ライフサイエンスコーパス: adduct formation

1 target for thiol-reactive molecules through adduct formation.

2 loxifene bioactivation, based on glutathione adduct formation.

3 n of metal-BMAA complexes in addition to the adduct formation.

4 operoxide was responsible for endogenous DNA-adduct formation.

5 and, at the same time, reduces analyte-salt adduct formation.

6 and 11-HETE but did not inhibit HepsilondGuo-adduct formation.

7 opposite to Ade by DNA polymerases following adduct formation.

8 nderstanding the mechanistic implications of adduct formation.

9 mbiguous assignment of the regiochemistry of adduct formation.

10 contact with the cysteine sulfur involved in adduct formation.

11 hotochemistry indicative of cysteinyl-flavin adduct formation.

12 much interest has focused on the role of DNA adduct formation.

13 (ERK)2 with hypothemycin confirmed covalent adduct formation.

14 s in 4-hydroxy-2-nonenal and 3-nitrotyrosine adduct formation.

15 relationship between PhIP metabolism and DNA adduct formation.

16 hat thiols serve to scavenge dopaquinones by adduct formation.

17 governing detoxification through the rate of adduct formation.

18 5'-neighboring (Me)C inhibited O(6)-guanine adduct formation.

19 hannels include multiple proton transfer and adduct formation.

20 fusion in vitro as measured by nitrotyrosine adduct formation.

21 analysis (COVINA) to investigate metabolite adduct formation.

22 s no increase in the extent of cisplatin-DNA adduct formation.

23 cisplatin inactivation or inhibition of DNA adduct formation.

24 ut do not reduce the extent of cisplatin-DNA adduct formation.

25 , and subsequent dehydration is proposed for adduct formation.

26 t with the perturbations expected upon C(4a) adduct formation.

27 , genomic hypomethylation, and/or enzyme-DNA adduct formation.

28 flavin charge-transfer intermediate prior to adduct formation.

29 lled by the cross-metathesis step but not by adduct formation.

30 -1-pyrroline N-oxide (DMPO) hydroxyl radical adduct formation.

31 ique class of fatty acids involved in HNE-dG adduct formation.

32 in a mechanism-based reaction involving heme adduct formation.

33 to and including enzyme-nucleotide covalent adduct formation.

34 ation at the active site and not to covalent adduct formation.

35 nsfer, hydrogen atom abstraction and radical adduct formation.

36 tensity enhancement concomitant with protein adduct formation.

37 ndancy of LC-MS metabolomics data comes from adduct formation.

38 perties inherent to phenolic compounds after adduct formation.

39 d by O3 exposure causes observable lipid-LXR adduct formation.

40 added base is suppressed by Lewis acid/base adduct formation.

41 ol moiety, thus leading to catalyst-acceptor adduct formation.

42 ess through reversal of formaldehyde-protein adduct formation.

43 ation, and there are no complications due to adduct formation.

44 ncrease in the pai-stabilization energy upon adduct formation.

45 503034 (boceprevir) benefited from covalent adduct formation.

46 ound that this insult leads to retinal isoLG-adduct formation.

47 rresponds to H154R of L-A Gag, abolishes cap adduct formation.

48 Feeding 5% LBRs also significantly inhibited adduct formation (64%) after NMBA administration at 0.50

49 However, MDA adduct formation, a marker of lipid peroxidation, was no

50 os found in vivo resulted in protein monomer-adduct formation across a range of concentrations.

51 Slow adduct formation also occurs starting with NADH and INH,

52 ation of even-electron molecular ions due to adduct formation also plays a major role in ion formatio

53 pendent aspects, i.e., (i) peak splitting by adduct formation and (ii) protein ion suppression.

54 tation of LKB1 lysine residue 97 reduced HNE adduct formation and attenuated the effect of HNE on LKB

55 nnotation process, such as isotope patterns, adduct formation and biochemical relations.

56 correlations were found between pimonidazole adduct formation and both baseline tumor R2* (r = -0.54,

57 The frequency of DNA adduct formation and c-Ha-ras mutations was the same in

58 and the H154R mutation abolishes both m(7)Gp adduct formation and cap snatching.

59 prevented 5, 5-dimethyl-1-pyrroline N-oxide adduct formation and changed the spectra of the MNP and

60 NE (10 mum for 1 h) and assayed for HNE-LKB1 adduct formation and changes in LKB1 kinase activity.

61 he cause and effect relationship between HNE adduct formation and COX inhibition was examined in vitr

62 Kinetic analysis of O2(*-) adduct formation and decay using singular value decompos

63 ed only marginal protection against [3H]BPDE adduct formation and did not affect sensitivity to BPDE-

64 t not arginine completely abrogated covalent adduct formation and DNA cleavage, whereas the DNA-bindi

65 O-aspirin 2 inhibited [3H]benzo[a]pyrene-DNA adduct formation and DNA damage elicited by TCDD or benz

66 for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in

67 HNE adduct formation and HO-1 expression were assessed by im

68 h tandem mass spectrometry confirmed monomer adduct formation and identified the major adduct species

69 have developed methods to measure cisplatin adduct formation and its repair at single-nucleotide res

70 l reaction showed direct correlation between adduct formation and miR-141 concentration.

71 ultraviolet A-induced 8-methoxypsoralen-DNA adduct formation and p53 protein accumulation were inhib

72 These findings demonstrate that adduct formation and protein ion suppression are indeed

73 direct proof of CYP1B1-mediated, E2-induced adduct formation and provide the experimental basis for

74 of NAEbeta mutants revealed slower rates of adduct formation and reduced adduct affinity for the mut

75 ctly as toxicity and directly measured bulky adduct formation and removal from the genome by slot blo

76 quitin adducts suggest that both the rate of adduct formation and the affinity between the adduct and

77 nd determine the relationship between stable adduct formation and turnover.

78 nge assays, and both a slow rate of covalent adduct formation and weak adduct binding to Uba6 contrib

79 g domain, protects the protein against DOPAL adduct formation and, consequently, inhibits DOPAL-induc

80 d a protective effect at the initiation (DNA adduct formation) and promotional (aberrant crypt foci)

81 s metabolic stability, plasma stability, GSH adduct formation, and aniline mutagenicity.

82 -Im induce cytoprotective genes, inhibit DNA adduct formation, and dramatically block hepatic tumorig

83 We quantified the cytotoxicity, DNA adduct formation, and induction of mutations in the cII

84 hich involves redox cycling and nucleophilic adduct formation, and it suggests possible routes of syn

85 cumulation and extravasation, chlorotyrosine adduct formation, and liver injury were reduced.

86 ation of nonmolecular ions, which arise from adduct formation, and the possibility of distinguishing

87 Covalent flavin adduct formation appears to be the only modification bec

88 For most carbonyls, rate coefficients for adduct formation approach the predicted maximum collisio

89 interactions), and product stabilization via adduct formation are found to be crucial for facilitatin

90 gene, suggesting that factors other than NNK adduct formation are responsible for mutagenesis at thes

91 Sites of the 2'-O-adduct formation are subsequently scored as stops to pri

92 rrelation suggests that H-abstraction and Cl-adduct formation are the major reaction mechanisms.

93 and also on intermediate markers such as DNA adduct formation, are discussed.

94 arly complete protection against HNE-protein adduct formation as well as HNE-induced apoptosis.

95 both stable and unstable (depurinating) DNA adduct formation as well as reactive oxygen species.

96 The extent of adduct formation at (15)N-labeled guanine was determined

97 Overall, the precise location of adduct formation at C5 vs C8 of guanine appears to be di

98 t codon 14 but did not affect carcinogen-DNA adduct formation at codon 12.

99 codon 12 also did not enhance carcinogen-DNA adduct formation at codon 12.

100 of codon 14, greatly enhanced carcinogen-DNA adduct formation at codon 14 but did not affect carcinog

101 This preferential carcinogen-DNA adduct formation at codons 12 and 14 could result from e

102 In contrast, this preferential DNA adduct formation at codons 12 and 14 was not observed in

103 reveal that RNF4 depletion impairs ubiquitin adduct formation at DSB sites and causes persistent hist

104 duct formation at those sites while reducing adduct formation at non-CpG sequences.

105 ubstitution to benzoic aldehyde/acid, and by adduct formation at the amine group ( N-acylation with a

106 us electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whereas the

107 ge) protein, couples light-induced cysteinyl adduct formation at the flavin ring to conformational ch

108 CpG sites greatly enhances MC and MS-NMA DNA adduct formation at those sites while reducing adduct fo

109 sures to aflatoxin (AFB1) and subsequent DNA adduct formation being a significant driver.

110 high in magnitude as -4, with the degree of adduct formation being inversely related to dendrimer ge

111 asis for this effect, demonstrating covalent adduct formation between 1 and the protein.

112 CO poisoning also causes adduct formation between myelin basic protein (MBP) and

113 uppression of the effect of the variation of adduct formation between samples, and (4) normalization

114 The reaction proceeds by preliminary adduct formation between the alkyne and OH radical, with

115 RIP3-deficient mice had no effect on protein adduct formation but attenuated all other parameters, in

116 tion hotspots coincided with sites of strong adduct formation, but not all of the adduct hotspots wer

117 e laboratories observed different amounts of adduct formation, but this did not appear to be related

118 an hepatic cytosolic samples to catalyze DNA adduct formation by 3-NBA.

119 n hepatic microsomal samples to catalyze DNA adduct formation by 3-NBA.

120 Intrastrand adduct formation by DEB was investigated by a novel meth

121 Inhibition of adduct formation by dicoumarol, an NQO1 inhibitor, suppo

122 able to conditions of immunoprecipitation or adduct formation by eight cross-linkers of diverse space

123 e mutagenicity and potential consequences of adduct formation by reactive intermediates in target ute

124 The kinetics of reversal of adduct formation by release of the conjugated 2,4-diene

125 Covalent adduct formation by sulfamethoxazole hydroxylamine was d

126 d in the minor groove of DNA is critical for adduct formation by the endogenous mutagens MDA and base

127 rces of information (e.g., isotope patterns, adduct formation, chromatographic retention times, and f

128 forth in which silane is activated via sigma-adduct formation cis to the ReX bond followed by heterol

129 Furthermore, sodium adduct formation commonly occurs using positive ion ESI

130 nous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts for

131 The rate of a given adduct formation depended on the combination of the solu

132 multiple proton transfer, with the degree of adduct formation dependent upon both the size of the pol

133 A sequences, with over 5-fold differences in adduct formation depending on sequence context.

134 nding with low-energy barriers or stable CO2 adduct formation depending on the phosphines donor abili

135 to a significant extent by HNE, but some HNE-adduct formation did occur.

136 Adduct formation disrupts hydrogen bonding in the active

137 e potential and terminating in oxidative DNA adduct formation, DNA strand breakage, and cell death.

138 east) an F(+) for O transposition occurs via adduct formation followed by 1,3-atom transfer and then

139 )2) showed that it proceeded by initial MeNC adduct formation followed by an isomerization involving

140 Several mechanisms are proposed for O2 adduct formation followed by decomposition to NO3- or by

141 Y(2)BCl, or by initial (heteroarene)AlCl(3) adduct formation followed by deprotonation and transmeta

142 the CYP1B1-mediated oxidation reaction, the adduct formation followed Michaelis-Menten kinetics.

143 factors control the thermodynamics of Lewis adduct formation for iodonium ions and carbenium ions.

144 mass difference between peaks can arise from adduct formation, fragmentation, or different biological

145 utilizes discrete oxidizing species in heme adduct formation from aldehydes.

146 mechanism of tumorigenesis that involves DNA adduct formation from COX-2-mediated lipid peroxidation

147 LS are reported to increase hydroxyl radical adduct formation from hydrogen peroxide as measured by s

148 served Gibbs reaction energies for the Lewis adduct formations from iodonium ions and Lewis bases ori

149 This slow process of stable adduct formation has the advantage that it may give time

150 electrospray ionization (nano-ESI) show less adduct formation; however, a decrease in the number of h

151 nine markedly decreased the observed O(2)(.) adduct formation; however, O(2)(.) generation from the e

152 rmore, vitamin E diminished aldehyde-protein adduct formation in activated extracts, which suggests t

153 The method can be applied to compare AA-DNA adduct formation in cells and tissues.

154 psoralen, have been shown to direct psoralen adduct formation in cells, leading to mutagenesis or rec

155 induced cytotoxicity, mutagenicity, and DNA adduct formation in Chinese hamster ovary (CHO) cells.

156 e charge carriers show essentially exclusive adduct formation in converting protonated peptides and p

157 LOV2 showed a nearly 5-fold slowing of adduct formation in D(2)O relative to H(2)O, indicating

158 , the results suggest a causal role for drug adduct formation in diclofenac enteropathy.

159 ulted in 70-90% reduction in the covalent 3H-adduct formation in DNA or RNA isolated from the GSTP1-t

160 Adduct formation in duplex DNA was somewhat dependent on

161 ces liver tumors in rodents and covalent DNA adduct formation in hepatic DNA.

162 , although important differences linked with adduct formation in high-salt conditions explain the mol

163 Therefore, it is necessary to analyze adduct formation in HILIC metabolomics.

164 Inhibition of DNA adduct formation in human liver microsomes by alpha-lipo

165 ization, and a lack of information regarding adduct formation in mass spectrometry techniques utilizi

166 only one low-energy transition structure for adduct formation in mPW1K calculations, but quasiclassic

167 nuclear DNA mutations and demonstrated B[a]P adduct formation in mtDNA.

168 neurotoxicity and formation of DNA-platinum adduct formation in neurons but not in cancer cells.

169 sk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vit

170 Dapsone hydroxylamine also caused covalent adduct formation in normal human epidermal keratinocytes

171 used to investigate the question of TAM-DNA adduct formation in primates.

172 not due solely to the blocking of sensitizer adduct formation in skin.

173 ptake, aqueous reactivity, and extent of DNA adduct formation in the A2780 ovarian carcinoma cells fo

174 associated with increased nitrotyrosine (NT) adduct formation in the lungs, heart, and plasma and inc

175 m treated women, suggesting that dG-N(2)-tam adduct formation in the p53 gene is not a prerequisite f

176 By comparing 3-NBA-DNA adduct formation in the presence of cofactors of NAD(P)H

177 of analytes in the MALDI plume and reducing adduct formation in the resulting mass spectra.

178 h which to evaluate the potential for LG-DNA adduct formation in vivo.

179 Hepatic DNA adduct formation, in vivo mutagenicity, and hepatocarcin

180 es showed the highest bioactivation rate for adduct formation, in which all four cysteines of hGSTP r

181 ) were added to cytosolic samples, 3-NBA-DNA adduct formation increased 10- to 35-fold.

182 etween the 2 sexes with higher levels of DNA adduct formation, increased CYP1A1 expression, decreased

183 Analysis of initial rates of adduct formation indicated that these reactions did not

184 h potassium cyanide prevented detectable MNP adduct formation, indicating heme involvement in the rea

185 By increasing DNA-platinum adduct formation, indicating increased access of the dru

186 of NDH significantly inhibited NDH-DMPO spin adduct formation, indicating involvement of protein thiy

187 17 alone, indicating that Seco A-LXR protein adduct formation inhibits LXR activation by traditional

188 DNA damage by adduct formation is a critical step for the initiation o

189 results suggest that targeted carcinogen-DNA adduct formation is a major reason for the observed high

190 alase-peroxidase (KatG) function, and IN-NAD adduct formation is catalyzed in vitro by M. tuberculosi

191 The monopyridine adduct formation is confirmed in solution by (1)H DOSY (

192 d substrate-assisted inhibition via covalent adduct formation is entirely consistent with the three-s

193 Calculations predict that the trans adduct formation is favored in alkoxycarbonyl nitrones,

194 ut the free energy loss in the initial Cu/Pd adduct formation is high.

195 Adduct formation is mediated through the boron atom of A

196 es, respectively, suggesting that bis-N7G-BD adduct formation is more efficient under low exposure co

197 Adduct formation is not prevented by mutating any of the

198 To some degree, hydride abstraction and adduct formation is observed, leading to [Ar*SnH2 (PtBu3

199 A structural model of adduct formation is presented, and binding constants are

200 To test whether a selectivity of AFB1 adduct formation is related to this peculiar mutational

201 s not induce p53R2, suggesting that DNMT/DNA adduct formation is the molecular trigger for p53R2 indu

202 Because VC acts by genotoxic mechanisms, DNA adduct formation is thought to be a sensitive biomarker

203 The stoichiometry of the adduct formation is two mole of TEMPOL consumed for one

204 Therefore, while SPE reduced in-source adduct formation, it also limited the range of compounds

205 exposure does not change the total BPDE-DNA adduct formation, it significantly inhibited the repair

206 percoiling, indicating that acrolein-protein adduct formation itself does not directly interfere with

207 The rate constant for monofunctional adduct formation, k(MF), for 1 (0.87 M(-1) s(-1)) is 3.5

208 Doxorubicin-GSH adduct formation kinetics are thermodynamically estimate

209 Despite DNA adduct formation, localized fork stalling was abrogated

210 Experimental evidence suggests that PAH-DNA adduct formation may preferentially target methylated ge

211 their vulnerability to cytotoxicity and DNA adduct formation mediated by activated PhIP metabolites.

212 d PIAS4 are required for effective ubiquitin-adduct formation mediated by RNF8, RNF168 and BRCA1 at s

213 The rate of adduct formation mediated by wild-type KatG was about 20

214 ulted in glutathione depletion, APAP-protein adduct formation, mitochondrial oxidant stress and perox

215 required for photostabilization, or Cy-thiol adduct formation, necessary for super-resolution microsc

216 oved renal tubular damage, 4-hydroxynanoneal adduct formation, neutrophil infiltration, fibrosis, and

217 Sulfenamide, sulfinamide, and sulfonamide adduct formation occurred at Cys(34) (AalphaC-Cys(34)).

218 However, no increase in heptanone-etheno adduct formation occurred in the aspirin-treated cells.

219 To this end, chemoassay analyses of the adduct formation of GSH with nine alpha,beta-unsaturated

220 The adduct formation of KAu(CN)(2)Calpha-cyclodextrin in aqu

221 osslinked moiety with a free SH group; (iii) adduct formation of the latter with the N-maleimide moie

222 specificity and time course of covalent DNA adduct formation of the novel platinum-acridine conjugat

223 In addition, this study reports cationic adduct formation of urinary pteridines under ESI-positiv

224 2) in the presence of BSA were indicative of adduct formation of VO(acac)(2) with albumin of 1:1 stoi

225 esis that HNE inhibits LKB1 activity through adduct formation on a specific reactive residue of the p

226 the structural perturbations induced by DAQ adduct formation on each of the three cysteine residues

227 nd proline oxidation as well as acetaldehyde adduct formation on lysine or histidine residues.

228 as well as the influence of protonation and adduct formation on the conformations of drug metabolite

229 To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression a

230 roximately 180 degrees in response to either adduct formation or reduction of the isoalloxazine ring

231 ciated with a change in either cisplatin-DNA adduct formation or repair over time.

232 s for quantitative detection due to variable adduct formation over many compound classes.

233 kg) caused glutathione depletion and protein adduct formation, oxidant stress, mitochondrial release

234 /-) silencing on steatosis, 4-hydroxynonenal adduct formation, oxidative stress, serum alanine amino

235 Adduct formation, [(phen)M(C6H11O2)](+), occurs with Pt

236 es-Acr(+) is observed to engage in off-cycle adduct formation, presumably as buildup of PhS(-) become

237 e oxygen species generation, Michael protein adduct formation, protein tyrosine phosphorylation, acti

238 Adduct formation provides an explanation for the dopamin

239 of the hydrogen atom transfer (HAT), radical adduct formation (RAF), sequential proton loss electron

240 electron proton transfer (SEPT), and radical adduct formation (RAF).

241 cated to measure reactive metabolite and DNA-adduct formation rates relevant to genotoxicity screenin

242 m mass spectrometry using acetonitrile as an adduct formation reagent.

243 a TOP2-independent mechanisms, including DNA adduct formation, redox activity, and lipid peroxidation

244 and ADP, instead of ATP, indicating that the adduct formation reflects hydrolysis of ATP.

245 ic forms of 5CQA conform to the HAT, radical adduct formation, sequential proton loss electron transf

246 Between pH 3.7 and 9.5, adduct formation showed minimal pH dependence, and adduc

247 CR method, we have determined DB[a,l]PDE-DNA adduct formation sites and repair rates in carcinogen-ex

248 Based on clinical observations, the speed of adduct formation, skin and in vitro tests to inert drug

249 rimate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous region

250 herent to nebulization, and thus avoids salt-adduct formation that can complicate ESI mass spectra.

251 s accompanied by concentration-dependent HNE adduct formation that was consistent with those found in

252 vant mutants demonstrates that for ubiquitin-adduct formation the presence or absence of the NH2-term

253 d that the fast reaction corresponds to beta-adduct formation (the kinetic product), while the slow r

254 Following adduct formation, the process of hydrazone formation may

255 arbene 23a, and the mechanisms of the borane adduct formation to 26a-h, NMR spectroscopic investigati

256 the first study directly linking tubulin-ITC adduct formation to cell growth inhibition.

257 r 11beta, which supplements conventional DNA adduct formation to promote cancer cell death.

258 In this model, EtHOBA significantly reduced adduct formation, tumorigenesis, and dysplasia severity.

259 ines, metabolite-generated DNA oxidation and adduct formation turnover rates from the array correlate

260 xyguanosine-N(2)-yl)-tamoxifen (dG-N(2)-TAM) adduct formation using TAM-DNA (DNA modified with dG-N(2

261 of that in the parental line at 1 h, and DNA adduct formation varied from 10 to 38% of that in the se

262 ect of transcription factor binding on bulky adducts formation varies, depending on the specific tran

263 formation on saturated fatty acids, covalent adducts formation via classical C-C bond, and Paterno-Bu

264 oxicity, cDDP cellular accumulation, and DNA adduct formation was compared in the CLDN3- and CLDN4-ex

265 No adduct formation was detected between lysine and the oth

266 e this with gene expression studies, PAH-DNA adduct formation was determined.

267 Significant adduct formation was found after 30 min at 50 degrees C.

268 Adduct formation was inhibited by extracellular domain o

269 ence of ion-pairing reagents and solvents on adduct formation was investigated.

270 On the contrary, radical adduct formation was not affected in peroxisome prolifer

271 A significant elevation of free radical adduct formation was observed in the penumbra region dur

272 Similar adduct formation was observed when T(pT)(8) was treated

273 Significant adduct formation was seen at the third base of codon 249

274 The degree of adduct formation was significantly affected by MS settin

275 Therefore, DNA-adduct formation was studied in C57BL/6JAPC(min) mice, a

276 Radical adduct formation was suppressed by aminoguanidine, N-(3-

277 etabolic activation of 3-NBA, catalyzing DNA adduct formation, was also examined using microsomes of

278 Because oxidative stress and aldehydic adduct formation were high after arrest, we tested a sma

279 ependent T-cell responses and SMX-NO-protein adduct formation were observed in the spleen and in ingu

280 es, which resulted in increased APAP protein adduct formation, were observed in livers of APAP-treate

281 rations of salts lead to ion suppression and adduct formation, which mask or complicate ion signals.

282 asure site-specific cytosine methylation and adduct formation will improve our ability to understand

283 Baseline separation was achieved after adduct formation with alkali metal ions, however, and ef

284 Also, cholesteryl esters were detected via adduct formation with ammonium cations.

285 ovine serum albumin (BSA) resulted in linear adduct formation with both proteins.

286 ganic chelates of VO(2+) may be dependent on adduct formation with BSA and possibly other serum trans

287 However, covalent Michael adduct formation with Cys-18, a residue present at the N

288 Model reactions examining adduct formation with ethanolamine produced stable produ

289 have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC a

290 Ipso adduct formation with protein thiols was demonstrated wi

291 Compound 9 was subsequently stabilized by adduct formation with pyridine (10).

292 PC cations undergo charge inversion via adduct formation with subsequent methyl cation and proto

293 bolites of paracetamol was mimicked by their adduct formation with the antioxidant glutathione.

294 er mitochondria could be attributable to HNE adduct formation with the enzyme complex.

295 roduct ion spectra characteristic of B[a]PDE adduct formation with the phosphate group of the 2'-deox

296 Thus, a folate analogue that is capable of adduct formation with the substrate on the enzyme active

297 mmation via mechanisms that are triggered by adduct formation with thiol redox switches.

298 Elevation of free radical adduct formation within the penumbra region during cereb

299 ted quinones also undergo arylation (Michael adduct formation) yielding covalent bonds with nucleophi

300 stry generated lysine radicals and led to C8 adduct formation, yielding 8-Lys-Sp and 5,8-diLys-Sp.