ライフサイエンスコーパス: additive effect

1 019; CL95 0.001-0.036), denoting a more-than-additive effect.

2 ing a more complex interaction than a simple additive effect.

3 The use of a water-based HS did not have an additive effect.

4 rogression and in combination showed a clear additive effect.

5 loci at least one of which has a significant additive effect.

6 served stalk HA and M2e that seem to have an additive effect.

7 while mixtures of two sizes primarily had an additive effect.

8 es in Solidago mass loss caused negative non-additive effect.

9 photobiomodulation plus ADS demonstrated an additive effect.

10 beyond what would be predicted for a simple additive effect.

11 optotic death to a degree well exceeding the additive effect.

12 considered jointly with smoking, has a supra-additive effect.

13 l activity of the two fractions displayed an additive effect.

14 xycycline-sitafloxacin group), suggesting an additive effect.

15 LNS with ezetimibe or pranlukast produced an additive effect.

16 .OH in SLF, while that of Cu-SRFA showed an additive effect.

17 ; CL95 -0.007-0.044), suggesting at least an additive effect.

18 Beyond this concentration, TAA showed an additive effect.

19 dherence to single interventions, indicating additive effects.

20 ic accumulation by many genes with small and additive effects.

21 n, amount of food and begging effort exerted additive effects.

22 ens, and combinations of the antibodies have additive effects.

23 hanges to mechanical properties arising from additive effects.

24 accounting primarily for the contribution of additive effects.

25 ltin with juvenoids resulted in greater than additive effects.

26 evere GN, whereas combination therapy had no additive effects.

27 ombined targeting of FLT3-ITD and BTK showed additive effects.

28 the power to detect additive and additive-by-additive effects.

29 -additive lethality is as common as strictly additive effects.

30 on in combination is twice as large as their additive effects.

31 phenotypic variance explained by genome-wide additive effects.

32 e cyclins and cdks might have synergistic or additive effects.

33 lternative, as it is more apt to capture non-additive effects.

34 can interact with one another to produce non-additive effects.

35 scenarios, including possible synergistic or additive effects.

36 ify and visualize QTLs with additive and non-additive effects.

37 of ahFAD2, and both loci showed significant additive effects.

38 inib and chemotherapeutic agents resulted in additive effects.

39 t reduced calcium or proton conductance have additive effects.

40 d HDAC functionality to exert synergistic or additive effects.

41 in a toxic unit of 1.85 indicating less than additive effects.

42 rom multiple pollen-pistil interactions with additive effects.

43 nant effect for MPH was partly identified as additive effect; 2) the ranking of factors affecting het

44 omosome 4 at 48 weeks of age had the largest additive effect (550.4 +/- 68.0 g, 11.5% of the phenotyp

45 ly used pesticide mixtures produce more than additive effects according to conventional combined effe

46 icantly body weight (BW) and adiposity, with additive effects after sequential exposure.

47 triaxone, cefixime or tetracycline showed an additive effect against four N. gonorrhoeae strains, sug

48 hus the dominant biotic interaction, but non-additive effects also impact the outcome of competition

49 Moreover, PAX2 and tamoxifen have an additive effect and both induce coding genes and enhance

50 g a transfusion and developing sepsis has an additive effect and is associated with even worse surviv

51 Each copy of the T risk allele has an additive effect and was associated with thinner global a

52 ons of these genes can be used to achieve an additive effect and whether this leads to enhanced yield

53 the paired-stressor combinations resulted in additive effects and 33% resulted in interactive (antago

54 ce is regulated by many genes with small and additive effects and is correlated with the susceptibili

55 s, the limit number of effects is 2q - 1 for additive effects and is the number of heterozygous genot

56 ction efficiency, together with the study of additive effects and mechanistic probes, is consistent w

57 anti-TB drug isoniazid and bergenin produces additive effects and significantly reduces bacterial loa

58 he high-permeability water channel AQP1 have additive effects and together increase the water permeab

59 Combination of sCAR-Fc and shRdRp2.4 exerted additive effects and was significantly more effective th

60 ween the additive model matrix and the h - 1 additive effects, and dominance values are factorized as

61 a function of the haplotype model matrix for additive effects, and genomic dominance relationship mat

62 hows a significant synergistic effect, while additive effects are observed for high-quality species.

63 and the potentiator ivacaftor, it showed an additive effect, as measured by the increase in the chlo

64 For example, MBNL1 is influenced by an additive effect at rs13069559, which itself is masked by

65 Thus, our study showed additive effects at the transcriptional and physiologica

66 Our study is highlighting more than additive effects at the transcriptional and physiologica

67 e accumulated to accurately define the Ag(+) additive effect, based on its role displayed in various

68 Haplotype analysis also revealed an additive effect between HLA-C, HLA-B, and MICA variants.

69 Analysis of double mutants showed no additive effects between mutations in ncs-1 and trp-1 or

70 n avoided neuronal excitotoxicity and had an additive effect both on hemodynamic variables and for pr

71 ntly, QTLs driven by dominance and other non-additive effects could be overlooked.

72 Most of the known organic additives effect coupling of iodoarenes, but not bromoar

73 een the vGWAS signals independent of the MHC additive effects, each with a weak effect but jointly ex

74 pairs of alleles that mediate 'co-operative additive' effects, either to improve disease suppression

75 e antagonistic, mixtures of juvenoids showed additive effects following a concentration addition mode

76 alyses were used to determine the predicted, additive effect for each dose pair within each drug mixt

77 TEMI to have a multiplicative rather than an additive effect for resource utilization since these mea

78 The sum of the significant and suggestive additive effects for bodyweight at specific ages account

79 a binary classifier, a nonlinear scale, and additive effects for each mutation.

80 Main components are additive and additive-by-additive effects for GCA and dominance-related effects f

81 Additive effects for past-year suicide ideation (AOR, 2.

82 (P < 0.001 and P < 0.0001), with no apparent additive effects for the combined treatment.

83 - and interspecific competition can have non-additive effects has rarely been tested.

84 igations into the origins of this unexpected additive effect have demonstrated that the carbon-carbon

85 the parasite growth independently but had an additive effect if combined together indicating involvem

86 t but from 12 weeks of age they exceeded the additive effect in a few cases.

87 m in dsRNA combinations (CI=0.4-0.82) vs. an additive effect in carboplatin/paclitaxel treatment (CI=

88 These results show a significant additive effect in cell killing and they provide initial

89 ct of C4 on I507-ATC DeltaF508 CFTR, but its additive effect in combination with VX-809, implies that

90 he presence of human complement, and have an additive effect in combination.

91 pretransplant anti-ARHGDIB antibodies has an additive effect in patients with DSA on the risk of graf

92 ylation increased TGF-beta1 release, with no additive effect in WASp(-/-) platelets, signifying that

93 T revealed that Notch and mecom did not have additive effects in blocking MCC formation, suggesting t

94 h heterogeneous systems, but antagonistic or additive effects in bulk oil.

95 chanisms of action to achieve synergistic or additive effects in cancer cell killing are outlined.

96 d 79, 58, 80 and 29 percent inhibition, with additive effects in combination as well.

97 iological and transcriptional end points but additive effects in heart rate and pepck1 upregulation,

98 Additive effects in human glioblastoma cells were also d

99 udy was designed to investigate the possible additive effects in liver of an acute dose of grape seed

100 Additionally, the mixtures displayed additive effects in most but not all parameters in adult

101 phage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment.

102 artment-specific IFN-gammaR signaling exerts additive effects in orchestrating intracerebral inflamma

103 both H1R and H4R in the challenge phase had additive effects in preventing the intestinal consequenc

104 FbaA and PAM (i.e., the M53 protein) had additive effects in promoting GAS survival in whole bloo

105 dual inhibition of DDT and MIF demonstrated additive effects in vitro, DDT plays a dominant role in

106 ompete with one another (ie, exert less-than-additive effects) in human laboratory studies of craving

107 These additive effects indicate that both GAPs collaborate in

108 the composition of the microbiota, while an additive effect is observed in obese asthma patients.

109 p53-dependent motor neuron death results in additive effects, leading to full correction of sensory-

110 are low in Swiss rivers, the possibility of additive effects may be of concern.

111 tions and could be responsible for the small additive effects, missing heritability and the lack of r

112 lization breadth was closely predicted by an additive-effect model and explained by complementary neu

113 Furthermore, we adapted an additive-effects model from complex-trait studies to sho

114 ly, we discuss their relationship with other additive-effects models and their advantages in inferenc

115 t was equal to that of dark rearing, with no additive effect observed.

116 Large r(2) values for additive effects observed among the QTLs for most traits

117 tions showed superior response rates without additive effects observed for carboplatin.

118 n of phenotypic variance attributable to the additive effect of all variants interrogated in these GW

119 s only partially reduced by Rac1 mKO with no additive effect of alpha2KD.

120 heart failure (HF) mortality, as well as the additive effect of an increasing number of cardiovascula

121 The additive effect of B(C(6)F(5))(3) resulted in significan

122 The additive effect of biotic (As-oxidizing bacteria) and ab

123 ypoxia and subsequent enrichment there is an additive effect of both conditions on hippocampal neurog

124 We also detected an additive effect of both polymorphisms in the multivariat

125 pgACC activation in relatives, indicating an additive effect of CACNA1C variation on familial risk.

126 Although any additive effect of cholesterol-enriched diet to ABL was

127 No additive effect of clofazimine was observed after the fi

128 ects of chronic fluoxetine, but there was no additive effect of CR in fluoxetine-treated mice.

129 r and nonvascular cell types; therefore, the additive effect of DDAH1 expression in multiple organ sy

130 Given that the additive effect of DeltamgtA and DeltamgtS mutations on

131 onmental stressors that promote CHD, but the additive effect of genetic susceptibility and environmen

132 of GLP-1 and PYY 3-36 (P = 0.03) next to the additive effect of GLP-1 (P = 0.006) on the composite ap

133 The pronounced additive effect of HDAC inhibition in DNA methylation-de

134 An additive effect of high-fat and high-sucrose diet on the

135 ants confer a substantial AF penetrance, the additive effect of many common variants explains a large

136 Surprisingly, this additive effect of nuclear tGIV/cytoplasmic pYGIV was ob

137 The supra-additive effect of overexpressing the three sRNAs result

138 ther systems; however, our results showed no additive effect of p53 and Arf coinactivation in promoti

139 ion, we demonstrate in both species that the additive effect of prestimulus activity on evoked activi

140 There was no additive effect of PRGF when used along with GTR in the

141 gistic stimulatory activity compared with an additive effect of the 3 individual bacteria.

142 as in human pancreatic cell lines showed an additive effect of the GEMCAP combination however, it in

143 llowed by a summation of evidence showing an additive effect of the regulators.

144 reduced Abeta levels in cells, more than the additive effect of the two compounds.

145 ay radiation are DNA-damaging stressors, the additive effect of these stressors is also independently

146 Additive effects of 20:4-PC and LY294002 were not observ

147 Further, we found that the additive effects of [warming x N deposition] and [warmin

148 The observations of the additive effects of advanced and delayed precipitation p

149 plains, at least in part, the synergistic or additive effects of alcohol and obesity on liver disease

150 The predictive model integrated the additive effects of all 11 single-nucleotide polymorphis

151 To investigate the potential additive effects of blood transfusion and sepsis on colo

152 entuated in obese asthma patients due to the additive effects of both disease states, while A. mucini

153 ew studies have examined the independent and additive effects of breastfeeding (BF) and sugar-sweeten

154 forced contingencies that may be a result of additive effects of cocaine and cannabis use.

155 x 10(4) variant FLAG peptides, exploring non-additive effects of combinations of mutations and discov

156 both GCTA and GWA are limited to the overall additive effects of common DNA variants, whereas twin st

157 GWA analysis, which, like GCTA, only detects additive effects of common DNA variants.

158 It has a potential to explain the additive effects of concomitant diseases or preexisting

159 c effects of histone acetylase inhibitors or additive effects of doxorubicin and dexamethasone, raisi

160 ation, which impairs SA synthesis, exhibited additive effects of enhanced susceptibility from both el

161 To determine the additive effects of excitotoxicity and overnutrition on

162 Thus, the additive effects of future, more frequent droughts may i

163 SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are commo

164 used a resampling procedure to simulate the additive effects of genetic variation on overall food-we

165 -type (Wt) and single knockout mice revealed additive effects of Gsta4(-/-) and Ppara(-/-) silencing

166 These 3 loci had independent, additive effects of HCV clearance, and account for 6.8%

167 ic outcomes so far, we did not see more than additive effects of HPV types on the risk of HSIL in wom

168 The additive effects of Hsp90 inhibition were abolished upon

169 orylation of both STAT1 and p65 mediated the additive effects of IFNgamma and TNFalpha on LCN2 expres

170 ew that specificity does not derive from the additive effects of individual interactions but rather f

171 regions either reflect stimulus intensity or additive effects of intensity and expectations, respecti

172 Non-additive effects of intra- and interspecific competition

173 n-activated protein kinase signaling and the additive effects of MEK and BRAF mutations are counterpr

174 mediated by heterodimer formation or by the additive effects of mixed chemokines on their respective

175 ty pathways observed for all DBPs caution of additive effects of mixtures and suggest further assessm

176 provide a quantitative basis for integrating additive effects of multiple global change drivers into

177 effects on calcium influx correlate with the additive effects of mutations in nodF and nodL on legume

178 ement of submarginal cell rows, resulting in additive effects of NHE1 and epidermal growth factor.

179 Also, the additive effects of our detected mouse loci more closely

180 These results demonstrate additive effects of p38 and JNK MAPK inhibition by MKP-1

181 out-breeding-to-selfing transition based on additive effects of segregating alleles.

182 elated intrinsic resistance results from the additive effects of several ND10 components and that the

183 ion in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome

184 tract (CSE) exposure as well as the possible additive effects of the combination therapy with a phosp

185 ability could be explained by the collective additive effects of the genotyped SNP from the discovery

186 es that differed from those expected for the additive effects of the individual chemicals.

187 -linking, we observed small but reproducible additive effects of the lack of A20 and CYLD.

188 ause and is at least partly explained by the additive effects of the same polygenic variants.

189 g sites in the developing brain and test for additive effects of their mutation on transcription and

190 kin aging is a complex process involving the additive effects of time-dependent intrinsic aging and c

191 drug users could show additive (or more-than-additive) effects of stress and cues on craving, using e

192 We predicted an interactive, rather than additive, effect of CO(2) and soil type on ANPP.

193 Niacin showed a selected additive effect on chemoattractant-induced activation of

194 ined addition of lipids and oxygen showed an additive effect on concentration of higher alcohols wher

195 LKB1 and transduction of HPV16 E6/E7 had an additive effect on constraining cell senescence while pr

196 se results reveal that TLR8 and TLR9 have an additive effect on controlling TLR7 function and TLR7-me

197 us and the 3'-UTR polymorphism status had an additive effect on DAT binding.

198 Flow has an additive effect on efficiency through 50 mL/min, when va

199 Exercise and RYGB had an additive effect on enhancing insulin sensitivity, but su

200 y 13 member A (FAM13A) were shown to have an additive effect on FEV1/FVC levels in the genetic risk s

201 tion alleles of MYB and bHLH proteins had an additive effect on GSL levels, as demonstrated by the an

202 of hCRM1 and hSRp40 resulted in a more-than-additive effect on HIV-1 release.

203 l and triglycerides genetic risk load has an additive effect on IHD risk.

204 oduction, concurrent blockade has a marginal additive effect on IL-2 production, IL-13 secretion, and

205 D, and X-ray radiation have an approximately additive effect on increasing the frequency of aberrant

206 at combining different mutations can have an additive effect on neuropathologies and associated co-mo

207 0 by chemical inhibitors or knockdown had an additive effect on NHE3.

208 l starvation alarmone (p)ppGpp, polyP has an additive effect on nucleoid dynamics and organization du

209 m for compensation, harvest began to have an additive effect on overall mortality (rho = 0.60; 90% BC

210 In adults, harvest had an additive effect on overall mortality throughout the 42-y

211 Knockdown of USP10 had an additive effect on PKA-dependent inhibition of NHE3.

212 that of allosteric modulators, which show an additive effect on R628E receptors.

213 binations of multiple mutations displayed an additive effect on reducing NS2-induced ubiquitination.

214 mulation with TNF-alpha and D-glucose had an additive effect on RUNX1 expression, which was downregul

215 25 at postnatal day 5 (PND5) demonstrated an additive effect on survival.

216 un and Ets2 co-immunoprecipitated and had an additive effect on Syk expression.

217 ion of MsFkh with Relish-RHD did not have an additive effect on the activity of moricin promoter, sug

218 tory of previous malignancy does not have an additive effect on the cancer-specific and overall survi

219 mber of NOD2 and ATG16L1 risk alleles had an additive effect on the proportion of abnormal Paneth cel

220 arriers and length of stay seemed to have an additive effect on the risk of contracting C difficile.

221 ivates both signaling pathways, producing an additive effect on viability and enhancing both prolifer

222 In addition, cyaY and yggX mutations have additive effects on 6-phosphogluconate dehydratase-depen

223 ody deficiency and anti-CD4 depletion has no additive effects on aortic root atherosclerosis.

224 roallergen sensitization and RV wheezing had additive effects on asthma risk at adolescence.

225 on of DLK protein expression and the lack of additive effects on axon growth upon co-manipulation sug

226 These additive effects on calcium influx correlate with the ad

227 tion with MSN2 and MSN4 deletion resulted in additive effects on CCC1 transcription, suggesting that

228 rwise silencing of ZAP70, SYK, or LCK showed additive effects on cell growth inhibition, providing a

229 Stress and cues have additive or more-than-additive effects on drug seeking in laboratory animals,

230 Ageing and Alzheimer's disease contributed additive effects on grey matter volume in nearly all net

231 a PYK2 inhibitor and Na2S did not result in additive effects on infarct size.

232 When used in combination, TAC and SRL had additive effects on inhibition of IFN-gamma- and IL-17-p

233 of both GIP and GLP-1, 3) additive to supra-additive effects on insulin secretion when combining SU+

234 concentrations, and their expression had no additive effects on LGP2-mediated negative regulation.

235 ic and environmental factors not only exerts additive effects on locomotor hyperactivity and sensorim

236 arameters and OCA + ELA combinations exerted additive effects on metabolic and histological endpoints

237 and PI3K inhibition, respectively, produced additive effects on p-Akt and cell growth, consistent wi

238 gly, the combination of RSV with NAM, exerts additive effects on PARP1 activation.

239 les ERK1/2 downstream of EGFR thus revealing additive effects on promoting OSCC cetuximab-sensitivity

240 egment in the Class I MHC demonstrated clear additive effects on schizophrenia risk, demonstrating th

241 ealed multiple loss-of-function alleles with additive effects on serum levels of the oxysterol, 24S-h

242 ombination, predation and parasitism had non-additive effects on the abundance of the intermediate co

243 d chloroplast function combined did not show additive effects on the circadian period, which suggests

244 and similarity-based friendship choices have additive effects on the clustering coefficient; and (3)

245 ctions of CHIKV HVD with CD2AP and FHL1 have additive effects on the efficiency of CHIKV replication.

246 Active movement and DBS had largely additive effects on the firing rate of most neurons, ind

247 blockade therapies similarly revealed mostly additive effects on the frequencies of T cell subsets al

248 ockdown of Lxralpha produced equivalent, non-additive effects on the lipogenic genes.

249 nhibition of adult neurogenesis did not have additive effects on the magnitude of volume loss but did

250 n types of substituents exert consistent and additive effects on the regioselectivity of substitution

251 esent together, PCSK9 and HMGCR variants had additive effects on the risk of both cardiovascular even

252 y weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and

253 tion factors and the chromatin template with additive effects on transcription.

254 additive genetic effects while ignoring non-additive effects, on the assumption that most QTL act ad

255 Synergistic or additive effects or both on cardiometabolic risk may be

256 ntly predicted the primary endpoint, with an additive effect particularly evident at postoperative na

257 The observed additive effect reinforces the central role of AC6 and c

258 C7 with significant additive, imprinting and additive effects, respectively.

259 T delivery and Activin A treatment showed an additive effect, resulting in on average 60% of the ESCs

260 with 2 single nucleotide polymorphisms with additive effects, rs2957692 (P=1.54x10(-13)) and rs29577

261 ndothelial permeability and that VEGF has no additive effect, suggesting a common pathway.

262 f both FXN and the M140I substitution had an additive effect, suggesting an acceleration of distinct

263 However, intrathecal PACAP did not show additive effects, suggesting that the agonist effect was

264 Strikingly, MEG, fMRI and MRI showed additive effects supporting distinct brain-behavior asso

265 pplication of 3,4-DAP plus GV-58 had a supra-additive effect that completely reversed the deficit in

266 rvive to warming, highlighting the potential additive effects that herbivory will have on ultimately

267 Antibiotic combinations typically have an additive effect: the efficacy of the combination matches

268 voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

269 significant independent inhibitory effect or additive effect to BAK efficacy on acanthamoebal surviva

270 Auxiliary subunits exert an additive effect to heteromerization, and thus relief of

271 n of HDAC6 and HDAC9 together resulted in an additive effect to increase cell movement but did not al

272 HDAC6 and -9 had additive effects to promote cell survival via modulating

273 hand, marijuana and alcohol might follow an additive effect trend.

274 Only small additive effects upon combined knockdown and no counter-

275 An additive effect was found for individuals with an additi

276 ession compared to control cells; whereas no additive effect was observed by co-depletion of both pro

277 But a slightly additive effect was observed when AAPH system was used.

278 nd one of the earliest examples of the metal additive effect was observed with silver ions (Ag(+)).

279 To compensate for these additive effects, we have developed an empirical method

280 ergism between WO(4)(2-) and NO(2)(-), while additive effects were observed with ClO(4)(-) and NO(3)(

281 Additive effects were seen for CDKN2A (hazard ratio, 2.3

282 Although individual additive effects were small, the fixation for alternativ

283 Furthermore, we did not detect an additive effect when combined with V600EBRAF, nor could

284 ter neurotoxic potential than cocaine and an additive effect when they are combined.

285 d by both OA and copper individually, but no additive effects when exposed as combined stressors were

286 hen fed individually but without predictable additive effects when fed as a mixture.

287 ve value is expressed as a function of h - 1 additive effects, where h = number of alleles or haploty

288 oinositide 3-kinase (PI3K) inhibitors had an additive effect, whereas Erk1/2 (extracellular signal ac

289 REI was identified on SSC8 with significant additive effect, which overlapped with QTL for nitrogen

290 RH5 combination consistently demonstrated an additive effect while the CyRPA/RIPR combination showed

291 ients with diabetes mellitus and may have an additive effect with diabetes mellitus on outcomes.

292 Through these studies, an unusual additive effect with DMAP has been uncovered that allows

293 Finally, insulin stimulation produced an additive effect with SOCS3 overexpression, further induc

294 ificant F508del-CFTR rescue and displayed an additive effect with the investigational drug VX-809.

295 Additional analyses suggested an additive effect with those who both received a blood tra

296 Experimental studies show that statins exert additive effects with agents, such as cisplatin, to impa

297 ted PC migration and invasion, demonstrating additive effects with AR inhibition.

298 on in vitro and in vivo, iguratimod also has additive effects with glucocorticoids.

299 uced all PDE4 isotypes expression and showed additive effects with rolipram enhancing cAMP levels.

300 ed by additivity, a third is governed by non-additive effects, with complete dominance having a key r