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1 , and a structurally unidentified nucleoside adduct.
2 oxidative cleavage of the intermediate diol adduct.
3 cess and in the stability of the final bound adduct.
4 d to the persistence of this detrimental DNA adduct.
5 etrachloro-o-benzoquinone to afford a Ge(IV) adduct.
6 own the recovery of the light-induced flavin adduct.
7 e and is required for DNA synthesis past the adduct.
8 carbene-carbodiimide (NHC-CDI) zwitterionic adduct.
9 three degradation products of the PBN-peroxy-adduct.
10 970 by Houk et al. and shown to give a [6+4] adduct.
11 r the monodentate attack leading to an ozone adduct.
12 precedented reactivity of metal-iodosylarene adduct.
13 u)ArO)(3)tacn)U(III)((Me)cy-C6)].((Me)cy-C6) adduct.
14 ed to affect the formation of the oligomeric adducts.
15 ding UV-induced photoproducts and bulky base adducts.
16 to fully protect ssDNA created by cisplatin adducts.
17 tions of expected and isomerized Diels-Alder adducts.
18 R titrations show exclusive formation of 1:1 adducts.
19 ABCC1 has strong selectivity for glutathione adducts.
20 rs such as NHC(H)[HCO(3)] salts or NHC-CO(2) adducts.
21 and twelve-membered rings are un-rearranged adducts.
22 e, along with elevated levels of MGO protein adducts.
23 s well as minor-groove and exocyclic guanine adducts.
24 veral three-dimensional bicyclic Diels-Alder adducts.
25 hyl, pentafluoroethyl, and heptafluoropropyl adducts.
26 quantum chemical characterizations of ozone adducts.
27 -226 in apoA-I are modified by ONE ketoamide adducts.
28 with increase in the steric bulkiness of the adducts.
29 ntion by forming intracellular macromolecule adducts.
30 dimethylfulvene (1978) gave [6+4] and [4+2] adducts.
31 atom or hydride transfer from the sigma-H(2) adducts.
32 rabbits and patients on hemodialysis had HNE adducts.
33 eath by forming intrastrand dinucleotide DNA adducts.
34 ffective approach for detection of bulky DNA adducts.
35 t of adenosine radicals as N-7 hydrogen atom adducts.
36 n) activity, as measured by formation of DNA adducts.
37 rge state nor on the presence of nonspecific adducts.
38 imilar appearance as covalent hapten-protein adducts.
39 tterionic carborane-1,2-bis(silylium) AdN(3) adduct 2 with an open-cage dianionic nido-C(2) B(10) clu
41 he positive ion mode analysis of [M + Na](+) adducts, a sensitivity increase by about a factor of 10
43 entify, locate, and quantify a mutagenic DNA adduct, advancing tools for linking DNA alkylation to mu
49 utions to form a zwitterionic alkylcarbonate adduct and was actively engaged in key catalytic steps s
52 on mechanisms, we directly monitored protein adducts and identified 120 and 37 unique peptides with i
55 a number of previously unrecognized complex adducts and neutral losses generated during the ionizati
56 at this source is prone to formation of salt adducts and noncovalent compounds in samples enriched wi
58 vide a general entry to redox-active NHC-CDI adducts and their persistent radical ions for various ap
60 ons with much fewer and low-intensity sodium adducts and therefore greatly simplified glycan profiles
63 butions created by residual solvation, ionic adducts, and post-translational modifications creates a
65 rmed experiments prove that water and alkoxy adducts are formed not only during temperature processin
67 simulations predicted that nonspecific salt adducts are less prevalent for IEM-generated protein ion
68 at higher fractional excretions of glycation adducts are potential biomarkers for early GFR decline i
70 stable, nonreducible copper(II)-glutathione adducts are recognized and, in turn, effluxed by ABCC1.
75 hanism allows access to both traditional C-N adducts at room temperature as well as a large range of
76 ylidene (BAC) on Au(111) using the molecular adduct BAC-CO(2) as a precursor and determine the struct
77 l-pyridine, the deprotonation of the initial adducts became faster, which allowed the rate of the att
78 ctural alternatives to peptides and covalent adducts between amino acids/peptides and other classes o
80 a neutral S= 1/2 and an anionic S=0 Co-H(2) adduct, both supported by a trisphosphine borane ligand
81 ial basis for site-specific detection of DNA adducts, but the availability of effective artificial nu
82 ficial nucleotides incorporated opposite DNA adducts by engineered DNA polymerases offers a potential
83 Impaired tubular reuptake of glycation free adducts by lysine and arginine transporter proteins in p
84 tein glycation, oxidation and nitration free adducts by stable isotopic dilution analysis liquid chro
86 -inositol hexakisphosphate (IP6) noncovalent adduct can substantially enhance IRMPD for nonphosphopep
92 rs independently of both O(6)-methyl guanine adduct cytotoxicity and MUTYH-dependent glycosylase acti
93 c molecular switch, donor acceptor Stenhouse adduct (DASA), that enable its use for self-regulating l
94 inetics of oxidation, spin trapping and spin-adduct decay should be known first in bulk oils for corr
96 idation of Gd(3)N@I(h)-C(80) tris- and tetra-adducts, density functional theory (DFT) calculations we
97 e amine employed in the synthesis of the Ugi adducts, different unsaturation degrees could be obtaine
98 us to infer the chemical compositions of the adducts directly from the data without any prior assumpt
99 One tether lead to a strikingly different adduct distribution for the E and Z isomers, indicating
100 NS-GAS mice and gerbils and attenuated isoLG adducts, DNA damage, and somatic mutation frequency.
102 d isoindolinones from 1,3-dicarbonyl Ugi-4CR adducts, employing an aromatic radical cyclization proce
104 Metadynamics simulations revealed that BTZ adducts favor a closed conformation of MGL that occludes
106 BX) oxidation of Morita-Baylis-Hillman (MBH) adducts followed by catalyst-free indolizine conjugate a
108 ctly as toxicity and directly measured bulky adduct formation and removal from the genome by slot blo
109 factors control the thermodynamics of Lewis adduct formation for iodonium ions and carbenium ions.
111 , although important differences linked with adduct formation in high-salt conditions explain the mol
113 neurotoxicity and formation of DNA-platinum adduct formation in neurons but not in cancer cells.
119 mass difference between peaks can arise from adduct formation, fragmentation, or different biological
120 es showed the highest bioactivation rate for adduct formation, in which all four cysteines of hGSTP r
122 required for photostabilization, or Cy-thiol adduct formation, necessary for super-resolution microsc
123 Based on clinical observations, the speed of adduct formation, skin and in vitro tests to inert drug
124 In this model, EtHOBA significantly reduced adduct formation, tumorigenesis, and dysplasia severity.
129 electrospray ionization (nano-ESI) show less adduct formation; however, a decrease in the number of h
130 served Gibbs reaction energies for the Lewis adduct formations from iodonium ions and Lewis bases ori
131 We present the structure of a novel solvate adduct formed by dissolving ferrocene, FeCp(2), in hexaf
133 sight into features driving the stability of adducts formed from the chemoselective coupling of oxazi
134 the relative stabilities of tris- and tetra-adducts formed upon Prato functionalization of the most
136 an exemplar, activation of an O-alkylisourea adduct, formed in situ, allows effective nucleophilic fl
138 step-by-step protocol to purify protein-RNA adducts, free protein and free RNA from the same sample.
140 GPL cations, UVPD of deprotonated or formate-adducted GPLs yields diagnostic fragment ions spaced 24
141 ment-based ligand discovery by modifying the adduct group (AG) and LG with functional groups of diffe
142 )] with a commercially available alane amine adduct (H(3)Al.NMe(2)Et) in toluene resulted in the form
143 howed how the compositions of the oligomeric adducts had typically only minor differences between win
144 domain by preventing the formation of lipoyl adducts, highlighting ABHD11 as a regulator of functiona
145 re the only primate that walk bipedally with adducted hips, valgus knees, and swing-side pelvic drop.
146 e double bond of the bicyclo[3.2.1]oct-2-ene adduct illustrated the potential postfunctionalization o
147 exposure on the formation of cysteine-phenol adduct in meat added 4-methylcatechol (4MC), a model pol
154 ylation to mutagenesis and for detecting DNA adducts in genes as potential diagnostic biomarkers for
155 leading to the corresponding hydroalkylated adducts in good isolated yields and high selectivity (38
156 ry methodology, we identified DNA nucleoside adducts in gravid females of the Baltic amphipods Monopo
157 nd facilitates the removal of 5-AR glycation adducts in live cells, supporting the dynamic regulation
159 el lesions, we show that HR induced by bulky adducts in mammalian cells predominantly occurs at post-
160 cts, glycation, oxidation and nitration free adducts in patients with type 1 diabetes (T1DM) during o
162 n of oligomeric proanthocyanidin-anthocyanin adducts in red wines have often focused only on a limite
167 (4)-pyridyloxobutylthymidine, which is a DNA adduct induced by tobacco-specific N-nitrosamines, in vi
171 reveal an irreversible mechanism of heme-ART adduct inhibition of heme crystallization, unique among
173 sed on the sodiated to protonated/ammoniated adduct ion ratios of applied internal standards to corre
174 results show that for some metabolites, the adduct ion signals can be >200-fold higher than the sign
180 inctly, the most electron-deficient superoxo adduct is observed to react the fastest, specifically wi
182 though the subsequent release from the IEDDA adduct is slower, we believe that this new reaction may
184 ificial nucleotides that insert opposite DNA adducts is extremely limited, and furthermore, there has
185 is postulated that formation of DNA-platinum adducts is responsible for both its cytotoxicity in canc
186 s catalytic intermediate-a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)-is stab
187 tabolites can modify macromolecules and form adducts known as nonenzymatic covalent modifications (NE
192 PA specificity for the helix-distorting base adduct N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene o
193 NHC nucleophile (IMe(4)) to yield the Lewis adduct [{(NHC)C(Ph)}P(IMe(4))]Fe(CO)(4) (5) [IMe(4) = C(
198 the formal dehydration of a hydroxyl radical adduct of dG as well as by deprotonation of the correspo
199 7-TM structural topology and an intermediate adduct of finasteride and NADPH as NADP-dihydrofinasteri
200 stem is provided by a protonated Schiff base adduct of retinaldehyde and taurine (A1-taurine, A1T) th
201 (1) H NMR spectroscopic studies on the 1:1 adduct of the pentasaccharide Fondaparinux (FPX) and the
202 of isotopically enriched (15)N(2) and (13)CO adducts of 1, HYSCORE experiments allowed for the measur
203 of stable CO and 2,6-xylylisocyanide (XylNC) adducts of 1, which display EPR features akin to those o
205 ic properties of megadalton-sized dityrosine adducts of alphaSyn that form in the presence of reactiv
206 pidemic LDLR(-/-) mice, including cross-link adducts of apoA-I His-165-apoA-I Lys-93, apoA-I His-154-
207 l theory calculations reveal pai stacking in adducts of complex 1 and NADH, facilitating photoinduced
208 a Michael-type addition to Diels-Alder (DA) adducts of furylated drugs and acetylenedicarboxylate de
209 nts measurements of pristine, bis-, and tris-adducts of Gd(3)N@C(80) suggested that the rotation of t
211 rystal structures of 18(1),18(2)-DHBV and BV adducts of JSC1_58120g3 along with structure-guided muta
215 However, the formation of hydroxy and alkoxy adducts of stevioside and of its hydrolysis products has
216 We further showed that covalent disulfide adducts of this residue promote autophosphorylation of t
217 ative reactive nitrogen species may generate adducts of tyrosine and/or cysteine residues, causing CY
226 amphipods Monoporeia affinis, and linked the adduct profiles to the frequency of embryo malformations
227 of a mass spectrometry method to identify OP-adducted proteins from complex mixtures in a nontargeted
229 ly ring-opened to produce ketone-based aldol adducts, providing an alternative to the Mukaiyama aldol
230 on the rates of both spin trapping and spin-adduct quenching affecting the levels of radicals observ
233 c) The generation of covalent hapten-protein adducts requires hours, either because the formation of
235 sidues of proteins to form glutathione (GSH) adducts, S-glutathionylation, that are selectively remov
236 s the potential for fast multienzyme protein adduct screening with high efficiency and accuracy.
237 k C-H bonds, suggesting that the alkyl azide adducts serve as viable species for C-H amination when t
242 Modeling studies suggest that the Tyr 85 adduct stabilizes the Keap1-Cul3 complex, thereby enhanc
243 Molecular modeling of the resulting Michael adduct suggested stabilization of the co-substrate and a
244 y conjugation with N-acetylgalactosamine, an adduct that targets their delivery to the primary site o
245 es not detect potentially carcinogenic bulky adducts that can arise when metabolic enzymes convert pr
246 in a partially oxidized state form cysteine adducts that induce an open-to-closed conformational cha
247 rs (e.g., at least 1140 isomers for the tris-adduct), the limited number of isomers obtained indicate
249 stabilities of the potential tris- and tetra-adducts, the structures of the isolated adducts were elu
250 rom ca. 35:65 (free FPX) to ca. 75:25 in the adduct; the first demonstration of a small molecule affe
252 nderthals, consistent with more extended and adducted thumb postures that may reflect habitual use of
256 ively reduces the number of nonspecific salt adducts to biological molecules, therefore increasing th
257 collision induced dissociation of amino acid adducts to discern (13)C- and (15)N- isotopologues of am
258 ituents to the phenolate caused the thiolate adducts to dissipate over time for p-QM regeneration.
259 e intramolecular Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield an
260 s the potential of synthetic heme superoxide adducts to mimic the bioinorganic chemistry of indole di
261 High levels of 4-hydroxynonenal protein adducts together with increased NADPH (nicotinamide aden
262 ve the expected iminophosphorane-phosphonium adduct, trialkylphosphines (PCy(3) and PEt(3)) surprisin
264 ted conjugated substrates can give different adducts via metal catalyst-, Lewis acid- and solvent-dep
268 Y(3)N@I(h)-C(80) adducts found that the tris-adducts were all-[6,6]- or [6,6][6,6][5,6]-isomers and t
269 mounts of acetaminophen metabolite and hGSTP adducts were compared with 10 different cyt P450 enzymes
272 oil demonstrated that mainly alkoxyl radical adducts were detected, to which rapidly decomposing pero
277 6 lysine and arginine-derived glycation free adducts were higher in patients with early decline in GF
278 dition, mono-substituted patulin-glutathione adducts were identified as the main type of generated co
282 inds to the DRS of ERK2 and forms a covalent adduct with a conserved cysteine residue (C159) within t
283 ase, generating a (mu-1,2-peroxo)diiron(III) adduct with a low O-O stretching frequency of 825 cm(-1)
285 ystallography on selected derivatives in the adduct with hCA II as a model study allowed to determine
286 eacts with PSD's substrate, PS, producing an adduct with lower fluorescence yield than that of PE.
287 1_58120g3 can also yield a far-red-absorbing adduct with the more widespread linear tetrapyrrole bili
289 hich favors isomerization as well as forming adducts with ancillary ligands, freeing coordination sit
291 lently to Keap1 by forming permanent Michael adducts with eight different cysteines, and acyl adducts
293 ross-linked by oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of anoth
296 urther analysis of specific proteins forming adducts with SecoA identified the phagocytic receptors C
297 We detected the formation of acrylamide adducts with thiol groups from both metabolites and prot
298 rotein binding and processing to the derived adducts) with HLA proteins that present the drug-peptide
300 ia coli leads to the accumulation of several adducts within RNA, including N(1)-methyladenosine (m(1)