ライフサイエンスコーパス: additively

1 ique pharmacological attributes that can act additively.

2 c lineage, they appear to act separately and additively.

3 or multiplicatively but contributes to costs additively.

4 s often been assumed that mutant alleles act additively.

5 ting that they can function independently or additively.

6 ibit G(1)-phase progression individually and additively.

7 of TNF alpha independently of each other and additively.

8 lpha production by T, NK, and NKT-like cells additively.

9 effects, on the assumption that most QTL act additively.

10 ulted in increased CD36 expression alone and additively.

11 tively when TF is limiting but otherwise act additively.

12 creased until inhibitor combinations behaved additively.

13 phine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) com

14 D28 costimulation coupled to TCL1 expression additively accelerates dose-dependent T cell growth.

15 ase and cytolysin did not increase virulence additively, accounting for 50.6% of the pathogenicity an

16 In particular, many non-additively accumulated proteins (61-62%) in the F(1) and

17 These phosphorylation events additively activate CPEB4 in M-phase by maintaining it i

18 ancisella infection and that these cytokines additively activate host cells to control LVS intracellu

19 In contrast, FOXA1 and NKX2.1 additively activate transcription from Ccsp, which inclu

20 tion, overexpression of both IRF-8 and IRF-1 additively activated IL-27 p28 promoter.

21 et1-3) that vary in responsiveness to TH and additively affect metamorphic timing.

22 al N291G and P294K substitutions in human RR additively affect substrate specificity.

23 hosphatase 1 docking at the KNL-1 N terminus additively affected checkpoint silencing, indicating tha

24 Mutations additively affected the affinity of the NELF-E-binding a

25 ssociated with withdrawal, independently and additively alter distinct brain circuits.

26 Many of these genes were additively altered in a coinfection with PMV+SPMV and co

27 king of 4-1BBL signaling and IL-17A activity additively ameliorated psoriasis.

28 Ectopic STM and WUS functions interacted non-additively and activated a subset of meristem functions,

29 f leaf complexity and that SGL1 and FCL1 act additively and are required for petiole development.

30 ons were tested where genotypes were modeled additively and dominantly.

31 Signals from cones are combined both additively and in opposition to create the perception of

32 Mutations in p7 and NS2 acted additively and increased the specific infectivity of vH-

33 del where the binding of each GABAergic drug additively and independently reduces the free energy of

34 mutants showed that each domain contributed additively and independently to binding affinity; in con

35 iants and (iii) specific dyes, appear to act additively and independently to increase terminator inco

36 erization process and that the NTDs function additively and independently.

37 point mutations that account for resistance additively and independently; one is in fabZ, a dehydrat

38 modulates the activity of the SC cells both additively and multiplicatively and changes the preferre

39 ividuals with mild cognitive impairment both additively and multiplicatively.

40 CP-1 inhibition was post-transcriptional and additively and synergistically enhanced by fluticasone a

41 upplementation, whereas Xrn2 depletion acted additively and thus independently of miR-122.

42 ch both electrical and gene therapies can be additively applied to treat diabetic wound healing.

43 QTL affecting sexual isolation act additively, are largely different in males and females,

44 Thus, WRKY38 and WRKY62 function additively as negative regulators of plant basal defense

45 presenting different vRNAs were not packaged additively, as would be expected under specific packagin

46 sity factors found in previous studies to be additively associated with child psychopathology; family

47 al cortical thickness were independently and additively associated with declining memory z-scores.

48 Seropositivity to more herpesviruses was additively associated with greater LTL attrition (3 herp

49 us (t = 2.74; p<.008) were independently and additively associated with increased DAT binding in the

50 The 5-HTTLPR short allele appeared to be additively associated with increasing gray matter volume

51 sites (all P<0.05) and, when combined, were additively associated with long-term survival (P=0.0001)

52 al volume index) were each independently and additively associated with risk of incident HF hospitali

53 oundary lubrication, either independently or additively, at an articular cartilage-cartilage interfac

54 Each gene additively augments embryonic lethality in crosses betwe

55 suspicion be high, and any partial solutions additively be implemented.

56 are essential throughout development and act additively but are dispensable at adulthood.

57 Stressors combined additively, but had opposing effects on life history tac

58 were not substantially changed when adjusted additively by baseline GRACE risk score (HR, 0.975 [95%

59 paradigm that extends the laser tuning range additively by employing multiple monolithically grown ga

60 is rapid open channel block was reduced (non-additively) by interventions that slow C-type inactivati

61 Data from multiple rotations can be additively combined, generating a chemical image of the

62 led-coil domain and aggregation-prone region additively contribute to competent mRNA export and stres

63 e results suggest that MCPIP1 and MCPIP4 may additively contribute to control IL-6 production in vivo

64 We conclude that TNFalpha and IGF-I may additively contribute to fibrosis during intestinal infl

65 y and do not have independent functions that additively contribute to HCMV latency.

66 rminal predicted alpha-helical/Motif 6 site, additively contribute to repression.

67 C-reactive protein and CAD independently and additively contributed to the risk prediction: low CRP a

68 elix transcription factors that are known to additively control jasmonate-related defense responses,

69 helix-loop-helix transcription factors that additively control jasmonate-related defense responses,

70 We show that the three arginines additively control the subcellular localization of SF2/A

71 Carvacrol was also shown to additively cooperate with antiretroviral therapy.

72 both TNFRSF4 and TNFRSF25 independently and additively costimulate vaccine-induced CD8(+) T cell pro

73 We identify a series of mutations that additively decouple the Pincer motif from the ATPase cor

74 Similarly, these interventions additively decrease cell viability.

75 TNF-Tg and GC treatment additively decreased mechanical strength and stiffness i

76 systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction

77 co-regulate target genes synergistically or additively, depending on the target transcriptional enha

78 additively while strong enhancers behave sub-additively due to competition with the target promoter.

79 h hy5 and cop1 revealed that BBX25 and BBX24 additively enhance COP1 and suppress HY5 functions.

80 nhibitors of these respective pathways super-additively enhance CPT's cytotoxicity, suggesting their

81 ctivators of gamma-globin gene expression to additively enhance HbF.

82 Eotaxin inhibition was transcriptional and additively enhanced by the glucocorticoid fluticasone an

83 low concentrations, ANP and beta-AR agonists additively enhanced expression of brown fat and mitochon

84 Topical H1/2r antagonists additively enhanced permeability barrier homeostasis in

85 mbination of these lipids synergistically or additively enhanced TH2 responses and, strikingly, induc

86 itant activation of the PKA and PKC cascades additively enhanced the amplitude of flow-induced [Ca(2+

87 normal T cells with fludarabine or rituximab additively enhanced the direct cytotoxic effect of these

88 expression of beta-defensin 2 and S100A9 and additively enhanced the expression of S100A7 and S100A8.

89 y increased when parasites were administered additively, even when the presence of the most pathogeni

90 6P9b combines with another P450, CYP6P9a, to additively exacerbate the reduced efficacy of insecticid

91 evel in the F1 hybrid, implying that the non-additively expressed siRNA clusters resulted in lower ac

92 roposed approach is that such systems can be additively fabricated as embedded parts of microarchitec

93 The tag is additively fabricated on flexible plastic foil and compr

94 gly, reporter gene expression also increased additively following each of seven doses of FIV delivere

95 monstrate that tandem LIM domains contribute additively, for SFSS localization.

96 l events that act either multiplicatively or additively found support in 8% and none of the trees, re

97 r dramatically: in V. harveyi, the sRNAs act additively; however, in V. cholerae, the sRNAs act redun

98 proportion to Gag, the S domain was packaged additively, implying that the Alu and S domains are pack

99 e and RYGB surgery-induced weight loss would additively improve S(I) and other cardiometabolic factor

100 Neuronal Sxl acts additively in 2 neuronal subpopulations, one of which co

101 ntrast, the hunchback enhancers function sub-additively in anterior regions containing saturating lev

102 Our findings suggest that azoles act additively in C. elegans which is in line with previous

103 The CI and CII proteins behave strictly additively in client protection.

104 Although these pathways act additively in culture, they act synergistically in vivo

105 nd IL-1 beta in combination appeared to work additively in promoting IgG2.

106 stered together, the two MAbs acted at least additively in providing protection against challenge wit

107 levels of the Bicoid activator, but function additively in regions where there are diminishing levels

108 and feature cue information were represented additively in shared frontal, parietal, and cingulate re

109 he nicotine biosynthetic pathway and may act additively in the activation of JA responses.

110 lso that the receptor uses multiple proteins additively in vivo.

111 e with plasma levels of VWF, individually or additively, in a large cohort of healthy subjects.

112 oexpress five FAD mutations (5XFAD mice) and additively increase Abeta42 production.

113 ing pathways were found to independently and additively increase alpha1(I) collagen gene expression b

114 suppress KLF1 and BCL11 gene expression and additively increase fetal hemoglobin in primary human er

115 suppress KLF1 and BCL11 gene expression and additively increase fetal hemoglobin in primary human er

116 h CBmp and IQmp are agonist ligands that non-additively increase L-type Ca2+ channel opening probabil

117 bodies that target a non-overlapping site to additively increase parasite inhibition.

118 with SMN2 splice-switching oligonucleotides additively increase SMN expression and improve survival

119 GTP and isoleucine, which independently and additively increase the affinity of CodY for its target

120 h C(6)-Cer and each of these same inhibitors additively increased ABCA12 expression, indicating that

121 t MASH1 overexpression and FGF-2 deprivation additively increased beta-III-tubulin and decreased cycl

122 a a Brca2/Rad51-dependent mechanism and were additively increased by deletion of the Blm helicase.

123 Rac1 activity was additively increased in CECs treated with CCL11 and VEGF

124 nd-expressing cells, TIGIT and PD-1 blockade additively increased proliferation, cytokine production,

125 However, the combination of EMD+PDGF-BB additively increased wound fill for both ALK PHOS (+) an

126 photoreceptors other than phytochrome A and additively increases ABA insensitivity conferred by the

127 taneous knockdown of supervillin and anillin additively increases cell division failure.

128 the association persisted with each C-allele additively increasing the FVIII:C level by 14.3 IU dL(-1

129 the val/val phenotype but instead interacts additively, indicating that these genes affect distinct

130 ence within the nucleosome entry-exit region additively influence nucleosomal DNA accessibility by in

131 Contrary to prediction, CO(2) and soil additively influenced grassland ANPP.

132 Finally, NPHP4 and Jade-1 additively inhibit canonical Wnt signaling, and this gen

133 In vitro, apoE and LRP1 additively inhibit macrophage apoptosis.

134 response using chemical inhibitors or siRNA additively inhibited HCV replication and induced viral c

135 359) peptide that inhibits G(q/11) signaling additively inhibited IGF-stimulated ERK1/2 activation, i

136 Rapamycin combined with IDEC-131 additively inhibited MLRs.

137 Sirt1 and Sirt2 inhibitors additively inhibited the constitutive AKT activity in th

138 Interruption of both signaling cascades additively inhibited the wound-healing process.

139 cts, DAC followed by either of ICI therapies additively inhibited tumor growth and prolonged mouse su

140 ed knockdown of both PLCepsilon and PLCbeta3 additively inhibits PI hydrolysis, suggesting independen

141 Depletion of Trimmer and Papi/Tdrkh additively inhibits trimming, causing accumulation of ap

142 be served by the intraparietal sulcus, which additively integrated a spatially specific activation ga

143 he unstructured tail of its Hec1 subunit are additively integrated to elicit gradual tuning of NDC80-

144 NPC1L1 and HMGCR polymorphisms had 5.8 mg/dl additively lower LDL-C and a 10.8% log-linearly additive

145 tal mechanical computation approach based on additively-manufacturable micro-mechanical logic gates.

146 Herein, we report a complete additively manufactured (AM) electrochemical sensing pla

147 Additively manufactured (AM) metallic materials commonly

148 ore than 5,500 alloys in use today cannot be additively manufactured because the melting and solidifi

149 re we report the first example of a class of additively manufactured carbon fiber reinforced composit

150 fication products such as castings, welds or additively manufactured components.

151 te its importance to the ultimate quality of additively manufactured materials.

152 Poor quality and low repeatability of additively manufactured parts are key technological obst

153 fatigue life of electron beam melting (EBM) additively manufactured parts is currently dominated by

154 There is a need to qualify additively manufactured parts that are used in highly re

155 d to the distribution of applied stresses in additively manufactured parts to maximise the fatigue li

156 s understanding the nature of variability in additively manufactured parts.

157 Using additively manufactured rock, we demonstrate that highly

158 pore architecture is a critical variable in additively manufactured scaffold design for functional t

159 The additively manufactured sensor has channel dimensions th

160 detect SARS-CoV-2 from VTM samples using an additively manufactured three-dimensional cartridge and

161 agnitude of the thermal gradients within the additively manufactured Ti6Al4V alloy in different direc

162 correlate with the microstructure evolved in additively manufactured Ti6Al4V alloy.

163 (Columnar grains in additively manufactured titanium components can result i

164 d bioceramic (BioCer) implants consisting of additively manufactured titanium frames enveloped with C

165 report that austenitic 316L stainless steels additively manufactured via a laser powder-bed-fusion te

166 h greater population activity, while that of additively modulated neurons decreased.

167 Anti-PD-L1 antibodies work additively, not redundantly, with exosomal PD-L1 blockad

168 from biological and adoptive relatives acted additively on adoptee AUD liability.

169 nd showed that the three variants each acted additively on gene expression.

170 MSX and rapamycin act additively on Gln3-Myc13 phosphorylation, but MSX clearl

171 TA-p63, repress endogenous AFP transcription additively or independently.

172 trait-based mortality to be modelled either additively or multiplicatively, and individual variabili

173 Seed infertility QTL act additively or recessively, consistent with findings in o

174 able in number, and seed-infertility QTL act additively or recessively.

175 can control whether the sRNAs appear to act additively or redundantly.

176 MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin to

177 n cells is affected at several levels, which additively or synergistically result in the appearance o

178 ed that glucocorticoids and beta(2)-agonists additively or synergistically suppress tumor necrosis fa

179 We discuss how Dorsal and Twist work either additively or synergistically to activate different targ

180 Several compounds also acted either additively or synergistically to inhibit enzyme activity

181 they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replicati

182 These may interact additively or synergistically, increasing the likelihood

183 ith inputs from other network nodes that act additively or synergistically.

184 pecific dynamics: neuronal responses sum sub-additively over time, reduce in amplitude with repeated

185 or overexpression of eIF4E individually and additively partially rescues the rapamycin-induced decre

186 n combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF-a

187 ingly, deficiency of both IL-1beta and IL-18 additively prevented LPS-induced mortality.

188 ternative exons, with multiple motifs acting additively rather than cooperatively.

189 norhizobium meliloti nodL and nodF mutations additively reduce infection of Medicago truncatula.

190 used in combination with MEK inhibitors, can additively reduce the transformation induced by p110beta

191 lts show that chronic hypoxia or hypokalemia additively reduced I(hERG) with fentanyl.

192 The combination of cells additively reduced the infarct size and promoted vascula

193 owever, combining eserine with methoctramine additively reduced the ISF Abeta further in both animals

194 Food fortification with iron and EDTA additively reduces BPb concentrations.

195 t manners, exemplifying that different MCTPs additively regulate a specific plant developmental proce

196 38 MAPK and Smad signaling independently and additively regulate alpha1(I) collagen gene expression b

197 ene, indicating that anaerobic expression is additively repressed by FadR and ArcA-ArcB.

198 Coexpression of p65 and E1A additively represses the transient MMTV but restores the

199 ned before BMT KGF + PFT-beta administration additively restored numbers of cortical and medullary TE

200 se, and well-spaced pulses of ligand combine additively, resulting in greater pathway output than wit

201 in TP53/PTEN double knockout GBM mouse model additively shortens the latency of glioma onset and surv

202 RT-PCR confirmed that NO* and SB could additively stabilize certain mRNA transcripts, an effect

203 -2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in

204 bitors (CNIs) in combination with prednisone additively suppressed IFNgamma production and degranulat

205 The rga and gai null mutations additively suppressed the recessive sly1 mutant phenotyp

206 s indicates that PAX-6 isoforms can interact additively, synergistically, or antagonistically, depend

207 CLA and OCS act non-additively to activate atNHE1, indicating convergent, ph

208 hypertensive and those who are normotensive, additively to antihypertensive treatments.

209 sesses two regions that appear to contribute additively to chaperone binding.

210 ariation between families and was decomposed additively to characterize the correlation structure wit

211 inhibitors we show that Rap1b and VEGFR2 act additively to control angiogenesis in vivo.

212 at three common SNPs in the DBH promoter act additively to control phenotypic variation in DBH levels

213 antly, in V. harveyi, the Qrr sRNAs function additively to control quorum sensing.

214 ALD1 and PAD4 can act additively to control SA, PATHOGENESIS RELATED GENE1 (PR

215 how that multiple, unlinked loci act largely additively to determine position along the major niche a

216 of these genes contributes independently and additively to E2-mediated silencing, indicating that E2

217 resources also responded dynamically and non-additively to eCO2 and warming, shaping the plant respon

218 The components of the combined adjuvant work additively to enable both antigen and adjuvant dose spar

219 tremes show that each amino acid contributes additively to enzyme function, with epistatic contributi

220 uggest that multiple sscat-binding sites act additively to fine-tune signaling via cytoplasmic retent

221 omoter element contributes independently and additively to gene expression-contradicts experimental m

222 These NB-LRR proteins then act additively to generate a full disease resistance respons

223 Wnt and Fgf function additively to generate dHb progenitors.

224 independently associated with and contribute additively to hippocampal cortical thinning.

225 most BVM resistance and PIR mutations acted additively to impair viral replication, particularly in

226 pathway, we hypothesized that they could act additively to improve infectivity and reduce toxicity to

227 thase kinase-3 (GSK-3) inhibitor lithium act additively to increase longevity in Drosophila Remarkabl

228 cose supplementation acted independently and additively to increase N-linked glycan branching.

229 GTP and the BCAAs were shown to act additively to increase the affinity of CodY for DNA; inc

230 at multiple diet components can interact non-additively to influence gut microbial diversity.

231 These effects work additively to inhibit tumor growth, achieving results si

232 derstanding is that these domains contribute additively to interfacial properties (Cassie's equation,

233 ncer contains three subelements contributing additively to its activity, and functionally important r

234 We found that these two pathways contribute additively to nutrient limitation-induced haploid invasi

235 Each pair contributed additively to overall affinity, with 61% from Lys-270/Ly

236 ndogenous GLP-1, but the hormones contribute additively to postprandial glucose regulation in healthy

237 kk3 and low expression levels of sFRP1/5 act additively to potentiate the Wnt/JNK signaling pathway g

238 common variant gene loci of weak effect act additively to predispose to common autoimmune diseases,

239 within the transcription activator Ets-1 act additively to produce graded DNA binding affinity.

240 ronising mechanism and interacts with it non-additively to produce more long-timescale synchrony than

241 2, whose products functioned identically but additively to promote degradation of Cdkn1b, cell cycle

242 de new evidence that portion size and ED act additively to promote energy intake at meals among presc

243 th arginine and leucine act individually and additively to propagate signals that are dependent on th

244 Proline-directed phosphorylation acted additively to regulate multiple aspects of ATF4 degradat

245 letion studies, functioned independently and additively to regulate the exit of tumor cells from quie

246 We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly act

247 Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition.

248 activity, with the 5-aryl group contributing additively to the allosteric enhancer activity.

249 ing mutations contributing independently and additively to the outcome.

250 anaphase resolution) and Src64B contributed additively to this form of cell death.

251 ally focus on detecting loci that contribute additively to trait variation.

252 e Gal11 activator-binding domains contribute additively to transcription activation and Mediator recr

253 ype (similar to N-type channels) contributed additively to transmitter release from the hair cell.

254 have found that these proteins cooperate to additively transactivate p21 and suppress cell prolifera

255 nce (based on a low-pH survival assay) supra-additively up to 8500-fold during active cell growth, an

256 , TGFbeta (transforming growth factor beta), additively upregulated myofibroblast-specific ECM genes

257 ect each trait in the same direction and act additively, we also found evidence for epistasis between

258 hibit no cross-resistance with Rif, function additively when co-administered with Rif, and suppress r

259 in isolation and contributed to the response additively when combined with other features.

260 B2 receptor, independently but also largely additively when combined, enhance senescence-associated

261 NRF-1 and NRF-2 act additively while NRF-2 synergizes with CREB/ATF at FMR1'

262 ggests that weakly active enhancers function additively while strong enhancers behave sub-additively

263 ed TrkA activation and eosinophil migration, additively with 1-NM-PP1, indicating a role for matrix m

264 First, we ask whether Taxol will combine additively with another stabilizer or whether one stabil

265 y-evoked potentials): fMRI activation scaled additively with attention, whereas evoked EEG components

266 t the inhibition of RAD52-ssDNA binding acts additively with BRCA2 or MUS81 depletion in cell killing

267 w that the chiral counterion can be combined additively with chiral ligands to enable an asymmetric t

268 These PxxP motif mutations affect signaling additively with CRIB domain mutations, indicating that B

269 Furthermore, xenon works additively with cyclosporin A to preserve post-transplan

270 Moreover, GSNO acted additively with decreased temperature, which promoted mu

271 e test the hypothesis that such peptides act additively with detergents when applied in parallel.

272 competitive manner but instead was packaged additively with endogenous 7SL.

273 hil-active chemoattractant that can function additively with eotaxin and a dual CCR3/5-HT2A receptor

274 y as an eosinophil chemoattractant that acts additively with eotaxin.

275 alysis indicates that ETR1 and EIN4 function additively with ETR2 to control this trait.

276 In conclusion, FGF21 acts additively with GLP-1 to prevent insulinopenic diabetes

277 The porcine cathelicidin peptide PR-39 acted additively with human cathelicidin LL-37 to kill group A

278 onstrated that insulin acts independently or additively with human chorionic gonadotropin to enhance

279 the synthesis of cell wall polymers and act additively with inhibitors or mutations disrupting cellu

280 caCaMKKalpha could stimulate glucose uptake additively with insulin in insulin-sensitive muscle, in

281 that caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle

282 LET2/MDS1 functions additively with LET1, another CrRLK1L, and acts genetica

283 on to shock caused by B. anthracis and works additively with LeTx.

284 l lines; and (d) PKCzeta inhibitors function additively with other inhibitors that target similar or

285 loss is, functionally, a stress that can act additively with other stresses to arrest cells in G1 in

286 de, a VR1 agonist in acidic conditions, acts additively with PDBu and remains effective after chronic

287 B(-/-) mice revealed that rosiglitazone acts additively with PTP1B deletion.

288 tably lack MC4Rs, function independently and additively with PVH(MC4R) neurons to account for the tot

289 Genetic analysis indicates that WIN3 acts additively with several known SA regulators, including P

290 anisms that lower the energy barrier and act additively with Syt1-dependent mechanisms to produce PTP

291 oid cells, simvastatin induced HbF alone and additively with tBHQ, but it did not increase KLF2 mRNA

292 ied a secondary interval on Chr 2 that works additively with the Chr 1 locus to increase lateral sept

293 ellin-deficient mutation dwarf1 and interact additively with the dominant gain-of-function mutations

294 signal 1 inhibitor cyclosporine A (CsA) and additively with the signal 3 inhibitor rapamycin to bloc

295 unilateral visual responses, and interacted additively with them, explaining much of the variance in

296 1P3, regulates epithelial integrity and acts additively with TNF in compromising respiratory barrier

297 nd that the proteases DegS and DegP function additively with VesC and a novel protease, TapA, to degr

298 thin templates, individual units contributed additively, with larger contributions from earlier-activ

299 The two signaling pathways are combined additively, without interactions, and epistasis only ari

300 al SUMO modifications may act redundantly or additively, yet they may mediate dedicated functions as