15, and intersectin

126 ion of FcalphaR results in the modulation of adaptor complexes containing tyrosine-phosphorylated Cbl

127 uronal transport granule proteins, and motor adaptor complexes, drives the long-distance RNA traffick

128 pgp-2(+) functions in parallel with the AP-3 adaptor complex during gut granule formation.

129 regulated assembly and disassembly of motor-adaptor complexes ensures that cargoes are loaded at the

130 ubunit, incorporated into both AP-2 and AP-1 adaptor complexes, exhibits both types of behavior.

131 rease its ability to inhibit dynein-dynactin-adaptor complex formation.

132 ly on a single Y-171 site for the binding to adaptor complex GRB-2-SKAP1.

133 The AP-1 adaptor complex has been cast as the major player in cla

134 A transcriptional adaptor complex has been discovered to house histone ace

135 A heterotetrameric AP-3 adaptor complex has been implicated in the formation of

136 The adaptor protein (AP) 3 adaptor complex has been implicated in the transport of

137 and the medium chain and endocytic clathrin adaptor complexes have been shown by protein-protein int

138 Here we show that AP2, a clathrin adaptor complex important for endocytosis, associates wi

139 r, we found a key role for the AP-1 clathrin adaptor complex in expanding the apical membrane domains

140 engage and require the dynein-dynactin motor-adaptor complex in order to transport along microtubules

141 Retromer, an adaptor complex in the endosome-to-Golgi retrieval pathw

142 1 has some functions independent of the AP-3 adaptor complex in trafficking to gut granules.

143 n, expression of the mu2 subunit of the AP-2 adaptor complex in virus producer cells was essential fo

144 e the real-time formation of dynein-dynactin-adaptor complexes in vitro.

145 The adaptor complex includes CpdR, a single-domain response

146 lation in a panel of RTK and their signaling adaptor complexes, including EGFR, MET/GAB1, and IGF1R/I

147 ne acetyltransferase within the Ada and SAGA adaptor complexes indicates the importance of histone ac

148 ucture reveals that binding of the substrate.adaptor complex induces unexpected conformational change

149 ts defective in the beta-subunit of the AP-3 adaptor complex, INT1 is correctly localized to the tono

150 The ssrA tag in the covalent adaptor complex interacted with ClpX.ATPgammaS but not C

151 cleate the adaptors, converting the cytokine-adaptor complex into a surrogate agonist for a different

152 The p97 adaptor complex involved in this function is the Ufd1-Np

153 GA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional

154 These studies establish that a kinesin motor-adaptor complex is critical for the anterograde axonal t

155 The AP1y1-mediated adaptor complex is essential for the formation of clathr

156 The AP-1 adaptor complex is found in all eukaryotes, but it has b

157 The heterotetrameric AP-1 adaptor complex is involved in the assembly of clathrin-

158 The AP-1B clathrin adaptor complex is responsible for the polarized transpo

159 The AP-2 adaptor complex is widely viewed as a linchpin molecule

160 f the abundance and activity of these ligase-adaptor complexes is critical for main-tenance of optima

161 , gamma-, delta-, zeta-COP subcomplex and AP adaptor complexes is related.

162 TPC), which is proposed to function as a CME adaptor complex, is only conserved in plants and a few o

163 fruit flies, is facilitated by a multimeric adaptor complex known as the apoptosome.

164 ance of AAGAB, AP2 subunits fail to form the adaptor complex, leading to their degradation.

165 HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/

166 The FTS-Hook-FHIP ('FHF') cargo adaptor complex links dynein to cargo in humans and fung

167 The AP2 clathrin adaptor complex links protein cargo to the endocytic mac

168 We assess the role of clathrin, adaptor complexes, lipid rafts, and Rab22a in an attempt

169 The COPII-cargo adaptor complex Lst1-Sec23 selectively sorts proteins in

170 In order to identify components of the adaptor-complex machinery, this study reports the clonin

171 diated by activated Arf GTPases, and the Arf-adaptor complexes mark sites of carrier formation.

172 ssibility that preference for one or another adaptor complex may result in selective mast cell respon

173 ficient for the micro 1B subunit of the AP1B adaptor complex, missort a large proportion of ERBB2 to

174 Like mutations in the AP-1 adaptor complex, mutations in INP53 exhibit synthetic gr

175 e (RNAi)-mediated gene silencing of the AP-2 adaptor complex only disrupts internalization of a subse

176 component, Apm1p, a subunit of the clathrin adaptor complex or For3p, an actin-polymerizing protein,

177 as universal recognition sites for the AP-2 adaptor complex or other clathrin-associated sorting pro

178 The AP-2 clathrin adaptor complex oversees endocytic cargo selection in tw

179 l sorting may not be related to the clathrin-adaptor complex pathway, as is the case for many basolat

180 The AP-1B clathrin adaptor complex plays a key role in the recognition and

181 AR via interaction with the CASK-mLIN7-MINT1 adaptor complex, presynaptic maturation promoted by FGF2

182 The CARMA1-Bcl10-Malt1 adaptor complex regulates NFkappaB activation by antigen

183 ysical interaction between M(5) and the AP-3 adaptor complex regulator AGAP1.

184 Exomer is an adaptor complex required for the direct transport of a s

185 unction and the beta(3)A subunit of the AP-3 adaptor complex, respectively.

186 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how t

187 ools of the checkpoint protein BubR1 and the adaptor complex RZZ contribute to the linkage.

188 s initiated when Sar1-GTP recruits the cargo adaptor complex, Sec23/Sec24, by binding to its GTPase-a

189 ein interactions that form the basis of AP-2 adaptor complex stabilization, key to initiating CCS for

190 ia base in part via localization of the AP-2 adaptor complex subunit DPY-23.

191 The AP2 adaptor complex (subunits alpha, beta2, mu2 and sigma2)

192 ular endosome-to-TGN sorting, is mediated by adaptor complexes, such as retromer and Golgi-localized

193 ndent and cyclic diguanylate (cdG)-dependent adaptor complex that accelerates CtrA degradation in vit

194 lates Miro, a component of the primary motor/adaptor complex that anchors kinesin to the mitochondria

195 identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its subunits mu1

196 Yeast GCN5 is one component of a putative adaptor complex that includes ADA2 and ADA3 and function

197 X-RICS, GABARAP and 14-3-3zeta/theta form an adaptor complex that interconnects GABAAR and dynein/dyn

198 beta-catenin is a central component of the adaptor complex that links cadherins to the actin cytosk

199 stigations showed that DVL3 is present in an adaptor complex that links IGFIR to RAS, which includes

200 CCMs arise from the loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 s

201 pose that Kar9p is a component of a cortical adaptor complex that orients cytoplasmic microtubules.

202 AP-1 is a clathrin adaptor complex that sorts cargo between the trans-Golgi

203 peculate that Mgr3p and Mgr1p function in an adaptor complex that targets substrates to the i-AAA pro

204 lude that ARABIDOPSIS encodes HAT-containing adaptor complexes that are related to the Ada and SAGA c

205 ic reaction, the phosphorylation of the AP-3 adaptor complex, that is linked with synaptic vesicle co

206 orms of the mu1 subunit of the AP-1 clathrin adaptor complex: the ubiquitous mu1A and the epithelial-

207 coexpress two almost identical AP-1 clathrin adaptor complexes: the ubiquitously expressed AP-1A and

208 ecognition site for interaction with the AP1 adaptor complex, thereby marking Kir2.1 for incorporatio

209 nd the recruitment of the beta2-adaptin, AP2 adaptor complex to clathrin as well as transferrin inter

210 -2, MIRO-1, and TRAK-1 form another distinct adaptor complex to mediate dynein-based transport.

211 also required with coatomer-related clathrin adaptor complexes to bud vesicles from the trans-Golgi n

212 , and DNA origami scaffolds that mimic motor-adaptor complexes to reveal that the myosin VI-Dab2 comp

213 ecognition of an N-end motif by the protease-adaptor complex uses both the identity of the N-terminal

214 Heterotetrameric adaptor complexes vesiculate donor membranes.

215 we show that SIV Nef interacts with the AP-2 adaptor complex via two elements located in the N-termin

216 c inhibitor of cargo recognition by the AP-2 adaptor complex via tyrosine motif-based endocytosis sig

217 ome core component, or components of exosome adaptor complexes, we identify ~2900 transcription start

218 ive in promoting the recruitment of the AP-1 adaptor complex, whereas yeast ARF2 was the least active

219 mutations in the beta3A subunit of the AP-3 adaptor complex, which exhibited increased routing of th

220 aenorhabditis elegans, the prototypical AP-2 adaptor complex, which is activated by the accessory fac

221 a-adaptin, one of the components of the AP-2 adaptor complex, which is involved in clathrin-mediated

222 The beta3A subunit of the AP-3 adaptor complex, which likely regulates protein traffick

223 site is via the micro 2 subunit of the AP-2 adaptor complex, which recognizes tyrosine-based interna

224 gene encodes the beta3A subunit of the AP-3 adaptor complex, which regulates vesicular trafficking.

225 e recognized by a family of heterotetrameric adaptor complexes, which then recruit clathrin.

226 ognition by Sla1p, part of an endocytic coat/adaptor complex with clathrin, Pan1p, Sla2p/End4p, and E

227 ermini and that these interact with clathrin adaptor complexes with differing affinities.