ライフサイエンスコーパス: addiction

1 on underlying loop of crucial importance for addiction.

2 language, autism spectrum disorder, and drug addiction.

3 , sleepiness, anxiety, depression and gaming addiction.

4 s the perceived loss of control seen in drug addiction.

5 the PVT->NAc->LH pathway for treating opioid addiction.

6 often have limited efficacy and can lead to addiction.

7 otor impairment and inform interventions for addiction.

8 tant implications for the pathophysiology of addiction.

9 ffects, and shed light on the development of addiction.

10 disorders including depression, anxiety, and addiction.

11 his target as potential treatment of cocaine addiction.

12 pamine that contribute to the development of addiction.

13 ng results that are relevant to learning and addiction.

14 ylcholine, serotonin, and dopamine) and drug addiction.

15 l conditions such as Parkinson's disease and addiction.

16 of RGS proteins in models of psychostimulant addiction.

17 em that is strongly implicated in reward and addiction.

18 tent with an incentive-sensitization view of addiction.

19 e modulate the dopaminergic system to induce addiction.

20 on to alcohol misuse- from binge drinking to addiction.

21 king a cancer vulnerability, transcriptional addiction.

22 herapeutic targets and mediators of nicotine addiction.

23 ed in the transition from casual drug use to addiction.

24 the actions of dopamine are critical to drug addiction.

25 e major obstacles in the treatment of opiate addiction.

26 ponses to opioids in models of analgesia and addiction.

27 ct effects of the drug and may contribute to addiction.

28 egulate cocaine consumption across stages of addiction.

29 tem are postulated to drive opioid abuse and addiction.

30 pressing cocaine seeking in animal models of addiction.

31 n of RGS proteins in models of analgesia and addiction.

32 lying opiate drug tolerance, dependence, and addiction.

33 cs for psychiatric disorders, including drug addiction.

34 n deficiency and hyperactivity disorder, and addiction.

35 , has been postulated to underlie relapse in addiction.

36 rkinson disease, anxiety disorders, and drug addiction.

37 ing the definition of controls in studies of addiction.

38 drawal, and contribute to the development of addiction.

39 RNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction.

40 ories, to outline how compulsion develops in addiction.

41 serious disorders, including depression and addiction.

42 NAc as a promising therapeutic lever in drug addiction.

43 ivity may yield approaches to treat nicotine addiction.

44 comorbid mood disorders and vulnerability to addiction.

45 ding risk taking, depression, anhedonia, and addiction.

46 in the brain have been suggested to lead to addiction.

47 uit of more accessible treatments for opioid addiction.

48 t associated with the "dark side" of alcohol addiction.

49 alleviate specific behavioral components of addiction.

50 is a potential therapeutic target in cocaine addiction.

51 l role in the development and maintenance of addiction.

52 rd-of-care maintenance medication for opioid addiction.

53 to develop interventions for treating opioid addiction.

54 ich plays a key role in reward, underpinning addiction.

55 ng better treatments for pain and for opioid addiction.

56 on's disease, schizophrenia, depression, and addiction.

57 drugs and the development of dependence and addiction.

58 re new chemical space of relevance to opioid addiction.

59 ng comorbidities among pain, depression, and addiction.

60 al functions including reward processing and addiction.

61 of abuse are critical for the development of addiction.

62 of disorders such as schizophrenia and drug addiction.

63 iome dysbiosis could accelerate the cycle of addiction.

64 nd its regulation of sleep-wake behavior and addiction.

65 administration, suggesting a trait marker of addiction.

66 oping more effective treatments for pain and addiction.

67 oline receptor (nAChR) subunits, to nicotine addiction.

68 rkinson disease, anxiety disorders, and drug addiction.

69 y brain region in developing and reinforcing addiction.

70 ed impairment as well as factors reinforcing addiction.

71 prevention maintenance treatment for opioid addiction.

72 al mechanisms that mediate susceptibility to addiction.

73 to misuse and diversion, and they may cause addiction.

74 omise as a treatment for people with cocaine addiction.

75 ool for interrogating the dopamine system in addiction.

76 the RMTg serves a vital role in response to addiction.

77 s of nicotine in the brain in the context of addiction.

78 control processes in groups with and without addictions.

79 rate and UE high behavioural similarity with addictions.

80 is common to both behavioural and substance addictions.

81 ability in young adults at elevated risk for addictions.

82 nd has been implicated in epilepsy, pain and addiction(1).

83 utics for cancer generally exploit "oncogene addiction," a phenomenon in which the growth and surviva

84 Compulsion theory of addiction also has weak support.

85 o study the role of operant social reward in addiction and addiction vulnerability in the context of

86 uction pathways regulated by RGS proteins in addiction and analgesia circuits.

87 s tissues, including brain regions mediating addiction and analgesia.

88 s believed to be central to the mechanism of addiction and drug reinforcement.

89 ed as potential therapeutics against cocaine addiction and for cognitive enhancement.

90 es, produces neurological effects that drive addiction and may damage the lungs in the process, produ

91 axwell Meighen Foundation via the Centre for Addiction and Mental Health Foundation.

92 erlie differences in vulnerability to opioid addiction and mood disorders.

93 is may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic

94 Opioid addiction and overdose are at record levels in the Unite

95 roin and fentanyl, has led to an epidemic in addiction and overdose deaths.

96 hine, heroin) has led to major problems with addiction and overdose.

97 nisms in pathological motivations, including addiction and paranoia.

98 ng maladaptive memories in disorders such as addiction and post-traumatic stress disorder.

99 nd molecular neuropathology of human cocaine addiction and provides a framework for translating biolo

100 er obesity and UE overlap behaviourally with addiction and psychiatric disorders, collectively referr

101 corticolimbic brain areas implicated in drug addiction and psychiatric disorders.

102 s of abuse influence both the development of addiction and relapse.

103 brain regions altered as a function of trait addiction and state withdrawal.

104 riched for pathways previously implicated in addiction and synaptic function.

105 as a mechanism for the development of opioid addiction and/or mood disorder.

106 ity and to compulsive-like cocaine intake in addiction, and document that these deficits persist at l

107 lved in processes such as pain, respiration, addiction, and feeding; and how receptor signaling and c

108 cant rate of unauthorized use, distribution, addiction, and opioid related deaths, an alternative met

109 roles in diverse functions including reward, addiction, and response to pain treatment.

110 nderstanding cancer-specific transcriptional addiction, and should provide important insight to both

111 ilencing of tumor-suppressor genes, oncogene addictions, and enhancement of immune responses.

112 the development of externalizing disorders, addictions, and other mental health problems.

113 ems associated with symbiosis, immunity, and addiction; and novel proteins for membrane abscission an

114 ing lead compounds for the treatment of drug addiction, anxiety, pain or obesity.

115 Critical features of human addiction are increasingly being incorporated into compl

116 nd others showed previously that cancer drug addiction arises also in the hematologic malignancy ALK-

117 ysicians have incorporated the management of addiction as part of their scope of practice, and here w

118 tify disulfiram, a drug for treating alcohol addiction, as an inhibitor of pore formation by GSDMD bu

119 However, smoking addiction assessed by the Fagerstrom test for nicotine d

120 Chronic opioid usage not only causes addiction behavior through the central nervous system, b

121 -significant loci previously associated with addiction, behavioral and personality traits, cognitive

122 ression of genes involved in psychostimulant addiction, blocks induction of immediate early genes by

123 norphine, methadone) is effective for opioid addiction but does not eliminate opioid use in all patie

124 oited to develop novel therapies for cocaine addiction, but a molecular target has not yet been ident

125 sis primarily target opioid use, misuse, and addiction, but because the opioid crisis includes multip

126 Regular drug use can lead to addiction, but not everyone who takes drugs makes this t

127 is the most widely studied neural process in addiction, but processes such as emotion, social cogniti

128 of the development of anxiety disorders and addiction, but such models also face several challenges,

129 Such addictions can also be defined in terms of the brain mec

130 dvanced technology (eg, infectious diseases, addictions), can eventually lead to further advancements

131 In both human and animal models of addiction, chronic food restriction increases rates of r

132 obehavioral phenotypes of susceptibility and addiction consequence is difficult to dissociate.

133 of reward, further establishes the course of addiction, consisting of desensitization, withdrawal, re

134 UD and also map onto the three stages of the addiction cycle.

135 diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step fo

136 cally poses significant challenges including addiction, dependence, tolerance, and the appearance of

137 Moreover, nicotine addiction drives repeated intake that results in chronic

138 give a name and define the role of these ID/addiction dual specialists.

139 ditions, including substance and behavioural addictions, eating disorders, and attention deficit/hype

140 interactions demonstrated that: (i) oncogene addiction effects are more robust than oncogene-related

141 Although animal and theoretical models of addiction emphasize the importance of different memory s

142 e risks of the collision of the COVID-19 and addiction epidemics.

143 s are prevalent within clinical contexts and addiction folklore ("chasing the first high"), little is

144 elated with oral opium use/abuse, history of addiction for over the preceding 12 years.

145 iously implicated candidates for cocaine use/addiction (FOSB, ARC, KCNJ9/GIRK3, NR4A2, JUNB, and MECP

146 Opioid addiction has been declared a public health emergency, w

147 Addiction has been proposed as a 'reward deficient' stat

148 g how epigenetic modifications contribute to addiction has focused on psychostimulants such as cocain

149 Opioid addiction has reached epidemic proportions in both indus

150 Habit theory of addiction has weaker support.

151 of individual memories during two phases of addiction: (i) downward spiral into persistent use and (

152 al abnormalities in amygdala due to Internet addiction (IA) associated with emotional disturbance.

153 eractivation is the key mechanism of ALK-TKI addiction in ALCL.

154 Here we reveal the mechanism of ALK-TKI addiction in ALCL.

155 the first time the mechanism of cancer drug addiction in ALK-positive ALCL and the benefit of schedu

156 highlight agents that target transcriptional addiction in cancer cells and suggest combination treatm

157 death represents a critical form of oncogene addiction in cancer cells.

158 concerns about e-cigarette use and nicotine addiction in children.

159 ed to link D2R to neuroplasticity in cocaine addiction in females.

160 ffect startle reflex that is correlated with addiction in humans, and increased htr1aa mRNA expressio

161 g of drug self-administration in animals and addiction in humans.

162 ata reveal a novel mechanism of ERG oncogene addiction in prostate cancer, whereby ERG facilitates AR

163 ribed mechanism of MEK/ERK pathway inhibitor addiction in solid tumors and found it does not apply to

164 that regulates HMGCR, defining an actionable addiction in that leads to MESN-subtype-dependent apopto

165 erences in addiction-like behaviors using an addiction index that incorporates the key criteria of op

166 Drug addiction is a chronic disorder characterized by compuls

167 Cocaine addiction is a chronic illness characterized by maladapt

168 Opioid addiction is a chronic, relapsing disorder associated wi

169 Cancer drug addiction is a paradoxical resistance phenomenon, well-d

170 Cocaine addiction is associated with compulsive drug-seeking, an

171 The development of drug addiction is associated with functional adaptations with

172 Addiction is characterized by a compulsive pattern of dr

173 Addiction is commonly identified with habitual nonmedica

174 Addiction is pathological because negative states powerf

175 These data suggest that human addiction is primarily driven by excessive goal-directed

176 ICANCE STATEMENT The biggest problem in drug addiction is the high propensity to relapse.

177 piny neurons (MSNs), one hallmark of cocaine addiction, is independent of DA signaling.

178 an effective therapeutic approach for opioid addiction, it is not as widely used as needed.

179 Individual variation in the addiction liability of amphetamines has a heritable gene

180 emical event contributing to methamphetamine addiction liability.

181 cellular adaptations associated with reduced addiction liability.

182 arguments over which animal models are more 'addiction like', as well as the facile assignment of beh

183 amygdala (CeA), we found that rats with high addiction-like behaviors (HA) exhibited a significant in

184 BA) transmission compared with rats with low addiction-like behaviors (LA) and naive rats.

185 that are responsible for the development of addiction-like behaviors in some but not all individuals

186 We characterized individual differences in addiction-like behaviors using an addiction index that i

187 nicotine vapor self-administration produced addiction-like behaviors, including somatic signs of wit

188 that is observed in individuals who develop addiction-like behaviors.

189 ndependently enhance the risk for developing addiction-like behaviors.

190 In the presence of very high reward, an addiction-like process emerges.

191 The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency

192 n neuropsychiatric disorders like autism and addiction, making a translationally relevant model of em

193 Drug addiction may be a goal-directed choice driven by excess

194 his distinction between different aspects of addiction may help to identify its neural substrates and

195 s are consistent with the early evolution of addiction mechanisms in simple generalist foragers as an

196 tibiotic and addiction team (IVAT), included Addiction Medicine and Infectious Diseases consultation

197 urce control (aHR, .57; 95% CI, .37-.87) and addiction medicine consultation (aHR, .57; 95% CI, .38-.

198 hat the NAc is a critical region influencing addiction, mood, and food consumption through its effect

199 necessitates a better understanding of human addiction neurobiology to develop efficacious treatment

200 For decades the broad role of opioids in addiction, neuropsychiatric disorders, and pain states h

201 This problem is not unique to addiction neuroscience, but it is an increasing source o

202 s highly expressed in, and supports oncogene addiction of, many cancers.

203 In melanoma, downregulation of the lineage addiction oncogene microphthalmia-associated transcripti

204 uld reflect transdiagnostic vulnerability to addiction or neuroadaptive consequences of long-term gam

205 s temptations - variously known as impulses, addictions, or bad habits; that it operates simultaneous

206 ne imposes a risk of adverse effects such as addiction, overdose, and death.

207 ability is low in youth at elevated risk for addictions, particularly those who frequently use cannab

208 of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of

209 We define the potential role of ID/addiction physicians in clinical care, health administra

210 ation of how memory retrieval influences the addiction process suggests novel treatment strategies.

211 coevolutionary origins of aesthetics and the addiction process.

212 unrecognized allostatic load that drives the addiction process.

213 rain is a canonical mechanism that initiates addiction processes.

214 fundamental to further our understanding of addiction processes.

215 d learning models and the identification of 'addiction-prone' animals.

216 also strong aversive effects that influence addiction propensity, but whose mechanisms are poorly un

217 and neurobiological contributions to cocaine addiction, provides a rapid approach for generating test

218 t sub-forums to analyze behavior underlining addiction recovery and relapse.

219 odel important latent constructs that impact addiction recovery and relapse.

220 also report factors that impact self-induced addiction recovery and relapse.

221 ss and physical pain significantly influence addiction recovery behavior.

222 were found to be positively associated with addiction recovery.

223 th the goal of analyzing factors influencing addiction recovery.

224 wn to be some of the factors associated with addiction recovery.

225 , appears to have a greater correlation with addiction relapse.

226 edisposing vulnerability in the causation of addiction, related to impaired goal-directed actions, as

227 hese epigenetic modifications and changes in addiction-related behavior.

228 ontaining (alpha3*) nAChRs in regulating the addiction-related behavioral or physiological actions of

229 Less well understood is how complex addiction-related behaviors emerge from activity pattern

230 on how these adaptations converge to produce addiction-related behaviors in rodent models.

231 ne-mediated responses that may predispose to addiction-related behaviors.

232 Gas5 in NAc neurons to determine its role in addiction-related behaviors.

233 ls relevant to anxiety-related conditions or addiction-related dysfunction.

234 we hypothesize that VU0364572 may oppose the addiction-related effects of cocaine by causing lasting

235 has been attributed to its ability to modify addiction-related neural circuitry through the activatio

236 cocaine dependence and molecular changes in addiction-related neurocircuitry, but have been understu

237 ion of the beta4 subunit gene resulted in an addiction-related phenotype characterized by low anxiety

238 of use, is especially effective in promoting addiction-relevant behaviors, and instead of tolerance,

239 on midbrain dopamine neurons to precipitate addiction-relevant changes in gene expression is unclear

240 aine that bypasses DA signaling and leads to addiction-relevant neuroadaptations, thereby providing c

241 the role of NAc FSIs in the context of drug addiction remains poorly understood, emerging evidence s

242 roups as addiction-vulnerable (high-risk) or addiction-resistant (low-risk).

243 nt factors in the development of obesity and addiction, respectively.

244 Drug addiction results in part from maladaptive learning, inc

245 o brain systems that have been implicated in addiction-risk.

246 plotypes with eQTL SNPs associated with drug addiction (rs510769) and obesity (rs9478496) in populati

247 ed infection prevention, harm reduction, and addiction services aimed at community and inpatient sett

248 Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).

249 Here, we describe a method for classifying addiction severity in outbred rats following intermitten

250 ith- vs. without MetS tended to have greater addiction severity.

251 h with and without clinically diagnosed drug addiction, siblings of addicted individuals, and control

252 f impulsivity-related disorders such as drug addiction.SIGNIFICANCE STATEMENT The claustrum is one of

253 education, academic detailing and access to addiction specialists or a control condition consisting

254 rophysiologists as well as behaviourists and addiction specialists to fully understand their impact o

255 llaborations between infectious diseases and addiction specialists, including increasing training in

256 rder treatment among infectious diseases and addiction specialists, we can decrease morbidity and mor

257 respond to rewards similarly to people with addictions such as alcohol abuse or smoking(6,7).

258 neurobiology and its contribution to opioid addiction susceptibility.

259 g our understanding of mechanisms underlying addiction susceptibility.

260 The protocol, the intravenous antibiotic and addiction team (IVAT), included Addiction Medicine and I

261 raving and anxiety, two critical features of addiction that often contribute to relapse and continued

262 Nicotine addiction, through smoking, is the principal cause of pr

263 to translate results from animal research on addiction to an understanding of the behavior of human d

264 Cancer cells can develop a strong addiction to discrete molecular regulators, which contro

265 Addiction to drugs and alcohol constitutes one of the si

266 ur integrative approach thus links glutamine addiction to glutamate excretion in cancer and points to

267 ral role in the development of tolerance and addiction to morphine and other drugs of abuse, understa

268 NRF2 inhibitor, showed that ischemia induces addiction to NRF2 in cells with NRF2 alterations.

269 vere side effects, especially dependence and addiction to opiates.

270 europsychological conditions that range from addiction to psychosis(1).

271 SIRT1, promoting anxiety, hyperactivity, and addiction to starvation, exacerbating the dieting and ex

272 ases the vulnerability of females to develop addiction to substances, such as alcohol.

273 rmline BRCA1/2 mutations, consistent with an addiction to TMEJ in these cancers.

274 est that ibogaine has the potential to treat addiction to various substances, including opiates, alco

275 The findings indicate that TNBC "addiction" to EGFR signaling is masked by the ELP comple

276 y of opioids, which have associated risks of addiction, tolerance, and dependence, for the management

277 t calls to a random sample of US residential addiction treatment facilities to investigate the availa

278 parenteral antimicrobial therapy (OPAT) with addiction treatment for people who inject drugs (PWID) w

279 atient parenteral antimicrobial therapy with addiction treatment may be feasible and safe for PWID wi

280 nistic gains have not led to improvements in addiction treatment.

281 ability for our OPAT program with concurrent addiction treatment.

282 ntagonists among people receiving outpatient addiction treatment.

283 considerable research on the neurobiology of addiction, treatment options for opioid abuse remain lim

284 search on neurobiological mechanisms of drug addiction, treatment options remain largely unchanged.

285 nisms might serve as therapeutic targets for addiction treatments.

286 lity of life and adverse outcomes, including addictions, violence, and suicide.

287 do not incorporate a critical facet of human addiction: volitional choices between drug use and non-d

288 le of operant social reward in addiction and addiction vulnerability in the context of choices.

289 The previous reports on an addiction vulnerability marker in the human SLC4A7 gene

290 ued probabilistic reward schedules can drive addiction vulnerability through multiple behavioral mech

291 Genetics plays a major role in addiction vulnerability, but cannot account for the rece

292 gulation and stress responsivity relevant to addiction vulnerability.

293 of habenular function that controls nicotine addiction vulnerability.

294 uals defy the risks associated with drugs or addiction vulnerability.

295 ine, which could serve as a novel target for addiction vulnerability.SIGNIFICANCE STATEMENT Cocaine p

296 -administration that identifies subgroups as addiction-vulnerable (high-risk) or addiction-resistant

297 accordance with neuropsychological models of addiction, we assume the tendency of a social-networks-u

298 king is a defining feature of drug abuse and addiction, we have yet to ascertain how cocaine self-adm

299 The likelihood of developing addiction, whether due to familial vulnerability or drug

300 drug experiences holds promise for treating addiction, yet accessing the distributed neural network