ライフサイエンスコーパス: adduction

1 central gaze and at 35 degrees abduction and adduction.

2 on via tyrosine nitration and 4-OH-2-nonenol adduction.

3 went oxidative dehalogenation or glutathione adduction.

4 B1, has been reported to be inhibited by HNE adduction.

5 dentify the sites and extent of iso[4]LGE(2) adduction.

6 topoisomerase II via redox-dependent protein adduction.

7 oach to detect styrene oxide-derived protein adduction.

8 ects, may be due to optic nerve tethering in adduction.

9 DOX; immunoprecipitation confirmed Mrp1-HNE adduction.

10 observed in concomitant esotropia in maximal adduction.

11 matic mechanisms underlying modification and adduction.

12 had lid fissure narrowing and retraction in adduction.

13 a change to this residue, specifically, DMPO adduction.

14 al fissure narrowing and globe retraction in adduction.

15 within cytochrome c as novel sites of NAC-BQ adduction.

16 amino acids contribute to the selectivity of adduction.

17 kward 4 degrees farther in abduction than in adduction.

18 oteins (desmin, tubulin) also underwent 4HNE adduction.

19 mycin activation and nucleophile (MeOH, DNA) adduction.

20 on, and retraction of the globe on attempted adduction.

21 , supraduction, infraduction, abduction, and adduction.

22 agments as the site of 5a-formylbicyclomycin adduction.

23 gaze, elevation, depression, abduction, and adduction.

24 ions included changes in gait, mobility, and adduction.

25 ted toward the 5'-direction from the site of adduction.

26 ure and retraction of the globe on attempted adduction.

27 eoxy structure of SNO-Hb that accommodate NO adduction.

28 anterior to the globe's geometric center in adduction.

29 sion carries a risk of induced limitation of adduction.

30 ent (OCD) averaged 41 +/- 7 mum in 30-degree adduction.

31 regeneration with a ptosis that improved on adduction.

32 and, has essentially no effect on alkali ion adduction.

33 rmal duplex velocities returned to normal in adduction.

34 ecially for downward saccades with the PE in adduction; (2) vertical drift was backward after upward

35 Reactive carbonyl (RC) adduction, a common feature of oxidative stress, has bee

36 At low levels of adduction, addition of MutS to the reaction further decr

37 In 20-degree and 30-degree adduction, all eyes exhibited significant progressive te

38 Both adduction and abduction compress the peripapillary choro

39 olled central gaze and multiple positions of adduction and abduction in 26 orbits of 15 normal volunt

40 pillary choroid averaged 9-19 mum thinner in adduction and abduction than in central gaze (P < .02).

41 netic resonance imaging in target-controlled adduction and abduction.

42 gaze and increasing (10, 20, and 30 degrees) adduction and abduction.

43 ome attributed to a combination of metal ion adduction and analyte conformation.

44 t is demonstrated that both N3-methyladenine adduction and cytotoxicity can be inhibited in vivo with

45 In addition, the adduction and femoral rotation increased internally at t

46 igosaccharides are described in which sodium adduction and fragmentation are avoided.

47 y is hindered by two processes: alkali metal adduction and fragmentation of the intact ionized molecu

48 negative ion electrospray MS in which sodium adduction and fragmentation were avoided.

49 However, success has been limited by cation adduction and high detection limits.

50 During abduction and adduction and internal and external rotation maneuvers w

51 of glenohumeral motion during abduction and adduction and internal and external rotation.

52 x additive can successfully eliminate cation adduction and lower the detection limits for DNA in the

53 ished research on aromatic amine-induced DNA adduction and mutagenesis are discussed.

54 In this model system, AFB(1)-induced DNA adduction and mutagenesis recapitulate the unique mutati

55 summarizes our current knowledge on the DNA adduction and mutagenicity of aromatic amines in relatio

56 a genotoxic mode of action, specifically DNA adduction and mutagenicity, for aromatic amines, which m

57 f younger subjects shifted temporally during adduction and nasally during abduction.

58 c pressure and the force exerted during claw adduction and observed a strong correlation between forc

59 for some complexes to reduce high levels of adduction and to obtain accurate molecular mass measurem

60 he thiol side chain is subject to oxidation, adduction, and chelation by thiol-reactive compounds.

61 including multimerization, nonproton cation adduction, and in-source fragmentation complicate interp

62 aut or lax in extension, flexion, abduction, adduction, and internal and external rotation.

63 triction or absence of abduction, restricted adduction, and narrowing of the palpebral fissure and re

64 ted the relationship between step width, hip adduction, and pelvic list during bipedalism by altering

65 ypically by absence of abduction, restricted adduction, and retraction of the globe on attempted addu

66 he most for downward saccades with the PE in adduction; and (5) the peak velocity-amplitude relations

67 such as the peak adduction moment (AddM) and adduction angular impulse (AddImp).

68 However, only the knee adduction angular impulse differed between subjects with

69 knee adduction moment and the external knee adduction angular impulse for the whole stance and for t

70 the peak knee adduction moment and the knee adduction angular impulse increased with K/L radiographi

71 Moreover, knee adduction angular impulse provides additional informatio

72 Peak knee adduction moment and knee adduction angular impulse were 19% and 30% higher, respe

73 external knee adduction moment and the knee adduction angular impulse were determined.

74 r suppressor gene that can result from these adductions are in turn correlated with specific cancers.

75 ss sections are largely independent of metal adduction as long as in-source excitation is minimized.

76 ant mutators identifies persistent cisplatin adduction as the cause for this acquired genome instabil

77 ated by analysis of kinetics for HNE Michael adduction at six targeted HSA histidine residues.

78 p elucidate the complex relationship between adduction at specific sites in DNA and the cytotoxicity

79 Adduction at the N7-position of G4 ([M]G, 4) is characte

80 uplex that were localized to the site of the adduction at X(7) x C(18) and its neighboring base pair,

81 ead to a significant reduction in sodium ion adduction but are not as effective as acetonitrile, acet

82 Adduction but not abduction was associated with signific

83 nward after downward saccades with the PE in adduction, but backward for downward saccades with the P

84 st to mimic those of chimpanzees affects hip adduction, but neither of these gait parameters dramatic

85 H242 adducts may be preferred products of adduction by lipophilic electrophiles and may comprise a

86 Enhancement of acrolein-DNA adduction by methylating CpGs in the supF sequence did n

87 thyl cytosines (MeC) on kinetics of p53 gene adduction by model metabolite benzo[a]pyrene-7,8-dihydro

88 ulations to improve understanding of protein adduction by N-phenylhydroxylamine (PhNHOH) and nitrosob

89 ryanodine receptor (RyR1) undergoes covalent adduction by nitric oxide (NO), redox-induced shifts in

90 ar, only Cys-3635, which undergoes selective adduction by NO, has been identified.

91 To investigate the role of UCHL1 and its adduction by reactive lipids in inhibiting repair and re

92 on the MALDI target plate was used to reduce adduction by sodium and other cations that are normally

93 etrics decreased when the viewing eye was in adduction, compared with primary position or abduction.

94 ied by mass spectrometry as sites of quinone adduction: Cys170, Cys392, Cys405, and Cys455.

95 while in cases that underwent MR recession, adduction declined from 0.4 to -0.3.

96 Adduction deficits indicate a stretched scar, which must

97 A total of 117 patients had preoperative adduction deficits, which were significantly associated

98 Large horizontal duction, particularly adduction, deforms the disc and peripapillary vasculatur

99 pecific with respect to the AB&CR agent, and adduction depends upon the presence of endogenous levels

100 (1) misalignment (10-12 degrees vertical in adduction, down; 10-12 degrees torsional in abduction, d

101 In vitro studies revealed that RC adduction enhanced Ag presentation with Th2 polarization

102 Five classes of limb movements (abduction, adduction, extension, retraction, elevation) and four cl

103 The microenvironment at the site of adduction governs both the initial specificity and the s

104 signature, which involves Psi-monobisulfite adduction, heat-induced ribose ring opening, and Mg(2+)-

105 Water adduction helps stabilize conformers that are otherwise

106 butions tend to be narrow and extensive salt adduction, heterogeneity, and so on tend to lead to sign

107 The functional relevance of this adduction, however, had not been evaluated.

108 ance imaging and biomechanical evidence that adduction imposes strain on the ONH and peripapillary ti

109 formation of 4-HNE-inhibitor of kappaBalpha adduction in both 4-HNE-treated hepatocytes and in the l

110 Sites of HNE adduction in human WRN were identified at Lys577, Cys727

111 ytoskeletal proteins are susceptible to 4HNE-adduction in patients with RV failure.

112 ated HCC, we investigated AFB(1)-induced DNA adduction in relation to mutagenesis in transgenic mouse

113 opia and a posterior shift from abduction to adduction in simulated Brown syndrome.

114 Thus, tamoxifen-DNA adduction in the liver may not have as significant biolo

115 a mitotically quiescent organ, tamoxifen-DNA adduction in the liver may, at least partially, prevent

116 ch organic vapor exposure reduces alkali ion adduction in the positive mode involves the depletion of

117 +/- 1.6 mum average temporal displacement in adduction in young subjects.

118 the extent and site of 5a-formylbicyclomycin adduction, indicates an overall C6 symmetry for rho subu

119 chanisms, specifically swallowing or glottic adduction, influenced cardiac autonomic activity and cor

120 The inability to elevate an eye in adduction is a common problem with a number of possible

121 Styrene oxide-cysteine adduction is predominantly involved in protein covalent

122 eness of this method for reducing sodium ion adduction is related to the low proton affinity (PA) val

123 soluble lysates is preferentially adducted, adduction is stereospecific with respect to the AB&CR ag

124 uggests that the mechanism for reducing salt adduction is the formation of small initial droplets wit

125 Because the major site of HSA adduction is the single free sulfhydryl group at Cys34,

126 Analysis of adduction kinetics together with HSA structure and targe

127 nds, in positive and negative mode and Cs(+) adduction, leads to a conclusive composition of Au329(SR

128 amined by trypsin-PRM, and a slightly higher adduction level was observed for the obesity group when

129 in measurement revealed two linear ranges of adduction levels (adducted-CE/HSA): 0.34-0.42 (R(2) > 0.

130 Maximal adduction levels of 613-1130 pmol alachlor-albumin adduc

131 This is the first report on determining adduction levels of blood proteins for long-term exposur

132 and highly correlated (R(2) > 0.91) protein adduction levels with a detection limit below the endoge

133 nsitivity and largely underestimated protein adduction levels.

134 ple preparation and detection as well as low adduction levels.

135 site of small ubiquitin-like modifier (SUMO) adduction, Lys-679 of Bcl11b, in a protein isolated from

136 How oxysterol-protein adduction modifies the function of lung macrophages is u

137 ers of dynamic knee loading such as the peak adduction moment (AddM) and adduction angular impulse (A

138 hoes, there was an 18% reduction in the knee adduction moment (KAM) by 24 weeks with the mobility sho

139 Peak knee adduction moment and knee adduction angular impulse were

140 re is a significant relationship between the adduction moment and OA disease severity.

141 Prior to THR, the peak external knee adduction moment and peak medial compartment load were s

142 was used to calculate the peak external knee adduction moment and the external knee adduction angular

143 it analysis, and both the peak external knee adduction moment and the knee adduction angular impulse

144 Both the peak knee adduction moment and the knee adduction angular impulse

145 We found that greater adduction moment at the knee during activities contribut

146 ic knee pain was associated with higher peak adduction moment at the knee during activities, measured

147 have supported earlier findings that a high adduction moment at the knee during ambulation was most

148 If the adduction moment contributes to progression of osteoarth

149 d only 8.9% of the variation in maximum knee adduction moment for the group of patients with knee OA.

150 improved, and statistical reductions in the adduction moment resulted in lower levels of vastus medi

151 he partial correlation between K-L grade and adduction moment was 0.71 in the left knees and 0.61 in

152 In the gait substudy, the adduction moment was greater in knees with a thrust comp

153 associated with the potential to reduce the adduction moment when walking at slower speeds and could

154 ed an 8% reduction in the peak external knee adduction moment with the mobility shoe compared with se

155 ed a 12% reduction in the peak external knee adduction moment with the mobility shoe compared with th

156 cessary to determine the contribution of the adduction moment, and its contribution in conjunction wi

157 ion beyond that available from the peak knee adduction moment, and may therefore be an important gait

158 For every 1.0-unit increase in adduction moment, there was a 0.63-mm decrease in joint

159 e knees, particularly the peak external knee adduction moment, which has been associated with the pro

160 The severity of the disease influenced the adduction moment-walking speed relationship; the individ

161 g, with an 11.9% reduction noted in the knee adduction moment.

162 gait analysis to determine the maximum knee adduction moment.

163 nt space width (r = -0.55), but not with the adduction moment.

164 late with joint space width but not with the adduction moment.

165 ith more-severe OA had significantly greater adduction moments (mean +/- SD 3.80 +/- 0.89% body weigh

166 ients with more severe knee OA had lower hip adduction moments compared with their matched control su

167 op new chronic knee pain had higher baseline adduction moments for all activities (P = 0.01), ranging

168 elf-selected walking speeds and maximum knee adduction moments of 44 patients with medial tibiofemora

169 e severe knee OA had greater first peak knee adduction moments than their matched control subjects (P

170 ed medial tibiofemoral OA should have higher adduction moments.

171 The subjects performed abduction-adduction movements of the index and little fingers and

172 The frequency content of abduction and adduction movements was recorded in 12 index fingers and

173 rve (nIV) produces intorsion, elevation, and adduction (not abduction).

174 d by IAB or BMCC in vitro indicated that IAB adduction occurred primarily in the central linker domai

175 Biotin-labeled OA-NO(2) showed this adduction occurs preferentially with latent forms of MMP

176 ia a novel mechanism that includes transient adduction of 3-DG by PM followed by irreversible PM-medi

177 Adduction of a 190-kDa protein with the reactive lipid p

178 istinct molecular ion species, involving the adduction of a singly charged cation, two singly charged

179 Sites of adduction of AalphaC to albumin were identified by data-

180 ansferases (GSTs) have been shown to inhibit adduction of activated PhIP metabolites to DNA in cell-f

181 The targeted adduction of aflatoxin B1- exo -8,9-epoxide (AFB1- exo -

182 In addition to previously reported adduction of beta(93)Cys of human Hb, two novel sites of

183 HNE adduction of blood proteins, such as human serum albumin

184 These data indicate that the bifunctional adduction of Cr to DNA phosphates (ICLs) constitutes a m

185 These findings indicate that adduction of Cys392 and Cys405 is important for the acti

186 dependent fashion indicative of irreversible adduction of dopaquinone to its nucleophilic active-site

187 S analysis of the peptide fragment confirmed adduction of either Tyr 127 or Tyr 129 residues.

188 ng environment upon electrophilic fatty acid adduction of functionally significant, nucleophilic cyst

189 The adduction of GAPDH and GSH by nitroalkenes significantly

190 e lipoxygenation of arachidonic acid and the adduction of glutathione to this eicosanoid backbone.

191 naling that acts to regulate the cholesterol adduction of Hh ligand or to affect Hh signaling in the

192 Adduction of IsoK to model proteasome substrates signifi

193 hesized that this was due to extremely rapid adduction of IsoLGs to proteins.

194 Taken together, our results suggest that adduction of LKB1 Lys-97 mediates the inhibitory effect

195 O3-derived oxysterols, our data demonstrate adduction of LXR with Seco A.

196 Covalent adduction of meta-azipropofol in vivo prolongs the prima

197 ure was characterized by an increase in 4HNE adduction of metabolic and mitochondrial proteins (16 of

198 l, a known antioxidant did not decrease 4HNE adduction of metabolic and mitochondrial proteins and di

199 In vitro adduction of model peptides containing nucleophilic side

200 y regulated by S-nitrosylation, the covalent adduction of nitric oxide (NO)-derived nitrosyl groups t

201 The shift in mass was consistent with adduction of NQO1 by the reactive iminium derived from E

202 loenzymes produced a concentration-dependent adduction of PP2A subunits, as observed by Western blot

203 known whether these two effects result from adduction of quinone to the same amino acid residue(s) i

204 , as well as to prevent and even reverse the adduction of retinal proteins by the toxic aldehyde was

205 Adduction of salt to protein ions decreases with decreas

206 s-319 is a functionally significant site for adduction of soft electrophiles such as OA-NO(2) and sug

207 oMMP-7 and proMMP-9 proteolytic activity via adduction of the conserved cysteine switch domain thiola

208 pectrometry extended our previous finding of adduction of the FAD in the active site of NQO2 by an in

209 antibody light chains in a process involving adduction of the hydrophobic aldehyde to lysine side cha

210 In one case, movements involved the adduction of the medial surface of D1 toward the lateral

211 A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-m

212 Tail-slaps were initiated by an adduction of the pectoral fins, a manoeuvre that changed

213 Pick up, medial rotation and adduction of the stone would employ a two-muscle chain o

214 large human thumb accompanied by the strong adduction of the thenar, hypothenar, and palmar inteross

215 ysfunction (VCD) typically involves abnormal adduction of the vocal cords during inspiration, mimics

216 Adduction of these receptors with ozone-derived oxystero

217 te, these results reveal that the reversible adduction of thiols by nitro-fatty acids is a mechanism

218 method is applied to ubiquitin with multiple adductions of sodium and potassium, single and mixed pol

219 near regression showed significant effect of adduction on absolute OCD (slope 1.09 +/- 0.36 mum/degre

220 ecular modeling, the impact of BQ and NAC-BQ adduction on cytochrome c was visualized, revealing the

221 sines increased the rate constant 3-fold for adduction on G at the major reactive CpG in codon 248 vs

222 rganic vapors can dramatically reduce sodium adduction on protein ions in positive ion mass spectra.

223 e that was to be merged with a fast discrete adduction or abduction in the shoulder triggered by an a

224 ackward after upward saccades with the PE in adduction or abduction, onward after downward saccades w

225 ng reaching 3.1 +/- 0.4 degrees in 30-degree adduction (P < .0001).

226 both gantacurium and AV002 via the cysteine adduction pathway.

227 DNPs, which in turn result in increased DNA adduction, play a role.

228 Cys(34) adduction products and Cys-SO2H, Cys-SO3H, and Met(329)

229 sulfinamides were identified as the primary adduction products, which were stable following tryptic

230 hich is consistent with its preferential DNA adduction profile.

231 These studies revealed that isoketal adduction profoundly altered protein function, inhibitin

232 In addition, divalent metal adduction provided improved positive mode ionization eff

233 m dots (QDs) nanohybrid via a Michael's type adduction, quenching the fluorescence of green-emitting

234 methylthiophenylethanols with an alpha-/beta-adduction ratio of 1.5.

235 The rate of this water adduction reaction can be used to distinguish the four h

236 Use of the water adduction reaction rate or the unreactive ratio provides

237 The selectivity of HNE in competing adduction reactions was evaluated by analysis of kinetic

238 These adduction reactions were inhibited by free KLH and by re

239 include analyte multiple charging and cation adduction (reduced sensitivity), oxidation of analyte on

240 es robustly correlated with the extent of RC adduction, regardless of the means of their generation.

241 o favored more extensive alkali metal cation adduction relative to MALDI-MS, with the [M + 2Na/K - H]

242 me-modifying fragments and the nature of the adduction remain to be established conclusively, the inc

243 ich damage proteins and DNA through covalent adduction resulting in "oxidative injury".

244 identified AMPK as a direct target of 4-HNE adduction resulting in inhibition of both H2O2 and 5-ami

245 1.3-29]), groin pain on passive abduction or adduction (sensitivity, 33%; specificity, 94%; LR, 5.7 [

246 95% CI, 2.4-8.4]), and decreased passive hip adduction (sensitivity, 80%; specificity, 81%; LR, 4.2 [

247 ts indicate that site selectivity of protein adduction should be a critical determinant of the abilit

248 led to the identification of the 14-3-3 zeta adduction site (K120) by mass spectrometry.

249 eine of TR1 was characterized as the primary adduction site of the IQ-derived reactive iminium using

250 ween residues 68 and 80 in TM1 as the ligand adduction site.

251 most pronounced within the preferential DNA adduction sites along the cII gene after the treatment w

252 gene neither the preferential N-OH-AABP DNA adduction sites nor the induced mutational hotspots are

253 al methodologies to localize the binding and adduction sites of the photoactivatable irreversible coc

254 Five preferential DNA adduction sites were established, of which four were maj

255 Six adduction sites were identified by trypsin (K20, C34, K7

256 ral gaze reaching 49 +/- 10 mum in 30-degree adduction (standard error of mean, P < .0001).

257 Further, the DNA adduction studies with the calf thymus DNA led to a mixt

258 in the stifle flexion, hock flexion and hock adduction, suggesting greater movement asymmetry with an

259 ted airway defense program-apnea, vocal fold adduction, swallowing, and expiratory reflexes.

260 Adduction temporally tilts and displaces the prelaminar

261 s a degree of crown-crown contact during jaw adduction that is unmatched among known crocodyliforms,

262 ith/without alkaline or alkaline earth metal adduction, the ratio of product ions resulting from eith

263 rdia onset was temporally matched to glottic adduction-the first phase of swallow motor program.

264 the PPR within 1 disc radius (P < .0001) in adduction; the nasal hemi-disc shifted 24.5 +/- 1.3 mum

265 Rotational axes from adduction to abduction averaged 1.1 +/- 0.2 mm medial an

266 h we hypothesized was due to extremely rapid adduction to amines.

267 rans-dG-N(2)-BPDE and (-)-trans-dG-N(2)-BPDE adduction to be 26.5% and 17.5%, respectively.

268 s inhibited by electrophilic lipids by their adduction to Cys521 proximal to its catalytic center.

269 activation studies demonstrated irreversible adduction to hSERT by all ligands, but the reduced (S)-c

270 ters significantly reduce the extent of salt adduction to ligand-DNA complex ions, including in the p

271 with G85R mutation show no difference in HNE adduction to NFH compared with controls.

272 en together, these studies indicate that HNE adduction to NFH is physiological, and its constancy fro

273 for biological effects mediated by covalent adduction to protein thiols.

274 This method of reducing sodium ion adduction to proteins is simple and requires no experime

275 significantly lower the extent of sodium ion adduction to the molecular ions of proteins and protein

276 and methylglyoxal while nonoxidative glucose adduction to the protein did not affect protein function

277 ons strongly support the hypothesis that HNE-adduction to tubulin is the primary mechanism involved i

278 the obtained results, we postulate that HNE adduction to WRN is a post-translational modification, w

279 These results suggest that Keap1 adduction triggers a switching of Cul3-dependent ubiquit

280 istance and to provide humeral abduction and adduction under cortical control.

281 ot the major site of AFB1 adducts and strong adduction was also observed at codons 226, 243, 244, 245

282 This sulfate adduction was determined to result from migration of neu

283 tals, the functional consequence of isoketal adduction was examined using a model membrane protein (a

284 Displacement of the nasal hemi-disc in adduction was greater at 38.5 +/- 1.7 mum (standard erro

285 The presence of normal passive hip adduction was most useful for suggesting the absence of

286 n-dependent increase in both alpha- and beta-adduction was observed in mouse liver microsomes incubat

287 Adduction was still observed while using the device, sug

288 e CpG methylation may intensify acrolein-DNA adduction, we examined whether the extent of CpG methyla

289 beta(93)Cys of human Hb, two novel sites of adduction were found; alpha(104)Cys and beta(112)Cys.

290 nd postoperative limitation of abduction and adduction were recorded using a 6-point scale.

291 in degrees, and limitation of abduction and adduction were reported and analyzed.

292 en eyes had limitation of both abduction and adduction, whereas two had limitations only of abduction

293 Conversely, NBu4Cl does not cause any adduction, while dramatically reducing the protein ion y

294 h normal lung function, expiratory laryngeal adduction with closure of the upper airway occurs and li

295 generated by eNOS or iNOS regulates protein adduction with GSH.

296 in addition to that in sarcolemma; however, adduction with HNE inhibits Mrp1 activity.

297 LDL are efficiently sequestered by covalent adduction with LDL-based amino groups.

298 o compete with GSH and cellular proteins for adduction with reactive metabolites of APAP in vitro.

299 PCs are ionized via adduction with salts, whereas PSs ionize via hydrogen ab

300 ation of abduction, or of both abduction and adduction, with palpebral fissure narrowing and globe re