ライフサイエンスコーパス: adeno-associated virus

1 1 was overexpressed by use of a cardiotropic adeno-associated virus.

2 y of CRISPR/Cas9 gene editing machinery with adeno-associated virus.

3 he murine heart was performed by means of an adeno-associated virus.

4 ll enough to be packaged efficiently into an adeno-associated virus.

5 er a single systemic delivery of recombinant adeno-associated virus.

6 ckout mice and mice injected with 3xMyc-FXR1 adeno-associated virus.

7 oteinaceous nanocontainers and genome-packed adeno-associated viruses.

8 time mice were intracranially injected with adeno-associated virus 1 expressing murine IL-6 (AAV1-mI

9 Transplantation of PCs pretransfected with adeno-associated virus 1-vascular endothelial growth fac

10 Adeno-associated virus 2 (AAV2) depends on the simultane

11 che for either virus to replicate.IMPORTANCE Adeno-associated virus 2 (AAV2) differs from most other

12 On the other hand, adeno-associated virus 2 (AAV2) is a helper-dependent de

13 Suppression of Sema3e using adeno-associated virus 2 carrying short hairpin RNA targ

14 replication, we constructed two recombinant adeno-associated-virus 2 (rAAV2) vectors encoding CIP fu

15 For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was a

16 AMT-060 combines an adeno-associated virus-5 (AAV5) vector with a liver-spec

17 We have used Cas9 and adeno-associated virus 6 to correct the DeltaF508 mutati

18 ntrols, were given injections of recombinant adeno-associated virus 8 vector that expressed the prima

19 d (fl/fl) Shc mice on FFD were injected with adeno-associated virus 8-thyroxine-binding globulin-Cre-

20 Adeno-associated virus 8-vascular endothelial growth fac

21 n-human primate model of HIV infection, with adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing

22 /iodide symporter) to noninvasively quantify adeno-associated virus 9 (AAV9)-mediated gene expression

23 Similarly, adeno-associated virus 9 (AAV9)-mediated restoration of

24 Here, we demonstrate that a recombinant adeno-associated virus 9 (rAAV9) is highly effective for

25 Adeno-associated virus 9 -mediated cardiac overexpressio

26 ic mice were injected with M7.8L packaged in adeno-associated virus 9 at 3 days of age and 60 days of

27 In the present study, we delivered adeno-associated virus 9 carrying green fluorescent prot

28 phy, we performed intramuscular injection of adeno-associated virus 9 carrying the TIPE2 gene in mdx

29 1-1-93 and treated with a sCAR-Fc expressing adeno-associated virus 9 vector 1, 3, and 7 days after C

30 exclusively in cardiomyocytes by using AAV9 (adeno-associated virus 9) to deliver multiplexed single

31 Moreover, adeno-associated virus 9- RHEB restored cardiac growth t

32 -type levels in a mouse model of I/R, as did adeno-associated virus 9-mediated ATF6 overexpression.

33 Adeno-associated virus 9-mediated Cdk5 inhibitory peptid

34 ior descending coronary artery ligation, and adeno-associated virus 9-mediated in vivo overexpression

35 An adeno-associated virus 9-mediated, cardiomyocyte-specifi

36 y cardiac-specific Lrg1 delivery mediated by adeno-associated virus 9.

37 was also increased in CPVT mice, and further adeno-associated virus-9-induced overexpression of SN at

38 e (RyR2 [ryanodine receptor 2]-R2474S) using adeno-associated virus-9-induced overexpression.

39 o synaptic damage in vivo, we have generated adeno-associated viruses AAV-Tat and AAV-Exo-Tat viruses

40 Adeno Associated Virus (AAV)-mediated gene expression in

41 We applied STN-DBS in an adeno-associated virus (AAV) 1/2-driven human mutated A5

42 Here we report a rationally designed adeno-associated virus (AAV) 6 capsid that demonstrates

43 ession in 1-month old mdx:utr (-/-) mice via adeno-associated virus (AAV) 9-mediated RNA interference

44 Using an adeno-associated virus (AAV) approach, coupled with geno

45 the VACV CRISPR antivirals was tested using adeno-associated virus (AAV) as a packaging vector for b

46 As an alternative, we developed an adeno-associated virus (AAV) based "Provector" whose cel

47 Adeno-associated virus (AAV) capsid modification enables

48 Adeno-associated virus (AAV) capsids can deliver transfo

49 We recently developed adeno-associated virus (AAV) capsids to facilitate effic

50 ice at 6 wks were injected unilaterally with adeno-associated virus (AAV) containing either NT3 or GF

51 g RNP delivery with naturally recombinogenic adeno-associated virus (AAV) donor vectors enables site-

52 roteostasis in AMD, we delivered recombinant adeno-associated virus (AAV) encoding Abeta42 and Abeta4

53 Adeno-associated virus (AAV) entry is determined by its

54 Adeno-associated virus (AAV) exhibits anterograde transn

55 Stable delivery of adeno-associated virus (AAV) expressing cKL to diabetic

56 uman alpha-synuclein (alpha-syn) fibrils and adeno-associated virus (AAV) expressing human wild-type

57 ats received nodose ganglia injections of an adeno-associated virus (AAV) expressing short hairpin RN

58 PVT involvement in conflict, we injected an adeno-associated virus (AAV) expressing the genetically

59 p an effective long-term therapy for NIU, an adeno-associated virus (AAV) gene therapy approach was u

60 fective therapy for corneal vascularization, adeno-associated virus (AAV) gene therapy, exploiting a

61 al cord via intrathecal administration of an adeno-associated virus (AAV) gene transfer vector signif

62 Adeno-associated virus (AAV) has been successfully used

63 PR/Cas9 systems that can be packaged into an adeno-associated virus (AAV) hold great promise for gene

64 However, in vivo delivery of mAgrin via adeno-associated virus (AAV) into FKRP mutant mice was u

65 Adeno-associated virus (AAV) is a leading vector for vir

66 Adeno-associated virus (AAV) is a promising gene therapy

67 Adeno-associated virus (AAV) is a promising vector for g

68 Adeno-associated virus (AAV) is a replication-deficient

69 Adeno-associated virus (AAV) is frequently used to manip

70 The adeno-associated virus (AAV) non-structural Rep proteins

71 ating protein (AAP) is a recently discovered adeno-associated virus (AAV) protein that promotes capsi

72 nervous system, we systemically delivered an adeno-associated virus (AAV) serotype 9 carrying the hum

73 ght to determine the efficacy of intrathymic adeno-associated virus (AAV) serotypes to transduce thym

74 The adeno-associated virus (AAV) serves as a broadly used ve

75 placement of SDS-PAGE for purity analysis of adeno-associated virus (AAV) therapeutic products of dif

76 show in adult animals successfully delivers adeno-associated virus (AAV) throughout the cervical, th

77 previously reported compassionate use of an adeno-associated virus (AAV) vector containing the human

78 The adeno-associated virus (AAV) vector effectively transduc

79 ed bilateral alBST-targeted injections of an adeno-associated virus (AAV) vector expressing short hai

80 Conventional methods to discern adeno-associated virus (AAV) vector transduction pattern

81 dministered a single intravenous dose of the adeno-associated virus (AAV) vector, AAV-BR1-CAG-NEMO, d

82 Intracerebroventricular injection of an adeno-associated virus (AAV) vector-based system encodin

83 Adeno-associated virus (AAV) vector-mediated gene delive

84 e a critical pre-clinical model for studying adeno-associated virus (AAV) vector-mediated gene therap

85 Neutralizing antibodies to adeno-associated virus (AAV) vectors are highly prevalen

86 Adeno-associated virus (AAV) vectors are preeminent in e

87 Adeno-associated virus (AAV) vectors are the leading pla

88 ants identified Anc80L65 from a set of other adeno-associated virus (AAV) vectors as a potent vector

89 that intramuscular or systemic injections of adeno-associated virus (AAV) vectors encoding nuclease-d

90 Herein, we review the use of adeno-associated virus (AAV) vectors for delivery of HIV

91 We investigated adeno-associated virus (AAV) vectors for gene delivery t

92 Gene therapy with adeno-associated virus (AAV) vectors has demonstrated ap

93 avoid these issues, and such approaches with adeno-associated virus (AAV) vectors have been shown to

94 Immune responses in gene therapy with adeno-associated virus (AAV) vectors have been the objec

95 Adeno-associated virus (AAV) vectors have been used succ

96 Adeno-associated virus (AAV) vectors have made great pro

97 Adeno-associated virus (AAV) vectors have shown promisin

98 anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for t

99 HiUGE employs adeno-associated virus (AAV) vectors of autonomous inser

100 rapeutics directly into the human body using adeno-associated virus (AAV) vectors.

101 iniaturized utrophin (uUtro), deliverable by adeno-associated virus (AAV) vectors.

102 We combined the adeno-associated virus (AAV) with the Cre-loxP site-spec

103 n mouse are systematically investigated with adeno-associated virus (AAV), an anterograde viral trace

104 ere we present two methods for radiolabeling adeno-associated virus (AAV), one of the most commonly u

105 a similar efficacy by gene augmentation via adeno-associated virus (AAV), providing a proof-of-conce

106 acrRNA)-independent CRISPR-Cpf1 systems with adeno-associated virus (AAV), we were able to build a st

107 Adeno-associated virus (AAV)-based gene therapies can re

108 Adeno-associated virus (AAV)-based gene therapy is a pro

109 lian MG proliferation, along with reports of adeno-associated virus (AAV)-based MG reprogramming and

110 Adeno-associated virus (AAV)-Cre-mediated Vgf ablation i

111 HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as

112 iant ribozymes enabled in vivo regulation of adeno-associated virus (AAV)-delivered transgenes, allow

113 A new adeno-associated virus (AAV)-driven somatic genome-editi

114 We found that delivery of Adeno-associated virus (AAV)-expressing miR760 in the ce

115 ficiency on atherosclerosis using a model of adeno-associated virus (AAV)-induced hypercholesterolemi

116 on as an inflammatory disease model and used adeno-associated virus (AAV)-mediated Ac45 RNA interfere

117 ine for HIV is a crucial public health need; adeno-associated virus (AAV)-mediated antibody gene deli

118 Here we report that a system of adeno-associated virus (AAV)-mediated clustered regularl

119 we report a genome editing approach in which adeno-associated virus (AAV)-mediated CRISPR/Cas9 delive

120 ment of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)-mediated expression of hACE

121 We found that recombinant adeno-associated virus (AAV)-mediated expression of IL-1

122 njection of recombinant sTREM2 protein or by adeno-associated virus (AAV)-mediated expression.

123 Primary adult rat ventricular myocytes, adeno-associated virus (AAV)-mediated gene delivery in m

124 enerated mice with elevated expression using adeno-associated virus (AAV)-mediated gene delivery.

125 We use adeno-associated virus (AAV)-mediated gene editing to kn

126 Adeno-associated virus (AAV)-mediated gene therapy is cu

127 Adeno-associated virus (AAV)-mediated gene therapy is un

128 Here, we describe the development of an adeno-associated virus (AAV)-mediated gene therapy to tr

129 To address this challenge, we first used adeno-associated virus (AAV)-mediated gene transfer to p

130 Adeno-associated virus (AAV)-mediated SaCas9-KKH deliver

131 d single guide RNA cassette are nested in an adeno-associated virus (AAV).

132 he efficient delivery of donor template with adeno-associated virus (AAV).

133 genomes derived from another parvovirus, the adeno-associated virus (AAV).

134 enic mice that receive systemic injection of adeno-associated virus (AAV)2/1-carrying truncated gRNAs

135 D1(+/L144F) MNs, and intrathecal delivery of adeno-associated virus (AAV)9-mir-17~92 improves motor d

136 To address this, we developed a novel adeno-associated virus (AAV-GLP-1R) that utilizes short

137 Adeno-associated viruses (AAV) are composed of nonenvelo

138 Adeno-associated viruses (AAV) are helper-dependent parv

139 hindered by large size (limiting delivery by adeno-associated virus [AAV] vectors), off-target editin

140 l of SCLC by delivering an adenovirus (or an adeno-associated virus [AAV]) that expresses Cre recombi

141 Here, we discovered that adeno-associated viruses (AAV1 and AAV9) exhibit anterog

142 dy(2j)/dy(2j) mouse model of MDC1A using an adeno-associated virus (AAV9) carrying a catalytically i

143 gene was delivered to the brains of mice by adeno-associated virus (AAV9) via stereotactic injection

144 ockout (L-G6pc(-/-) ) mice were treated with adeno-associated viruses (AAVs) 2 or 8 directed against

145 Adeno-associated viruses (AAVs) are attractive gene ther

146 Adeno-associated viruses (AAVs) are commonly used for in

147 Adeno-associated viruses (AAVs) are dependoparvoviruses

148 Adeno-associated viruses (AAVs) are frequently used for

149 Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and

150 Adeno-associated viruses (AAVs) are typically single-str

151 es of CRISPR-associated protein 9 (Cas9) and adeno-associated viruses (AAVs) evades adaptive immune r

152 Adeno-associated viruses (AAVs) from clade E are often u

153 in defined cell types, recombinase-dependent adeno-associated viruses (AAVs) have become the tool of

154 fficient AAV genome transcription.IMPORTANCE Adeno-associated viruses (AAVs) have proven to be effect

155 rity and tight junction integrity.IMPORTANCE Adeno-associated viruses (AAVs) have recently emerged at

156 Delivery via adeno-associated viruses (AAVs) is limited by AAV packag

157 sting neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) pose a major, unresolved

158 ified here by stamping cultured neurons with adeno-associated viruses (AAVs), is completed in a few m

159 bout 75 Snord115 genes were packaged into an adeno-associated virus and administered to a mouse model

160 D1-MSNs versus D2-MSNs using a Cre-inducible adeno-associated virus and Cre lines during cocaine cond

161 urb a specific molecular interaction between adeno-associated virus and its host cell, which can be r

162 eta receptor 2 [sTGFbetaR2]) delivered using adeno-associated viruses and explored their ability to m

163 cargo including nucleic acids, polypeptides, adeno-associated viruses, and nanodots.

164 Using an adeno-associated virus approach, we validate that miR-19

165 B19 is a long-known human pathogen, whereas adeno-associated viruses are nonpathogenic.

166 Systemic injection of adeno-associated virus-BAG3(Ile81) (n=9), but not BAG3(M

167 e treatment of a mouse model of OPMD with an adeno-associated virus-based gene therapy combining comp

168 Leading the way has been the use of adeno-associated virus-based strategies for factor IX ge

169 Adeno-associated virus-based transduction of Dnase1l3 in

170 ntramuscular administration of a recombinant adeno-associated virus-based vector (rAAV vector) expres

171 Moreover, intra-articular injection of adeno-associated virus carrying HPIP-specific short hair

172 versely, overexpression of VZVsncRNA13 using adeno-associated virus consistently increased VZV spread

173 We present 15 adeno-associated virus constructs and 6 mouse reporter l

174 We have designed a double-stranded adeno-associated virus containing a rat proglucagon prom

175 We injected recombinant adeno-associated virus containing the CRRY coding sequen

176 d deep sequencing results confirmed that our adeno-associated virus-CRISPR/Cas9 strategy was very eff

177 by a single-dose systemic administration of adeno-associated virus-delivered CRISPR-Cas9 components

178 tment of the gyrencephalic brain by systemic adeno-associated virus delivery in human neurological di

179 Intratumoral adeno-associated virus delivery of CRISPRa libraries eli

180 iabetes and two models of type 2 diabetes by adeno-associated virus delivery of renin (ReninAAV).

181 Here, we show that adeno-associated virus-driven expression of progranulin

182 reated with a single intrathecal infusion of adeno-associated virus encoding a microRNA targeting SOD

183 BALB/c mice treated with adeno-associated virus encoding the BL6 BAG3 variant (Il

184 hydrodynamic injection or transduction with adeno-associated virus encoding the HBV genome (AAV-HBV)

185 We treated mice with either adeno-associated viruses encoding a control (green fluor

186 We investigated whether exosome-associated adeno-associated virus, (exo-AAV) enabled broad retinal

187 ta signaling in the substantia nigra through adeno-associated virus expressing a constitutively activ

188 Next, the anterograde transport of an adeno-associated virus expressing DREADDs was paired wit

189 of stress-susceptible or mice injected with adeno-associated virus expressing shRNA against Cldn5 ca

190 Local injection of adeno-associated viruses expressing sgRNA-guided CjABE i

191 of tauopathy utilizing neonatal delivery of adeno-associated viruses expressing wild-type (WT) or mu

192 noted similar results in mice infected with adeno-associated virus-expressing small hairpin RNAs tar

193 e that overproduce sclerostin as a result of adeno-associated virus expression from the liver.

194 es; disruption of anchoring in vivo using an adeno-associated virus gene therapy vector inhibited car

195 Additionally, adeno-associated virus has demonstrated outstanding pote

196 n of c-Fos using photoreceptor-specific AAV (adeno-associated virus)-hRK (human rhodopsin kinase)-sh_

197 We injected Cre-dependent adeno-associated virus in an Rbp4-Cre transgenic mouse l

198 rformed by orotracheal transgene delivery of adeno-associated virus in mouse models of PH.

199 ng reporter genes into the safe-harbor locus adeno-associated virus integration site 1 in human embry

200 In addition, introduction of 3xMyc-FXR1 via adeno-associated virus into mice leads to the redistribu

201 of CRISPRa, we injected CRISPRa-recombinant adeno-associated virus into the hypothalamus, which led

202 s when the packaging capacity of recombinant adeno-associated virus is limited while tissue-specific

203 Systemic delivery of dCas9/gRNA by adeno-associated virus led to reductions in pathological

204 nd loss of KLF5 function approaches and AAV (adeno-associated virus)-mediated Klf5 delivery in mice s

205 gulation and that induction of NRF2 using an adeno-associated virus-mediated approach in hepatocytes

206 of spared axons, using projection-specific, adeno-associated virus-mediated chemogenetic neuronal si

207 imary striatal cell culture model of HD, and adeno-associated virus-mediated Elk-1 overexpression all

208 llel, we explored the effects of recombinant adeno-associated virus-mediated expression of Abeta38 an

209 Furthermore, adeno-associated virus-mediated expression of CCN1 rever

210 ene deletion in the NAc in adult mice, using adeno-associated virus-mediated expression of cre recomb

211 tem, we intravitreally delivered recombinant adeno-associated virus-mediated expression of soluble Fm

212 To assess efficacy in vivo, we used adeno-associated virus-mediated expression of the most p

213 Conditional gene deletion and adeno-associated virus-mediated gene delivery in the mou

214 u scFvs and tested their efficacy in vivo by adeno-associated virus-mediated gene transfer to the bra

215 Adeno-associated virus-mediated increase in AKT activati

216 sue of the JCI, Wang et al. demonstrate that adeno-associated virus-mediated overexpression of TGF-be

217 ma cells and in mice by peptide injection or adeno-associated virus-mediated overexpression.

218 Adeno-associated virus-mediated Snapin overexpression in

219 We also show that targeted adeno-associated virus-mediated suppression of claudin-5

220 Adeno-associated virus-mediated targeting of RGMa to mou

221 In contrast, transgenic or adeno-associated virus-mediated TNFAIP3 gene delivery in

222 Here we developed an adeno-associated virus-mediated, autochthonous genetic C

223 e injection of an engineered virus, often an adeno-associated virus or herpes simplex virus, among ma

224 s9 mRNA, compared with cells transduced with adeno-associated virus or lentivirus expressing SaCas9.

225 n via stereotactic hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse

226 We generated multifunctional hybrid adeno-associated virus/phage (AAVP) particles to enable

227 Adeno-associated virus-progranulin also corrected lysoso

228 The adeno-associated virus-progranulin vector only transduce

229 teral, intranigral injections of recombinant adeno-associated virus pseudotype 2/5 to overexpress wil

230 At day 28, recombinant adeno-associated virus (rAAV) (5 x 10(12) viral particle

231 Infusion of a recombinant adeno-associated virus (rAAV) containing a functional Av

232 The recent market approvals of recombinant adeno-associated virus (rAAV) gene therapies in Europe a

233 Recombinant adeno-associated virus (rAAV) is an attractive tool for

234 trolled release of a therapeutic recombinant adeno-associated virus (rAAV) vector overexpressing the

235 that the non-tumor-bearing (NT), recombinant adeno-associated virus (rAAV) vector-treated GSD-Ia mice

236 tional microdystrophin genes and recombinant adeno-associated virus (rAAV) vectors is an attractive s

237 ne therapy in G6pt-/- mice using recombinant adeno-associated virus (rAAV) vectors, directed by eithe

238 Recombinant adeno-associated viruses (rAAVs) are currently considere

239 Recombinant adeno-associated viruses (rAAVs) are efficient gene deli

240 ved by transducing the BSCs with recombinant adeno-associated viruses (rAAVs) that express alpha-synu

241 Adeno-associated virus receptor (AAVR) (also named KIAA0

242 Delivery of apoptotic RASER by adeno-associated virus selectively ablated ErbB-hyperact

243 bly of 3 types of icosahedral viral capsids: Adeno Associated Virus serotype 2 (AAV2) and Minute Viru

244 Specifically, we labeled adeno-associated virus serotype 10 expressing the coding

245 gets by performing intraspinal injections of adeno-associated virus serotype 2 (AAV2)-BDNF vector.

246 elation to recent clinical translation in an adeno-associated virus serotype 2-mediated human aromati

247 Adeno-associated virus serotype 5 (AAV5) is being develo

248 single intravenous dose of a codon-optimized adeno-associated virus serotype 5 (AAV5) vector encoding

249 Finally, adeno-associated virus serotype 8 (AAV8)-mediated reexpr

250 rphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy ve

251 acy of gene therapy for NPC1, we constructed adeno-associated virus serotype 9 (AAV9) vectors to deli

252 es and human leukocyte antigen (HLA)-A2.1 by adeno-associated virus serotype 9 (AAV9) vectors.

253 We modulated expression of FTO by using adeno-associated virus serotype 9 (in vivo), adenovirus

254 23a was expressed using a self-complementary adeno-associated virus serotype 9 (scAAV9) viral vector

255 Adeno-associated virus serotype 9 carrying cardiac-speci

256 h SMA1 received a single dose of intravenous adeno-associated virus serotype 9 carrying SMN complemen

257 In contrast, mice injected with adeno-associated virus serotype 9 encoding PDE4B (10(12)

258 Similarly, adeno-associated virus serotype 9 encoding PDE4B slowed

259 cyte-specific overexpression of PDE4B and an adeno-associated virus serotype 9 encoding PDE4B.

260 An in vivo rescue experiment with adeno-associated virus serotype 9 TnT-MEK1-CA nearly abo

261 CRISPR/Cas9-based cardiac gene editing using adeno-associated virus serotype 9 to deliver a single sh

262 In vivo, AAV9 (adeno-associated virus serotype 9)-mediated cardiac over

263 Using intrathecal adeno-associated virus serotype 9-based delivery, the gl

264 ic implications, we found that prior in vivo Adeno-associated virus serotype 9-mediated gene delivery

265 METHODS AND Using an in vivo Adeno-associated virus serotype 9-mediated gene transfer

266 ons, we employed systemic administration via adeno-associated virus serotype 9.

267 Pak2 activation by genetic overexpression or adeno-associated virus serotype-9-based gene delivery wa

268 Moreover, IRE-1 activator, Quercetin, and adeno-associated virus serotype-9-delivered XBP-1s were

269 Adeno-associated virus-Sesn2 was delivered to aged heart

270 R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was s

271 Cbeta was genetically targeted using a novel adeno-associated virus shuttle vector to deliver microRN

272 ticular administration of miR-204-expressing adeno-associated virus significantly decelerates OA prog

273 g within the VTA, we delivered Cre-inducible adeno-associated virus that drives the expression of flu

274 er a single intravenous administration of an adeno-associated virus that encodes CRISPR (AAV-CRISPR).

275 ice (NTS-HIF-1alpha(-/-) ) by microinjecting adeno-associated virus that expressed Cre-recombinase in

276 injected into NAc variants of a new designer adeno-associated virus that permits robust retrograde ac

277 from a transgene or after infection with an adeno-associated virus that transferred an overlength HB

278 in mice, using Cre recombinase delivered by adeno-associated virus to knockout endogenous hepatic In

279 Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools

280 of HCC in patients with hepatitis B virus or adeno-associated virus type 2 infection might involve ac

281 patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the

282 fferent transgenic Cre mice or injected with adeno-associated virus type 8 (AAV8) Cre and fed diets t

283 G of CXCL10(-/-) mice, using the neurotropic adeno-associated virus type 8 (AAV8) vector, boosted the

284 cus aureus) and guide RNA constructs into an adeno-associated virus vector and systemically delivered

285 SG -( K(b) D(b)) (null) ( IA(null)) mice via adeno-associated virus vector increased human CD45(+) ce

286 Genomic integration of the adeno-associated virus vector into Cas9 target sites cau

287 F21 by administration of an FGF21-expressing adeno-associated virus vector recapitulated these compli

288 Intravascular injection of certain adeno-associated virus vector serotypes can cross the bl

289 erapy approach for Alzheimer's disease using adeno-associated virus vector-based knockdown of CD33 re

290 receptor retargeting.IMPORTANCE Recombinant adeno-associated virus vectors (rAAVs), based on AAV8 an

291 Using retrograde adeno-associated virus vectors and transgenic mice expre

292 Intrahippocampal injections of adeno-associated virus vectors containing the astrocyte-

293 atory elements in the context of recombinant adeno-associated virus vectors has enabled cell-type-res

294 we show that expression of these genes from adeno-associated virus vectors in C57BL/6 mice is able t

295 gnaling in a common mouse model of AD, using adeno-associated virus vectors normalized glutamate sign

296 human patients, and gene augmentation using adeno-associated virus vectors robustly sustained the re

297 assemblies, similar to the best recombinant adeno-associated virus vectors.

298 wild-type mice via stereotaxic injection of adeno-associated virus, we found that adult cerebellar n

299 l vectors can package larger transgenes than adeno-associated viruses, yet lentiviral vectors remain

300 liver-specific overexpression of human ZIP8 (adeno-associated virus-ZIP8 [AAV-ZIP8]) resulted in incr