ライフサイエンスコーパス: adenine

1 le), and its sequence (aside from the target adenine).

2 , is highly mutagenic due to mispairing with adenine.

3 d monitoring oxidation signal of guanine and adenine.

4 iaminopurine (DAP) is a nucleobase analog of adenine.

5 ndo- and exocyclic nitrogens of cytosine and adenine.

6 for mutagenic bypass of 8OG by insertion of adenine.

7 ing cytosine and a syn conformation opposite adenine.

8 xy-2'-(18)F-fluoro-9-beta-d-arabinofuranosyl-adenine ((18)F-CFA), a PET radiotracer that measures deo

9 al alkyne functionality at position 2 of the adenine (2-alkyne adenosine or 2YnAd) is suitable for se

10 Here, we incorporate a new analogue of adenine, 2CNqA, into both DNA and RNA, and evaluate its

11 sfer of the threonylcarbamoyl (TC) moiety to adenine-37 of tRNA by the TC-transfer complex comprised

12 he C5 and N6 positions of cytosine (5mC) and adenine (6mA) nucleobases, respectively, enabling the st

13 gnizing and removing the adenine from 8-oxoG:adenine (8-oxoG:A) sites.

14 r B-form double-helix with the base pairs of adenine (A) and thymine (T) or cytosine (C) and guanine

15 erous DNA lesion because it can mispair with adenine (A) during replication resulting in guanine to t

16 ion of DNA nucleobases i.e., guanine (G) and adenine (A) in physiological pH (7.4) buffer solution.

17 nine oxidation by recognition and removal of adenine (A) misincorporated opposite 8-oxo-7,8-dihydrogu

18 ion of nucleobases, for example guanine (G), adenine (A), and thymine (T) in a beef and chicken liver

19 We explore how proteins recognize adenine: a planar rigid fragment found in the most commo

20 ccounts for a recently identified colibactin-adenine adduct.

21 featuring unobstructed Watson-Crick faces of adenine (Ade) pointing towards the MOF cavities.

22 o-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can occur in two ways.

23 -tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe)

24 Targeting adenine allows their modular system to act orthogonally

25 APRT can also process adenine analogs, which are involved in plant development

26 as a guanine analogue and secondarily as an adenine analogue resulting in the accumulation of transi

27 ith A(1)AR-enhancing N(6)-dicyclobutylmethyl-adenine and 1,2,4-triazole-3-carboxamide (40, MRS7451) n

28 ditor (RESCUE-S) capable of deaminating both adenine and cysteine.

29 APOBEC-nCas9-Ung supplements the current adenine and cytidine BEs (ABE and CBE, respectively) and

30 RNA modifications, including methylation of adenine and cytidine residues, are now recognized as key

31 We developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing b

32 Existing adenine and cytosine base editors induce only a single t

33 Moreover, the conversion of adenine and cytosine bases can be achieved by fusing Sau

34 a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that can concurrentl

35 ents, verified by using two isotopologues of adenine and further confirmed by digital blinking and bl

36 d, we recently reported an important role of adenine and guanine mononucleotides that bind to the reg

37 The oxidation signals of adenine and guanine were in linear range when the device

38 IN phosphorolytically cleaves adenosine into adenine and ribose-1-phosphate.

39 ine interactions in the Watson-Crick edge of adenine and shows that all of adenine's edges may contri

40 ure of the homoazanucleoside containing both adenine and thymine, is a left-handed helix formed throu

41 mine moieties, and the third containing both adenine and thymine.

42 Proangiogenic transcripts containing adenine and uridine-rich elements were bound to ILF3 thr

43 on specific sequences of RNA hexamers (poly-Adenine and viral genomic 5') in vitro, and determined t

44 ersion to 2'-deoxyadenosine by reaction with adenine, and 2-deoxyribose by hydrolysis.

45 e DNA methylations occurring at cytosine and adenine are carried out by SAM-dependent methyltransfera

46 N6-methylated adenine at box D/D' interferes with the function of the

47 Thymine substitutions for adenine at position -7 in the three rRNA promoters stron

48 s the binding of p50 at kappaB sites with an adenine at the -1 position.

49 Our findings suggest that adenine base editing can be used for the correction of g

50 er system that indicates precise cytosine or adenine base editing in situ with high sensitivity and s

51 ments the effectiveness and applicability of adenine base editing.

52 improves the targeting scope of cytosine and adenine base editing.

53 l-vein injection of plasmid DNA encoding the adenine base editor (ABE) and a single-guide RNA (sgRNA)

54 The adenine base editor (ABE), capable of catalyzing A*T to

55 ter jejuni CRISPR-associated protein 9-fused adenine base editor (CjABE).

56 The optimized chemical modifications of adenine base editor mRNA and guide RNA expand the applic

57 engineer a chemically modified mRNA-encoded adenine base editor that mediates robust editing at vari

58 Finally, we show that an adenine base editor(7) can also induce transcriptome-wid

59 ere rare in embryos edited by CRISPR-Cas9 or adenine base editor, with a frequency close to the spont

60 Adenine base editor-induced cytosine substitutions occur

61 of base editors, we engineered six optimized adenine base editors (ABEmax variants) that use SpCas9 v

62 Cytosine base editors and adenine base editors (ABEs) can correct point mutations

63 Applications of adenine base editors (ABEs) have been constrained by the

64 cular basis for DNA adenosine deamination by adenine base editors (ABEs), we determined a 3.2-angstro

65 Cytosine and adenine base editors (CBEs and ABEs) are promising new t

66 ce-activity relationships of 11 cytosine and adenine base editors (CBEs and ABEs) on 38,538 genomical

67 Cytosine or adenine base editors (CBEs or ABEs) can introduce specif

68 The foundational adenine base editors (for example, ABE7.10) enable progr

69 n addition to converting adenine to guanine, adenine base editors also convert cytosine to guanine or

70 CRISPR-guided DNA cytosine and adenine base editors are widely used for many applicatio

71 However, the existing cytosine and adenine base editors can only install transition mutatio

72 nstrated that different forms of cytosine or adenine base editors containing SpCas9-NG worked efficie

73 AAVs for the delivery of split cytosine and adenine base editors that are then reconstituted by tran

74 9 variants to produce four cytosine and four adenine base editors with an editing window expanded fro

75 key embryos using CRISPR-based cytidine- and adenine-base editors.

76 inhibitors, such as antiparasitic agents, or adenine-based substrates.

77 Our analysis suggests that adenine binding has emerged multiple times in evolution.

78 hibits unique structural features such as an adenine bulge and a G.G.T base triple capping structure

79 of small self-cleaving ribozymes containing adenine bulges are consistent with the hypothesis that t

80 We assessed 9 SNP and cytosine-adenine (CA) repeats in IFNG by nucleotide sequencing in

81 to the ligand binding pocket of the guanine/adenine class to achieve a change in ligand preference.

82 Within the guanine/adenine class, seven groups of RNAs were identified that

83 computational pipeline that extracts protein-adenine complexes from the Protein Data Bank, structural

84 ns use the same themes when binding the same adenine-containing ligands.

85 ure these themes and are thus likely to bind adenine-containing ligands.

86 Milk adenine correlated positively with both continuously dis

87 The adenine, cytosine, and guanine bases of DNA are suscepti

88 Thus, using adenine de novo biosynthesis as a proof of concept, we s

89 talyzing the entire Saccharomyces cerevisiae adenine de novo biosynthesis pathway with the human path

90 revealed other pathways that play a role in adenine de-novo pathway regulation.

91 RNA-targeting CRISPR-Cas13 (dCas13) with the adenine deaminase domain of ADAR2.

92 eved by fusing SauriCas9 to the cytidine and adenine deaminase.

93 nation in genomic DNA and very low levels of adenine deamination in cellular mRNA.

94 gle guide RNA (sgRNA)-independent off-target adenine deamination in genomic DNA and very low levels o

95 First, adenine depletion promotes transcriptional upregulation

96 Cytokinins (CKs) are adenine derivatives that act as phytohormones.

97 was induced in Sprague-Dawley rats by a high adenine diet supplemented by high P and Ca for 28 days t

98 e two wasteful and inhibitory compounds into adenine, dihydroxyacetone phosphate and acetaldehyde or

99 beta-Nicotinamide adenine dinucleotide (beta-NAD) is a key inhibitory neur

100 Prior studies suggest that beta-nicotinamide adenine dinucleotide (beta-NAD) is an important inhibito

101 ntain other metabolite caps including flavin adenine dinucleotide (FAD) and dephosphoCoA (dpCoA).

102 1) so that covalent attachment of the flavin adenine dinucleotide (FAD) cofactor is supported.

103 methylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine

104 nzyme EIS sensor, which used DET-type flavin adenine dinucleotide (FAD) dependent glucose dehydrogena

105 ovalently attach to the LSD1 cofactor flavin adenine dinucleotide (FAD) to inhibit demethylase activi

106 NADP(+) ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of inte

107 D(+) biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD(+) Some members of th

108 ical evidence suggests that the nicotinamide adenine dinucleotide (NAD(+) ) precursor nicotinamide ri

109 hat catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD(+)) and is a candidate molecul

110 (m(7)G) cap, a non-canonical 5' nicotinamide adenine dinucleotide (NAD(+)) cap can tag certain transc

111 in the de novo biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) in mammals.

112 Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for redox re

113 Nicotinamide adenine dinucleotide (NAD(+)) is a critical coenzyme for

114 Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor f

115 Nicotinamide adenine dinucleotide (NAD(+)) is essential not only for

116 Changes in nicotinamide adenine dinucleotide (NAD(+)) levels that compromise mit

117 e show that exogenously applied nicotinamide adenine dinucleotide (NAD(+)) moves systemically and ind

118 Nicotinamide adenine dinucleotide (NAD(+)) plays a critical role in e

119 side (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD(+)) precursor vitamin.

120 T), an evolutionarily conserved nicotinamide adenine dinucleotide (NAD(+)) synthase and neuroprotecti

121 Mitochondria require nicotinamide adenine dinucleotide (NAD(+)) to carry out the fundament

122 t cell-autonomous generation of nicotinamide adenine dinucleotide (NAD(+)) via the kynurenine pathway

123 Supplementation of nicotinamide adenine dinucleotide (NAD(+)) with nicotinamide riboside

124 (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD(+)), a coenzyme essential for

125 Nicotinamide adenine dinucleotide (NAD(+))-dependent ADP-ribosylation

126 sor for de novo biosynthesis of nicotinamide adenine dinucleotide (NAD(+)).

127 tase 1, the final enzyme of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway.

128 ase knockout mice display lower nicotinamide adenine dinucleotide (NAD) levels, and an imbalance in t

129 eterminant of dependence on the nicotinamide adenine dinucleotide (NAD) metabolic pathway in cancer.

130 Nicotinamide adenine dinucleotide (NAD) provides an important link be

131 HAAO or KYNU, two genes of the nicotinamide adenine dinucleotide (NAD) synthesis pathway, are causat

132 Nicotinamide adenine dinucleotide (NAD), a ubiquitous coenzyme, is re

133 cently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cell

134 discovered vitamin precursor of nicotinamide adenine dinucleotide (NAD).

135 trochemical immobilization with nicotinamide adenine dinucleotide (NAD).

136 ases such as PARPs that utilize nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer mo

137 evated levels of the redox coenzyme nicotine adenine dinucleotide (NAD+), elevated total intracellula

138 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme

139 cellular energy in the form of nicotinamide adenine dinucleotide (NAD+).

140 ransfer (PCET) reaction between nicotinamide adenine dinucleotide (NADH) and a protein-bound flavin (

141 AAA + NA), tryptophan residues, nicotinamide adenine dinucleotide (NADH) and vitamin A were scanned o

142 talytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)-an important coenzyme in liv

143 cleotide phosphate (NADPH), and nicotinamide adenine dinucleotide (NADH).

144 mplex I activity, elevating the nicotinamide adenine dinucleotide (NADH/NAD(+)) ratio and decreasing

145 r lactate levels, disrupted the nicotinamide adenine dinucleotide (NADH/NAD(+)) ratio, and decreased

146 The tryptophan-kynurenine-nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely

147 namide adenine dinucleotide and nicotinamide adenine dinucleotide + hydrogen.

148 rmediate in the biosynthesis of nicotinamide adenine dinucleotide and its derivatives in all organism

149 s of increased NAD+ synthesis-nicotinic acid adenine dinucleotide and methyl nicotinamide-were elevat

150 harbors typical FMO aspects with the flavin adenine dinucleotide and NAD(P)H binding domains and a C

151 eins, and loss of intracellular nicotinamide adenine dinucleotide and nicotinamide adenine dinucleoti

152 oncomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic

153 trochemical regeneration of the nicotinamide adenine dinucleotide cofactor.

154 ve phosphorylation, diminishing nicotinamide adenine dinucleotide concentrations and impairing cytoki

155 Flavin adenine dinucleotide dependent glucose dehydrogenase (FA

156 ns why premixing of FDHs with reduced flavin adenine dinucleotide generally results in abolishment of

157 osed of an Aspergillus flavus-derived flavin adenine dinucleotide glucose dehydrogenase (AfGDH) and a

158 Fungi-derived flavin adenine dinucleotide glucose dehydrogenases (FADGDHs) ar

159 is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD(+)) durin

160 re enzymes capable of degrading nicotinamide adenine dinucleotide in its oxidized form (NAD(+)).

161 We establish that our hybrids can target all adenine dinucleotide PAM sequences and possess robust an

162 RSV alone reduced nicotinamide adenine dinucleotide phosphatase oxidase (NADPH oxidase)

163 duced, whereas the NOX2 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 2) and

164 ase subunit 2) and NOX4 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 4) wer

165 Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most poten

166 ging the nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP(+) ) for the NA gro

167 Nicotinamide adenine dinucleotide phosphate (NADP(+)) is essential fo

168 ogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP(+) are c

169 tivity of dFB neurons through a nicotinamide adenine dinucleotide phosphate (NADPH) cofactor bound to

170 , reducing power in the form of nicotinamide adenine dinucleotide phosphate (NADPH) is required to mi

171 ME1 also promotes nicotinamide adenine dinucleotide phosphate (NADPH) production, lipog

172 r concentration of glutathione, nicotinamide adenine dinucleotide phosphate (NADPH), and nicotinamide

173 ad significantly higher reduced nicotinamide adenine dinucleotide phosphate levels, reduced reactive

174 3K/Akt signalling axis and that nicotinamide adenine dinucleotide phosphate oxidase (NOX)-dependent R

175 receptor-mediated activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).

176 Nicotinamide adenine dinucleotide phosphate oxidase isoform 2 is an e

177 These pathways include nicotinamide adenine dinucleotide phosphate oxidase, which generates

178 (2)O(2)), likely by stimulating nicotinamide adenine dinucleotide phosphate oxidase.

179 ialdehyde, 3-nitrotyrosine, and nicotinamide adenine dinucleotide phosphate oxidases).

180 rotection by generating reduced nicotinamide adenine dinucleotide phosphate to enhance biosynthesis a

181 d NADP(+) (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and p

182 ion, markers of senescence, and nicotinamide adenine dinucleotide phosphate, reduced form oxidases (N

183 together with increased NADPH (nicotinamide adenine dinucleotide phosphateoxidase) activity and mito

184 y discovered DNA damage-induced nicotinamide adenine dinucleotide(+) depletion to underlie AF.

185 with NADH (the reduced form of nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleoti

186 namide adenine dinucleotide) and FAD (flavin adenine dinucleotide) in vitro.

187 Sirtuin 1 (SIRT1), an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase in the proxi

188 activity, which generates NADH (nicotinamide adenine dinucleotide, reduced form) from NAD, underlies

189 the Krebs cycle to generate NADH and flavin adenine dinucleotide, which are further oxidized by the

190 consumes and depletes cellular nicotinamide adenine dinucleotide, which leads to mitochondrial dysfu

191 known as acetolactate synthase, is a flavin adenine dinucleotide-, thiamine diphosphate- and magnesi

192 Here we report a flavin adenine dinucleotide-dependent enzyme, Morus alba Diels-

193 within Complex I (Ndufs1, NADH [nicotinamide adenine dinucleotide] dehydrogenase [ubiquinone] iron-su

194 rates of production of reduced nicotinamide adenine dinucleotides from 91 potential energy substrate

195 C-terminal segment is found broadly in N4/N6-adenine DNA methyltransferases, some of which are human

196 step degrade sequences with high A content (adenine) due to depurination and chain cleavage.

197 be readily incorporated into DNA opposite to adenine during DNA replication leading to non-mutagenic

198 Adenine-enriched diet in mice induced 2,8-DHA nephropath

199 is captured by a BHD2/3 groove, while the 3' adenine extrudes episodically, facilitating ensuing inse

200 ast differentiation and expansion in UUO and adenine-fed mice.

201 The 5' partner adenine first flips out and is captured by a BHD2/3 groo

202 10, which was condensed with a Boc-protected adenine, followed by deprotection, furnished the target

203 o a diet-induced model of CKD by delivery of adenine for six weeks.

204 tly select only these inappropriately placed adenines for excision.

205 n Data Bank, structurally superimposes their adenine fragments, and detects the hydrogen bonds mediat

206 responsible for recognizing and removing the adenine from 8-oxoG:adenine (8-oxoG:A) sites.

207 lhomocysteine nucleosidase (MTAN) hydrolyzes adenine from its substrates to form S-methyl-5-thioribos

208 roach to map A(syn)-T Hoogsteen and unpaired adenines genome-wide in vivo.

209 ph disease (SCA3/MJD), the expanded cytosine adenine guanine (CAG) repeat in ATXN3 is the causal muta

210 using the disease burden score and cytosine-adenine-guanine age product score.

211 nset after age 18 years, 36 or more cytosine-adenine-guanine repeats in the huntingtin gene, motor sy

212 ing (SAXS) methodologies to demonstrate that adenine/guanine dinucleoside polyphosphates bind to the

213 s in vitro by efficiently competing with the adenine/guanine mononucleotides for the allosteric sites

214 [(14)C]6-MP and [(3)H]adenine had K (m) values (+/-S.D.) of 163 +/- 126 and 37

215 tylphosphonium ([P(4444)](+)) hydroxide with adenine (HAd) and thymine (HThy) led to hydrated salts o

216 illustrated that YTHDC1 binds the methylated adenine in a single-stranded region flanked by duplexed

217 ases by adopting Hoogsteen base pairing with adenine in a Watson-Crick-like geometry.

218 Relative to unpaired adenines in a bulge, Watson-Crick A-T base pairs in dsDN

219 owing the voltammetric signal of guanine and adenine, increase in the presence of 7ESTAC01.

220 DHA crystal nephropathy induced by excessive adenine intake is unknown.

221 analysis extends the known motifs of protein-adenine interactions in the Watson-Crick edge of adenine

222 single base editors, A&C-BEmax's activity on adenines is slightly reduced, whereas activity on cytosi

223 the 'humanized' yeast grew in the absence of adenine, it did so poorly.

224 e promutagenic nature of the major oxidative adenine lesion.

225 nd dual-coding nature of the major oxidative adenine lesion.

226 We show that antibiotic-induced adenine limitation increases ATP demand, which elevates

227 catalyzes m6A methylation on 2-O-methylated adenine located at the 5' ends of mRNAs.

228 e approaches, we present the single-molecule adenine methylated oligonucleosome sequencing assay (SAM

229 DNA N6-adenine methylation (6mA) has recently been described in

230 potential eukaryotic epigenetic mark, DNA N6-adenine methylation (6mA) varies across species in abund

231 DNA adenine methylation by Caulobacter crescentus Cell Cycle

232 basis for hypothesizing the functions of DNA adenine methylation in MTBC physiology and adaptive evol

233 (2019) create a synthetic self-propagating adenine methylation system for epigenetic control in hum

234 This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis com

235 f interest (POI) to the Escherichia coli DNA adenine methyltransferase (Dam).

236 Our study identifies a diverged DNA N6-adenine methyltransferase and defines the role of 6mA in

237 gle-molecule sequencing method that combines adenine methyltransferase footprinting and single-molecu

238 fectively combines two existing methods: DNA adenine methyltransferase identification (DamID) and CEL

239 understanding chromatin biology in vivo DNA adenine methyltransferase identification (DamID) profile

240 in-DNA contacts by combining single-cell DNA adenine methyltransferase identification (DamID) with me

241 in immunoprecipitation (ChIP-seq) and/or DNA adenine methyltransferase identification (DamID-seq).

242 ession of an active HP1369-1370 fusion N (6)-adenine methyltransferase, designated M.HpyAXVII.

243 ite DNA templates using nonspecific DNA N(6)-adenine methyltransferases.

244 MutY glycosylase excises adenines misincorporated opposite the oxidatively damage

245 photoisomerized polyazobenzene (PETAzo) with adenine-modified ZnS (ZnS-A) nanoparticles (NPs) via nuc

246 es of homoazanucleosides, one possessing two adenine molecules, the other with two thymine moieties,

247 ther a templating cytosine (nonmutagenic) or adenine (mutagenic).

248 (HThy) led to hydrated salts of deprotonated adenine, [N(4444)][Ad].2H(2)O, and thymine, [P(4444)][Th

249 only conferred ~130-fold protection against adenine-N1 methylation, and this protection was reduced

250 on assays, we measured the susceptibility of adenine-N1 to methylation by dimethyl sulfate (DMS) when

251 The adenine nucleobase is stacked into the helix and forms a

252 analogues modified at the 2-position of the adenine nucleobase.

253 mmalian ciliary and flagellar beating via an adenine nucleotide homeostasis module.

254 ctivity was insensitive to inhibitors of the adenine nucleotide translocase (ANT) and of the voltage-

255 was attenuated by knockdown or inhibition of adenine nucleotide translocase (ANT), cyclophilin D (Cyp

256 trometry analysis identified this protein as adenine nucleotide translocase (ANT), represented by two

257 Proteomics screening identified adenine nucleotide translocase 3 (ANT3) as a previously

258 Unexpectedly, we find that the adenine nucleotide translocator (ANT) complex is require

259 uctions in the concentrations of cytoplasmic adenine nucleotide, creatine, and phosphate pools that o

260 (HPLC-ESI-MS/MS) to simultaneously quantify adenine nucleotides (AMP, ADP, and ATP), pyridine dinucl

261 Here, we show that guanine and adenine nucleotides exert positive and negative effects,

262 sults in complete loss of interrupting (LOI) adenine nucleotides in this region [(CAG)n-CAG-CAG].

263 DNA was sequence independent, and binding of adenine nucleotides to the protein induced the formation

264 he MMC/PTP, and were inhibited by Mg(2+) and adenine nucleotides, which also inhibit the PTP.

265 suppress depurination during the addition of adenine nucleotides.

266 rases, those that act on the amino groups of adenine or cytosine in DNA, have conserved motifs in a p

267 current base editors can only convert either adenines or cytosines.

268 Adenine phosphoribosyltransferase (APRT) deficiency is a

269 Adenine phosphoribosyltransferase (APRT) deficiency is a

270 Here, we developed an adenine phosphoribosyltransferase (APT)-based RNAi techn

271 Hereditary deficiency of adenine phosphoribosyltransferase causes 2,8-dihydroxyad

272 Patients with adenine phosphoribosyltransferase deficiency showed simi

273 The reversible adenine phosphoribosyltransferase enzyme (APRT) is essen

274 anism for catalysis in one of these enzymes, adenine phosphoribosyltransferase.

275 approach relies on the incorporation of poly-adenine (polyA) blocks in both nucleic acid probes and a

276 This site lies immediately adjacent to the adenines previously implicated in the RNAP3 TSS motif (C

277 successfully reversed calcification in this adenine rat model of CKD.

278 ogical applications, we utilize PESRS to map adenine released from bacteria due to starvation stress.

279 The induced phage DNA contains a methylated adenine residue in a specific motif.

280 This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks i

281 48.8 nmol L(-1) were recorded by guanine and adenine respectively.

282 t of the rRNA, and the aptamer domain of the adenine riboswitch) are in excellent agreement with expe

283 is discussed in light of their existence in adenine riboswitches, as well as the turnip yellow mosai

284 models of CKD, we induced CKD in rats by an adenine-rich diet or by 5/6 nephrectomy; we also used Ah

285 sulfate to the drinking water of rats fed an adenine-rich diet, we found an increase in indoxyl sulfa

286 lateral ureteral obstruction (UUO) or fed an adenine-rich diet-as well as in cultured primary human f

287 lize a parallel A-form-like duplex with a 5' adenine-rich pocket, which binds a metallic, trapezoidal

288 pecies that use the scanning model showed an adenine-rich region immediately upstream of the TSS that

289 at the leader-repeat junction as well as an adenine-rich sequence block in the mid-repeat.

290 cAMP modifications at position N (6) of the adenine ring (PKA) and position 2'-OH of the ribose (Epa

291 tyrosine side chain involved in locking the adenine ring after ATP binding.

292 -Crick edge of adenine and shows that all of adenine's edges may contribute to molecular recognition.

293 ENBT1 also mediated adenine-sensitive efflux of 6-MP from the SLC43A3-HEK293

294 In the adenine series, most ribose modifications and 1-deaza an

295 Second, adenine supplementation favors the pyridine salvage rout

296 pyridine metabolism in response to external adenine through two separable mechanisms.

297 Here, we show that in addition to converting adenine to guanine, adenine base editors also convert cy

298 measured and expected current values as each adenine travels through a pore.

299 in conferring specificity for the methylated adenines, whereas an extended basic surface present in T

300 Met's methyl group is then transferred to an adenine within the DNA recognition sequence.