ライフサイエンスコーパス: adaptor molecule

1 on myeloid cells and associates with a novel adaptor molecule.

2 C maturation requires TLR2 and MyD88, a TLR2 adaptor molecule.

3 ptive immunity without the need for this TLR adaptor molecule.

4 yrosine kinases: Btk, Lyn, Syk, and the Blnk adaptor molecule.

5 tion and suggest the involvement of multiple adaptor molecules.

6 crotubule motors as well as actin-associated adaptor molecules.

7 ation, and the relative abundance of certain adaptor molecules.

8 ly required for the recruitment of signaling adaptor molecules.

9 function previously assigned exclusively to adaptor molecules.

10 rocytic markers, and ionized calcium-binding adaptor molecule 1 (IBA1) as a constitutive microglial m

11 is factor alpha, and ionized calcium binding adaptor molecule 1 (Iba1) expression levels in at least

12 ry markers including ionized calcium-binding adaptor molecule 1 (Iba1), glial fibrillary acidic prote

13 d within accumulated ionized calcium binding adaptor molecule 1 (Iba1)-positive microglia and Ly6C(+)

14 w that the beta-arrestin1.signal-transducing adaptor molecule 1 (STAM1) complex, initially identified

15 In mammals, Toll-IL-1R-containing adaptor molecule 1 (TICAM1)-dependent TLR pathways induc

16 ike receptor 3 (TLR3) and Toll-like receptor adaptor molecule 1 (TRIF).

17 ription factor 3 and ionized calcium binding adaptor molecule 1 for neurons and glia, respectively, a

18 Furthermore, ionized calcium-binding adaptor molecule 1 staining revealed reduced damage patt

19 f CD68(+), F4/80(+), ionized calcium binding adaptor molecule 1(-) macrophages containing Congo red-s

20 -4(-/-), TLR-2/4(-/-), MyD88(-/-), MyD88/TLR adaptor molecule 1(-/-), interleukin-1 receptor [IL-1R1]

21 c protein (GFAP) and ionized calcium binding adaptor molecule 1(IBA1) immunostaining indicated morpho

22 he adaptor protein STAM1 (signal-transducing adaptor molecule 1) because disruption of the interactio

23 its adaptor protein TRIF (Toll-like receptor adaptor molecule 1) but does not require the MyD88 (myel

24 in), and microglial (ionized calcium binding adaptor molecule 1) markers was performed.

25 ta (4G8), microglia (ionized calcium binding adaptor molecule 1), astrocytes (glial fibrillary acidic

26 nificantly increased ionized calcium-binding adaptor molecule 1-positive microglial activation surrou

27 munostained with the ionized calcium-binding adaptor molecule 1; Iba-1) and the interaction of microg

28 ron (TRIF, also called TIR-domain-containing adaptor molecule-1 (TICAM-1)) is a signaling adaptor mol

29 adaptor protein Toll/IL-1R domain-containing adaptor molecule-1 (TRIF) did not develop larger brain d

30 crophage activation (Ionized calcium binding adaptor molecule-1 [Iba-1]) and interleukin-6 [IL-6]) an

31 tion and duration of ionized calcium-binding adaptor molecule-1-positive microglial reactivity in the

32 ntaining 2A (SH2D2A), and signal transducing adaptor molecule 2 (STAM2) as novel candidate adaptors t

33 that Rin1 interacts with signal-transducing adaptor molecule 2 (STAM2), a protein that associates wi

34 did not require TLRs 2, 4, or 9 or MyD88/TLR adaptor molecule 2 but did require MyD88, indicating a r

35 We previously identified the adaptor molecule Act1 as a negative regulator of BAFF-me

36 d of IL-17RA and IL-17RB, which recruits the adaptor molecule Act1 for downstream signaling.

37 a biallelic missense mutation (T536I) in the adaptor molecule ACT1 in two siblings with CMC.

38 The use of His-tagged protein A as adaptor molecule allows Affinity Grids to be used for th

39 litated by duplication of the genes encoding adaptor molecules and charging enzymes.

40 n which ICP0 promotes the degradation of TLR adaptor molecules and inhibition of the inflammatory res

41 it may perform this function by trafficking adaptor molecules and kinases to the pericentrosomal and

42 ifying the host sensors that detect WNV, the adaptor molecules and signaling pathways that regulate t

43 ng CD64 and FcepsilonR1alpha, with signaling adaptor molecules, and we confirm experimentally that eq

44 ium sensor protein hippocalcin, the clathrin adaptor molecule AP2, the postsynaptic density enriched

45 Adaptor molecules are essential in organizing signaling

46 We identify the MyD88 adaptor molecule as responsible for the majority of cyto

47 er PYHIN family members) associates with the adaptor molecule ASC (apoptosis-associated speck-like pr

48 ient in either caspase-1 or the inflammasome adaptor molecule ASC after rVSV immunization was not sig

49 NALP3, with the adaptor molecule ASC, has been proposed to form a caspas

50 by crossing with IL-1 receptor-deficient or adaptor molecule ASC-deficient mice, but not NLRP3-defic

51 shment and the up-regulation of adhesion and adaptor molecules at the plasma membrane.

52 und that ROMK bound directly to the clathrin adaptor molecule autosomal recessive hypercholesterolemi

53 ays of NF-kappaB activation and utilizes the adaptor molecule BCL10 (B-cell leukemia/lymphoma 10).

54 composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.

55 Adaptor molecules bearing immunoreceptor tyrosine-based

56 Furthermore, Shc, an adaptor molecule between antigen receptors and the Ras/E

57 erts its therapeutic effect by serving as an adaptor molecule between FKBP12 and the cell proliferati

58 Here, we investigated the role of Arl8B, an adaptor molecule between lysosomes and kinesins.

59 Fibulin-5 thus serves as an adaptor molecule between monomeric elastin and the matri

60 actin cytoskeleton and because they serve as adaptor molecules between PSGL-1 and Syk, we examined th

61 endosomes, we identified signal-transducing adaptor molecule-binding protein (STAMBP) and ubiquitin-

62 ated substrate) and STAM (signal transducing adaptor molecule), both of which harbor multiple ubiquit

63 We previously demonstrated that the adaptor molecule breast cancer antiestrogen resistance 3

64 s indicate that PGC1alpha represents a novel adaptor molecule capable of recruiting the necessary tra

65 nd c-Kit are generally deemed as independent adaptor molecules capable of transducing cytokine-specif

66 ed mice, we found that signaling through the adaptor molecule caspase activation and recruitment doma

67 Recently, the CLR-adaptor molecule caspase recruitment domain family membe

68 nction of IPS-1, an essential RIG-I and MDA5 adaptor molecule, completely disabled the innate antivir

69 t these limitations by the use of a chimeric adaptor molecule comprising the extracellular domains of

70 Bcl10 is an essential adaptor molecule connecting antigen receptor signaling c

71 TLRs and downstream adaptor molecules contain a conserved cytoplasmic TIR do

72 complexed with the IgG-specific CD64-IgE Fc adaptor molecule could provide a substitute for human re

73 cyte phosphoprotein of 76 kDa (SLP-76) is an adaptor molecule critical for immunoreceptor and integri

74 ic 'YEEP' motif that was able to recruit the adaptor molecule Crk-L and phosphatidylinositol-3-OH kin

75 d zebrafish genome to identify six different adaptor molecules: Dap10, Dap12, Cd3zeta, Cd3zeta-like,

76 atural killer (NK) receptor NKG2D and the NK adaptor molecule DAP12, which promoted cytotoxicity agai

77 with human TLRs and macrophages from TLR and adaptor molecule-deficient mice and evaluated macrophage

78 Here, we demonstrate that the endocytic adaptor molecule Disabled-2 (Dab2), which we have previo

79 stimulating signaling pathways that coax the adaptor molecule ezrin (EZR) to tether rPhe508del-Na(+)/

80 ule (TRADD), the Fas-associated death domain adaptor molecule (FADD), caspase-8, TNFR-associated fact

81 e peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death do

82 cleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA recep

83 nitiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and th

84 DNAX-activating protein of 12 kDa is an adaptor molecule for different myeloid expressed recepto

85 ary response gene 88 (MyD88) is an essential adaptor molecule for IL-1 as well as most Toll-like rece

86 esults indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA viru

87 ndings for animals lacking MAVS, the central adaptor molecule for RLR signaling.

88 with SRY and hypothesized to function as an adaptor molecule for SRY by tethering the KAP1-NuRD-SETD

89 Fas-associated death domain (FADD) is an adaptor molecule for the death receptor subfamily of the

90 We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Del

91 ivator 1alpha (PGC1alpha) serves as a unique adaptor molecule for the recruitment of additional coact

92 alphaSNAP, the adaptor molecule for the SNARE-priming enzyme N-ethylmal

93 MyD88 is the main adaptor molecule for TLR and IL-1R family members.

94 Mice deficient in MyD88, an adaptor molecule for TLR9 and IL-1R signaling, also had

95 ignaling, since MyD88 and TRIF are the major adaptor molecules for all bacterial TLRs.

96 F2-induced ERK activation through binding to adaptor molecule GRB2 to interfere with its association

97 atory responses, and an involvement of other adaptor molecules has not been suggested in TLR5-depende

98 rn recognition receptors and their signaling adaptor molecules has recently emerged as an essential c

99 ts (TOG and RNA) are modulated by a bivalent adaptor molecule (hnRNP A2).

100 ds on NF-kappaB activation, partially on the adaptor molecule IFN-promoter stimulator-1 and the novel

101 o mycobacteria, the possible function of the adaptor molecule IL-1R-associated kinase (IRAK)-4 agains

102 ssociated factor (TRAF)1 is an intracellular adaptor molecule important for signaling by TNFR.

103 ining a caspase-recruitment domain (ASC), an adaptor molecule important for TLR-mediated caspase-1 ac

104 TRIF is an adaptor molecule important in transducing signals from i

105 MyD88 is a key adaptor molecule in inflammatory pathways involved in in

106 TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contai

107 s with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding.

108 ion have focused primarily on its role as an adaptor molecule in signaling pathways in the cytoplasm,

109 RhoH serves as adaptor molecule in T cell receptor signaling and RhoH e

110 nt domain-containing protein 9 (CARD9) is an adaptor molecule in the cytosol of myeloid cells, requir

111 ntified full-length presenilin as a critical adaptor molecule in the dephosphorylation of VEGFR1.

112 ACT1 is an essential adaptor molecule in the IL-17 signaling pathway.

113 cess is primarily through its function as an adaptor molecule in the IL-1R signaling pathway.

114 ng recruiting domain (ASC)/PYCARD, a central adaptor molecule in the Nod-like receptor (NLR) pathway,

115 Here, we show that expression of MAVS, a key adaptor molecule in the RIG-I-like receptor RNA-sensing

116 inker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell

117 Second, iOPN played a role as an adaptor molecule in TLR2 and dectin-1 signaling pathways

118 ibution of pattern recognition receptors and adaptor molecules in immunity to malaria remains poorly

119 s (PI(3)Ks) are activated through associated adaptor molecules in response to G protein-coupled and t

120 the cytoplasm where they serve as essential adaptor molecules in translation.

121 does not associate with any known signaling adaptor molecule, including DAP10, DAP12, or the FcRgamm

122 omponents, these TLRs associate with several adaptor molecules, including myeloid differentiation fac

123 ith increased surface expression of critical adaptor molecules, including the growth factor receptor

124 e immune signaling pathway that includes the adaptor molecule interferon promoter stimulator 1 (IPS-1

125 nducing interferon-beta (TRIF), TRIF-related adaptor molecule, interferon regulatory factor 3 (IRF-3)

126 As such, stimulator of IFN genes (STING), an adaptor molecule involved in cytosolic DNA sensing, is r

127 otein, CD2-associated protein (CD2AP), is an adaptor molecule involved in podocyte homeostasis that c

128 X-activation protein 12 (DAP12), a signaling adaptor molecule involved in signal transduction of acti

129 tance of the LPS receptor TLR4 and MyD88, an adaptor molecule involved in the activation of the major

130 Paxillin is an adaptor molecule involved in the assembly of focal adhes

131 CD2AP, an adaptor molecule involved in the internalization of ubiq

132 mRNA expression of MyD88, the adaptor molecule involved in TLR4 signaling, was signifi

133 r herpesviruses, occurs independently of the adaptor molecule IPS-1.

134 The p14 adaptor molecule is part of the late endosomal/LAMTOR (l

135 nition responses, that controlling levels of adaptor molecules is a recurring strategy in regulating

136 shown to interact with a number of cytosolic adaptor molecules, it is possible that the interaction o

137 in-protein interactions of the receptor with adaptor molecules, kinases, and G proteins.

138 These results suggest that TLR adaptor molecules knockdown, such as MyD88 or TRAM, can

139 Mutations in the adaptor molecule LAT can lead to autoimmunity.

140 ing immunoreceptors associate with signaling adaptor molecules like FcepsilonR1gamma or CD247.

141 n-radixin-moesin (ERM) proteins, a family of adaptor molecules linking the cortical actin cytoskeleto

142 Here we identify Mlf1-adaptor molecule (Madm), a novel tumour suppressor that

143 ells and that signaling through the helicase adaptor molecule MAVS (mitochondrial antiviral signaling

144 h recognize viral RNA and signal through the adaptor molecule MAVS (mitochondrial antiviral signaling

145 he present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon

146 The mitochondrial adaptor molecule MAVS plays critical roles in coordinati

147 ORF-9b targets the mitochondrial-associated adaptor molecule MAVS signalosome by usurping PCBP2 and

148 ensing pathway mediated by the mitochondrial adaptor molecule MAVS, the TLR3 adaptor TRIF, or the tra

149 re, we show that the mitochondria-associated adaptor molecule, MAVS, is required for optimal NLRP3 in

150 eptors, RIG-I and MDA5, and their downstream adaptor molecule, MAVS.

151 hways by promoting filament formation of the adaptor molecule, MAVS.

152 naling pathways by affecting the function of adaptor molecules may provide new strategies to countera

153 adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-inde

154 eceptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associat

155 ugh TLR2 and requires the recruitment of the adaptor molecule MyD88 but not CD14.

156 naling by Toll-like receptors and the common adaptor molecule MyD88 in intestinal epithelial homeosta

157 In this study, we show that the adaptor molecule MyD88 is critical for the magnitude of

158 scription factors XBP1 and CHOP nor the TLR4 adaptor molecule MyD88 is necessary for caspase-8 activa

159 The adaptor molecule MyD88 is necessary for responses to all

160 engagement, colocalization of Opn-i and the adaptor molecule MyD88 was associated with induction of

161 In macrophages, TLR4 and the adaptor molecule MyD88, but not TLR2 or TLR5, are requir

162 retch-induced EMT requires the innate immune adaptor molecule MyD88.

163 through Toll-like receptor 7 (TLR7) and its adaptor molecule MyD88.

164 cells is greatly reduced in mice lacking the adaptor molecule MyD88.

165 HSCs from mice deficient in TLR9 or the TLR adaptor molecule MyD88.

166 that does not require the Toll-like receptor adaptor molecule MyD88.

167 t governed by the IL-1R family/TLR signaling adaptor molecule MyD88.

168 n TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal.

169 vates two signaling pathways mediated by the adaptor molecules MyD88 and Toll/IL-IR domain-containing

170 Toll-like receptor signalling through the adaptor molecules MyD88 and TRIF in turn mediates effici

171 ng TLR-7, type I IFN receptor, and CCR2, the adaptor molecules MyD88, IL-1R-associated kinase (IRAK)-

172 Toll-like receptors (TLRs) associate with adaptor molecules (MyD88, Mal/TIRAP, TRAM, and TRIF) to

173 LRs, the IL-1R, and the IL-18R, use a common adaptor molecule, MyD88, for transducing activation sign

174 Early studies indicated that the adaptor molecule, MyD88, might be important for this cha

175 ling is dependent on the presence of another adaptor molecule, MyD88.

176 through Toll-like receptor 7 (TLR7) and its adaptor molecule, MyD88.

177 s severely impaired in mice deficient in the adaptor molecule myeloid differentiation antigen 88 (MyD

178 Toll-like receptor 3 (TLR3), signal via the adaptor molecule myeloid differentiation factor 88 (MyD8

179 role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD8

180 l blood through a mechanism dependent on the adaptor molecule myeloid differentiation primary respons

181 However, deficiency of the adaptor molecule myeloid differentiation primary respons

182 ciated molecular patterns and signal through adaptor molecules, myeloid differentiation factor 88 (My

183 he purified, recombinant SH3.1 domain of the adaptor molecule noncatalytic region of tyrosine kinase

184 cking for protein kinases, phosphatases, and adaptor molecules obligate for resensitization and recyc

185 ffold for protein kinases, phosphatases, and adaptor molecules obligate for resensitization and recyc

186 B-lymphocyte adaptor molecule of 32 kDa (Bam32) is a known mediator o

187 that Cdc42-mediated migration relies on the adaptor molecule p130(Cas).

188 established binding partners of BCAR3 is the adaptor molecule, p130(Cas).

189 between protein kinase C (PKC) iota and the adaptor molecule Par6.

190 containing adaptor-inducing IFN-beta-related adaptor molecule produced equivalent cytokines as wild-t

191 We achieved this by expressing the adaptor molecule Protrudin which is normally found at lo

192 downstream signaling pathways and/or shared adaptor molecules, rather than through direct extracellu

193 rs NOD1 and NOD2 and their common downstream adaptor molecule, receptor interacting protein 2 (RIP2;

194 of the TLR-4 signaling adaptor TRIF-related adaptor molecule reduced nuclear factor-kappaB activity

195 range of activation receptors with distinct adaptor molecules require additional stimulation for IFN

196 MyD88 is an adaptor molecule required for activation of proinflammat

197 MyD88, a key adaptor molecule required for many innate immunity recep

198 al caspase recruitment domain (ASC) is a key adaptor molecule required for the inflammatory processes

199 bachia bacteria demonstrated similar TLR and adaptor molecule requirements.

200 daptor family that includes Rap1-interacting adaptor molecule (RIAM) and lamellipodin, proteins invol

201 ntially associated with Rap1-GTP-interacting adaptor molecule (RIAM) both in vitro and in vivo, which

202 e of Rap1-guanosine triphosphate-interacting adaptor molecule (RIAM) for talin-1 recruitment and thus

203 Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates

204 llipodin (MRL) protein (Rap1-GTP-interacting adaptor molecule (RIAM) or lamellipodin), talin and acti

205 l GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a member of the MRL (Mig-10/RIA

206 n of Rap1-guanosine triphosphate-interacting adaptor molecule (RIAM), a Rap1 effector, blocks this re

207 dent integrin regulator Rap1-GTP-interacting adaptor molecule (RIAM), the recruitment of talin into T

208 eractions--vinculin and Rap1-GTP-interacting adaptor molecule (RIAM)--in the formation and maturation

209 (Q204L) did not reverse Rap1-GTP-interacting adaptor molecule (RIAM)-dependent increases in cell adhe

210 red in mice lacking the Rap1-GTP-interacting adaptor molecule (RIAM).

211 egulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM).

212 ges by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 ma

213 receptor complex that includes the essential adaptor molecule RIP.

214 ked upregulation of FAS, FAS ligand, and the adaptor molecules RIPK1 and CFLAR.

215 The adaptor molecule SAP (signaling lymphocytic activation m

216 Finally, although mice that lack the adaptor molecule SAP (SLAM-associated protein) resemble

217 Instead, apoptosis required the TLR adaptor molecule SARM1, which localized to the mitochond

218 We found that the adaptor molecule SH2 domain-containing leukocyte protein

219 ion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of

220 elocytic leukemia zinc finger (PLZF) and the adaptor molecule signaling lymphocyte activation molecul

221 The adaptor molecule signaling lymphocytic activation molecu

222 ative (XLP) disease due to deficiency in the adaptor molecule signaling lymphocytic activation molecu

223 hus, SARM appears to be unique among the TIR adaptor molecules, since it functions to restrict viral

224 SH2D1A encodes the adaptor molecule SLAM-associated protein (SAP), which is

225 M costimulation requires the presence of the adaptor molecule SLAM-associated protein.

226 our studies demonstrate a novel role for the adaptor molecule SLP-76 in regulating HIV-1 infection in

227 proximal signaling complex nucleated by the adaptor molecules SLP-76 and LAT1 is required for activa

228 mechanism, we investigated the role of a key adaptor molecule SQSTM1/p62.

229 We used timed deletion of the TCR-signaling adaptor molecule Src homology 2 domain-containing phosph

230 We demonstrate that signal transduction adaptor molecule STAM-1A interacts with C. elegans LOV-1

231 e with the SH3 domain of signal transduction adaptor molecule (STAM) (AMSH) is a conserved metallopro

232 Signal-transducing adaptor molecule (STAM)-1, but not related STAM-2, inter

233 Src homology 3 domain of signal transducing adaptor molecule (STAM)] was fused to the carboxyl termi

234 Mice deficient in an adaptor molecule, STAT1(-/-), for interferon signaling h

235 ors IFI16 and cGAS as well as the signalling adaptor molecule STING.

236 ates whether knocking down two important TLR adaptor molecules, such as myeloid differentiation prote

237 adaptor molecule-1 (TICAM-1)) is a signaling adaptor molecule that is critically involved in the Toll

238 s-induced signaling adaptor (VISA), a unique adaptor molecule that is essential for retinoic acid ind

239 receptor-associated factor (TRAF)2 is a key adaptor molecule that is known to mediate proinflammator

240 CIKS/ACT1 is an adaptor molecule that is necessary for signaling by memb

241 PDLIM2 is an adaptor molecule that links different components of the

242 The LAT gene encodes an adaptor molecule that links receptor engagement to criti

243 Grb2 is an adaptor molecule that mediates Ras-MAPK activation induc

244 previously unknown requirement for MyD88, an adaptor molecule that mediates signals at most TLRs, for

245 -associated factor 6 (TRAF6) is an important adaptor molecule that mediates the TNFR family and inter

246 ptosis or "anoikis." TMS1/ASC is a bipartite adaptor molecule that participates in inflammatory and a

247 vation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymp

248 target cell through expression of ezrin, an adaptor molecule that tethers proteins to the actin cyto

249 aptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in N

250 alpha and TIR-containing motif 1 (SARM1), an adaptor molecule that we found to be directly involved i

251 g is negatively regulated by beta-arrestins, adaptor molecules that also activate different intracell

252 ic intracellular compartment is conducted by adaptor molecules that bind to target motifs within the

253 ociated factor (TRAF) 2 and TRAF6, which are adaptor molecules that couple TNF and interleukin-1 rece

254 Transcription factors are adaptor molecules that detect regulatory sequences in th

255 tor substrate (IRS) proteins are cytoplasmic adaptor molecules that function as signaling intermediat

256 The Dok proteins are a family of adaptor molecules that have a well defined role in regul

257 CAP/Ponsin belongs to the SoHo family of adaptor molecules that includes ArgBP2 and Vinexin.

258 llection of regulatory RNA-binding proteins, adaptor molecules that link Brk to signaling pathways ge

259 A genes is essential for generating the tRNA adaptor molecules that link genetic sequence and protein

260 activation and proliferation dependent upon adaptor molecules that mediate formation of the immunolo

261 human TLR that associates directly with the adaptor molecule TIR domain-containing adaptor inducing

262 iation primary response 88- and TRIF-related adaptor molecule/TIR domain-containing adapter-inducing

263 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and the adaptor molecule TIRAP between 205 African American wome

264 level of similarity between TcpB and the TLR adaptor molecule TIRAP.

265 nd 6; NOD-like receptor 2; and the signaling adaptor molecule TIRAP.

266 n 4 TLR genes (TLR1, TLR2, TLR4, TLR6) and 2 adaptor molecules (TIRAP, MyD88) were associated with C.

267 In contrast, other TIR adaptor molecules, TIRAP/Mal, TRIF, and TRAM, are not re

268 We demonstrate that CRKL serves as an adaptor molecule to facilitate focal adhesion formation,

269 ochips that can be decorated with switchable adaptor molecules to select for target proteins of inter

270 Similarly, TLR signaling through the adaptor molecule Toll/IL-1R domain-containing adapter in

271 was determined using siRNA against the TLR3 adaptor molecule Toll/IL-1R homologous region-domain-con

272 proinflammatory pathway is dependent on the adaptor molecules Toll/IL-1 receptor domain-containing a

273 imilarly, macrophages from mice deficient in adaptor molecules Toll/IL-1R domain-containing adaptor-i

274 The TLR adaptor molecule, Toll/IL-1R domain-containing adaptor i

275 TNF-alpha, the TNFR-associated death domain adaptor molecule (TRADD), the Fas-associated death domai

276 MEKK1 was recruited to CD40 and adaptor molecule TRAF2 after CD40 ligation, and Map3k1(d

277 R) family member, forms a complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating

278 ese findings show an unexpected role for the adaptor molecule TRAF6 in Smad-mediated TGF-beta signali

279 K)-related kinases, but not for TRIF-related adaptor molecule (TRAM) and TRAF3.

280 TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistan

281 ing interferon-beta (TRIF), and TRIF-related adaptor molecule (TRAM) to activate transcription factor

282 ntiation protein 88 (MyD88) and TRIF-related adaptor molecule (TRAM), could affect mRNA expression of

283 erentiation protein (MyD88) and TRIF-related adaptor molecule (TRAM), using small interfering RNA abo

284 that TF4 binds to TLR4 but not TRIF-related adaptor molecule (TRAM), whereas TF5 binds to TRAM stron

285 ing adapter-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM), which recruits TRIF.

286 ducing interferon-beta (TRIF)-, TRIF-related adaptor molecule (TRAM)-, and STING-deficient mice.

287 ng IFN-beta (TRIF) requires the TRIF-related adaptor molecule (TRAM).

288 This stimulation leads to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain

289 absence of caspase-8 activity, required the adaptor molecule TRIF, and proceeded in a cell autonomou

290 NA helicases DDX1, DDX21, and DHX36, and the adaptor molecule TRIF, by isolation and sequencing of po

291 sive effect was not dependent on TLR3 or its adaptor molecule Trif.

292 signaling events, which are mediated by the adaptor molecule TRIF.

293 pter-inducing interferon-beta (TRIF)-related adaptor molecule), TRIF, and MyD88, whereas A52 binds to

294 iating TLR3- or TLR4-induced signaling as an adaptor molecule, TRIF can participate in proteolytic mo

295 association of TLR4 with MD-2 and downstream adaptor molecules, TRIF and MyD88, into lipid rafts lead

296 A prominent difference was at the level of adaptor molecules; TRIF, MyD88, MAVS, and STING.

297 Phosphorylation of the LAT adaptor molecule was observed in 4 s, and diacylglycerol

298 Here, we introduce the concept of His-tagged adaptor molecules, which eliminate the need for the targ

299 domain protein 2 (Fhl2) is an intracellular adaptor molecule with a high protein-protein interaction

300 Eukaryotic cell adaptor molecules, without any intrinsic enzymatic activ