ライフサイエンスコーパス: additivity

1 ous application of multiple antibiotics (non-additivity).

2 well as negative deviations from the linear additivity.

3 ases we observed significant deviations from additivity.

4 l explanation for the observed recovery time additivity.

5 nct binding sites follows standard energetic additivity.

6 t are not statistically distinguishable from additivity.

7 s expected in both arms, with no significant additivity.

8 y Gaussian curvature and display nonpairwise additivity.

9 orrelation with intensity as rationalized by additivity.

10 d a statistically significant departure from additivity.

11 ug to the statistical model could only yield additivity.

12 e alpha-CTD as a mechanism for their lack of additivity.

13 of Escherichia coli exhibits partial sensory additivity.

14 s that were greater than predicted by simple additivity.

15 greater than that predicted on the basis of additivity.

16 either Sp1 or NF1 alone, indicating lack of additivity.

17 en probability calculated assuming energetic additivity.

18 e dispersion data clearly indicate a lack of additivity.

19 gous genes should result in a deviation from additivity.

20 rom the time average, leading to fitness non-additivity.

21 cocorticoid transcriptional cooperativity or additivity.

22 iting one factor alone associated with infra-additivity.

23 f the same magnitude is termed an isobole of additivity.

24 mbinations in the absence of drug synergy or additivity.

25 imental MPs of the mixtures to evaluate dose-additivity.

26 xifloxacin zones of synergy, antagonism, and additivity.

27 D to a mixture and test the assumption of AH additivity.

28 se a structural mechanism that explains this additivity.

29 of (Gly)n are linear in n, suggesting group additivity.

30 ty and age class on the rate of compensation-additivity.

31 a simple metric for the rate of compensation-additivity.

32 bition assay to determine Bliss' and Loewe's additivities.

33 ile most phenotypic variance is explained by additivity, a third is governed by non-additive effects,

34 nology, but remain unanswered because of non-additivity- a fundamental synergy which allows quantum d

35 mensionless number that, by virtue of stress additivity, accounts for all interactions.

36 SE additivity also has practical utility as the SEs can be

37 ombined toxicity according to the concept of additivity, although slight deviations from additivity w

38 SGNs under depolarizing conditions involves additivity among a depolarization-independent autocrine

39 free energy coupling limit suggested by this additivity analysis ( approximately 4 kcal/mol) is also

40 By applying a free energy additivity analysis to these variants, we quantified the

41 ntify combination effects including synergy, additivity and antagonism.

42 he context of NMDA's roles in neuronal super-additivity and as crucial for evidence integration for d

43 Assuming additivity and biallelism we estimate that identified QT

44 Data were analyzed using Loewe additivity and Bliss independence models for synergy, an

45 esponse surfaces formed by generalized Loewe Additivity and Bliss Independence models of interaction

46 in cause-specific mortality exists, of which additivity and complete compensation constitute particul

47 lasmon resonance binding analysis to dissect additivity and cooperativity in a complex formed between

48 Additivity and maternal dominance accounted for approxim

49 s assessed through departure from risk ratio additivity and multiplicativity after adjustment for age

50 Particularly remarkable is the lack of additivity and potential antagonism found between the pa

51 The method assumes additivity and scales linearly with the number of waters

52 ression alleles revealed substantial genetic additivity and some dominance for both system architectu

53 lation, cis-regulation tends to show greater additivity and stability across different genetic and en

54 perimental agents used in combinations where additivity and synergy have been assessed.

55 n dek1 and cr4 showed elements of epistasis, additivity and synergy, suggesting that the gene product

56 The low degree of both non-additivity and trans-effects on gene expression may pres

57 The additivity and transferability hypotheses underlying thi

58 Assuming intrascaffolding additivity and using the Ka values obtained for OMTKY3 v

59 Sub-additivity and variability are ubiquitous response motif

60 s. Thus, the connection between response sub-additivity and variability quenching may be a canonical

61 ing approaches all predict that response sub-additivity and variability quenching often co-occur.

62 Spearman correlation, additivity and variance stabilization for regression for

63 We identify drugs with synergy, additivity, and antagonism with the Bruton's tyrosine ki

64 are structurally independent show energetic additivity, and changes that intersect show energetic ov

65 e dynamic nature of differential expression, additivity, and regulatory variation imply abundant vari

66 ve natural selection because of their higher additivity, and that the disruption of gene expression b

67 variation due to cis-regulation shows higher additivity; and (iv) genetic divergence between second c

68 liar distance properties, such as metric and additivity, appear to have much less effect on the perfo

69 Herein, we describe a Group Additivity approach to obtain Pourbaix diagrams with ful

70 The additivity approach was also compared with standard mole

71 However, deviations from additivity are common, and molecular interpretations are

72 demonstrate that: 1) curvilinear isoboles of additivity are predicted by a concerted transition model

73 ombinations, we conclude that antagonism and additivity are the most frequent interaction types, in s

74 However, it is not clear how much the additivity assumption affects the reliability of the res

75 We conclude that despite the fact that the additivity assumption does not fit the data perfectly, i

76 ts, combined with potential violation of the additivity assumption in many-species communities, sugge

77 f multiple parallel mass transfer paths, the additivity assumption interestingly overestimates the tr

78 actions with each species in the community ('additivity assumption').

79 hese studies the main conclusion is that the additivity assumption, usually applied in methods to sea

80 nergy could be approximated using a pairwise additivity assumption.

81 tion methods that relax the independence and additivity assumptions between genetic markers.

82 ecourse to crudely justified mean-field-like additivity assumptions.

83 amined for zones of synergy, antagonism, and additivity based on a whole exposure-response surface.

84 were consistent with the findings from Loewe additivity-based drug-interaction modeling.

85 an efficient inhibitor of subtilisin A by an additivity-based sequence to reactivity algorithm (Lasko

86 An additivity-based sequence to reactivity algorithm for th

87 ed, thus providing an additional test of the additivity-based sequence to reactivity algorithm.

88 ion is biased toward greater deviations from additivity because of recessive and dominant alleles, wh

89 est mean FICs for S. aureus, with synergy or additivity being seen in 60% to 80% of isolates.

90 ngst base-paired and neighboring residues to additivity between distant residues.

91 e, while the N218A/I99A variant disrupts the additivity between P2 and P4 specificity.

92 We have previously shown additivity between Taxol and the MEK inhibitor, U0126 in

93 fore, the discrepancies in the extent of sub-additivity between the macaque and the human measurement

94 ghly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depend

95 larger NITM than the EMMs and exhibited NITM additivity, but the EOMs also exhibited prolonged decay

96 I measured quantitative genetic additivity by heritability.

97 I analysed metabolic additivity by the distribution of epistatic effects of p

98 lows successful application of the component additivity (CA) approach based surface complexation mode

99 phases of F-Area sediments), and a component-additivity (CA) based surface complexation model (SCM) w

100 Although the isobole of additivity can be a straight line in some special cases,

101 indicate that epistasis is common, and that additivity can be an emergent property of underlying gen

102 design, the accuracy limitations of pairwise additivity can now be eliminated via polarizable or quan

103 f the scaled-particle theory model, assuming additivity, can also describe the behavior of mixtures o

104 tivity in this system, and allow some of the additivity coefficients to be rationalized on a structur

105 Assuming additivity, combination therapy with both ARBs and beta

106 Such non-additivity, commonly termed an emergent multi-predator e

107 significantly higher level of transcriptomic additivity compared to old polyploids; only 22% were non

108 We draw thermodynamic additivity cycles analyzing the interdependence of P(1)

109 Deviations from bond enthalpy additivity (DeltaBEA) are frequently used to assess the

110 Metabolic additivity describes the interaction between changes in

111 Our findings show that the interplay between additivity, dominance, and epistasis underlies a complex

112 ibiotic sequences and those that lead to non-additivity during antibiotic combination.

113 llic acid, caffeic acid, trolox), synergy or additivity effects were noticed.

114 Response sub-additivity enables the construction of useful interpreta

115 CIs and tested interaction as departure from additivity, estimating relative excess risk due to inter

116 result under dominance and potentially under additivity, even in populations where associated overdom

117 CA) and independent action (IA) to formulate additivity expectations, and Schild plot analyses to inv

118 rimination-with-noise and the brightness-non-additivity experiments showed a double-dissociation betw

119 Additivity experiments suggested the distinct epitopes w

120 n between metabolic and quantitative genetic additivity explained some of the variation in performanc

121 n process adsorption energies based on group additivity fingerprints, combined with transition-state

122 chemical-specific approach that assumes dose additivity for carcinogenic PAHs and (ii) a bioassay-bas

123 pmental dynamics of differential expression, additivity for gene expression, and regulatory variation

124 the nature of the interactions tended toward additivity for most bath salts mixtures, supra-additive

125 in alpha-lytic proteinase, interscaffolding additivity for OMTKY3 and eglin C holds well for the fou

126 hly connected networks had greater metabolic additivity for perturbations to individual networks, but

127 ative pairwise interactions produce apparent additivity for the stabilizing effects of the single mut

128 t be ruled out as it shows similar levels of additivity for two to three substituent systems, which w

129 For those cases where group additivity (GA) results are available, the thermodynamic

130 y new sources of APR have been reported, and additivity has been described for some of these resistan

131 nce onto multisensory sites exhibiting supra-additivity has been proposed as the principal mechanism

132 odes of gene action were observed, including additivity, high- and low-parent dominance, underdominan

133 The degree of additivity, however, was typically small in terms of the

134 ng the recently-developed incremental effect additivity (IEA) synergy theory.

135 However, the deviation from additivity, if it exists, is small.

136 shielding of the CFTR N-terminus, and their additivity implies different modes of action.

137 f a perfect channel; but, our work shows non-additivity in a simple low-noise channel.

138 obust method for determination of synergy or additivity in antibody combinations.

139 nds, cluster calculations also reveal linear additivity in beta(vec) with catenation for all benzoic

140 heir impact on disease liability and exhibit additivity in combination.

141 hoice of concentration scale and demonstrate additivity in DeltaG(tr) of the peptide backbone unit fo

142 rs, highlighting the potential for subgenome additivity in fiber improvement.

143 hat on the gamma and delta subunits shows an additivity in free energy changes for carbamylcholine an

144 Several combinations of inhibitors exhibited additivity in impairing LS or CLSE activity at a lower c

145 Dark-release experiments showing additivity in phase advances suggest that the arrthymici

146 Thus, vitronectin and mAbs demonstrated additivity in the effects on the reaction with target pr

147 Dominance deviance-deviation from additivity in the main or interaction effects-is key to

148 haps surprisingly high degree of substituent additivity in this system, and allow some of the additiv

149 Our data confirmed additivity in those cells lines that undergo paclitaxel-

150 Cytotoxicity assays demonstrated at least additivity in three of the cell lines.

151 ng a bioassay-derived method (BDM) (i.e., an additivity-independent approach).

152 Thus, partial additivity indicates cooperativity, synergy indicates an

153 Near-linear binocular additivity (instead of ocularity invariance) was also fo

154 The principal origin of non-additivity involves the so-called indirect component of

155 As additivity is a very useful property for a distance meas

156 The origin of the lack of additivity is analyzed in detail and qualitatively expla

157 Additivity is defined analogously to a fractional inhibi

158 The high degree of additivity is reflected in a summary statistic for adapt

159 The implication of complete additivity is that structures resistant to both agents (

160 ause of the precomputations and the regional additivities, it is nearly as fast to compute as gammaA

161 e, yet they display a strong and predictable additivity leading to a kinetic resolution of imines der

162 case of endocrine disruption, deviation from additivity may occur and render predictions inconclusive

163 single network, whereas quantitative genetic additivity measures the consistency of phenotypic effect

164 This bond-centered group additivity method for the thermochemical properties of P

165 n of the widely employed atom-centered group additivity method originally proposed by Benson.

166 This is in contrast to the standard additivity method which consistently overestimates the t

167 or ion activity) of the varied metal and the additivity model (concentration-addition or independent-

168 the null hypothesis for both the Loewe dose-additivity model and the Bliss effect-independence model

169 by them provides a quantitatively stringent additivity model for identifying combination effects wit

170 combination analysis is the selection of an additivity model to identify combination effects includi

171 n energies can be accurately described by an additivity model with four parameters that describe the

172 gO(100) bond energies within a pairwise bond additivity model.

173 ) of the varied metal but independent of the additivity model.

174 Additivity observed across a number of series R'(3-n)R(n

175 The strong functional additivity observed for MA-8H9D4 and MA-55F4C12 demonstr

176 There was some association between super-additivity of accessibility and multiplicative or super-

177 ombined transcriptional responses, while sub-additivity of accessibility associated with additive tra

178 uble mutants was studied to characterize the additivity of binding at such sites.

179 ers of such cationic groups of each protein (additivity of binding enthalpies).

180 rse and offers a quantitative definition for additivity of drug effects, relative to which synergism

181 presenting opportunities for explaining non-additivity of effects of multiple factors.

182 ) provides a useful metric of departure from additivity of effects on a relative risk scale.

183 h within the bubble, confirming the expected additivity of effects.

184 We defined interaction as departure from additivity of effects.

185 rigidity within molecular structure and non-additivity of free energy is demonstrated using a thermo

186 The principle of additivity of functional group contribution to partition

187 ip provides a unique system for studying the additivity of gene expression levels in reciprocal hybri

188 pectra of the constructs are consistent with additivity of independently and fully folded CC and CL d

189 s two-state folding is based on the observed additivity of individual mutations to the overall DeltaG

190 It is now shown that the additivity of molar rotations, [M](D) (herein, abbreviat

191 Monte Carlo simulations show that pairwise-additivity of nearest-neighbor interactions is inadequat

192 PMs, but not SMs, exhibited additivity of NITM.

193 The method relies on concepts of additivity of nucleic acids hybridization free energies

194 ne segment, is allele specific and shows non-additivity of phenotypes indicative of a physical intera

195 This additivity of phenotypic manifestations indicates that I

196 Evidence supports biological additivity of phthalate mixture exposures, including the

197 rt a simple thermodynamic model that assumes additivity of preferential interaction between GB and va

198 Assuming additivity of refractive index and using an appropriate

199 gic definition of "interaction" leads to the additivity of risk differences (RDA) as the fundamental

200 This study examined the degree of additivity of several physiologically relevant protein a

201 The additivity of shifts, holding with no exception so far,

202 nt structure and biological activity, assess additivity of substituent effects, identify missing anal

203 tion, a freedom that can explain the partial additivity of the aspartate and maltose responses that i

204 nism responsible for both positivity and non-additivity of the coherent information.

205 he model's predictive power by utilizing the additivity of the driving force.

206 cutoff effect of long-chain alcohols and the additivity of the effect of general and local anesthetic

207 the wild-type enzyme, indicating approximate additivity of the effects of the two arginine mutants on

208 of this study was to experimentally test the additivity of the electrostatic substituent effects (SEs

209 activity as evidenced by (1) the absence of additivity of the Ha-Ras- and c-Fos-mediated inhibition

210 Pairwise additivity of the hydrophobic effect is indicated by rel

211 X and Y positions appears to reflect simple additivity of the individual residues, except when X is

212 of this ordering from Z is attributed to the additivity of the inductive stabilization of XYZCO(-) by

213 uted oligonucleotides were used to probe the additivity of the interactions.

214 By using burst pairs, temporal additivity of the muscle responses was demonstrated both

215 The additivity of the SEs was assessed using a small molecul

216 The additivity of the two drugs on glutamate release is cons

217 mixture could not be accounted for by simple additivity of the two individual spectra, indicating a c

218 r of the singly modified Hbs, with a partial additivity of the two modifications.

219 Of these, 408 proteins showed quantitative additivity of the two parental profiles in T. mirus (bot

220 lumacaftor and tezacaftor) and demonstrated additivity of these treatments.

221 Several studies imply pervasive non-additivity of transcription, transgressive segregation a

222 rmally fluctuating DNA, we conclude that the additivity of writhe applies also to randomly distorted

223 ental manipulations that elicit response sub-additivity often also quench response variability.

224 epidemiologists believe that departure from additivity on a log scale implies that two factors inter

225 lations reveal strong deviations from linear additivity on a prototypical surface comprising surface

226 n of both pairs is consistent with models of additivity on either the log odds of the penetrance, or

227 We assessed departures from additivity on the absolute risk scale between 9 establis

228 and Idd5 we would also not reject a model of additivity on the penetrance scale, which might indicate

229 icoid-dependent transcription reduced (infra-additivity) on cotreatment.

230 : (i) combination therapy is consistent with additivity or (ii) combination therapy is equivalent to

231 s represent limiting cases of either partial additivity or antagonism.

232 Even when drug combinations exhibit additivity or synergy in pre-clinical models, patient-to

233 Exposures associated with additivity or synergy were then combined and the regimen

234 and various cancer cell lines, exert potent additivity or synergy with existing chemotherapeutics in

235 ture was 1.05 (95% CI: 1.02, 1.09), assuming additivity, or 1.13 (95% CI: 1.06, 1.20), considering po

236 The additivity parameters reflect the role of fluorine as an

237 ood understanding of the synergistic and the additivity phenomena.

238 calculated from the assumption of component additivity possibly caused by surface modifications stem

239 Applying this Group Additivity-Pourbaix approach to Group 13 elements, we ar

240 This assay was validated through linearity, additivity, precision and recovery, demonstrating that t

241 ive organo-metal complexes, analogous to the additivity principle for predicting molar volumes of org

242 nd (i.e. overshadowing), consistent with the additivity principle posited by theories of associative

243 capacity could be distinguished by applying additivity principles.

244 ned directly from the measurements using the additivity properties of polarization.

245 mine if dual inhibition of these pathways is additivity protective.

246 Departures from additivity reflect interaction of the two residues.

247 A similar additivity relationship describes the enthalpies of prot

248 in aqueous mixed-salt solution by using the additivity rule of the Setschenow coefficients of the in

249 ecific volume than that expected from volume additivity rules, indicative of specific protein-deterge

250 o those expected on the basis of bond dipole additivity rules.

251 An additivity scheme for approximating the energy of a mixe

252 A new additivity scheme, the layered composite method (LCM), y

253 Stabilities predicted on the basis of additivity show good agreement with experimental values

254 Pharmacological additivity studies showed that this Q-component contribu

255 cant anesthetic potency, individually and in additivity studies with hexanol, using immobility in tad

256 Cotransfection and additivity studies with the poly(A) RNase (PARN) demonst

257 Pairwise additivity suggests that the hydrophobic effect is prima

258 concentrations applied, mixtures resulted in additivity, synergism, or antagonism in terms of total w

259 hods for data analysis for the assessment of additivity, synergy, and antagonism that can be applied

260 Additivity, synergy, or competition was observed with MI

261 cell culture; however, no determinations for additivity/synergy have been applied with these compound

262 tiviral and F508del-CFTR correction potency, additivity/synergy with lumacaftor, and a promising in v

263 Numerous studies have demonstrated additivity/synergy with several HDAC inhibitors and stan

264 Applying Giddings' additivity test, based on alternatingly making the diffu

265 tes in real proteins show significantly more additivity than those obtained from random simulations.

266 sites, and evaluated the assumption of dose additivity that is routinely employed to calculate the r

267 ially, however, on the deviation from payoff additivity that occurs when both interacting individuals

268 polyploids can show deviation from parental additivity (the arithmetic average of the parental expre

269 Assuming additivity, these five interactions can contribute 7.4 k

270 ured by real-time polymerase chain reaction, additivity to clinical factors, and reclassification of

271 However, the lack of Deltalog(d) additivity undermines quantitative comparisons of distin

272 controlled through controlling the amount of additivities using the MCU.

273 0 +/- 4.1 kcal/mol that agrees with the bond additivity value of 109.3 +/- 2.1 kcal/mol.

274 Neighbor-pair additivity was also observed for (dA@dT)-tracts at melti

275 Additivity was assessed by estimating the reduced excess

276 Good additivity was found for the concerted action of magaini

277 Additivity was found to work well for m-benzoquinone, bu

278 Previously, non-additivity was known to occur in very noisy channels wit

279 Considerable departure from additivity was not observed for other defects.

280 nonsilent sites than in silent sites, while additivity was observed only in silent sites.

281 dest additive antitumor effects; however, no additivity was observed with maximal VEGF inhibition in

282 as observed in intact cell studies, and this additivity was recapitulated in experiments in which act

283 To explain this unexpected additivity, we examined the Epo gene and found that its

284 However, no analyses for additivity were conducted in these studies.

285 additivity, although slight deviations from additivity were observed at a few mixture concentrations

286 The efficacy of polypharmacy showed additivity when gentamicin or ceftazidime/gentamicin wer

287 ations to individual networks, but had lower additivity when measured by the average effect of a gene

288 t was with beta2GRK(-), with no evidence for additivity when PKA sites were also removed.

289 tic interactions near the data, but approach additivity where data is sparse or absent.

290 There was also evidence of PCB-DDE additivity, where exposure to both compounds reduced ant

291 consistent with neighbor-pair thermodynamic additivity, where the stability constant, sij , for diff

292 start with the evaluation of consistency and additivity with a sufficiently large number of different

293 dot1Delta, but rad18Delta and rad5Delta show additivity with bre1Delta, dot1Delta, and each other.

294 IL-1beta-induced transcription showed infra-additivity with IL-1beta-plus-glucocorticoid.

295 and degradation of this protein, and showed additivity with N-benzoyloxycarbonyl (Z)-Leu-Leu-leucina

296 ibiting synergy with platinating agents, and additivity with paclitaxel.

297 ver, this effect was transient and showed no additivity with shock.

298 r bovine and human microvascular EC, with an additivity with VEGF.

299 Deviations from parental chromosome additivity within T. mirus individuals also did not reac

300 th the moxifloxacin-linezolid regimen in the additivity zone vs 0.083 +/- 0.011 per day with standard